巻号一覧
前身誌
54 巻, 12 号
選択された号の論文の11件中1～11を表示しています
- |<
- <
- 1
- >
- >|
-
松崎 宸1978 年 54 巻 12 号 p. 1307-1313
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (539K) -
井林 博1978 年 54 巻 12 号 p. 1314-1323
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (733K) -
荒井 清1978 年 54 巻 12 号 p. 1324-1330
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (467K) -
玉田 太朗1978 年 54 巻 12 号 p. 1331-1340
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (607K) -
三好 秋馬1978 年 54 巻 12 号 p. 1341-1346
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (426K) -
鎮目 和夫1978 年 54 巻 12 号 p. 1347-1352
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (579K) -
松木 駿, 原納 優, 繁田 幸男, 七里 元亮, 池田 義雄, 石川 勝憲, 山本 章, 近森 一正, 西村 典三, 末広 史恵, 和泉 ...1978 年 54 巻 12 号 p. 1353-1366
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (1298K) -
入江 実, 末松 弘行, 吉植 庄平, 加藤 達雄, 鈴木 裕也, 松木 駿, 末松 弘行, 加藤 弘巳, 森本 靖彦, 高原 二郎, 細木 ...1978 年 54 巻 12 号 p. 1367-1384
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (1424K) -
矢追 良正, 熊坂 高弘, 西 望, 斉藤 幹, 有村 章1978 年 54 巻 12 号 p. 1385-1398
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーLH-RHを用いての排卵誘発の試みは, その血中消極が極めて速やかであるために, 排卵成功率は芳しくなかった.その後LH-RHのanaloguesが次々と開発され, そのうちの一つ [Des-Glylo] [Pro9-ethy-lamide] -LH-RHはLH-RHよりも強力で持続性のあるもの, 即ちpotentanalogとして紹介された.われわれはこのanalogを用いて, 臨床的検討を行うと共に, 続発性無月経の婦人に対し排卵誘発を試みた. [Des-Gly10] [Pro9-ethylamid。] -LH-RH (以下EA-LH-RHと略す) 100μ9を続発性無月経婦人に連日皮下投与すると, 血中FSH値の前値は最初の数日間はやや上昇し, 反応性も保たれているが, FSH, LH共に反応性は日を追って低下する.Estrogen値はFSH前値の動きに対必し, 1～2日遅れで変動した.卵胞の発育・成熟度は頸管粘液 (CMと略す) の量・牽糸性・結晶度を, 排卵の有無は基礎体温 (BBTと略す) の変動を以って指標とした.続発第1度無月経の症例で, 数日間 (3-6日) のanalog連日投与によりCMの改善されたものではanalogのみで14%に, analog投与によりCMが改善された時点でHCGを追加投与したものでは22%に排卵を誘発し得た.続発第2度無月経症例では, CMの改善後HCG投与にも拘らず排卵率は極めて僅かであり, 多くは消槌出血に終った.連日投与にも拘らずCMの改善されなかった症例では, 投与期間を延ばしても (10日間) 無変化であった.即ち短期間analogを連日投与することによってCMのの改善される症例では, このanalog-HCGtherpyによって排卵が期待できる.しかしanalog-HCGtherapyを数周期にわたって反復施行している間に, 排卵障害の程度が改善され, 遂に自然排卵を起こすに到り, 引き続き妊娠した例があったことは, いわゆるdelayedreactionとして注目される.抄録全体を表示PDF形式でダウンロード (1048K) -
石井 均, 森 徹, 高山 英世, 小西 淳二, 笠木 寛治, 遠藤 啓吾, 鳥塚 莞爾1978 年 54 巻 12 号 p. 1399-1406
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーIn 1913 Plummer presented the concept of two distinct types of hyperthyroidism : exophthalmic goiter and adenomatous goiter. Thereafter the latter was divided into two; these are multinodular toxic goiter (MTG) and toxic nodular goiter. MTG is known to be somewhat prevalent in foreign countries; however, the incidence of MTG in Japan is extremely low.
In this paper, we present three cases of MTG disclosed by clinical and laboratory findings. The main features of these patients are as follows :
1) They were all young females with no apparent exophthalmos-and no history of antecedent non toxic multinodular goiter.
2) On palpation, their goiters were found to be multinodular and soft, and cyst formation was found in two of them.
3) On thyroid scintiscanning, two of them showed diffusely irregular uptake patterns, and one of them had a cold nodule simultaneously; however, the remainder showed uniform accumulation.
4) Serum T4 concentrations were normal or slightly elevated, but serum T3 values were markedly elevated (T33 toxicosis). Positive suppression by oral T3 administration was ob-served in two of them, but TRH tests were negative in all.
5) LATS and HTACS (Human Thyroid Adenyl Cyclase Stimulator) levels were normal in all, but an abnormal TBII (Thyrotropin Binding Inhibitor Immunoglobulin) level was found transiently in one.
6) Histopathologic examinations revealed pictures of adenomatous goiter with hyperplastic epithelium in all. But in one case with transient TBII, chronological observations of a needle biopsied specimen revealed gradual resemblance to that of Graves' disease.
7) From the above findings, we concluded that the patients had MTG, but that it was slightly different in nature from that frequently seen in foreign countries. Furthermore, we would like to propose the possibility that MTG might develop into Graves' disease.抄録全体を表示PDF形式でダウンロード (1311K) -
本山 敏彦1978 年 54 巻 12 号 p. 1407-1420
発行日: 1978/12/20
公開日: 2012/09/24
ジャーナル フリーSteroid receptors in benign human uterine tumors and disorders were characterized and investigated to clarify their clinical significance.
A 248,800x g supernatant of tissue homogenates was used for the cytosol, where the steroid receptor was characterized and determined by a Scatchard plot. In the myo-metrial cytosol, the estrogen receptor (=ER) was sedimented to the 7S, 5S and 4S regions, and the estradiol-17β (=E2) -ER complex demonstrated the dissociation constant (=Kd) = 4.5×10110M (at 4°C, by dextran coated charcoal=DCC). The progesterone receptor (=PR) was sedimented to the 7S and 4S regions, and the Kd of the progesterone-PR complex was 1.5x 10-9M (at 4°C by DCC). The androgen receptor (=AR) was sedimented to the 7-6S and 5S regions, and the dihydrotestosterone (=DHT) -AR complex demonstrated Kd=4.0x 10-10M (at 4°C by DCC). All of these steroid-7S bindings were easily degraded during sucrose gradient centrifugation. A ligand specificity study characterized the specificity of the receptors.
There was no relation between the steroid receptor level in the myometrium and the corresponding myoma. The steroid receptor level was determined during the menstrual cycle and did not show a constant tendency.
In adenomyosis, the histological dating showed a delay in the aberrant endometrium of adenomyosis when compared with the dating of a normal endometrium. This indicates that the steroid is less responsive to the aberrant endometrium in adenomyosis than to the corresponding normal endometrium. ER and AR were detected in all cases, but PR was not detected in some of them. Thus it would seem that the lower responsiveness of adenomyosis tissue to progestogen is derived from the lower content of PR.
In most cases of endometriosis the steroid receptor was detected; however, the level of PR in endometriosis was much lower than that of a corresponding normal endometrium. This indicates that most cases of endometriosis respond to steroids, but to a lesser extent than to progestogen.抄録全体を表示PDF形式でダウンロード (1175K)
- |<
- <
- 1
- >
- >|