Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 30, Issue 1
Displaying 1-23 of 23 articles from this issue
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  • The significance of the value of the molar ratio (Val+Ile+Leu/Phe+Tyr) on portal hypertension
    Kohei HAYASHI
    1989 Volume 30 Issue 1 Pages 1-10
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1
    JOURNAL FREE ACCESS
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    The significance of the value of the molar ratio (Val+Ile+Leu/Phe+Tyr) is investigated in cases with portal hypertension.
    The value of the molar ratio, which was correlated with the degree of hepatic encephalopathy by Fischer, is not so much correlated with the rate of slow waves in the EEG (θ+δ/α+θ+δ) as blood ammonia levels, and changed in few cases irrespective of the presence of hepatic encephalopathy.
    Because a highly significant correlation existed between the value of the molar ratio and that of ICGR15, the value of the molar ratio was suggested to be useful to estimate the degree of liver damage.
    Comparing the hepatofugal group with the hepatopetal group, the plasma branched amino acid concentrations had reciprocal relation with blood ammonia levels. So I supposed both had some mural relation on the matabolism of peripheral tissues.
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  • Effects of propranolol and nitroglycerin on hepatic circulation, and the mechanism of thier reducing portal pressure
    using hydrogen gas generated by electrolysis and ultrasonic pulsed Doppler system
    Mitsuhiro TERADA
    1989 Volume 30 Issue 1 Pages 11-19
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.11
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    To elucidate the mechanism of their reducing portal pressure, liver tissue blood flow, portal blood flow, hepatic arterial blood flow, heart rate and mean arterial pressure were measured on 50 patients with chronic liver disease before and after infusion of propranolol (10mg) and nitroglycerin (0.5mg).
    After infusion of propranolol, liver tissue blood flow decreased by 28.5±10.3% (p<0.001), portal blood flow decreased by 26.6±10.9% (p<0.001), hepatic arterial blood flow decreased 16.7±10.5% (p<0.01), heart rate decreased by 18.6±3.4% (p<0.001) and mean arterial pressure decreased by 4.9±5.9% (p<0.001).
    After infusion of nitroglycerin, liver tissue blod flow, portal blood flow and hepatic blood flow were not changed significantly, but heart rate increased by 13.2±14.1% (p<0.01) and mean arterial pressure decreased by 14.5±5.9% (p±0.001).
    From these results, it seems that propranolol reduced portal venous pressure by decreasing the portal blood flow and that nitroglycerin reduces portal venous pressure by decreasing the resistance of portal-hepatic bed. Then, it was suggested that nitroglycerin might be useful for reducing portal venous pressure because of keeping the hepatic inflow.
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  • Intratumoral combination therapy of human fibroblast interferon and controlled-release needle of antitumor drug on human hepatocellular cacinoma cells in nude mice
    Akihiko FURUSAWA
    1989 Volume 30 Issue 1 Pages 20-27
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.20
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    The growth inhibitory effects of human fibroblast interferon (IFN-β) and controlled-releas needle of antitumor drugs, Mitomycin (MMC) or Adriamycin (ADM) on human hepatocellular carcinoma (HCC) cell line PLC/PRF/5 by intratumoral injection were examined. Nude mice with xenografted tumors derived from the PLC/PRF/5 cell line were treated with IFN-β twice a week for 5 weeks. Neither an IFN dose of 6×104IU/day nor 3×105IU/day was able to reduce the tumor weight and the AFP production. On the other hand, the combination of controlled-release needles plus IFN-β at a dose of 3×105IU was more effective than these needles alone. These results suggest that intratumoral injection of IFN-β may be of benefit to the patients with HCC when administered in combination with antitumor chemotherapy.
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  • Pathomorphological study on early hepatocellular carcinoma
    A study of capsule and septum formation
    Osamu NAKASHIMA
    1989 Volume 30 Issue 1 Pages 28-34
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.28
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    In order to clarify the pathomorphological characteristics of the capsule and fibrous septum of hepatocellular carcinoma (HCC), 47 surgically resected HCCs smaller than 3cm in diameter were studied grossly and histologically. Grossly, the majority of the resected HCCs shows an expansive growth pattern. Thirty six out of 47 the cases (76.6%) were single nodular type with or without perinodular tumor growth. Thin fibrous capsule and fibrous septa were observed in 29 (61.7%) and 38 cases (80.9%), respectively. Both capsule and septum were found in 26 cases (55.3%). Among 7 HCCs smaller than 1cm in diameter, the capsule and septum were seen only in one case, respectively. Thus, the capsule and septum of HCC seem to be formed when the tumor size reaches around 1.5cm in diameter in most cases. According to the fact that more thantwo-third of small HCC have the capsule and/or the septum, the imaging demonstration of them in space occupying lesions of the liver is quite helpful in diagnosis of HCC.
