巻号一覧
116 巻 (1975)
- 4 号 p. 299-
- 3 号 p. 205-
- 2 号 p. 103-
- 1 号 p. 1-
116 巻, 2 号
選択された号の論文の13件中1～13を表示しています
- |<
- <
- 1
- >
- >|
-
AKIRA OHNEDA, KIYOSHI MATSUDA, MASAMICHI CHIBA, YASUO IIMURA, SHOICHI ...1975 年 116 巻 2 号 p. 103-110
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーEight normal subjects and ten diabetic patients were studied to compare the response of plasma insulin to glucagon with that to glucose and tolbutamide. Oral glucose tolerance test, glucagon test and tolbutamide-glucagon test were performed at intervals of several days. In glucose tolerance test, insulin response was reduced in the patients with severe diabetes. Plasma insulin increased and reached the peak 3 min after glucagon injection (glucagon I) in the normal controls, while plasma insulin response was reduced in diabetic patients, especially in the severe diabetics. In the normal controls plasma insulin rose and reached the peak 6 min after the tolbutamide injection and thereafter fell to the initial level. Glucagon injection following tolbutamide (glucagon II) caused the rise in insulin in the control subjects. In diabetics insulin response to either tolbutamide or glucagon 1 was reduced. Tolbutamide or glucagon II caused a significant difference in plasma insulin response in all the diabetic groups compared with the normal subjects, while glucose or glucagon I showed a significant increment of plasma insulin between the normal subjects and the severe diabetics. These results suggest that injection of tolbutamide as well as glucagon II provides a definite discrimination of insulin response in diabetics from the normal controls. The usefulness of the tolbutamide-glucagon test in the diagnosis of diabetes mellitus was discussed.抄録全体を表示PDF形式でダウンロード (445K) -
HIROSHI OHTA, KAZUYUKI SHIMIZU1975 年 116 巻 2 号 p. 111-125
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーIngestion by mononuclear cells in bone marrow, peripheral blood and the peritoneal cavity of red cells treated with antibodies and various chemicals was studied in an attempt to characterize these cell lines during development and to clarify the interrelationship among them. Bone marrow mononuclear phagocytes became intensively phagocytic during the second day of culture, indicating that the maturation time from progenitor cells to macrophages was about 48hr. Blood monocytes exhibited very active erythrophagocytic activity after 24 to 48 hr cell culture. Uptake of sensitized red cells by both the cell lines was markedly inhibited by IgG irrespective of time periods of cell culture. Majority of peritoneal lymphocyte-like cells (LLC) separated from other forms of mononuclear cells were shown to become capable of erythrophagocytosis with maturation time to macrophages between 24 to 48hr. Under non-stimulated steady state, uptake of sensitized red cells by peritoneal macrophages was far less sensitive to IgG inhibition than that by bone marrow mononuclear phagocytes and blood monocytes, suggesting that IgG receptor does not play main role for the erythrophagocytosis by peritoneal macrophages. Peritoneal cells collected under inflammatory stimulus exhibited a character similar to bone marrow mononuclear phagocytes and blood monocytes with regard to IgG receptor. It was suggested that under steady state peritoneal macrophages arise and mature from local proliferative pool with some different phagocytic mechanism from that of bone marrow mononuclear phagocytes.抄録全体を表示PDF形式でダウンロード (2773K) -
HIROKATSU KUMATA, KAZUO WAKUI, HIROSHI SUZUKI, TAKEHISA SUGAWARA, INSU ...1975 年 116 巻 2 号 p. 127-132
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーGlutathione reductase activity of both serum and liver tissue homogenates was measured in normal controls and in cases of hepatic parenchymatous diseases, and the results were compared with those from animal experiments in which hepatic damage was produced by CCl4 injection. Glutathione reductase showed a different attitude from those of transaminases and alkaline phosphatases under these clinical and experimental conditions. Glutathione reductase activity increased in both serum and liver in patients with hepatic damage, and this increase occurred earlier than the changes in alkaline phosphatase activity.抄録全体を表示PDF形式でダウンロード (415K) -
TAKEHIKO TAKATORI, YOH IMAI1975 年 116 巻 2 号 p. 133-139
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーStereospecificity as well as the dependency on reduced pyridine nucleotides of the enzymatic reduction of acetoacetyl CoA and crotonyl CoA in lactating rabbit mammary glands are reported. In the reduction of both acetoacetyl CoA and crotonyl CoA as substrates the tritium from NADP3H was stereospecifically incorporated into the β-position of n-butyric acid. The reaction of acetoacetyl CoA reduction was much more dependent on NADH while the reduction of crotonyl CoA was rather more dependent on NADPH. There was no difference between the dependencies on NADH and NADPH in the reduction of 2-hexenyl CoA.抄録全体を表示PDF形式でダウンロード (397K) -
