巻号一覧
72 巻 (1996)
- 6 号 p. 1003-
- 5 号 p. 1-
- 4 号 p. 587-
- 3 号 p. 449-
- 2 号 p. 20-
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前身誌
72 巻, 3 号
選択された号の論文の15件中1～15を表示しています
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櫻井 昌禄, 廣谷 淳, 檜垣 実男, 福尾 恵介, 森本 茂人, 荻原 俊男1996 年 72 巻 3 号 p. 449-455
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーA case of Cushing's syndrome due to ACTH-independent bilateral macronodular adrenal hyperplasia is reported. A 46-year-old male was admitted to our hospital for further examination of hypertension. He was diagnosed as suffering from hypertension for the first time at the age of 44. Antihypertensive drug therapy with a calcium-channel antagonist or a beta blocker was tried but both had little effect. Physical examination revealed moon face and central obesity.
Complete blood counts and blood chemistry were within normal ranges but endocrinological studies showed that plasma cortisol was high (24.0μg/dl) with a lack of diurnal rhythm, and plasma ACTH was suppressed (<5pg/ml). Two or 8 mg of dexamethasone did not suppress the plasma cortisol levels. Intravenous infusion of ACTH (0.25mg) greatly raised plasma cotrisol level (380%of control). Scintigraphic imaging with 131I-adosterol revealed abnormal uptakes of bilateral adrenal glands, and computed tomography also demonstrated abnormal nodules at bilateral adrenal glands. Brain CT and MRI had no abnormal findings.
He was diagnosed as Cushing's syndrome with bilateral adrenal hyperplasia, and bilateral adrenalectomy was performed. Right and left adrenal glands were 95g and 70g, respectively, and were occupied by yellow nodular lesions. Histologically, hyperplastic lesions were composed of clear cells. Finally he was diagnosed as ACTH-independent bilateral adrenocortical macronodular hyperplasia (AIMAH).抄録全体を表示PDF形式でダウンロード (1639K) -
石原 隆, 池窪 勝治, 日野 恵, 梶川 麻里子, 服部 尚樹, 森寺 邦三郎, 倉八 博之1996 年 72 巻 3 号 p. 457-466
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーOf 139 patients with metastasis resulting from differentiated thyroid cancer, 16 (11.5%) who underwent 131I therapy five times or more were assessed for therapeutic results, therapeutic intervals and side effects.
Of the 16 patients (2 males and 14 females), 10 suffered from papillary carcinoma and 6 from follicular carcinoma. In terms of the metastatic site, 7 were lung metastatic cases, 4 bone metastasis and 5 both lung and bone metastases. The therapeutic results were as follows: none (0%) of the patients were cured, 50% improved (Group A), 19% showed no change (Group B), and 31% showed deterioration and died (Group C).
The onset of the first symptom occurred at the age of 22±7 years in Group A, 29±14 years in Group B and 52±14 years in Group C. Group A received initial therapy at 29±6 years of age, Group B at 39±24 years and Group C at 54±14 years. The serum Tg level in Group A continuously declined by repetitive 131I therapy and the ratio (serum Tg level after the last 131I therapy/Tg level before 131I therapy) was significantly lower (P<0.01) in Group A (17±13%) than that in Group B (59±39%) and in Group C (131±121%).
The reduction rate of serum Tg level was 42±15%with 131I therapy given twice yearly and 17±22% once yearly. The difference was significant (P<0.02). Side effects were hardly shown.
From these results, it may be concluded that frequent 131I therapy is more effective among the subjects in Group A, who started the initial therapy when younger than 30 years of age, and underwent subsequent 131I therapy once every 6 months, and that a successive decline in serum Tg levels is a useful marker for a good prognosis.抄録全体を表示PDF形式でダウンロード (849K) -
竹内 美保子, 内田 健三, 石井 隆, 北沢 光孝, 中野 茂, 木越 俊和, 森本 真平1996 年 72 巻 3 号 p. 467-472
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーThymic hyperplasia is commonly associated with Graves' disease. A radiologically visible thymic mass, however, is rare. Herein we describe a huge thymic hyperplasia which is unresponsive to antithyroid drug therapy.
