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50 巻, 10 号
選択された号の論文の8件中1～8を表示しています
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深瀬 政市, 永山 洋一, 恒松 徳五郎, 中野 裕1974 年 50 巻 10 号 p. 1341-1352
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーAbout 19 female patients with systemic lupus erythematosus, plasma luteinizing hormone and follicle stimulating hormone were determined following intravenous rapid injection of luteinizing hormone-releasing hormone 100 microgram.
In 9 patients, response of plasma luteinizing hormone was poor comparing with that of control. And the time reaching to the peak of response of plasma luteinizing hormone delayed in 11 patients from that in the controls.
No correlation was observed between glucocorticoids, which were administered for therapy, and the level and delay of maximal response of luteinizing hormone.抄録全体を表示PDF形式でダウンロード (1153K) -
-下垂体成長ホルモン分泌能に対するTolbutamideの作用-笠井 貴久男, 菊地 敏徳, 下田 新一1974 年 50 巻 10 号 p. 1353-1366
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーIt has been established that hypoglycemia stimulates the secretion of human growth hormone (HGH) from the pituitary gland. If the secretion of endogenous insulin from the pancreatic-cells was temporally increased by tolbutamide i.v. injection and hypoglycemia was produced, the serum HGH would be increased as well as the insulin-induced hypoglycemia. In the present study, 1 g tolbutamide was injected i.v. into normal subjects, hyperthyroidism, primary or secondary hypothyroidism, diabetes mellitus and into nephrotic syndromes with or without adrenocortico-steroid hormones in order to know some of the aspects of the mechanism concerning the secretion of HGH from the pituitary gland under hypoglycemia.
In the normal subject, maximum response of serum IRI (Immunoreactive Insulin) was seen within 15 min and the lowest value of blood sugar (50 mg/100 ml) was observed at 30-45 min after the injection of tolbutamide. The serum HGH was clearly increased at 15 min, the highest value of HGH (approximately 15 ng/ml) was achieved 60 min after the I.V. administration of tolbutamide and then the value declined to the fasting level, i.e. around 5 ng/ml. The response-patterns of serum IRI and blood sugar to tolbutamide injection in the patient with hyperthyroidism and primary or secondary hypothyroidism were similar, but HGH showed quite different patterns. Although maximum increase of HGH was slightly lower than that of normal subject, the HGH value was still high even 3 hrs after tolbutamide injection in cases of hyperthyroidism. In primary hypothyroidism, the pattern of response of HGH secretion by the tolbutamide test was clearly impaired, compared with normal subjects. These results suggested that thyroid hormones would be necessary for production and secretion of HGH. No response of HGH was observed in the secondary hypothyroidism after the tolbutamide administration.
As is well known, the tolbutamide test was clinically used for the diagnosis of diabetes mellitus. Decrease of blood sugar level by tolbutamide administration in diabetics contrasted greatly with the normal subject. Because of the difference in the response-pattern of blood sugar in the diabetics from the normal subject, hypoglycemia itself was not a reasonable stress to secrete HGH from the pituitary. However, maximum increase of serum HGH in the diabetics produced by the injection of tolbutamide was only 1/3 of the normal subject, indicating a possible retardation of HGH secretion in the diabetics.
The results from nephrotic syndromes treated with adrenocorticosteroid hormone indicated that the hormone partially blocked the secretion of HGH as reported previously.抄録全体を表示PDF形式でダウンロード (1551K) -
竹下 吉樹, 依田 純三, 服部 宏, 上田 淑行, 福山 一郎, 阿部 秀康, 吉田 俊秀, 中埜 幸治, 若林 保良, 吉田 秀雄1974 年 50 巻 10 号 p. 1367-1372
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーThe simultaneous occurence of thyroid crisis and severe diabetic ketoacidosis is rare. This coexistence of two life-threatening illnesses is most dangerous for the patient. The case reported in this paper is a 41 year old woman with goiter of 4 years duration. In family history, her mother died of diabetes mellstcs.
For 2-3 weeks prior to admission the patient was treated with the diagnosis of diabetes mellitus. And one day prior to admission she complained of vomitting, palpitation and dyspnea.
