巻号一覧
151 巻 (1987)
- 4 号 p. 363-
- 3 号 p. 253-
- 2 号 p. 129-
- 1 号 p. 1-
151 巻, 4 号
選択された号の論文の10件中1～10を表示しています
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SHIGERU ASAKI, HIROSHI SATO, AKIRA SATO, SHUICHI OHARA, DAISUKE SHIBUY ...1987 年 151 巻 4 号 p. 363-371
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーASAKI, S., SATO, H., SATO, A., OHARA, S., SHIBUYA. D., MOTOJIMA, T., MEGURO, S. and TAMURA, T. Endoscopic Findings of Bleeding Esophageal Varices and Experimental Study. Tohoku J. exp. Med., 1987, 151(4), 363-371 - It has been considered that the rupture of esophageal varices occurs with high incidences, and once bleeding occurs it sometimes cause fetal massive bleeding. However, from our experiences with the active application of emergency endoscopy, the incidence of bleeding from varix was unexpectedly low. From these results, we studied the rupture signs of esophageal varices in experiments on dogs and clinical cases. The actual rupture signs of varices were summarized as (1) active bleeding, (2) adhesion of fresh clot, (3) mucosal protrusion in a conical shape and white discoloration of its top area and (4) mucosal slight elevation and attachment of fibrin thrombi. Further studies, however, are required to determine whether there are any varicose bleedings which do not show the above rupture signs.抄録全体を表示PDF形式でダウンロード (4550K) -
SHIN FUKUDO, JINICHI SUZUKI1987 年 151 巻 4 号 p. 373-385
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーFUKUDO, S. and SUZUKI, J. Colonic Motility, Autonomic Function, and Gastrointestinal Hormones under Psychological Stress on Irritable Bowel Syndrome. Tohoku J. exp. Med., 1987, 151(4), 373-385 - Effects of an artificial mental stress on colonic motility, autonomic nervous system, and gastrointestinal hormones were examined in patients with irritable bowel syndrome (IBS). The subjects were 20 patients with typical IBS and 12 controls. A transducer was inserted to the sigmoid colon from the anus for measuring colonic intraluminal pressure, and mirror drawing test was loaded as psychological stress. At the same time, coefficient of variation of R-R interval on ECG (CV-RR) was measured and the levels of plasma catecholamines, gastrin, glucagon, and motilin were assessed. Colonic motility showed a significant increase in the IBS patients during the stress compared with that in controls (p<0.01). Motilin also increased significantly in the IBS patients after the stress (p<0.01). CV-RR and motilin revealed positive relationship with colonic motility alteration in the IBS patients although no significant change was detected in controls. These phenomena are thought to be due to autonomic nervous dysfunction and/or gastrointestinal hormonal derangements induced by psychological stress. It is suggested that organ specificity of the alimentary tract for the stress exists in this disease.抄録全体を表示PDF形式でダウンロード (1333K) -
YASUYUKI ENDO, SHIGEO MAMIYA, HIDETAKA NIITSU, KEIKO IWAMOTO, SUMIKO H ...1987 年 151 巻 4 号 p. 387-394
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーENDO, Y., MAMIYA, S., NIITSU, H., IWAMOTO, K., HAMANAKA, S. and MIURA, A. B. An Unclassified Platelet Function Disorder Associated with Bleeding Tendency. Tohoku J. exp. Med., 1987, 151(4), 387-394 - A 7-year-old boy with a history of bleeding tendency showed a prolongation of bleeding time and a decrease in platelet adhesiveness. The platelets of the patient, however, had a normal reaction to ADP, collagen, epinephrine, arachidonic acid, bovine fibrinogen, ristocetin, A-23187 and thrombin-induced aggregation, and their shape was determined by electron microscopy to be normal. Therefore, this disorder could not be thought to belong to any known platelet dysfunction. On the other hand, an increase in clot retraction, a reversal of ATP/ADP, a decrease in β-thromboglobulin and platelet factor 4 in the platelets, and an elevation of plasma levels of released β-thromboglobulin from the platelets were observed in the patient. We don't know any cases with such an association of hypo- and hyperfunction of platelets.抄録全体を表示PDF形式でダウンロード (3196K) -
TATSUMI KUSAKABE, KAZUKO ISHII, KOSEI ISHII1987 年 151 巻 4 号 p. 395-408