A 16-year-old female was admitted to the Kanazawa Medical University in July 1992, with complaints of finger tremors, hypersweating, palpitation and loss of body weight. Her physical examination was notable for tachycardia and goiter. There was no exophthalmus and no symptoms of blepharoptosis, double vision, dyspnea or muscle weakness, suggesting no evidence of myasthenia gravis. Her thyroid function test showed a serum-free T4 of 9.5ng/dl (normal range is 83-1.45), a serum-free T3 of 26.0pg/ml (normal range is 2.8-6.0), and undetectable serum TSH levels before and after infusion. TSH receptor antibodies (TBII and TSAb) were positive, and antithyroid antibodies (TGHA and MCHA) were negative. A chest roentgenogram showed a right hilar enlargement, suggesting an anterior mediastinal mass. A chest CT scan revealed an unenhanced solid anterior mediastinal mass. Neither a gallium nor an iodide scan showed an abnormal uptake in the mass.
The female was treated with MMI 30mg/day for three months and her thyroid function was gradually normalized. The size of the anterior mediastinal mass on a follow-up chest CT scan remained unchanged. She underwent a thymectomy. The thymus weighed 25 grams and revealed microscopic lymphoid hyperplasia with germinal centers surrounded by Hassall's corpuscles in the medulla.
Thymic hyperplasia accompanying Graves' disease should be surgically treated when its regression does not occur or when there is a clinical suspicion of malignancy in spite of appropriate antithyroid therapy.抄録全体を表示PDF形式でダウンロード (1256K) -
山本 宝, 金 共子, 北脇 城, 本庄 英雄1996 年 72 巻 3 号 p. 473-479
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーMCF-7 human breast cancer cells possess both aromatase activity and estrogen receptors. In this study, we examined how transforming growth factor-α (TGF-α) and insulin-like growth factor-I (IGF-I) influenced cell proliferation through the action of aromatase in MCF-7 cells.
We discovered that TGF-α suppressed the aromatase activity in MCF-7 cells and that IGF-I enhanced the activity. Both TGF-α and IGF-I stimulated [3H] thymidine incorporation into these cells. Estradiol-17β (E2) or testosterone (T)-generally after being converted to estrogen by aromatase-stimulated both [3H] thymidine incorporation and IGF-I production in MCF-7 cells when compared to the untreated cells by E2 or T. However, IGF-I, like TGF-α, reduced the stimulation of [3H] thymidine incorporation by E2 or T when either was added to the cell culture, suggesting that IGF-I interferes with estrogen-dependent proliferation.
This result may also suggest the presence of an autoregulatory system between estrogen-dependent and estrogen-independent proliferation channels in MCF-7.抄録全体を表示PDF形式でダウンロード (681K) -
川崎 君王, 鬼原 彰, 今井 浩三1996 年 72 巻 3 号 p. 481-488
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーWe describe a case of central diabetes insipidus deteriorating NIDDM. A 42-year-old male visited our hospital's outpatient department with complaints of xerostomia, polydipsia and polyuria, and was found to have hyperglycemia and glycosuria in spite of a small quantity of urinary specific gravity.
He was immediately diagnosed as diabetes mellitus, and treated with insulin and a restricted caloric intake. His blood sugar level came under control, however his urinary specific gravity remained low with a volume of about 5,000ml/day.
Diabetes insipidus was suspected. His pituitary gland was examined. The failure of antidiuretic hormone (ADH) release was revealed by water deprivation and hypertonic saline tests.
The functions of the anterior lobe were normal; and an MRI study of the pituitary gland showed that the sella turtica had neither tumor nor high intensity area of the T1-weighted image which was suggested in the posterior lobe.
The male was diagnosed as idiopathic central diabetes insipidus, and subsequently treated with DDAVP. bringing his urinary specific gravity within normal levels. His blood sugar level was controlled and normal without insulin. Dehydration from the diabetes insipidus is suspected to have deteriorated the NIDDM and to have caused the hyperglycemia.抄録全体を表示PDF形式でダウンロード (790K) -
吉沢 祥子, 横山 淳一, 溝渕 杏子, 景山 茂, 千田 道雄, 肥塚 直美, 田嶼 尚子1996 年 72 巻 3 号 p. 489-500
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーA 63 year-old-man was admitted for severe hypoglycemia. Insulin levels were constantly low and the anti-insulin antibodies were negative in his serum. Basal levels of counter-regulatory-insulin hormone were within normal ranges.
