巻号一覧
7 巻 (1992)
- 6 号 p. 411-
- 5 号 p. 331-
- 4 号 p. 259-
- 3 号 p. 157-
- 2 号 p. 77-
- 1 号 p. 5-
7 巻, 5 号
選択された号の論文の10件中1～10を表示しています
- |<
- <
- 1
- >
- >|
-
吉田 純, 若林 俊彦, 水野 正明1992 年 7 巻 5 号 p. 331-339
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーPatients with brain tumor of malignant have a very poor prognosis because of the aggressive infiltration into normal brain tissue. Successfull treatment of this formidable disease requires targeting therapy for selective killing of tumor cells. Monoclonal antibody (MCA) against a glioma associated antigen, and liposomes are very promising reagents for this purpose. MCA coupled liposomes could bind with glioma cells and lead to a significant increase in the uptake of liposomal contents. A variety of chemotherapeutic agents and biological response modifiers, and also cytokine genes of interferon or tumor necrosis factor were entrapped into the liposomes. We described here the usefulness and possibility of targeting therapy using these drug delivery systems based on results of our experimental and clinical studies.抄録全体を表示PDF形式でダウンロード (1730K) -
―マウスにおける検討―萩原 明於, 高橋 俊雄, 伊藤 通敏, 阪倉 長平, 友田 寛, 村西 昌三1992 年 7 巻 5 号 p. 341-344
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーA new dosage format(ETOP-CH)which comprised activated carbon particles adsorbing etoposide was examined for anticancerous effects on the metastases in paraaortic lymph nodes in mice. Eight days after inoculation of P388 leukemia cells into the left hind foot-pad of mice (donors), when cancer metastases had been established in the paraaortic nodes, etoposide at 5 mg/kg was administered intraperitoneally in the form of ETOP-CH or etoposide aqueous solution. Ten days after inoculation, a tissue suspension of paraaortic nodes and left iliac nodes taken from each donor mouse was intraperitoneally transferred individually to a new mouse (recipient). Because it is known that the recipients' survival time correlates inversely to the implanted P388 leukemia cell number, the therapeutic effects of treatment on the metastases in the donors' paraaortic nodes was compared through the comparison of survival time of the recipients. The mean survival time of the recipients was statistically significantly (by Student's τ test, P<0.05) long in the group given ETOP-CH than in the groups given etoposide aqueous solution and given activated carbon without etoposide, as well as than in the non treatment group.抄録全体を表示PDF形式でダウンロード (655K) -
丸山 一雄, 岡本 亜紀, 小島 周二, 杉中 昭典, 岩鶴 素治1992 年 7 巻 5 号 p. 345-350
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーLarge unilamellar liposomes (LUV), which have a large entrapped volume and efficient drug capture characteristics, are rapidly and efficiently taken up by the RES cells in liver and spleen. A prolonged residence of the drug-entrapped liposomes in the circulation is important for the sustained release of drug form liposomes. Incorporation of 6 mol% of GM1 into LUV composed of DSPC/CH (GM1/DSPC/CH 0.13 : 1 : 1 m/m, 200 nm in size) showed a significant increase of circulation time in the blood circulation. The GM1/DSPC/CH liposomes have been tested for their utility as a sustained release system for adriamycin (ADM) in vivo. ADM was encapsulated into GM1/DSPC/CH liposome with>95% in trapping efficiency by employing the pH gradient method. Mice were given i.p. injection of 2 million L1210 leukemia cells. Twenty-four hrs later, mice were treated with single shot of ADM-GM1/DSPC/CH liposome, ADM-DSPC/CH liposome or free ADM (5 mg/kg). Treatment with ADM-GM1/DSPC/CH liposome significantly increased mean survival times as compared with two controls. Our data indicate that GM1 can significantly enhance the DSPC/CH liposome residence time in bloodstream and GM1/DSPC/CH liposomes with prolonged circulation time are important for the sustained relase of drug in circulation.抄録全体を表示PDF形式でダウンロード (1024K) -
大泉 幸雄, 生子 孝広, 前沢 博, 母里 知之1992 年 7 巻 5 号 p. 351-355