EIETSU OUCHI, KIYOMI MIURA, SHOICHI YAMAGATA1975 年 116 巻 2 号 p. 141-147
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーThe reticuloendothelial system function test using 131I-labeled aggregated human albumin (131IAA) as test particle is thought to be one of the best methods for the study of RES function of human beings. This method needs a large amount of 131IAA, but 131IAA has been used as a tracer of liver scintiscanning, and we tried to study RES function by using commercially available 131IAA specially made as tracer of liver scintiscanning. Because the amount of 131IAA used in this study was smaller than the critical dosis, our interest was focussed on the catabolic activity of 131IAA phagocytized by Kupffer's cells. The plasma obtained 60 min after 131IAA injection was fractionated into two distinct peaks by gel column chromatography; ionic 131I and protein-bound 131IAA. The ratio between ionic 131I and bound 131IAA (F/B ratio) was studied in various diseases. The F/B ratios of liver cirrhosis and hepatoma were significantly lower than that of the control. The lowered F/B ratio had no correlation with other liver function tests, data of hepatic scintiscanning, or with clinical findings. The F/B ratio was also not correlated with congo red index as RES function test.抄録全体を表示PDF形式でダウンロード (351K) -
YOICHI OTSUKA, KEISHI ABE, TETSUO SAITO, NOBUO IROKAWA, HARUKI AOYAGI, ...1975 年 116 巻 2 号 p. 149-160
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーPlasma renin activity (PRA) in peripheral and renal vein blood was determined in 25 patients with renovascular hypertension. Significant elevation of resting peripheral vein PRA was observed in only 9 (36%) of them. 11 (61%) out of 18 patients whose conditions were improved by surgery had shown normal levels of resting peripheral vein PRA preoperatively. Provocation test for renin secretion was done in 20 patients. 10 patients showed a hyper-response. 7 out of 15 patients who benefited from surgery had shown 'no response in PRA on the stimulation. Renal vein PRA was determined in 23 patients. In 16 significantly higher renal vein PRA was found on the affected side. However, measurement of renal vein PRA failed to predict the surgical results in one-third of the patients. Postoperative PRA and blood pressure were followed serially in 10 patients. PRA became normal within 3 days postoperatively in 9 patients. While the normalization of blood pressure following operation was more rapid in 3 revascularized patients than in 7 nephrectomized, the normalization of PRA was quicker in the latter patients than in the former. These data indicate that measurement of PRA in peripheral and renal vein is not an infallible mean to determine the functional significance of renal arterial lesions.抄録全体を表示PDF形式でダウンロード (707K) -
KENJI KOYAMA, ISAO MUTO, HIDEMI YAMAUCHI, YASUSHI TAKAGI, TAKUMI ANEZA ...1975 年 116 巻 2 号 p. 161-172
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーIn an attempt to study the collagen formation in the liver occurring in association with obstructive jaundice, the authors carried out an experiment with liver slices from common bile duct-ligated rats. Hepatic collagen was fractionated into the neutral soluble, acid soluble and insoluble fractions, and the hydroxyproline synthesis rate of each fraction was measured using 14C-proline. Determination was also made for hexosamine content in the same liver tissue. The hydroxyproline content of hepatic collagen increased as biliary obstruction was prolonged, particularly from the 4th week, which is the transitional period of liver histology into biliary cirrhosis. The hexosamine content of hepatic collagen showed a similar tendency. The neutral soluble, acid soluble and insoluble collagen fractions all increased as biliary obstruction was prolonged. The collagenosynthetic activity of the neutral soluble fraction, attained a peak in 1 to 2 weeks of biliary obstruction, which indicates that collagen fibers are formed actively in the early stage of jaundice, although there is only a slight increase in the absolute amount of fibers developed then. Serum monoamine oxidase level tended to be parallel to collagenosynthetic activity but not to collagen content.抄録全体を表示PDF形式でダウンロード (2293K) -
KATSUJI TSUDA, SUSUMU YAMAGATA, YOSHIKUNI MIURA, TAKESHI KAWAMURA, HIR ...1975 年 116 巻 2 号 p. 173-177
