巻号一覧
前身誌
65 巻, 11 号
選択された号の論文の9件中1～9を表示しています
- |<
- <
- 1
- >
- >|
-
森 豊, 横山 淳一, 野原 勉, 三村 明, 武石 昌則, 吉越 富士雄, 秋山 雅昭, 池田 義雄, 磯貝 行秀, 徳田 忠昭, 佐々木 ...1989 年 65 巻 11 号 p. 1209-1218
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーA deceased 59-year-old woman with insulin dependent diabetes mellitus complicated by chronic thyroiditis and chronic hepatitis was autopsied. She had had diabetes mellitus since she was 30 years old, and insulin therapy was started at 34 years. Laboratory findings were as follows : s-GOT 85, s-GPT 31, γ-globulin 2.45 g/dl. Immunological tests were positive for anti-smooth muscle antibody and anti-ENA antibody with high titers of antithyroglobulin and anti-microsome antibodies. HLA analysis revealed the presence of DR-4. The thyroid biopsy specimen showed microscopic features characteristic of chronic thyroiditis at 52 years of age. She had been repeatedly admitted for the control of diabetes mellitus. She was admitted for the 9th time in June, 1987 following complaints of abdominal pain. After admission, her general condition became gradually worse, and she died of peritonitis in September, 1987.
Pathological examination of the liver revealed an expansion of fibrous tissue on Glisson's capsule accompanied by lymphocytic infiltration and was diagnosed to be chronic inactive hepatitis. As for the thyroid gland, fibrous tissue replaced an extensive area of the thyroid gland, and normal thyroid tissue was not observed. Lymphocytic infiltration was less in comparison with that in the previous biopsy. As for the pancreas, atrophy of exocrine pancreatic tissue and fibrous change in interstitial tissue was observed. Lymphocytic infiltration was also seen in the interstitial exocrine tissue but not in the islet. Immunohistochemical examination of the islets using anti-insulin, glucagon and somatostatin antibodies by ABC peroxidase method showed the selective disappearance of B cells in the islets.
The pathological changes in the thyroid gland, liver and pancreas suggest that autoimmune mechanism may be involved in the pathogenesis of chronic thyroiditis, chronic hepatitis and IDDM with exocrine pancreatic impairment in this case.抄録全体を表示PDF形式でダウンロード (3406K) -
甲状腺亜全摘術のホルモン抗体価に及ぼす影響長井 孝太郎, 前川 博行, 亀谷 正明, 時光 直樹, 小牧 卓司, 小嶋 範子, 坂田 茂樹1989 年 65 巻 11 号 p. 1219-1225
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーWe experienced two cases of Graves' disease associated with anti-thyroid hormorie autoantibodies (Case 1 : anti-T4, Case 2 : anti-T3). Both cases underwent subtotal thyroidectomy, and titers of anti-thyroid hormone antibodies and anti-Tg antibodies were compared before and after operation. In case 1, titers of both anti-T4 and anti-Tg antibodies decreased after operation, whereas in Case 2, titers of both anti-T3 and anti-Tg were unchanged before and after operation. There was a significant positive correlation between titers of anti-T4 and anti-Tg antibodies in Case 1 (r=0.90, P<0.01), and anti-T3 and anti-Tg antibodies in Case 2 (r=0.64, P<0.01). These results strengthen the possibility that the antigen of antithyroid hormone autoantibodies in both cases is the Tg molecule.抄録全体を表示PDF形式でダウンロード (579K) -
宮森 千明, 村田 明聡, 井村 英一, 佐藤 保1989 年 65 巻 11 号 p. 1226-1238
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーThe effects of TRH and its metabolite, histidyl-proline diketopiperazine (cyclo (His-Pro)) on catecholamine metabolism in the central nervous system, peripheral tissues and plasma were examined in adult and young Wistar rats aged 3 weeks. The intravenous administration of 50μg of TRH produced an increase in plasma epinephrine, cerebral dopamine and a reciprocal decrease in norepinephrine and dopamine in diencephalon and midbrain. In contrast, 50μg of cyclo (His-Pro) induced a rise in plasma dopamine and a decrease of dopamine in cerebellum, pons and medulla oblongata.
After intraperitoneal injection of 3mg of α-methyl-p-tyrosine, which blocked reuptake of catecholamines in synapses, intrathecal administration of 30ng TRH accelerated. 2 times metabolic turnover of norepinephrine and dopamine in cerebral hemisphere, diencephalon and midbrain as well as norepinephrine turnover in cerebellum, pons, medulla oblongata, heart and brown adipose tissue. Consecutive intrathecal administration of TRH for 6 days enhanced cerebral catecholamine content.