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーModifing effect of epinephrine injected intratumorously (i.t) on the effect of anti-cancer drugs injected i.t was studied using Lewis lung carcinoma. Intratumoral injection of epinephrine (0.05 ml/tumor, 1.4 mg/kg) had no effect on tumor growth delay nor development of metastases. Intratumoral injection of epinephrine (0.028∼1.4 mg/kg) before intratumoral injection of anti-cancer drugs prolonged growth delay, as 2∼3 times in DWA2214R, (-)-(R)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II) monohydrate, and as 1.3∼1.4 times in peplomycin or mitomycin C as each drug alone, respectively. Low dose of epinephrine (0.014 mg/kg) enhanced the effect of DWA2114R as well as high dose. However, epinephrine reduced the effect of SMANCS, a derivative of neocarcinostatin conjugated with copolymer of styrene and meleic acid. The mechanism of enhancement effect was discussed. It was considered that epinephrine was useful in intratumoral injection of some drugs.抄録全体を表示PDF形式でダウンロード (857K) -
小島 周二, 久保田 和彦, 粟屋 昭, 油田 勉, 丸山 一雄, 岩鶴 素治1992 年 7 巻 5 号 p. 357-361
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーThe suppressive effects of facteur thymique serique (FTS) on alloxan-induced mouse diabetes were investigated in a detailed manner. The elevation of blood glucose was suppressed at a dose of 1 μg to 100 μg per animal in a biophasic manner. The timing of FTS injection was effective only within 5 min before alloxan treatment. The administration of and-FTS antibody prevented the suppressive effect of FTS on alloxan-induced diabetes. The clearance of FTS from blood circulation was significantly fast with a calculated initial half life of 2 to 3 min following i.v injection. The frequent administration of FTS would be necessary due to the rapid clearance of it from circulation. So, a potential sustained-release drug delivery system was developed by using liposomes. Liposomes containing gangliosides GM1 (GM1-LP) were effective in extending the timing of FTS pretreatment. These results suggest that liposomal FTS might be applicable as a therapeutic agent for diabetes.抄録全体を表示PDF形式でダウンロード (984K) -
庄林 智, 高橋 俊雄, 萩原 明於, 伊藤 通敏, 阪倉 長平1992 年 7 巻 5 号 p. 363-366
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーA new dosage format of peplomycin (PEP-CH), which was composed of activated carbon particles adsorbing peplomycin, was tested for its acute toxicity on subcutaneous adminstration in mice, compared with an aqueous peplomycin solution (PEP-SOL). The LD50 value of PEP-CH was 41 mg/kg, and that of PEP-SOL was 27 mg/kg. There were no differences of intoxication symptoms, time of death and body weight change. We concluded that acute toxicity of peplomycin was reduced by using activated carbon particles as a drug carriar.抄録全体を表示PDF形式でダウンロード (728K) -
山本 裕司, 阿部 英喜, 土肥 義治, 久保 秋夫, 松本 昭彦1992 年 7 巻 5 号 p. 367-371
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーThe releasing rate of poly(3-hydroxybutyrate)-P(3HB)-microspheres containing Lastet, an anti-cancer agent, was investigated both in vitro and in vivo. The rate of the release of Lastet from P (3HB) microspheres was very small and only 20% was released during a 15-day period. The addition of glycerol tristearate (GTS) to P (3HB) increased the releasing rate of Lastet and P (3HB) microspheres which contained 25% GTS released 100% of the Lastet during a 10-day period. P (3HB) microspheres which contained 25% GTS and 10% Lastet were administered intraperitoneally to rats and the change of Lastet concentration in blood and tissue was investigated. Although in low levels, Lastet was detected in the blood up to day 3 after administration but not on day 7. Lastet was detected in high levels in the peritoneal tissue up to day 3, but not on day 7, although the microspheres were confirmed histologically. The change of the surface property of microspheres confirmed by scanning electron micrographs suggested that the decomposition of P (3HB) in vivo may be accelerated by some enzyme to increase the release of drugs.抄録全体を表示PDF形式でダウンロード (848K) -
