Nippon Saikingaku Zasshi
Online ISSN : 1882-4110
Print ISSN : 0021-4930
ISSN-L : 0021-4930
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Volume 79, Issue 4
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  • Population genetics of enterohemorrhagic Escherichia coli using whole-genome sequencing analyses
    Ken-ichi LEE
    2024Volume 79Issue 4 Pages 283-289
    Published: 2024
    Released on J-STAGE: December 05, 2024
    DOIhttps://doi.org/10.3412/jsb.79.283
    JOURNAL FREE ACCESS
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    Enterohemorrhagic Escherichia coli (EHEC) is an important pathogen since more than 3,000 cases have been reported annually in Japan. With the advent of next-generation sequencing, it has become feasible to analyze numerous strains using whole-genome sequence (WGS) analysis, making its application to surveillance a realistic possibility. In this paper, we introduce the following research outcomes achieved by our group utilizing WGS analysis of EHEC: 1) development of a WGS analysis pipeline to enhance the accuracy of the surveillance, 2) investigation of the dynamics of mobile elements such as plasmids and phages, and 3) analysis of the phylogeny and pathogenicity of newly identified highly pathogenic EHEC strains.

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