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーPlasma gastrin response to the intravenously administered secretin was investigated in various clinical entities. The marked increase of plasma gastrin was found in response to secretin in a case of suspected Zollinger-Ellison syndrome in contrast to various degrees of plasma gastrin decrease seen in patients with ordinary or postoperative recurrent peptic ulcer. The diagnostic value of secretin provocation test was stressed especially in relation to differentiation between Zollinger-Ellison syndrome and recurrent ulcer due to retained pyloric antrum kept away from the food-passing route, both of which are characterized by hypergastrinemia and acid hypersecretion.抄録全体を表示PDF形式でダウンロード (325K) -
NORIYOSHI SUKENO, HIROYUKI SHIRAISHI, NAKAO ISHIDA1975 年 116 巻 2 号 p. 179-182
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーThe amino acid composition of hepatitis B surface antigen (HBsAg) purified from plasma of asymptomatic carriers was examined for further structural analyses. The protein of HBsAg spherical particles was characterized by the high contents of cystine, proline and tryptophan residues. A high α-helical content of HBsAg was discussed on amino acid composition.抄録全体を表示PDF形式でダウンロード (215K) -
TOGO HORIUCHI, YASUYUKI SUZUKI, EIJI ISHIZAWA, TETSUO SATO, ATSUSHI YO ...1975 年 116 巻 2 号 p. 183-189
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーLeft subclavian artery - left coronary artery end-to-end anastomosis was successfully performed on a six-month-old female infant with anomalous origin of the left coronary artery from the pulmonary artery and severe mitral regurgitation. A piece of pulmonary arterial wall including the opening of the anomalous left coronary artery (ALCA) was isolated and was used for anastomosis instead of utilizing the left coronary arterial wall itself. Her postoperative course was uneventful and mitral regurgitation disappeared 6 months after surgery. This improved technique seems to be applicable for this anomaly, regardless of the age of patient or size of the left coronary artery.抄録全体を表示PDF形式でダウンロード (1639K) -
MAMORU NAKAMURA, YOSHIKAZU SAWAI, SOITSU FUKUCHI, KATSUO NAKAJIMA, MIT ...1975 年 116 巻 2 号 p. 191-199
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーThe adrenal scintigram was performed after administration of [19-131I]cholesterol. A high/low ratio of both adrenal glands was calculated to evaluate whether there is a difference between the left and right sides in adrenal diseases. During scanning, information was stored in a 64×64 matrix and then punched out on a computer compatible paper tape. This paper tape was processed with a small digital computer. The areas of interest were selected over adrenal glands. The computer decided mean counts per unit area. After subtraction of back-ground counts, a high/low ratio of adrenal gland was calculated. In five patients with Cushing's syndrome due to bilateral hyperplasia, a high/low ratio ranged from 1.0 to 2.0. In four patients with primary aldosteronism due to adenoma, a high/low ratio ranged from 1.33 to 4.0. This method may be useful to differentiate bilateral hyperplasia from unilateral adrenocortical adenoma.抄録全体を表示PDF形式でダウンロード (2810K) -
MASAFUMI SHIRAI, SHOTARO MATSUDA, SHIRO MITSUKAWA, MAMORU NAKAMURA, KE ...1975 年 116 巻 2 号 p. 201-202
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーTestosterone levels in the seminal plasma of 5 normal males, and 30 male sterility patients were measured by radioimmunoassay. In 9 random cases, seminal plasma levels of FSH and LH were determined by radioimmunoassay. The average level of seminal plasma testosterone for the normal males was 72±52ng/100ml, higher than that of the patients: 52±41ng/100ml. The average levels of FSH and LH in the seminal plasma of the 9 random cases were 4.4±2.0mIU/ml and 35.4±5.4mIU/ml, respectively.抄録全体を表示PDF形式でダウンロード (114K) -
MASARU MAEBASHI, NORIMITSU KAWAMURA, MITSUO SATO, KAORU YOSHINAGA, MAS ...1975 年 116 巻 2 号 p. 203-204
発行日: 1975年
公開日: 2008/11/28
ジャーナル フリーA colorimetric method for the deter-mination of carnitine and its derivatives is described. Free carnitine, acetylcarni-tine and palmitoylcarnitine were extracted with chloroform-methanol. After evaporation, the residue was dissolved in n-butanol and water; palmitoylcarnitine in the organic phase, and free carnitine and acetylcarnitine in the aqueous phase. Acetylcarnitine was separated from free carnitine by passing the aqueous phase through a column of Amberlite CG-120 (H+). Separated carnitine derivatives were hydrolyzed to free carnitine which was followed by the Amberlite column chromatography. After eluting with 2N NH4OH solution, the samples were esterified and determined colorimetrically.抄録全体を表示PDF形式でダウンロード (161K)
- |<
- <
- 1
- >
- >|