川西 孝和, 唐木 芳昭, 佐伯 俊雄, 藤巻 雅夫, 前田 正敏, 二本松 博子, 本田 昂1992 年 7 巻 5 号 p. 373-380
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーWe have developed In-111 labeled activated carbon microspheres (111In-CH44) for use in mammary lymphoscintigraphy and analysis of mammary lymph flow. 111In-CH44 was made by the NaI complex method. In 14 patients with breast cancer studied by double isotope method using 111In-CH44 and 99mTc-CH44 which we devoloped formerly. About 1 ml (11.1MBq, 0.3mCi) of 111In-CH44 was injected before operation into the outer side of the mammary gland, and 1 ml (74MBq, 2mCi) of 99mTc-CH44 inner side. The axillary and parasternal lymph nodes were visualized clearly using two isotopes at the same time and radioactivity of each isotope in surgically dissected lymph nodes was counted. In 8 patients with parasternal lymph nodes dissection, mean distribution of radioactivity of, respectively, 111In-CH44 and 99mTC-CH44 in each regional lymph node group was as follows : brachial and subscapular 2.3% and 0.5% : central, pectoral and subpectral 79.1% and 72.9% : interpectoral 0% and 1.8% : infraclavicular 1.9% and 5.7% : highest infraclavicular 0.4% and 0% : and parasternal 16.3% and 19.1%. Thus mammary lymph flow in the same patient can be evaluated using two isotopes at the same time. These results suggest that double isotope method using 111In-CH44 and 99mTc-CH44 is useful for the detailed analysis of mammary lymph flow.抄録全体を表示PDF形式でダウンロード (1281K) -
夏目 秀視, 坂之上 和稔, 杉林 堅次, 森本 雍憲, 宮川 晃, 池口 祥一1992 年 7 巻 5 号 p. 381-388
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーGelatin films and lipid dispersed gelatin films were prepared by various crosslinking and/or fixing conditions and their utility as an implant was estimated, In vitro degradation of the gelatin films in pH 7.4 phosphate buffer at 37°C was prolonged by increase in fixing. In vivo degradation period was 2-3 times longer than in vitro. In vitro mitomycin C (MMC) permeation profiles through these films were changed by fixing condition. The permeation rate of MMC through the films was delayed with increase in the amounts of fixing agent and lipid (soy bean oil and lethitin) in the film. In vitro MMC release from MMC suspended-gelatin film was also changed by the fixing condition. Based on these results, further in vitro release experiments were carried out by 2-and 3-layer films, prepared by several layers as above, where release rate of MMC from one side was designed to be much faster than that from the other side. As a result, observed data were consistent with calculated value. It was suggested that gelatin and lipid dispersed gelatin film were available as a dosage form for delivery of drug by desired release or permeation rate.抄録全体を表示PDF形式でダウンロード (1254K) -
小久保 武政, 杉林 堅次, 森本 雍憲1992 年 7 巻 5 号 p. 391-395
発行日: 1992/09/10
公開日: 2009/02/23
ジャーナル フリーThe diffusion coefficient of prostaglandin E1 (PGE1) in the pressure sensitive adhesive (PSA) matrices at 37°C were calculated from the release profiles. 2-ethylhexylacrylate and acrylic acid copolymers were used as model PSAs. The viscosity of the PSA, as measured by a shear creep method, increased with increasing acrylic acid contents, average molecular weight of copolymer and contents of crosslinking agent in the PSA. The diffusion coefficient of PGE1 was inversely proportional to the viscosity of the PSA with varying acrylic acid content, whereas it was independent of the viscosity with varying other two factors. To interpret this conflicting results, changes in activation energy on the diffusion of PGE1 were measured. The results suggested that diffusion resistance increased only when increasing the content of acrylic acid.抄録全体を表示PDF形式でダウンロード (815K)
- |<
- <
- 1
- >
- >|