However the response of counter-insulin hormones to hypoglycemia was inhibited, and administration of glucagon failed to adequately elevate the glucose level. The FDG-PET images showed an immense FDG uptake in the adipose tissues, and a low FDG uptake in the liver. In contrast, the tumor FDG uptake was relatively low. The plasma FDG activity was also low, reflecting accelerated plasma glucose turnover, which was attributed to the massive FDG uptake by the adipose tissues. The patient suffered a myocardial infarction and died. The autopsy confirmed a small gallbladder carcinoma and hypertrophic subcutaneous adipose tissue. The concentrations of IGF-11 did not increase in either the tumor or the serum, suggesting that the tumor did not produce IGF-11.
These findings strongly suggest that the hypoglycemia in this patient was due primarily to massive glucose consumption in the adipose tissues and by the inhibited glucose metabolism in the liver. In addition, the counter regulation activities failed and actually worsened the hypoglycemia. The mechanism of this abnormal glucose metabolism is unclear. However, it is likely that the tumor may have produced an unknown insulin-like material which prominently acts as an adipose tissue.抄録全体を表示PDF形式でダウンロード (5262K) -
小寺 隆雄, 野村 隆, 櫻田 俊郎1996 年 72 巻 3 号 p. 501-505
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーA 74-year old man was admitted to the Yamagata City Hospital with complaints of dyspnea and a gripping sensation of the throat. He first noticed this symptom 10 years prior to this episode, but only recently had it become frequent. On adminssion, Trousseau and Chvostek signs were positive. Serum examinations revealed very low calcium (3.4mg/dl), high inorganic phosphorus (8.3mg/dl), a remarkably low parathyroid hormone count, and 1,25 (OH)2 vitamin D concentration. Computed tomography showed calcification of the basal ganglia and cerebellar hemisphere. The patient was diagnosed with idiopathic hypoparathyroidism complicated by spasms of the larynx as one symptom of tetany. First we administered CaCl2 solution intravenously and then alfacalcidol with CaCO3 orally. The constriction in his throat disappeared with the recovery of the serum calcium level. However, central sleep apnea syndrome was observed in his sleep. We investigated his respiratory state by apnomonitor which registered the apnea index of 44.1 times per hour, at one week after admission. Four weeks later, the apnea index improved to 3.6 times per hour as serum calcium was maintained at the lower limits of normal concentration. In this case, it appears that the idiopathic hypoparathyroidism contributed to spasms of the larynx which brought on obstructive sleep apnea syndrome, this appears to have then complicated the central sleep apnea syndrome.抄録全体を表示PDF形式でダウンロード (956K) -
富澤 由雄, 清水 弘行, 入内島 徳二, 正田 純史, 青木 秀夫, 佐藤 則之, 森 昌朋1996 年 72 巻 3 号 p. 507-514
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーWe report two cases of hyponatremia due to hypoaldosteronism, accompanied by adult onset still's disease.
Case 1. A 76-year-old man was admitted because of elevated body temperature. He had been diagnosed with adult onset still's disease and had received 5mg predonisolone a day for 4 years. After the predonisolone had been discontinued his body temperature increased. Upon admission, both serum Na and plasma aldosterone levels were obviously low and plasma aldosterone level did not in respond to the intravenous injection of 0.25mg ACTH, suggesting a disturbance in mineralcorticoid production. A hydrocortisone supplement normalized serum Na levels.