These results indicate that (1) TRH accelerates metabolic rate of catecholamine in the central nervous system as well as peripheral tissues, and (2) TRH acts on both noradrenergic and dopaminergic neurons in cerebral hemisphere, diencephalon and midbrain, whereas cyclo (His-Pro) acts mainly on dopaminergic neurons in cerebellum, pons and medulla oblongata.抄録全体を表示PDF形式でダウンロード (1034K) -
第2編 胎児から新生児期におけるグルカゴンの機能的動態藤井 良造, 森川 肇, 上田 康夫, 望月 眞人1989 年 65 巻 11 号 p. 1239-1252
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーIn order to clarify the potential roles of glucagon for energy induction during the perinatal period, the developmental changes of serum glucagon concentration, the ontogenesis of hepatic glucagon receptor and glucagon-sensitive adenylate cyclase system were estimated in comparison with insulin in rats.
In fetal rats on day 18 to 20 of gestation, serum glucose levels and hepatic glycogen contents gradually increased as pregnancy progressed. The levels of serum glucagon and its binding to liver microsomal membranes were significantly lower than in adults, and glucagon-sensitive c-AMP production was also markedly suppressed. On day 21 of gestation, hepatic glycogen contents markedly increased to the maximal level, serum glucagon level increased, and glucagon receptors in the fetal liver were already estimated at the same level as in the adult. However, glucagon-sensitive c-AMP production was still suppressed the same as in the fetuses of earlier gestational ages. On the other hand, serum insulin levels in fetuses were higher than those in adults, and the abundant receptor could also be observed in liver microsomal membranes.
After delivery, serum glucose rapidly decreased with a marked decline of hepatic glycogen contents until 5 hours in the neonatal period. Serum glucagon and its hepatic receptors were significantly incrased with a gradual development of the glucagon-sensitive adenylate cyclase system. Conversely, serum insulin levels were suppressed without any remarkable change in its receptor.
From these results, it is suggested that glucagon plays an important role in the neo natal adaptation mechanism, especially in the production of endogenous glucose in place of the transplacental supply from the mother, such effects of glucagon are already initiated by the induction of its receptor in target tissues in the fetus on late gestation.抄録全体を表示PDF形式でダウンロード (1296K) -
主として用量反応関係について白木 正孝, 井藤 英喜, 折茂 肇1989 年 65 巻 11 号 p. 1253-1263
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーIn order to clarify the effect of 1, 25 (OH) 2 D3 on the bone mineral content in senile osteoporosis, we examined the radial mineral density in 41 female cases of senile osteoporosis treated with 1, 25 (OH) 2D3. The diagnostic criteria of senile osteoporosis were as follows.
1) Radial mineral density at below 0.5g/cm2 by SPA
2) Bone dystrophy score in vertebra at over I degree
3) Presence of vertebral fracture
4) Over 60 years of age
The subjects were divided into 5 groups : a control group (n=11), a 0.25μg of 1, 25 (OH) 2D3 once-a-day group (n=5), a 0.5μg of 1, 25 (OH) 2 D3 once-a-day group (n=8), a 0.25μg of 1, 25 (OH) 2D3 twice-a-day group (n=8) and a 0.25μg of 1, 25 (OH) 2D3 three times-a-day group (n=9). There was no significant difference in background data among these groups except for serum Al-P activity. The radial mineral density was measured in these 5 groups before and every 3 months after, starting the treatment by single photon absorptiometry in 1/3 distal site of radius for 1 year. No significant difference was detected in the serum levels of Ca, Pi and Al-P activity after starting the treatment among the 5 groups. The area under curve (AUC) of the radial mineral content after the treatment was calculated in each group. There was a significant dose-related increase in the AUC (p<0.05). However, the urinary Ca/Cr ratio was increased in the group receiving 0.75μg/day of 1, 25 (OH) 2D3. The final AUC in the group receiving 0.5μg/day of 1, 25 (OH) 2 D3 tended to be very high compared with that in the other groups. From the above, it was suggested that 1, 25 (OH) 2 D3 might be effective for the treatment of senile osteoporosis especially at the dose of 0.5μg/day.抄録全体を表示PDF形式でダウンロード (896K) -
井上 幹人, 楽木 宏実, 中丸 光昭, 真杉 文紀, 荻原 俊男, 高井 新一郎1989 年 65 巻 11 号 p. 1264-1269
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーA 37-year-old female with Graves' disease was reported. An abnormally high concentration of serum IgE was observed by radioimmuno-sorbent test before treatment. Laboratory findings showed no evidence of atopic diseases or other known diseases with hyperglobulinemia E. There is no reported case of Graves' disease associated with remarkably elevated plasma IgE level.
