巻号一覧
170 巻 (1993)
- 4 号 p. 207-
- 3 号 p. 135-
- 2 号 p. 63-
- 1 号 p. 1-
170 巻, 3 号
選択された号の論文の6件中1～6を表示しています
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KAZUHIRO HOSHI, SHIZUKA HONDA, CHIKARA ENDO, AKIRA SATO, SHOJI SEKIMOT ...1993 年 170 巻 3 号 p. 135-146
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーHOSHI, K., HONDA, S., ENDO, C., SATO, A. and SEKIMOTO, S. Wound Healing Process in the Portio Vaginalis Uteri after CO2-Laser Treatment. Tohoku J. Exp. Med., 1993, 170 (3), 135-146 - In order to determine the wound healing process in the portio vaginalis uteri, 3[H] -thymidine incorporation and hydroxyproline concentration in the granulation tissue were measured histochemically after CO2-laser treatment. As a result, the squamous epithelium showed the thymidine uptake in extended regions in the first week and in basel cell hyperplastic regions in the second week. The uptake was seen in the reserve cell hyperplastic regions of the epithelium from the 2nd week. Hydroxyproline concentration peaks mostly appeared within one week after the laser treatment. After cryosurgery, the peaks mostly appeared after two weeks or more. These results indicated that, the stromas and then the squamous and columnar epithelial cells in turn were regenerated after CO2-laser treatment, and that the regeneration occurred earlier after laser treatment than after cryosurgery. - CO2-laser; basal cell; hyperplasia; reserve cell hyperplasia; hydroxyproline抄録全体を表示PDF形式でダウンロード (3930K) -
HIDEMI YAMAUCHI, ATSUSHI NITTA, TSUNEO NAMIKI1993 年 170 巻 3 号 p. 147-156
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーYAMAUCHI, H., NITTA, A, and NAMIKI, T. Carcinoma of the Papilla of Vater Accompanied by Non-invasive Adenomatous Component (NAC). Tohoku J. Exp. Med., 1993, 170 (3), 147-156 - Surgical specimens from 40 patients with carcinoma of the papilla of Vater were submitted to histopathological analysis of tumor. The lesions were divided into two groups: non-invasive adenomatous component (NAC)-positive carcinoma and NAC-negative carcinoma. NAC was observed in 44% of our series. The incidence of the NAC-positive carcinoma declined with advancing cancer stage, but there was no significant relationship between the tumor size and the presence of NAC. NAC was shown to co-exist in 65% of tumor-forming type carcinomas, 0% of ulcerating type and 38% of the mixed type. The NAC-negative carcinoma invaded or metastasized to the pancreas, duodenum, lymph nodes or veins more frequently than NAC-positive carcinoma. Five year survival rates of patients with NAC-positive and NAC- negative carcinomas were 78% and 21%, respectively (p<0.01). Patients with NAC-positive carcinoma, most of which were detected preoperatively by endoscopic biopsy, underwent a standard pancreatoduodenectomy with Level 1 lymph node (peripancreatic) dissection. It is considered that pylorus and duodenal bulb-preserving pancreatoduodenectomy is an alternative for patients with localized lesion, while patients with NAC-negative carcinoma should be treated by performing pancreatoduodenectomy together with extended lymph node dissection. - carcinoma of the papilla of Vater; non-invasive adenomatous component (NAC); precancerous condition抄録全体を表示PDF形式でダウンロード (1712K) -
HAREAKI SEKI, ITARU KIMURA, AYUMU OHNUMA, SHUN-ICHI SASO, KYUYA KOGURE1993 年 170 巻 3 号 p. 157-167
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーSEKI, H., KIMURA, I., OHNUMA, A., SASO, S. and KOGURE, K. The Auditory Evoked Middle-Latency Responses (MLRs): Their Normative Variation and Generators. Tohoku J. Exp. Med., 1993, 170(3), 157-167 - Auditory evoked middle- latency responses (MLRs) to clicks were recorded in 68 normal adults (ages from 21 to 59 year-old) at 16 scalp locations, all referred to a balanced non-cephalic reference. Both Na and Pa components were clearly demonstrated in all the subjects studied through the digital high-pass filtering. Both Na and Pa components were distributed dominantly over the frontal area in all subjects. The amplitudes of Na and Pa were significantly higher with binaural stimulation than with a monaural stimulation, and the existence of binaural interaction was also suggested. Binaural effect was more prominent in Pa than in Na component. When the data recorded from F3 and F4 electrodes were compared, most of F3/F4 amplitude ratios of Na and Pa were included between 0.7 and 1.5. The F3/F4 ratio should be useful indices for the diagnosis of excessive laterality. We also demonstrated gradual phase shifts of Na and Pa between the frontal and temporo- occipital area in about one-third of the records. This phenomenon strongly suggests that both Na and Pa components are derived from complex generators. - evoked potentials; auditory evoked potentials; middle latency; normal adults抄録全体を表示PDF形式でダウンロード (1100K) -
TOMOYUKI MASUDA, RYOICHI SATODATE, KINICHI TSURUGA, TOSHIFUMI KASAI1993 年 170 巻 3 号 p. 169-179