    Three possible mechanisms were considered in the septum formation in HCC. Type 1. Engulfing of the old capsule within the tumor following extra-capsular tumor growth. Type 2. Condensation of fibrous components at the boundary of cancerous tissues exhibiting different histologic features. Type 3. In confluent multinodular tumor, fibrous stromas between each tumor nodule are retained within the tumor as the septum when tumors become confluent. Among the 38 resected HCCs with septum, Type 1 septum was seen in 24 cases (63.2%) and was the most common.
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  • Clinical significance of α-L-fucosidase activity in liver diseases
    Especially in hepatocellular carcinoma
    Seiji IDEGUCHI
    1989 Volume 30 Issue 1 Pages 35-42
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.35
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    Serum α-L-fucosidase (AFU) activity was examined in 110 cases of various liver diseases. Serum AFU activity was 599.1±115.1nmol/ml/hr in normal contorols, while it was above 1, 000nmol/ml/hr in acute hepatitis, hepatocellular carcinoma (HCC) and alcoholic liver diseases. Serum AFU correlated well with γ-GTP and alkaline phosphatase levels, but not with GPT and GOT. In HCC, AFU and AFP tended to have a weak correlation, but there was no statistical significance. In 55% of AFP-negative HCC, AFU was positive. It was suggested that AFU was useful as a new tumor marker in HCC. Furthermore, it was reccognized that AFU had a pretty good correlation with tumor size. In transcatheter arterial embolization (TAE) of HCC, AFU increased on the next day and two weeks after TAE, which implicated not only release from necrotized tumor but also production by viable cells. AFU activity of the liver tumor were analyzed by Sephadex G-200 column chromatography, which resulted in the appearance of three peakes, the third peak of which was not noted in non-cancerous liver tissue. The above experiment might suggest the pressence of tumor specific AFU. Thus, AFU activity could become another tumor marker in the diagnosis of HCC.
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  • Hepatic necrosis and fibrosis after ethanol injection
    Kenichiro MATSUZAKI, Yukio YOKOI, Hiroyuki KURODA
    1989 Volume 30 Issue 1 Pages 43-48
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.43
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    Absolute ethanol has been widely proposed for several years as an agent for therapeutic injection against small hepatocellular carcinomas. We measured necrotic areas in normal rat livers caused by injections of varied concentrations of ethanol (25%, 50%, 75%, 99.5%) after a period of 72hr. Necrotic areas increased significantly in relation to increasing ethanol concentrations (p<0.01). We have reported that desmin existed in cytoplasma of Ito cells and that, conversely, Ito cells were easily found by desmin staining of damaged livers. Fibrosis in hepatic lobules was suggested to depend upon Ito cells. We observed Ito cells and hepatic fibrosis after absolute ethanol injections by using desmin staining. After 24hr, the number of Ito cells slightly increased around necrotic areas and polymorphonuclear leukocytes infiltrated into necrotic areas. After 48hr, Ito cells were observed around necrotic areas, formed into layers, and their cytoplasmic processes were elongated. However, fibrosis was slight. After 72hr, coagulation necrosis was apparently observed and fibrous bands were evident. Ito cells increased in number around necrotic areas, and their cytoplasmic processes elongated, and they attached themselves to that of neighboring cells. Ito cells decreased with the progress of fibrosis thereafter. These findings suggest that Ito cells show a close relationship to hepatic fibrosis.
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  • Splenic dynamics after hepatectomy
    Naoki YAMANAKA, Eizo OKAMOTO, Akihiro TOYOSAKA, Toshihiro KATO, Shiro ...
    1989 Volume 30 Issue 1 Pages 49-54
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.49
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    Serial changes in splenic volumes after hepatectomy were studied in relation to the massiveness of resection in the 18 non-cirrhotics (N) and 22 cirrhotics (LC). The massiveness, resection rate (%), was categolized to three classes S (30%), M (30-50%) and L (50%<), based on CT measurements. Changing patterns roughly constituted three types including no significant change (A), and increases with (B) or without (B') subsequent return to the initial level. The patterns were regulated strongly by the resection rate in the two group. That is, S, M, and L class tended to demonstrate type A, B and B', respectively. Maximal increases in the volumes were observed mostly in one to five months, that was later in LC, and found largest in the L class of LC group. Thus, the massiveness of hepatectomy and coexisting cirrhosis were likely to determine the changing types of splenic size.
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  • A case report of 19-year-old HB virus carrier with chronic δ infection for 10 years died of acute hepatic failure
    Hiroshi YASUDA, Hitoshi FUJINO, Kazumi TAGAWA, Tadao UNUUMA, Tomoyuki ...