In the present patient, a further elevation of serum IgE concentration was observed when the dose of methimazole reached about 500mg in total. Allergic mechanism may be the cause of this phenomenon. Serum IgE level was decreased gradually after replacement of methimazole by propylthiouracil. IgE level was not parallel with thyroid functions, and even when her thyroid function was normalized after subtotal thyroidectomy, IgE concentration was still increased around 900IU/ml. The mechanism of hyperglobulinemia E in this case was discussed.抄録全体を表示PDF形式でダウンロード (517K) -
第一報 : Peptide YY (PYY) 受容体の脳内局在大家 学, 乾 明夫, 馬場 茂明1989 年 65 巻 11 号 p. 1270-1277
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーPeptide YY (PYY) was discovered in the porcine gut by Tatemoto in 1982. PYY has recently been found in the central nervous system. This has provoked studies of PYY effects when centrally administrated.
We investigated the specific binding of radioactive PYY (125 I-PYY) to brain membranes in pigs and dogs. PYY chiefly bound to the hippocampus, as well as to the pituitary gland, hypothalamus, and amygdala, suggesting that PYY acts on the limbic-hypothalamicpituitary axis.
PYY binding in the brain had a high-affinity and a low-affinity component (dissociation constant, 1.39×10-10M and 3.72×10-8M, respectively). The binding sites were highly specific for PYY and neuropeptide Y (NPY), but not for pancreatic polypeptide (PP) or other peptide hormones such as cholecystkinin octapeptide, methionine enkephalin, adrenocorticotropic hormone, and thyrotropic releasing hormone. The similar affinities for PYY and NPY imply that these peptides regulate brain functions through interaction with common receptor site (s).抄録全体を表示PDF形式でダウンロード (741K) -
田島 朝信, 河野 哲郎, 岩政 仁, 本田 賀裕, 岡村 均, 宮北 隆志, 越田 光伸1989 年 65 巻 11 号 p. 1278-1285
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーIn an effort to determine the reliability of the midluteal progesterone (P) /estradiol (E2) ratio as an index of the potential for conception, we measured the midluteal P and E2 levels in 76 infertile women who had been treated at our infertility clinic. This parameter in conception cycles was compared with that in non-conception cycles.
Eighty cycles of the 76 women were classified into two groups, depending upon whether pregnancy occurred or not. Group 1 and group 2 were composed of 31 conception cycles and 49 drug-induced cycles, respectively. Midluteal concentrations of P and E2 did not show any significant differences between the two groups. The P/E2 ratios were 106.4 ± 71.3 (mean ± SD) and 71.5 ± 44.16, respectively. This difference was statistically significant (p<0.05). Discriminant function analysis showed that the smallest probability of misclassification between the two groups decreased from 44% when using P only to 36% when using the combined P and E2. The following equation : Y = 0.0727X1 - 0.00456X2 - 0.130 was obtained (when X1 = P, X2 = E2).
These results suggest that the midluteal P/E2 ratio gives clinicians the best indication of luteal function for the achievement of pregnancy.抄録全体を表示PDF形式でダウンロード (563K) -
佐々木 純, 多田 隆士, 斎藤 和好, 栗原 英夫1989 年 65 巻 11 号 p. 1286-1293
発行日: 1989/11/20
公開日: 2012/09/24
ジャーナル フリーAn 11-year-old girl with diffuse goiter is presented. She had no clinical evidence of thyrotoxic symptoms or signs of palpitation, excessive sweating, tachycardia or finger tremor. Both the serum T4 (24.0μg/dl) and T3 (282ng/dl) were high, and thyroid 131I uptake rate (63.2%) was significantly elevated, but T3/T4 ratio was not elevated (11.8). BMR was measured three times and remained within normal limits. Her serum TSH was 1.9μU/ml, and a TRH stimulation test resulted in a normal rise of serum TSH (13.4μU/ml). The TSH secretion was not suppressed by medication (p.o.) of 75μg of L-triiodothyronine given for 8 days. The autoantibodies of T4, T3 and TSH were negative. No sign of pituitary tumor was observed by plain X-ray film. No defect in her sight-field was found. From these clinical figures and data, Refetoff's syndrome was suspected.
She was eumetabolic without any treatment, but the goiter gradually enlarged and dysphagia developed. A large dose of L-thyroxine (450μg/day) was given for a period of one year and four months. She has been eumetabolic. Her goiter disappeared and the dysphagia completely subsided. After she was given large doses of L-T4, her serum TSH was reduced to 0.07μU/ml and was slightly elevated to 0.244.μ/ml at 30 min after i.v. infusion of 500μg TRH. Thyroid 123I uptake rate was suppressed to 8.3%. According to Refetoff's papers, this case was classified as being in the group with generalized resistance to thyroid hormone.抄録全体を表示PDF形式でダウンロード (1407K)
- |<
- <
- 1
- >
- >|