Nippon Saikingaku Zasshi
Online ISSN : 1882-4110
Print ISSN : 0021-4930
ISSN-L : 0021-4930
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Volume 34, Issue 5
Displaying 1-6 of 6 articles from this issue
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  • Recent Development of β-Lactam Drugs
    Shogo KUWAHARA
    1979 Volume 34 Issue 5 Pages 713-730
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.713
    JOURNAL FREE ACCESS
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  • Studies on Release Mechanism of Bactericidins from Blood Platelets
    Akira ISHIBASHI, Teiko ISHIBASHI, Tetsuo HIRUMA, Hidehiko UCHIYAMA, Hi ...
    1979 Volume 34 Issue 5 Pages 731-743
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.731
    JOURNAL FREE ACCESS
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    Studies were undertaken to elucidate the mechanism of extracellular release of thermostabile bactericidins (β-lysin) from rabbit blood platelets. The results obtained are summarized as follows.
    (1) When platelet-rich plasma and washed platelets were treated with cytochalasin B in the presence of IgG-coated latex particles, including zymosan, immune complexes and Ca++, a marked enhancement was seen in the extracellular release of β-lysin and lysosomal enzymes from platelets.
    (2) The extracellular release of β-lysin and lysosomal enzymes from platelets was reduced by pretreatment with cAMP, colchicine, and EDTA. It was enhanced by pretreatment with cGMP and addition of trypsin-treated guinea pig C5 and C3.
    In conclusion, it was revealed that latex particles and zymosan and immune complexes accelerated the extracellular release of β-lysin from platelets. The release was regulated by the intracellular levels of cyclic nucleotides, and enhanced significantly in the presence of complement components, particularly trypsin-treated C5 and C3, IgG and Ca++. Furthermore, it was suggested that microfilaments and microtubules might play an important role in the release mechanism of β-lysin and lysosomal enzymes from platelets.
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  • Intestinal flora and bile acids metabolism
    Influence of bile acids on rejection of Shigella flexneri 2a from the intestine
    Seiki TAZUME, Kazuo HASHIMOTO, Shogo SASAKI
    1979 Volume 34 Issue 5 Pages 745-754
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.745
    JOURNAL FREE ACCESS
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    The purpose of this report is to describe the influence of bile acids on antagonism between Shigella flexneri 2a and the artificial flora in the intestine of germfree mice.
    (1) The strain of Shigella had no activity of metabolizing bile acids in vitro. The strain of Streptococcus faecalis was capable of hydrolyzing conjugeted bile acids in vitro. The strain of Escherichia coli was able to oxidize cholic acid to 7-ketodeoxycholic acid (7-KDCA) in vitro. The strain of Bacteroides distasonis had an in vitro action to cause both deconjugation and oxidation of bile acids.
    (2) After 1 week of monoassociation with Shigella, germfree ICR mice were given E. coil and S. faecalis orally. When examined by the culture of feces, Shigella showed the following attitude. Shigella organisms in feces decreased gradually in number and disappeared in about 45 days. E. coli and S. faecalis persisted at a full growth level during the experimental period. The metabolites of bile acids having appeared in the small intestine were analyzed quantitatively by gaschromatography at the time of rejection of Shigella. Besides, 7-KDCA was detectedd from an artificial bacterial flora having persisted for 6 weeks.
    (3) After 1 week of monoassociation with Shigella, germfree ICR mice were given Bacteroides orally. Shigella in feces from the infected mice did not decrease in number even 80 days after superinfection with Bacteroides. At this point of time, no 7-KDCA was detected. When these mice were inoculated additionally with E. coli, 7-KDCA appeared aid the Shigella began to decrease in number in them.
    (4) No 7-KDCA was detectable in the intestinal contents inspite of the presence of Bacteroides, which could produce 7-KDCA in in vitro experiments.
    These results seem to indicate the importance of the 7-KDCA production for the rejection of Shigella from the intestine.
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  • Analysis of the Mode of Binding between Antigen and Antibody Investigated by the Monomolecular Film Technique
    Kan SUZUKI, Ichiro KIMURA, Teruko SUZUKI
    1979 Volume 34 Issue 5 Pages 755-757
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.755
    JOURNAL FREE ACCESS
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  • A new K type of Vibrio parahaemolyticus isolated from cases of food poisoning
    Masanori ISHIBASHI, Yoshio KINOSHITA, Tomio NIIHARA, Nobuharu KUNITA, ...
    1979 Volume 34 Issue 5 Pages 759-760
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.759
    JOURNAL FREE ACCESS
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  • A New K Antigen of Vibrio parahaemolyticus
    Shigeichi YAMAZAKI
    1979 Volume 34 Issue 5 Pages 761-762
    Published: September 25, 1979
    Released on J-STAGE: February 19, 2009
    DOIhttps://doi.org/10.3412/jsb.34.761
    JOURNAL FREE ACCESS
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