巻号一覧
6 巻 (1991)
- 6 号 p. 415-
- 5 号 p. 331-
- 4 号 p. 259-
- 3 号 p. 151-
- 2 号 p. 77-
- 1 号 p. 5-
6 巻, 5 号
選択された号の論文の10件中1～10を表示しています
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山口 俊晴, 高橋 俊雄1991 年 6 巻 5 号 p. 331-337
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーDrug delivery system using monoclonal antibody as a carrier of anticancer agents were reviewed. The conjugates composed of antibody and anticancer agents were classified into chemoimmunoconjugate, radioimmunocojugate and immunotoxin, Experimental studies of these three types of immunoconjugates were overviewed. Selected clinical studies using immunoconjugates were introduced. And side effects, immune responses and limited clinical effects were presented. Human antimouse antibody and nonspecific uptake of immunoconjugates by normal tissues such as liver are the most important problem to resolve. Chimeric antibody and more refined immunoconjugates were doveloped for further clinical trials. Our clinical trial was carried out against colorectal carcinoma using immunoconjugate(A7-NCS) composed of anti-colorectal carcinoma monoclonal antibody A7 and anticancer drug neocarcinostatin. Objective responses were observed in 4 of 15 metastatic liver tumor, although the long time survival could not be obtained. Finally we emphasized that many problems, most of them had been evident during clinical trials, should be evercome by the cooperations of scientists in the field of immunology, biotechnology, pharmacology and clinicians.抄録全体を表示PDF形式でダウンロード (1422K) -
難破 幸弘, 奥 直人1991 年 6 巻 5 号 p. 339-348
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーPhospholipids are noticed not only as components of biomembranes, but also as materials for clinical applications. Liposomes have been used as carrier vehicles of drugs, such as antifungal and anticancer drugs, and are expected for a new drug delivery system. Many clinical trials of these drugs encapsulated in liposomes have been progressed in the world wide area. Liposomes encapsulating hemoglobin have been investigated as an artificial blood. Specific drugs for infant respiratory distress syndrome using dipalmitoylphosphatidylcholine (DPPC), which is known as a main component of lung surfactant, have been developed, and some of these drugs have already come on market. Alkyl lysophosphatidylcholine derivatives have an unique antineoplastic function. In this review, we described recent progress and a prospect for the medical applications using phospholipids.抄録全体を表示PDF形式でダウンロード (1792K) -
纐纈 正和, 小林 武弘, 鈴木 賢二, 西村 穣, 高木 一平, 甕 久人, 馬場 駿吉, 四ツ柳 智久1991 年 6 巻 5 号 p. 349-353
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーModification of drug forms on and cancer agents followed the concept of drug delivery system is one of many attempts to obtain full efficacy of chemotherapy against cancer, and reduce its side-effects. In this paper, we made a basic research to give chemotherapy with cisplatin in liposome microcapsules an assured status in expecting the efficacy of blood vessel-embolism produced by the capsule itself, and gradual discharge of the agent from those capsules.抄録全体を表示PDF形式でダウンロード (843K) -
山本 正幸, 瀬川 徹, 岩田 亨, 門原 留雄, 井沢 邦英, 角田 司, 土屋 涼一, 権藤 禎彦, 大畑 教昭, 石井 伸子, 小路 ...1991 年 6 巻 5 号 p. 355-359
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーAlthough normal liver parenchymal cells have galactose-specific asialoglycoprotein receptors, little is known about the other regulatory factors except for terminal non-reduced galactose. We investigated the in-vitro uptake of liposomes coated with polysaccharides (pullulan)(control), galactosamine pullulan, and 1-amino-lactose pullulan into a rat hepatoma cell line(AH66 cells)and isolated rat hepatocytes(parenchymal cells). The uptake of 1-amino-lactose pullulan into AH66 cells was about 1.4 times as great as that of pullulan, and that of galactosamine pullulan about 1.2 times as great. The uptake of these substances into hepatocytes, however, was almost the same as that of pullulan. Consequently the elevated uptake of pullulan with galactose groups into AH66 cells might not be connected with galactose receptors. However, it is also possible that the viability of AH66 cells and isolated hepatocytes in vitro might be different, Considering that polysaccharide-coated liposomes become more stable, both physiochemically and biochemically, than conventional liposomes, 1-amino-lactose pullulan coated liposomes may be useful in targeting hepatoma cells.抄録全体を表示PDF形式でダウンロード (828K) -
冨田 康裕, 岡野 善郎, 薬師寺 道明, 平井 賢治, 谷川 久一1991 年 6 巻 5 号 p. 361-363
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーIntra-arterial injection therapy with anticancer agent and lipiodol (LPD) suspension is recently performed in many cases, which is very useful for hepatocellular carcinoma. Cisplatin (CDDP) has been used in the treatment of hepatocellular carcinoma. However, its toxicity to kidney, blood and neuron are unsolved yet. We prepared CDDP-phosphatidylcholine (PC)-LPD suspension. Furthermore, we simultaneously tested suspensions composed of LPD with varying PC and CDDP contents. Various amounts of CDDP and PC were gradually mixed with 10 ml of LPD, respectively. The stability of these suspensions and size of these particles were affected by concentration of PC. Superior compositions of CDDP-PC-LPD suspensions were as follows : CDDP-PC-LPD : 50 mg-100 mg-10 ml and 100 mg-100 mg-10 ml. Nausea, vomiting and fever were noted in most cases as adverse effects, but they were slight. These results suggest that the intra-arterial injection therapy with CDDP-PC-LPD suspension can be an effective chemotherapy for the treatment of unresectable hepatocellular carcinoma.抄録全体を表示PDF形式でダウンロード (516K) -
