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66 巻, 11 号
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松岡 良, 森 宏之, 友成 廉平, 友成 美鈴1990 年 66 巻 11 号 p. 1127-1137
発行日: 1990/11/20
公開日: 2012/09/24
ジャーナル フリーThe circadian and pulsatile secretions of prolactin were studied in 15 pregnant and 5 puerperal women. Blood samples were taken every 15 minutes for 3 hours during daytime and at night. Diurnal levels of prolactin and estradiol were examined in 135 pregnant women. In addition, prolactin and estradiol of 8 partrient women were measured every 15 minutes until 24 hours after delivery.
Prolactin and estradiol levels increased gradually in advance of pregnancy, and a positive correlation was revealed between prolactin(Y) and gestational weeks (X):Y=7.125X-42.997, r=0.9955. Furthermore, a positive correlation between prolactin (Y) and estradiol(X) levels was observed: Y=4.439X+44.115, r=0.7590.
The circadian secretion of prolactin was observed in 15 out of 20 cases studied. The pulsatile secretion of prolactin was revealed in all 20 cases. The daytime pulse-frequency significantly decreased in the 2nd trimester and that of the nighttime also decreased in the 3rd trimester. The pulse - amplitude increased in advance of pregnancy, but amplitude/baseline value ratio was stationarily 28% during the daytime and 34% during the nighttime in every trimester of pregnancy. 63.0% of coincidence in prolactin pulse with increase of immunoreactive LH-hCG was observed. The pulsatile secretion of hCG has not been yet reported. However, the pulsatile increase of immunoreactive LH-hCG was observed in 10 pregnancies, while LH was not detected in any pregnancy by highly specific LH assay. This suggested that immunoreactive hCG changed in a pulsatile manner in the blood of pregnant subjects.
A highly significant decline of prolactin levels was observed from 10 hours before until 4 hours after delivery, which did not correlate with changes of estradiol levels.
These results indicated that the pulsatility and circadian secretion of prolactin were preserved during pregnancy and puerperium and also suggested that prolactin secretion during pregnancy, delivery and puerperium was regulated by at least 3 factors: estradiol, dopamine and LH-hCG.抄録全体を表示PDF形式でダウンロード (850K) -
細島 弘行, 宮内 英二, 岡田 博司, 森本 真平1990 年 66 巻 11 号 p. 1138-1147
発行日: 1990/11/20
公開日: 2012/09/24
ジャーナル フリーHyperglycemia and impaired glucose tolerance are frequently observed in patients with hyperthyroidism. However, little is known about whether altered polyol metabolism in hyperthyroidism is present or not. To examine changes in polyol metabolism in hyperthyroidism, we investigated changes in erythrocyte sorbitol, glyceraldehyde reductase (GAR) and sorbitol dehydrogenase (SDH) activities during hyperthyroid and euthyroid states in patients with thyrotoxicosis. Mean levels of erythrocyte sorbitol and GAR were 32.0±1.6nM/g.Hb and 147.1±0.3mU/g.Hb, respectively. In thyrotoxic patients in a hyperthyroid state, these values were significantly higher than those in euthyroid controls. Mean level of erythrocyte SDH in thyrotoxic patients was weak but was significantly increased in comparison with that of euthyroid controls. However, mean levels of erythrocyte sorbitol and GAR were remarkably reduced to 23.6±1.4nM/g.Hb and 125.3±4.6mU/g.Hb in thyrotoxic patients in a euthyroid state after treatment with anti-thyroid drugs or by subtotal thyroidectomy. Mean level of SDH, on the other hand, was increased after the treatment. In addition, positive correlations were observed between the level of erythrocyte sorbitol or GAR, and the level of free thyroxine (FT4) or free triiodothyronine (FT3). A negative correlation was observed between the level of erythrocyte SDH and the level of FT4 or FT3. These results suggest that the level of erythrocyte sorbitol may be increased through direct acceleration of erythrocyte GAR activity by increased thyroid hormone levels in patients with thyrotoxicosis.抄録全体を表示PDF形式でダウンロード (976K) -
神谷 敦, 森本 茂人, 高本 勝之, 名畑 孝, 宮下 善行, 北野 昇一, 荻原 俊男1990 年 66 巻 11 号 p. 1148-1157
発行日: 1990/11/20