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーKUSAKABE, T., ISHII, K. and ISHII, K. A Possible Role of the Glomus Cell in Controlling Vascular Tone of the Carotid Labyrinth of Xenopus laevis. Tohoku J. exp. Med., 1987, 151 (4), 395-408 - To clarify the physiological significance of the g-s connection (intimate apposition of the glomus cell to the smooth muscle) in the Xenopus carotid labyrinth, experiments were carried out morphologically and physiologically. Results obtained are as follows. 1. Efferent electrical stimulation of the glossopharyngeal nerve resulted in concentrating dense-cored vesicles on the peripheral region of the glomus cell, and a decrease of vesicles as a whole. 2. In the carotid labyrinth perfused artificially, outflow of the internal and the external carotid arteries decreased with administration of catecholamines (adrenaline, noradrenaline and dopamine). 3. Acetylcholine reduced only the internal outflow. This response was depressed by atropine, hexamethonium and phenotolamine, whereas accelerated by propranolol. 4. Sodium cyanide reduced the internal outflow without affecting the external outflow, and its effect is depressed by phentolamine. From these results, a possibility that the glomus cell participates in controlling the blood flow in the labyrinth through the intervention of the g-s connection was discussed.抄録全体を表示PDF形式でダウンロード (1765K) -
TAIZO KATO, TADASHI TERUI, HACHIRO TAGAMI1987 年 151 巻 4 号 p. 409-417
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーKATO, T., TERUI, T. and TAGAMI, H. Lucigenin-Induced Chemiluminescence in Human Neutrophils in the Process of Adherence and Chemotactic Migration Measured in a Modified Boyden Chamber System. Tohoku J. exp. Med., 1987, 151 (4), 409-417 - To answer the question of whether an oxidative burst in neutrophils occurs in the process of adherence and chemotactic migration, we estimated their lucigenin-induced chemiluminescence (CL) responses in a specially devised Boyden chamber that utilized a vial for CL measurement. Neutrophils placed in the upper compartment immediately after isolation induced lucigenin-dependent CL even in the absence of chemotactic factors in the lower chamber, which was completely scavenged by superoxide dismutase at a concentration of 100μg/ml. This response was suggested to be caused by neutrophils in the process of adherence to a filter. When formyl peptide (FMLP) or zymosan-activated serum (ZAS) was placed in the bottom compartment, they were effective to induce CL in the neutrophils already adhered to the membrane filter. These chemotactic factors induced light emission in neutrophils maximally at the concentration of 10-7M for FMLP and 5% for ZAS in the reaction mixture without any more increase in CL being observed above these concentrations. This makes a sharp contrast to the findings observed in the so far used unphysiological experimental system, in which neutrophils are abruptly exposed to chemotactic factors likewise in present study. When FMLP or ZAS was directly added to the cells in a upper compartment, CL increased dose-dependently from 10-9 to 10-5M for FMLP, and from 5 to 50% for ZAS. These findings suggest that our method is potentially useful because it enables to assess the respiratory burst of neutrophils in the process of adherence and in that of chemotaxis in a way that closely simulates the in vivo situations. Furthermore, we can expect that they become a hopeful simple and rapid alternative for the tedious conventional assays for cell adherence and chemotaxis.抄録全体を表示PDF形式でダウンロード (787K) -
IWAO SASAKI, TAKASHI TUCHIYA, HIROO NAITO, YUJI FUNAYAMA, MORIHIKO TOD ...1987 年 151 巻 4 号 p. 419-428
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーSASAKI, I., TUCHIYA, T., NAITO, H., FUNAYAMA, Y., TODA, M., SUZUKI, Y., SATO, T. and OHNEDA, A. Effect of Ileo-Jejunal Transponsition on Intestinal Adaptation after Total Colectomy in Dogs. Tohoku J. exp. Med., 1987, 151 (4), 419-428 - The effect of ileo-jejunal transposition (IJT) on the intestinal adaption after total colectomy was investigated in 4 mongrel dogs. Hyperenteroglucagonemia was observed in the IJT with colectomy group, especially in postprandial state. Obvious hyperplastic changes were observed in all part of the small intestinal mucosa in the colectomy with IJT group. However, there were no significant differences in body weight changes between the colectomy with IJT group and the colectomy group. Postprandial plasma gastrin levels were lower in the colectomy with IJT group compared to the control. These results suggest that IJT causes hyperenteroglucagonemia and intestinal mucosal hypertrophy in colectomized dogs. Enteroglucagon may have an inhibitory effect on postprandial gastrin release.抄録全体を表示PDF形式でダウンロード (2378K) -
RAMON CACABELOS, ATSUSHI YAMATODANI, HIROYUKI FUKUI, HISAYOSHI NIIGAWA ...1987 年 151 巻 4 号 p. 429-442
