Nippon Saikingaku Zasshi
Online ISSN : 1882-4110
Print ISSN : 0021-4930
ISSN-L : 0021-4930
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Volume 68, Issue 3
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  • Studies on the mode of action of bacterial AB5 toxins
    Masatoshi NODA
    2013 Volume 68 Issue 3 Pages 299-311
    Published: 2013
    Released on J-STAGE: August 28, 2013
    DOIhttps://doi.org/10.3412/jsb.68.299
    JOURNAL FREE ACCESS
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    Bacterial AB5 toxins are proteins, produced by pathogenic bacteria including of Vibrio cholerae, Shigella dysenteriae, and enterohaemorrhagic Escherichia coli, which are usually released into the extracellular medium and cause disease by killing or altering the metabolism of target eukaryotic cells. The toxins are usually composed of one A subunit (a toxic domain) and five B subunits (a receptor-binding domain). This article overviews the characteristics and mode of actions of AB5 toxins including cholera toxin, Shiga-like toxin, and subtilase cytotoxin, and highlights current topics related to the roles of the effectors in promoting bacterial infection.
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