    1989 Volume 30 Issue 1 Pages 55-59
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.55
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    19-year-old male HB virus carrier was admitted to our hospital because of fulminant hepatic failure. He was gotten diagnosis of nephrotic syndrome when he was 3 year old. Adrenocorticosteroid had been administerd from 5 years-old to 3 months prior to the admission. He'd been diagnosed of early liver cirrhosis by liver biopsy 2 months prior to the admission. Although plasma exchange and glucagon-insulin therapy were performed, severe hepatic failure progressed. He died on 10th hospital day.
    In this case δ antibody was highly positive and re-examination proved persistant δ infection for 10 years. δ antigen was found in autopsy liver tissue. There was no evidence of super infection of another hepatitis virus. Hepatic failure in this case may be induced by acute exaggration of chronic δ infection.
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  • Fulminant hepatitis type B, complicated by acute renal failure prior to hepatic coma onset: Report of two cases
    Katsuyoshi HIGASHI, Katsuhiko TSUKADA, Junichi YAMADA, Takashi MONOE, ...
    1989 Volume 30 Issue 1 Pages 60-66
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.60
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    Two cases of fulminant hepatitis type B complicated by acute renal failure prior to hepatic coma onset were encountered.
    The first case was a 31 year-old male, who had been given a blood transfusion following gastrointestinal bleeding. One and half months later, he was admitted to this hospital with liver dysfunction, anuria and encephalopathy. Laboratory tests revealed a PT of 15.8% and HBs antigen (+). Fulminant hepatitis type B was diagnosed, and he subsequently underwent in ICU. Although encephalopathy progressed to hepatic coma grade V, the patient survived.
    The second case was a 50 year-old male who was admitted to this hospital with anuria. After admission, he developed encephalopathy. A laboratory examination revealed a PT of 12.0% and HBs antigen (+), consequently fulminant hepatitis type B was diagnosed. Although liver function recovered (PT=71.5%) after ICU treatment, the patient died of DIC due to pulmonary hemorrhage. Cases of fulminant hepatitis complicated by acute renal failure, have a very poor prognosis. However, in our experience, one case recovered, and the other case with respect to liver function tests.
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  • CEA-producing hepatocellular carcinoma with extensive lymph node metastases: Report of a case
    Hideo MORIMOTO, Tokio WAKABAYASHI, Kunihiko SUZUKI, Gorou SUGIOKA, Kis ...
    1989 Volume 30 Issue 1 Pages 67-74
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.67
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    A 61-year-old man having been diagnosed as chronic hepatitis for 7 years was admitted for closer examination for elevated CEA in serum. The serum level of CEA on admission was 48.0ng/ml, but AFP was not increased. Ultrasonography revealed two nodulous lesions in the liver. These were enhanced by CT arteriography and had no evidence of metastasis by various diagnostic maneuvers, especially to the gastrointestinal tract, leading to a diagnosis of hepatocellular carcinoma (HCC). The tumors were treated in vain with intraarterial injection of cisplatin dissolved in lipiodol and with transcatheter arterial embolization. Autopsy revealed liver cirrhosis concomitant with two nodules of HCC. One was histologically classified as Edmondson type I, the other as type II HCC. Immunoperoxidase staining for CEA was positive in the latter. Lymph nodes involved by widespread metastases (periportal, para-aortic, perigastric, peripancreatic, mediastinal, and cervival lymph nodes) were also positive by the same staining.
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  • A case of multilocular cystic hepatocellular carcinoma without underlying cirrhosis
    Yasutsugu MIZUNO, Kazuo NOTSUMATA, Akihiko FURUSAWA, Yoshiharu MOTOO, ...
    1989 Volume 30 Issue 1 Pages 75-81
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.75
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    A 52-year-old woman was admitted to our hospital because of marked hepatomegaly. The findings of Ultrasound, CT scan and Angiography suggested a hepatocellular carcinoma (HCC) associated with multiple cysts. The open biopsy was performed to confirm the diagnosis. A huge massive tumor about 10cm in diameter partially associated with multiple cystic lesions was observed in the right lobe of liver at laparotomy. The histological finding of the tumor was HCC, and the nontumorous part was almost normal liver.
    TAE, intraarterial administration of 5-FU and CDDP, and oral administration of UFT were performed, resulting in the improvement of hepatomegaly (reduction rate: 63.8%, partial response). The marked reduction of the tumor and cystic lesions was shown using CT scan. It is characteristic in this case that HCC developed in the normal liver and was associated with multiple cystic lesions. This case seems to be interesting from the viewpoint of the pathogenesis of multicystic HCC and the therapeutic effect of TAE and chemotherapy.
