Nippon Saikingaku Zasshi

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Some R factors have been shown to confer atabrine sensitivity to host cells. In consideration of phylogenetic multiplicity, it was supposed that some other R factors might fail to confer this character. In fact, it was demonstrated in the present study that there were two types of R factors with this respect; i.e., one which confers this character to host cells (ats⁺) and the other which does not (ats^-). It was examined whether there was any interrelationship between this character and any other genetic characteristic, such as fertility inhibition (fi), suppression (or restriction and modification) of plaque formation of phages (spp), or the genus of host bacteria from which the respective R factor was derived. The results obtained are summarized as follows.
1. fi⁺, spp^- R factors: Eleven out of the 13 R factors tested were ats⁺ and the remaining two ats^-. The latter two had already been known to differ from other fi^- and fi⁺ R factors with respect to incompatibility tests.
2. fi^-, spp⁺ R factors: All the five R factors of this group were shown to be ats^-.
3. fi^-, spp^- R factors: All the eight R factors derived from Salmonella were ats⁺, except two which were derived from Shigella and Proteus, respectively.
These findings were discussed in relation to their clinical, as well as genetical, significance.

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