On arrival at our hospital, the body temperature was 36.7°C and the blood pressure was 140/80 mmHg. The pulse was 90-100 per minute, but about two hours later it was elevated to 174 per minute.
After two days, acetone was detected in urine in spite of treatment for diabetes and hyperthyroidism. Four days later she died of heart failure.
In this patient, moist skin, extremely high blood and urinary sugar and no heat intolerance were suspected of diabetic coma, but hypertension, tachycardia, thyromegaly and delirium were suspected of thyroid crisis.
Although the specific signs and symptoms of diabetic coma and thyroid crisis were almost present in this case, the typical symptoms of these two diseases were partially absent.抄録全体を表示PDF形式でダウンロード (817K) -
-測定法ならびに正常者および各種内分泌性高血圧症患者における成績-小島 元子1974 年 50 巻 10 号 p. 1373-1385
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーAldosterone and DOC can be measured by the present assay in a single extract of 1.0-2.0 ml of plasma. The method consists of extracting plasma with dichromethane, separating the aldosterone and DOC on a Sephadex LH-20 column, and quantitating each steroid by radioimmunoassay. This method was demonstrated to be sensitive, accurate, and precise. The values obtained were in agreement with those previously reported by the other investigators using different methods.
In 15 normal subjects, the mean level of plasma aldosterone was 4.8 ± 3.4 SD ng/100 ml and the corresponding level of DOC was 8.9 ± 3.8 SD ng/100 ml.
Fifteen patients with Cushing's syndrome were studied. In 10 patients with adrenocortical hyperplasia, the mean level of DOC (29.8 ± 11.1 SD ng/100ml) was significantly higher than normal (P<0.001), and the mean level of aldosterone (2.5 ± 2.0 SD ng/100 ml) was slightly lower than normal (P<0.01). The mean value for plasma DOC in the remaining 5 patients with adrenal adenoma was 20.6 ± 8.5 SD ng/100 ml and this was significantly higher than normal (P<0.001). But the mean value for plasma aldosterone (4.8 ± 2.0 SD ng/100 ml) was not significantly different from normal. In 2 patients with adrenal hyperplasia and in 2 with adrenal adenoma, plasma DOC and aldosterone levels returned to normal after treatment of Cushing's syndrome.
Three patients with 17α-hydroxylase deficiency had clearly elevated plasma DOC levels and normal aldosterone levels. In these patients plasma DOC returned to normal after treatment with betamethasone.
Five of 6 patients with primary aldosteronism had elevated plasma DOC levels and the mean of 33.4 ± 11.2 SD ng/100 ml was significantly greater than normal (P<0.001) The mean level of plasma aldosterone (31.7 ± 12.8 SD ng/100 ml) was also significantly higher than normal (P<0.001). In 2 patients, plasma DOC and aldosterone returned to normal after the adenoma was removed.抄録全体を表示PDF形式でダウンロード (1397K) -
第1報 Testosteroneとの同時測定法について丹田 均, 藤田 征隆, 黄 朝松, 熊本 悦明1974 年 50 巻 10 号 p. 1386-1391
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーRadioimmunoassay using the antiserum of Δ4-Androstenedione-3-oxime-BSA for estimaton of androstenedione is described. Assay of plasma volume is an adequate 0.2 ml in the adult male.
Radiochemical isolation of androstenedione and testosterone simultaneously was achieved with Sephadex LH-20 microcolumn chromatography.
With this method, water blank controls showed values of 7.7 ± 4.0 pg/sample (N=5) in androstenedione and 93.3 ± 9.4 pg/sample (N=5) in testosterone. Normal adult male plasma contain 858.8 ± 225.7 (N=5) pg/ml (N=5) in androstenedione and 6.94±1.09 ng/ml (N=5) in testosterone.抄録全体を表示PDF形式でダウンロード (433K) -
福地 総逸, 中嶋 凱夫, 竹内 孝彦, 西里 弘二1974 年 50 巻 10 号 p. 1392-1397
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーA radioimmunoassay procedure has been developed to measure 11-deoxycorticosterone (DOC) in human peripheral plasma. DOC-oxime was coupled with porcine gamma globulin and antibodies produced in rabbits. One to 3 ml of plasma, with 1, 2 3H-DOC added for recovery, was extracted with dichloromethane and purification achieved by a silica gel column and by one paper chromatograph. After overnight incubation of the antibodysteroid mixture at 4°C, bound and free fractions were separated using ammonium sulfate. The mean recovery of 3H-DOC, after extraction and chromatography, was 84.6 ± 7.4%. The method showed adequate specificity, precision and accuracy.