藤原 由紀子, 松田 泰行, 海野 勝男, 鈴木 敏夫, 黒崎 勇二, 中山 太二, 木村 聰城郎1991 年 6 巻 5 号 p. 365-374
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーBoth hydrophilic steroid derivatives, methyl 20-α-glucopyranosyloxy prednisolonates(9 and 10) and methyl prednisolonate 20-sodium sulfates(11 and 12) were synthesised from prednisolone via methyl 20 (S/R)-dihydroprednisolonates(1 and 2) based on a new colon-specific drug-delivery system. Optimal conditions for the syntheses of each isomers (1) and (2) were found by the extensive studies on the reaction rates from prednisolone under various concentrations of cupric acetate in dry methanol. Their configurations at C20 in (1) and (2) were determined by their formation mechanism and 1HNMR spectroscopic studies of the corresponding acetates (3) and (4).抄録全体を表示PDF形式でダウンロード (1933K) -
木村 聰城郎, 山口 武宏, 臼杵 久美, 黒崎 勇二, 中山 太二, 藤原 由紀子, 海野 勝男, 鈴木 敏夫1991 年 6 巻 5 号 p. 375-379
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーThe fate of 20 (R/S)-glucopyranosyloxy methyl-prednisolonates after the oral administration was examined in rats and guinea-pigs. The glycosides were stable in the small-intestinal contents, but the glycoside bonds were cleaved by the action of bacteria in the large-intestinal contents to release methyl 20 (R/S)-dihydroprednisolonates, which were rapidly hydrolyzed to inactive carboxylates in the plasma. The high recovery of the glycosides and the aglycons in the large-intestinal contents after intrajejunal administration of 20 (R/S)-glucopyranosyloxy methylprednisolonates in guinea-pigs proved the glycosides to be poorly absorbed from the small intestine. These results suggest that 20 (R/S)-glucopyranosyloxy methylprednisolonates may be orally effective pro-antedrugs, which express the anti-inflammatory activity specifically in the colonic mucosa with no systemic effect.抄録全体を表示PDF形式でダウンロード (775K) -
小野田 正, 阪上 賢一, 松岡 順治, 内田 晋, 塩崎 滋弘, 藤原 俊義, 藤岡 敬治, 高田 義博, 折田 薫三1991 年 6 巻 5 号 p. 381-385
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーWe have investigated the antitomor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma in these years. In this study we used IL-2 mini-pellet with a small dose of nHuTNF-α and examined of its antitumor efficacy compared with the administration of IL-2 mini-pellet alone. Even a single administration of IL-2 mini pellet alone could inhibited the growth of Meth-A sarcoma that had transplanted in mice, the combined use was more effective. The lytic activity of splenocytes against YAC-1 cells was prolonged in the combined use, but the maximum level of that was same. In histological examination on day 7 afterthe administration, the infiltration of lymphocytes was found in a same extent.抄録全体を表示PDF形式でダウンロード (856K) -
本多 佐保, 今井 浩三, 青木 繁雄, 渥美 進一, 光内 正樹, 石田 禎夫, 辻崎 正幸, 近藤 吉宏, 日野田 裕治, 谷内 昭1991 年 6 巻 5 号 p. 387-393
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーPeripheral circulation of the fingers were analyzed by use of thermography in eight patients with PSS and MCTD. Skin temperature of the fingers in those patients was lower than that in controls. Recovery after exposure of the chilled water in the fingers of the patients tended to be much delayed than in those of controls. Patterns of the recovery of the temperature in the fingers were different between patients with severe damage of peripheral circulation and controls : the former was recovered from the paroximal part to distal part, whereas the latter was recovered from the tips of the finger. Raynaud's phenomenon, pain as well as the ulcer of the tips of the fingers were recovered after infusion of lipo-PGE1. Thermography examination revealed that the duration of the effect of lipo-PGE1, is 2-3 hours. It is speculated that the administration of lipo-PGE1 might be useful for preventing fingers from the severe damage due to vascultis.抄録全体を表示PDF形式でダウンロード (1228K) -
河島 進, 浜谷 和雄, 川崎 直司, 前川 裕, 中井 正彦, 山田 志郎, 山谷 明正1991 年 6 巻 5 号 p. 395-399
発行日: 1991/09/10
公開日: 2009/02/23
ジャーナル フリーThe rapid initial absorption and the subsequent prolonged absorption of morphine were obtained simultaneously by using sustained-release suppository (MA), which can be prepared simply by mixing sodium alginate with morphine hydrochloride in VOSCO® H-15 base, in rabbits. The clinical effects of MA were evaluated in patients with severe pain such as the terminal cancer patients. Of 35 patients receiving MA, 21 and 13 could achieve acceptable analgesia on a twice and a once daily dose schedule, respectively. Conventional morphine suppository without alginic acid, however, relieved pain only for 8 hours on the same single-dose. The efficacy of MA is also supported by the sustained plasma morphine level in six female operating patients receiving MA. The MA dosing interval lengthened to every 12 to 24 hours resulted in a decrease in the total daily morphine requirement below 40 mg, The clinically desirable sedation was obtained during night and day in all patients, and the side effects such as vomitting and constipation observed in 29 percent of the patients were mild and controlled by simptomatic treatment. The advantage of less frequent dosing by MA may lead to improvement of the quality of life of terminal patients with pain.抄録全体を表示PDF形式でダウンロード (879K)
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