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  • Case of hepatocellular carcinoma associated with microhamartoma
    Hiromu TANAKA, Katsuji SAKAI, Hiroaki KINOSHITA, Kazuhiro HIROHASHI, Y ...
    1989 Volume 30 Issue 1 Pages 82-87
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.82
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    A 57-year-old man who had been found to have high serum levels of α-fetoprotein at different times was admitted to our hospital. He was diagnosed as having hepatocellular carcinoma in the right anterior segment of the liver by computed tomography and ultrasonography. Blood tests showed that cirrhosis of the liver was not present, and portal vein pressure, mesured during percutaneous transhepatic portography (PTP), was within the normal limits. We thought the patient also had severe liver fibrosis because of the hard consistency of the liver at PTP. Transcatheter arterial embolization (TAE) was followed by percutaneous transhepatic portal embolization (PTPE), after an interval of two weeks, and right anterior segmentectomy was done later. In the specimen, the tumor was found to be a solitary nodule with intrahepatic metastatic lesions and portal emboli. The tumor had the trabecular pattern of hepatocellular carcinoma histologically, and was classified as Edmondson's type II. Another area of the liver had microhamartoma; there were small yellowish multiple nodules of fibrous tissue in which there were many irregularly dilated bile-duct-like structures. Bile duct carcinoma with biliary anomalies are occasionally reported. This is the first case of hepatocellular carcinoma with microhamartoma to be reported, to the best of our knowledge.
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  • A case report of heaptic myelolipoma
    Tadao HIROMURA, Yutaka MORITA, Jun-ichi UCHINO, Miri FUJITA, Ken-ichi ...
    1989 Volume 30 Issue 1 Pages 88-92
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.88
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    A case of hepatic myelolipoma of a 73-year-old woman was reported.
    Hepatic myelolipoma was vey rare entity and this case was first report which was demonstrated by magnetic resonance (MR). Sonography, computed tomography and angiography was performed, however, their findings could not allow to distinguish our case from hepatocellular carcinoma (HCC) with fatty metamorphosis. T1-weighted MR image of this case showed hypointense, which is different from that of HCC with steatosis reported previously. MR findings may be useful for differentiation of this tumor from HCC with steatosis.
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  • Induction of endogenous tumor necrosis factor in hepatocellular carcinoma
    Yoshihiro FUKUDA, Shuuji SEKO, Masahiro NAGAMUTA, Hiroyuki KOKURYU, Ka ...
    1989 Volume 30 Issue 1 Pages 93-94
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.93
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  • Controlled study of the conjugal infection with nonA nonB chronic liver disease
    Hajime TOKITA, Mineo KOJIMA, Masaru SHIMIZU, Naoki HOSHIYAMA, Masaaki ...
    1989 Volume 30 Issue 1 Pages 95-96
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.95
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  • Immunohistochemical study of HBeAg on the hepatocyte membrane in chronic hepatitis B
    Takafumi SAITO, Toru MIYAJIMA, Takashi TSURUYA, Norio OGATA, Hideki KA ...
    1989 Volume 30 Issue 1 Pages 97-98
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.97
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  • Investigation of the chelate formation between D-penicillamine disulfide and Cu (II) Ion by 1H NMR spectroscopy
    Masaoki MIZUTANI, Mikio NAKAMURA
    1989 Volume 30 Issue 1 Pages 99-100
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.99
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  • Adoptive immunotherapy with tumor-infiltrating lymphocytes against metastatic liver tumors
    Tadatoshi TAKAYAMA, Masatoshi MAKUUCHI, Teruaki SEKINE, Hisazo KITAOKA ...
    1989 Volume 30 Issue 1 Pages 101-102
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.101
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  • Experimental studies on the pathogenesis of fulminant hepatitis with respect to tumor necrosis factor (TNF)
    Hiroo OHNISHI, Hisataka MORIWAKI, Kazuo NAGURA, PEI Ryu, Masahito NAGA ...
    1989 Volume 30 Issue 1 Pages 103-104
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.103
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  • Production of monoclonal antibodies against mannose-binding protein
    Atsushi SANO, John A SUMMERFIELD
    1989 Volume 30 Issue 1 Pages 105-106
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.105
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  • Immunoelectron microscopic observation of HBeAg in hepatocytes of patients with chronic hepatitis B
    Gotaro YAMADA, Kouichi TAKAGUCHI, Kazuhiro MATSUEDA, Shigeatsu FUJIKI, ...
    1989 Volume 30 Issue 1 Pages 107-108
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.107
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1989 Volume 30 Issue 1 Pages 109
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.109
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1989 Volume 30 Issue 1 Pages 110-164
    Published: January 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.110
    JOURNAL FREE ACCESS
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