Case 2. A 71-years-old man was admitted because of body temperature elevation. He was diagnosed with adult onset still's disease and also had received 5mg predonisolone a day for 4 years. After the predonisolone was discontinued, his body temperature increased. On admission, serum Na, plasma aldosterone and serum cortisol levels were low. Neither the serum cortisol nor plasma aldosterone level increased after intravenous injection of 0.25mg ACTH. The response of plasma ACTH and serum cortisol levels to intravenous injection of 100μg CRF was attenuated. Hydrocortisone supplement normalized serum Na levels. These data indicated the existence of disturbed mineralcorticoid production and a hypothalamic-pituitary axis. The present cases raise the possibility that long-term predonisolone treatment for still's disease may disturb the adrenal mineral-corticoid production long after treatment has ended, resulting in hyponatremia.抄録全体を表示PDF形式でダウンロード (653K) -
坪井 久美子, 勢川 真理, 宮地 幸隆1996 年 72 巻 3 号 p. 515-521
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーA case of a 64-year-old female with atypical mycrobacterial disease experienced tachycardia and body weight loss. Her serum CA19-9 was elevated(285.0U/ml), and both CT and ultrasonography (US) showed a tumor mass in the pancreatic body. She was operated on for partial pancreatomy. Histological examination of pancreatic sample revealed true cysts. The elevated serum CA19-9 did not change after the operation. She had goiter and laboratory data showed latent thyrotoxicosis. Thyroid US showed multinodular goiter with cystic change and a 123I scintigram revealed autonomously functioning thyroid nodules (AFTN). A fine needle aspiration biopsy of the thyroid did not show any malignant cells. Reduction of serum CA19-9 was demonstrated after every aspiration of the thyroid cyst. We supposed that the high serum level of CA19-9 was due to leakage from the thyroid cyst into the serum.
To determine whether a benign thyroid cyst produces CA19-9 and causes elevation of serum concentration, we studied 15 patients with benign cysts of the thyroid. Eleven patients were diagnosed as having adenomatous goiter (AG) with cystic change and four as having Hashimoto disease (HD) with cystic change. A patient with AG showed latent thyrotoxicosis and two patients with HD showed subclinical hypothyroidism. Serum CA19-9 was within normal range in all patients. The CA19-9 content of cystic fluid was higher than the normal serum range (from70.6 to 727000.0U/ml), except in one patient who lacked the Lea and Leb antigen. In every patient of this study, the CA19-9 content of cystic fluid was higher than their individual serum CA19-9.
Our results indicate that every thyroid cyst contains CA19-9, and that thyroidal CA19-9 caused an elevation of serum CA19-9 in some cases. CA19-9 is not an indicator for malignant thyroid disease.抄録全体を表示PDF形式でダウンロード (917K) -
石突 吉持, 広岡 良文, 谷川 俊一, 三浦 義孝1996 年 72 巻 3 号 p. 523-532
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーThere has as yet been no report concerning the safety of iodine-overloaded women during lactation in Japan. Especially, Lipiodol administered via vagina is known to stay over two years in the body. This raises the fear that Lipiodol may cause damage to the thyroid of neonates. We therefore attempted to ascertain the safety of lactation to the thyroid gland of neonates born from the women who have been overloaded with iodine.
We selected 32 subjects who had been given Lipiodol (containing 480 mg of iodine in 10 ml of solution) through hysterosalping-graphy (H. S. G.) which had been performed more than six months before conception and 13 cases of iodine-overloaded women. An additional 118 cases who had not overloaded on iodine, aged 23-43, were carefully chosen as controls.
Iodine in milk and serum non-hormonal iodine were measured by each of the following chemical methods.
One week after delivery, concentrations of iodine in milk were at the highest levels and a gradual decrease was observed each week thereafter in the cases received H. S. G. as well as in the control. Iodine levels in the milk of the H. S. G. cases was significantly higher than those of the controls only in one week after delivery, and then they showed almost the same levels as the controls. Iodine levels in the milk of the iodine-overloaded cases were significantly higher than both those of the controls and the H. S. G. cases only in two weeks after delivery. The biological half life (B. H. L.) of iodine in the milk of two cases which received Lipiodol was 2-3 times as long as that in the iodine-overloaded cases. The B. H. L. of milk iodine was practically a quarter of the serum nonhormonal iodine level. When the iodine in the milk of the H. S. G. cases was analyzed using HPLC, no appreciable peaks of Lipiodol were recognized on the chromatogram. Three of the H. S. G. cases revieled more than 100 ug/dl of iodine in their milk; the levels in 2 of them declined to within normal range within 2-4 weeks after delivery.