Normal plasma DOC levels were found to be 4.4 ± 2.5 ng/100 ml (n=8). Plasma DOC levels were almost normal (0.3-26.8 ng/100 ml) infifteen patients with benign essential hypertension. The mean level of 8.1 ± 8.2 ng/100 ml obtained in hypertensive patients with suppressed plasma renin activity, was not significantly different from normal. Plasma DOC showed a high level, 3.0-30.5 (11.4 ± 7.5) ng/100 ml, in 9 patients with primary aldosteronism. Four out of 8 patients with Cushing's syndrome were found to have elevated plasm a DOC levels. Higher levels of 21.2 ± 15.8 ng/100 ml were found in 5 patients with adrenal hyperplasia than those of 12.3 ± 8.0 ng/100 ml in 3 with adrenal adenoma. Plasma DOC levels were high levels of 113-176 ng/100 ml in 2 patients with 17α-hydroxylase deficiency. ACTH administered to 5 subjects produced a mean increase in plasma DOC from 4.8 to 25.8 ng/100 ml. Angiotensin II infused at a rate of 10 ng/kg/min for 30 min into 4subjects did not increase mean plasma DOC. Similarly, dietary sodium restriction or postural change did not increase plasma DOC.
These results confirm that DOC secretion is primarily under anterior pituitary control. From the basal level of 4.4 ng/100 ml and from its biological activity compared to aldosterone, the major mineralocorticoid, it would seem that DOC plays a minor role in electrolyte homeostasis in normal humans. However, the elevated levels seen in some cases of adrenal cortical hyperfunction may mean that DOC contributes significantly to the characteristic symptoms of hypertension and hypokalemia.抄録全体を表示PDF形式でダウンロード (684K) -
布川 修, 川越 慎之助, 新田 公子, 広井 正彦1974 年 50 巻 10 号 p. 1398-1407
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーIn reproductive physiology the precise role of FSH, LH and prolactin (H. Pr.) has not been clarified yet. In order to know the correlation among FSH, LH and H. Pr. secretion in human females, serum FSH, LH and H. Pr. levels were determined by double antibody radioimmunoassay in normal menstrual cycles and several menstrnal disorders, and also responses of their hormones following intravenous injection of synthetic LH/FSH-RH (LH-RH) were estimated.
Following results were obtained,
1) In normal menstrual cycles FSH and LH showed highest levels at ovulatory phase, but H. Pr. was not seen so remarkable change in menstrual cycles.
2) Serum FSH and LH increased markedly at ovulatory phase after intravenous injection of LH-RH 200 ug. Increased ratio of each hormone showed highest level at ovulatory phase but gradually decreased from follicular phase to luteal phase. Conversely serum H. Pr. was increased at ovulatory phase but decreased at follicular and luteal phase.
3) In several menstrual disorders such as Turner's syndrome, Sheehan's syndrome, streak gonad and hypogonadotropic hypogonadism, the response of FSH, LH and H. Pr. in LH-RH loading test was not so good as normal menstrual cycles. On the other hand the response of H. Pr. decreased in Sheehan's syndrome and hypogonadotropic hypogonadism.
From these results it may be suggested that synthetic LH-RH release FSH and LH from the anterior pituitary, but do not release prolactin in the females, Prolactin was said to be regulated by prolactin inhibiting and releasing factor from the hypothalamus, but prolactin was not effected by LH-RH.
It is necessary to clarify the relationship between LH, FSH and prolactin secretion from pituitary or PIF, PRF and LH-RH from the hypothalamus in reproductive physiology.抄録全体を表示PDF形式でダウンロード (1016K) -
1974 年 50 巻 10 号 p. 1408-1422
発行日: 1974/10/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (2265K)
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