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーMASUDA, T., SATODATE, R., TSURUGA, K. and KASAI T. Quantitative Assessment of a Changes of Hemosiderin Deposition with Age in Splenic Compartments of Rats. Tohoku J. Exp. Med., 1993, 170 (3) 169-179 - Hemosiderin deposition was quantitatively estimated in paraffin sections stained using Perls' iron reaction in the spleens of untreated male rats aged from 0 to 28 months. Hemosiderin was deposited in the periarteriolar lymphocyte sheath (PALS), lymph follicles, and marginal zone, as well as in the red pulp which was the main compartment of hemosiderin deposition. Special attention was paid to the PALS and marginal zone. Marked hemosiderin deposition was evident from 4 months, although only few hemosiderin-laden macrophages appeared in the first 3 months. Hemosiderin deposition peaked at 12 months in the red pulp and at 20 months in the white pulp and marginal zone. The deposition in the white pulp and marginal zone was about 1/9 to 1/4 of that in the red pulp. A few hemosiderin-laden macrophages were found in the lymph follicles after 2 months. In the periarterial region of the splenic hilus, deposition of hemosiderin granules was observed even at 1 month when there was little hemosiderin deposition elsewhere. Since no arteries open there, the presence of hemosiderin-laden macrophages in the PALS and lymph follicles suggested movement of some macrophages from the red pulp and/or the marginal zone. In addition, hemosiderin deposition in the PALS increased with age after it decreased in the other compartments. - spleen; histology; morphometry; hemosiderin; rat抄録全体を表示PDF形式でダウンロード (6993K) -
YUKIKO SUZUKI, KENJI HARADA, KOICHI KAWAMURA, HIROTAKE MASUDA, GORO TA ...1993 年 170 巻 3 号 p. 181-195
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーSUZUKI, Y., HARADA, K., KAWAMURA, K., MASUDA, H. and TAKADA, G. Limited Adaptation in Chronically Hypertrophied Hearts from Aortic Constricted Rats: Increased Inhomogeneity in Cross-Sectional Area of Card iomyocytes and Intercapillary Distance. Tohoku J. Exp. Med., 1993, 170 (3), 181-195 - To study the sequential changes of myocardial structure in pressure-overloaded heart, rats were subjected to banding of ascending aorta at 8 weeks of age, and electronmicroscopical morphometry was performed at weeks 1, 2, 4, 8, 16, and 24 postoperatively. Not only was the cross-sectional area of cardiomyocyte greater in banded rats but the degree of inhomogeneity increased in correspondence with development of hypertrophy. Intercapillary distance was significantly longer in banded rats than in controls. In banded rats, the distance around larger-than-normal cells (with a cross-sectional area exceeding 600μm2) was significantly longer than that around normal-sized cells (with a cross-sectional area under 600μm2) at 4, 16, and 24 weeks following surgery. Morphologically, intracellular capillaries were shown to develop; however, single or several necrotic cells were observed in 8- to 16-week banded rats and were attributed to acute ischemia. In 24-week banded rats, advanced interstitial fibrosis as well as collapsed intracellular capillaries were observed. - cardiac hypertrophy; electron microscopy; morphometry; aortic constriction抄録全体を表示PDF形式でダウンロード (7387K) -
KIYOO KUROE, AYAKO YOSHIHARA, MASAHIRO AKIYAMA, HIROMITSU TAKEMORI, YU ...1993 年 170 巻 3 号 p. 197-205
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーKUROE, K., YOSHIHARA, A., AKIYAMA, M., TAKEMORI, H., and YOSHIDA, Y. The Growth of Mouse Hybridoma Cells between Peyer's Patch Lymphocyte and Myeloma Cell in the Gastrointestinal Tract. A model for Human Multiple Lymphomatous Polyposis of the Gastrointestinal Tract. Tohoku J. Exp. Med., 1993, 170 (3), 197-205 - To elucidate the mechanism of multiple lesions in human primary lymphoma or multiple lymphomatous polyposis of the gastrointestinal tract, we developed a experimental model utilizing mouse hybridoma cells. Syngeneic mice were immunized with human hemoglobin via gastric incubation and a hybridoma clone (13c) between the Peyer's patch cell and mouse myeloma cell was obtained. The 13c cells were infused into normal syngeneic mice through a lateral tail vein. About 2 months after injection mice were sacrificed and their viscera were scrutinized histologically. All 11 mice receiving 13c showed multiple tumors at the colon, microscopic massive invasions at the small intestine, and scattered invasions at Peyer's patch, mesenteric lymph nodes and the spleen, exhibiting the similar distribution patterns as in human multiple lymphomatous polyposis of the gastrointestinal tract. ME-1 or MU-1 cells (hybridomas between P3 and mouse spleen cell) were distributed at the liver, spleen and paraaortic lymph nodes. Such migration patterns of 13c cells and their adherence to vessel walls suggest that multiple invasions may be lymphocyte homing receptor- mediated phenomena. - multiple lymphomatous polyposis of the gastrointestinal tract; gastrointestinal lymphoma; Peyer's patch; mouse hybridoma; lymphocyte homing抄録全体を表示PDF形式でダウンロード (2279K)
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