This indicates that the iodine in milk of the cases exposed to Lipiodol should be inorganic and that its disappearance was considerably rapid compared to that of the serum non-hormonal iodine. Therefore, it is suggested that in the cases of conception where more than six months had lapsed since H. S. G. administration, the lactation might not be harmful to the neonatal thyroid gland.抄録全体を表示PDF形式でダウンロード (948K) -
石橋 里江子, 中石 滋雄, 河野 茂夫, 隠岐 尚吾1996 年 72 巻 3 号 p. 533-542
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーA 58-year-old female was admitted to the hospital because of loss of consciousness, poor appetite and general malaise. She had had radiation therapy for nasopharyngeal cancer two years before. Serum sodium concentration was 115 mEq/l, and serum cortisol and ACTH levels were extremely low. Endocrinological dynamic tests indicated panhypopituitarism and a pituitary tumor was disclosed by an MRI study. Since metastases were detected nowhere other than the pituitary gland, transsphenoidal subtotal resection of the pituitary tumor was performed. Histological diagnosis was an undifferentiated squamous cell carcinoma. After the operation, carboplatin and fluorouracil were administered. She has since been in good condition with the replacement therapy consisting of 1-thyroxine and cortisone acetate.
A 74-year-old female who had undergone right, upper lobectomy for lung cancer one year before was admitted because of thirst, polydipsia and polyuria. Water deprivation tests revealed partial pituitary diabetes insipidus. Endocrinological tests on the anterior pituitary function indicated multiple disturbances of hormones, including the gonadotropin, the growth hormone and the thyrotropin. She died due to respiratory infection one month after the appearance of her symptoms. Multiple metastases to the lung, liver, kidney and bone were confirmed during autopsy. The pituitary posterior lobe and part of an anterior lobe had been replaced by squamous cell carcinoma.
The metastatic pituitary tumor is relatively rare and most cases are asymptomatic. In these two cases, the metastases to the pituitary gland were diagnosed by endocrinological signs and symptoms. In addition, the prognosis of pituitary metastasis is improved by early and appropriate therapy.抄録全体を表示PDF形式でダウンロード (2364K) -
和田 聡子, 木村 健一, 水野 石一, 馬場 泰人1996 年 72 巻 3 号 p. 543-550
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーWe report the case of aceruloplasminemia in a patient having insulin dependent-diabetes mellitus (IDDM), cerebellar ataxia and retinal degeneration. It should be noted that the parents of this patient were related to each other as cousins.
Blood analyses revealed microcytic hypochromic anemia, a decrease of serum Fe and Cu, an increase of serum ferritin, and a deficiency of ceruloplasmin. An MRI study revealed that the basal ganglia of the brain, red nuclei, substantia nigra and dentate nuclei of the cerebellum showed low signals in both T1-and T2-weighted images, indicating the deposition of paramagnetic material (i. e. iron and copper). The liver showed high density in the CT scan and low signals in the T1-weighted image of the MRI, whereas the pancreas showed normal density both in the CT and the MRI. A liver microscopy showed hemosiderin lying within the parenchymal cells. The copper content in the patient's liver was slightly increased (15.9μg/g), and the iron was remarkably increased (3951.2μg/g), compared to normal levels.
There was no history of iron overloading, and ceruloplasmin plays a very important role as ferroxidase in iron metabolism. This case was therefore suspected to be an iron metabolism disorder due to aceruloplasminemia, and distinct from Wilson's disease and Menke's disease.抄録全体を表示PDF形式でダウンロード (1378K) -
菅原 隆, 清水 公, 瀬川 郁夫1996 年 72 巻 3 号 p. 551-560
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーWe reported a case of a 72-year-old man with an extra-adrenal pheochromocytoma secreting excessive epinephrine (E). He had been treated for diabetes mellitus and essential hypertension. His diabetes was controlled poorly, but his blood pressure was controlled well. He was admitted to our hospital for weight loss evaluation. An upper gastrointestinal series and computed tomography of the abdomen revealed an ovoid mass (diameter, approximately 5×6 cm) overlying the abdominal aorta and the inferior vena cava between the second and the third lumbar vertebra. Aortography showed a hypervascular mass. Analysis of catecholamine (CA) and its metabolites showed elevations in plasma norepinephrine (NE, 3850 pg/ml) and E (560 pg/ml) levels as well as the urinary NE (1200-1400μg/day), E (310-350μg/day) and vanillylmandelic acid (26.8 mg/day) levels. Vena caval CA sampling indicated that the peak levels for both NE and E were at the third lumbar vertebra. The tumor (104 g) was removed in April 1991. Histological analysis revealed a typical pheochromocytoma with paraganglia adjacent to the tumor. The tumor cells were immunoreacted to phenylethanolamine-N-methyltransferase (PNMT). NE and E granules appeared on electron microscopy, and the urinary NE and E were normalized by the surgery. These findings suggest that our case may be an E-secreting extra-adrenal pheochromocytoma.