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーCACABELOS, R., YAMATODANI, A., FUKUI, H., NIIGAWA, H., MIYAKE, A., WATANABE, T., NISHIMURA, T. and WADA, H. Time- and Dose-Dependent Responses of Brain Histamine to Intracerebroventricular and Intraperitoneal Administrations of Growth Hormone-Releasing Factor (GRF1-44). Tohoku J. exp. Med., 1987, 151 (4), 429-442 - Changes in the level of histamine (HA) in rat brain induced by intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administrations of growth hormone-releasing factor (GRF1-44) were studied. HA was determined by high-performance liquid chromatography (HPLC) in the anterior hypothalamic region, posterior hypothalamic region, median eminence, adenohypophysis, neurohypophysis, hippocampus and prefrontal cortex. GRF1-44 (1-10μg, i.c.v.) induced significant time- and dose-dependent increases in the concentration of HA in the hypothalamo-hypophyseal system and time-dependent decrease of HA in the hippocampus. In contrast, after i.p. administration of GRF1-44 (10μg) the level of HA in the hypothalamus tended to decrease but the total amount of H-1 receptors in the hypothalamo-hypophyseal system did not change. Circadian variations in the GRF-induced HA and growth hormone responses were also observed, responses being lower in the evening than in the morning. It is concluded that GRF interacts with HA at the central level to optimize the function of the somatotropinergic system.抄録全体を表示PDF形式でダウンロード (1321K) -
KAZUSHIGE SAKAI, TAMOTSU TAMAZAKI, MICHIRO TAKAGI1987 年 151 巻 4 号 p. 443-451
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーSAKAI, K., YAMAZAKI, T. and TAKAGI, M. Antiarrhythmic Effects of a Novel Diamine Derivative, AN-132, on Several Animal Models of Cardiac Arrhythmias. Tohoku J. exp. Med., 1987, 151 (4), 443-451 - The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2', 6'-dimethylpropionanilide•2H3PO4, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane-adrenaline.抄録全体を表示PDF形式でダウンロード (765K) -
KOICHI TABAYASHI, ATUSHI IGUCHI, SATORU ARAI, YOSHIHITO SEKINO, YOSHIM ...1987 年 151 巻 4 号 p. 453-463
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーTABAYASHI, K., IGUCHI, A., ARAI, S., SEKINO, Y., MOIZUMI, Y, and HORIUCHI, T. Biochemical and Hemodynamic Changes in the Hypertrophied Dog Heart Subjected to Chronic Protein-Calorie Malnutrition. Tohoku J. exp. Med., 1987, 151 (4), 453-463 - Biochemical and hemodynamic changes were assessed in 13 dogs subjected to sub-coronary valvular aortic stenosis and chronic protein-calorie malnutrition (PCM). Red blood cell, hemoglobin, serum albumin, free fatty acids, blood glucose, cholinesterase and blood amino acid levels were measured. The dynamic geometry of the left ventricle (LV) was assessed with chronically implanted sonomicrometric piezoelectric crystals. Cardiac function was evaluated by mean velocity of circumferential fiber shortening (mean VcF) and the relationship between LV end-systolic pressure (LVESP) or LV wall stress (LVWst) and LV end-systolic diameter (LVESD). The following results were obtained: 1) A decrease in body weight and increases in free fatty acids and 3-Methylhistidine were observed following long-term PCM. 2) Mean VcF was not depressed in dogs subjected to PCM. 3) The relationship between LVESP or LVWst and LVESD shipted downward and to the right after PCM, indicating reduced myocardial contractility. These findings suggest that the left ventricle in hypertrophied dog hearts subjected to PCM retains normal pump function, despite a low state in the myocardium.抄録全体を表示PDF形式でダウンロード (1715K) -
KAZUHIKO OYANAGI, AKIRA TSUCHIYAMA, YOSHIHIRO ITAKURA, YAEKO TAMURA, T ...1987 年 151 巻 4 号 p. 465-475
発行日: 1987年
公開日: 2006/08/31
ジャーナル フリーOYANAGI, K., TSUCHIYAMA, A., ITAKURA, Y., TAMURA, Y., NAKAO, T., FUJITA, S. and SHIONO, H. Clinical, Biochemical and Enzymatic Studies in Type I Hyperprolinemia Associated with Chromosomal Abnormality. Tohoku J. exp. Med., 1987, 151 (4), 465-475 - A severe mentally retarded infant with type I hyperprolinemia associated with chromosomal abnormality is reported. The patient had a characteristic facial appearance of hyperprolinemia and suffered from convulsions after the age of 10 months. The child developed severe mental and motor retardation. The karyotype of the patient revealed partial duplication of the short arm in chromosome 10 using G banding techniques. The patient and her mother showed a fasting hyperprolinemia and an abnormal clearance curve after the proline load in the serum. The proline oxidase activities of the liver tissues obtained by biopsy in the patient was about 9% of those of controls. Kinetic studies and mixed experiments of the enzyme were with normal limits. Restriction of dietary proline at the age of 12 months revealed a prompt fall of the plasma levels of proline to the normal range, and a low proline diet was continued until the present time. During the period of dietary treatment, growth was satisfactory, but her mental development did not improve. From the developmental patterns of proline oxidase activities postnataly, we speculated that restriction of dietary proline intake should be relieved with age.抄録全体を表示PDF形式でダウンロード (1378K)
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