公開日: 2012/09/24
ジャーナル フリーWe treated a 29-year-old male patient with pseudohypoparathyroidism type I, who showed a slight increase in serum indirect bilirubin without any signs of liver dysfunction. Serum levels of total, direct and indirect bilirubins were 2.4, 0.7 and 1.7mg/dl, respectively (normal ranges: 0.2-0.8, 0-0.2 and 0.2-0.6mg/dl, respectively). The cause of the increases in serum bilirubin levels was not clear; however, hemolytic anemia, hereditary unconjugated hyperbilirubinemia or ineffective erythropoiesis were ruled out as causes for the increase, since 1) his serum level of haptoglobin was normal, 2) increase in serum level of indirect bilirubin 120 minutes after the infusion of 50mg nicotinic acid was within the normal range, and 3) severe anemia was not observed. Osmotic fragility of his circulating red blood cells was also within normal range. Three other patients with pseudohypoparathyroidism visiting our clinic also showed slightly high levels of serum indirect bilirubin, although four outpatients with idiopathic hypoparathyroidism showed no such abnormality. Abnormality in the responsiveness to parathyroid hormone and/or to that in the cyclic AMP productivity in this disease may cause the increase in the circulating unconjugated bilirubin.抄録全体を表示PDF形式でダウンロード (1357K) -
工藤 美穂子, 工藤 剛, 松木 明知1990 年 66 巻 11 号 p. 1158-1163
発行日: 1990/11/20
公開日: 2012/09/24
ジャーナル フリーDelta sleep-inducing peptide (DSIP) is described as being an endogenous sleep factor. This DSIP inhibits ACTH release induced by CRF from rat anterior pituitary tissue. Prostaglandin D2(PGD2) is regarded as another endogenous sleep factor. However, little information has been accumulated concerning the involvement of PGD2 in the regulation of hormone secretion from the anterior pituitary. It was, therefore, interesting to observe the effect of PGD2 on ACTH release from rat anterior pituitary cells.
Rat anterior pituitary cells were obtained by enzymatic digestion of the pituitary gland of male Wister rats. The cell pellet was suspended in Hank's balanced salt solution containing 0.1% BSA and distributed in a 800μl aliquot to 12×75mm glass tubes. The samples were preincubated for 90 min. in a 37°C waterbath under 5% CO2/95% O2. After preincubation, aliquots of various concentrations of CRF, PGD2 and PGE2 were added in a 100μl volume and incubated for 4 hr. ACTH in the incubation medium was determined by radioimmunoassay.
0.01-1.0nM CRF significantly increased the ACTH release from rat anterior pituitary cells in a dose dependent manner. Each concentration of 0.1, 1, 2nM PGD2 or PGE2 had no effect on basal ACTH levels. 2nM PGD2 showed a significant inhibition of the CRF-induced ACTH secretion from rat anterior pituitary cells. Similarly, 2nM PGE2 significantly inhibited the CRF-induced ACTH release from rat anterior pituitary cells. The magnitude of the inhibitory effect of PGE2 was slightly higher than that of PGD2.
From these results, we concluded that PGD2 inhibited CRF-induced ACTH secretion at the level of pituitary gland.
This inhibitory action of PGD2 on ACTH secretion could be attributed to a stress attenuating effect of this eicosanoid.抄録全体を表示PDF形式でダウンロード (586K) -
奥村 健二, 伊藤 隆之1990 年 66 巻 11 号 p. 1164-1169
発行日: 1990/11/20
公開日: 2012/09/24
ジャーナル フリーA high performance liquid chromatographic method with electrochemical detection is described for simultaneously measuring the concentrations of the endogeneous catecholamines and the deaminated catecholamine metabolite 3, 4-dihydroxyphenyglycol (DHPG) in plasma. Plasma DHPG concentrations as determined by the present method were734±77pg/ml after 30 min. of supine rest whereas plasma norepinephrine (NE) concentrations were 114±20pg/ml in 5 healthy subjects. The DHPG and NE concentrations increased to 891±64 and 266±36pg/ml, respectively, after 30 min. of upright position following 30 min. of supine rest. The simultaneous measurement of plasma DHPG and NE concentrations may provide a more comprehensive assessment of the sympathetic nervous system.抄録全体を表示PDF形式でダウンロード (464K)
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