The conversion of NE to E is catalyzed by PNMT found primarily in the adrenal medulla and the organ of Zuckerkandl. An E-secreting pheochromocytoma is generally located at either of these two sites. The classic location of the tumor to the Zuckerkandl organ is in the retroperitoneal tissue lateral to or overlying the lower portion of the abdominal aorta in the vicinity of the inferior mesenteric artery. Our case was at the typical location and had a microscopic pattern of paraganglia adjacent to the tumor. In our case, the pheochromocytoma appears to have originated in the Zuckerkandl.抄録全体を表示PDF形式でダウンロード (2841K) -
斎藤 幾重1996 年 72 巻 3 号 p. 561-571
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーTwenty-four patients with essential hypertension were classified as salt-sensitive (SS) or non-salt-sensitive (NSS) depending on the changes in mean blood pressure (MBP) when salt intake was increased from 2 g (low-sodium) to 15 g (high-sodium). Although the plasma immunoreactive endothelin-1 (irET-1) levels remained unchanged, fractional excretion of irET-1 (FEET) levels elevated on a high-sodium diet in both groups. Positive correlation was observed between elevation of FEET and fractional excretion of Na (FENa) with a high sodium diet (r=0.53, p<0.05). FEET level on a high-sodium diet were significantly smaller in SS than in NSS group (p<0.05). In addition, FEET was inversely correlated with MBP on high-sodium diet (r=-0.47, p<0.05). The decrements of plasma renin activity was significantly smaller in the SS than in the NSS group (p<0.01). These findings indicate that a large part of the urinary ET is of renal origin, increasing sodium excretion, and that the greater rise in blood pressure in SS patients with sodium loading is attributed to greater sodium retention due to an attenuated secretion of renal ET in addition to a low response of renin.抄録全体を表示PDF形式でダウンロード (916K) -
左右田 裕生, 中後 聡, 船越 徹, 望月 眞人, 森川 肇1996 年 72 巻 3 号 p. 573-586
発行日: 1996/05/20
公開日: 2012/09/24
ジャーナル フリーThe effects of the difference of nutritional intake on the kinetics of IGF-I secretion were investigated by 48 hours refeeding with standard, low-protein, low-fat, or low-sugar diet after 72 hours fasting in nonpergnant rats. The effects of hormonal and nutritional changes on the plasma level of IGF-I were also examined in pregnant rats by administration of hGH (100μg/day) for 3 days from day 12 or day 17 of pregnancy and by fasting for 48 hours from day 18. Plasma levels of GH and IGF-I were measured by radioimmunoassay, and the nitrogen balance was determined by the Plegl-Damas method.
When nonpregnant rats were fed diets containing different nutrients after 72 hours of fasting, feeding with a low-protein diet, decreased plasma levels of total protein and albumin, and a decreased nitrogen balance were found to be closely related to a fall in the plasma level of IGF-I. In the nonpregnant rats, it appeared that nutrient intake and protein metabolism were important factors in the control of IGF-I.
When the pregnant rats were administered 100μg/day of GH from day 12 to day 14 or day 17 to day 20 of gestation, the plasma levels of IGF-I were not significantly higher than in the control group given physiological saline intramuscularly.
The IGF-I level in pregnant rats was 87.6±17.5 ng/ml on day 18. When the rats fasted for 48 hours from day 18, the IGF-I level fell to 60.6±10.7 ng/ml on day 20, a value significantry lower than that in rats allowed free access to food (118.6±24.8 ng/ml). A significant decrease in the plasma levels of total protein, albumin, triglycerides, and total cholesterol was seen after 48 hours of fasting from day 18. The nitrogen balance was 48.6±38.5 mg/day on day 18, and became markedly negative (-279.4±94.1 mg/day) on day 20 after fasting for 48 hours. The plasma level of IGF-I decreased as the nutritional status of the rats worsened, and changes in the IGF-I concentration were in close agreement with changes of the simultaneously measured nitrogen balance.
These findings suggest that plasma levels of IGF-I in pregnant rats are influenced by changes of nutrient metabolism, especially protein metabolism.抄録全体を表示PDF形式でダウンロード (1277K)
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