巻号一覧
173 巻 (1994)
- 4 号 p. 361-
- 3 号 p. 283-
- 2 号 p. 199-
- 1 号 p. 1-
173 巻, 2 号
選択された号の論文の8件中1～8を表示しています
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TERUO NAKAMURA, KAZUO TAKEBE, KEN-ICHI IMAMURA, TADASHI MIYAZAWA, MASA ...1994 年 173 巻 2 号 p. 199-208
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーNAKAMURA, T., TAKEBE, K., IMAMURA, K., MIYAZAWA, T., ISHII, M., KUDOH, K., TERADA, A., MACHIDA, K., KIKUCHI, H., KASAI, F., TANDOH, Y., ARAI, Y. and YAMADA, N. Decreased Gastric Secretory Functions in Diabetic Patients with Autonomic Neuropathy. Tohoku J. Exp. Med., 1994, 173 (2), 199-208-A total of 37 subjects consisted of 10 healthy subjects (Group III), 15 diabetic patients without autonomic neuropathy (Group II), and 12 diabetic patients with autnomic neuropathy including gastroparesis in 6 cases (Group I). All three groups were comparable in age. In order to clarify the gastric function in diabetic patients with autonomic neuropathy, secretion of serum gastrin, gastric secretory function, endoscopic Congo red test of fundic glands, and coefciency of variance of electrocardiographic beat-to-beat intervals (C.V.R-R) were examined. In Group I, 5 patients had hypergastrinemia, but its elevation was inhibited when an acid solution was injected into the stomach. Gastric secretion and C.V.R-R were markedly lower in Group I, compared with Groups II and III. In Group I, the area of fundic glands (parietal cells) was reduced considerably. The C.V.R-R was significantly correlated with fasting serum gastrin concentration and with maximal acid output. From these results, in diabetic patients with autonomic neuropathy (vagal neuropathy), gastric acid secretion in response to tetragastrin stimulation was lowered with a reduction in area of fundic gland distribution. Hypergastrinemia may reflect a negative feedback mechanism responding to decreased acidity of gastric content in the antrum.抄録全体を表示PDF形式でダウンロード (908K) -
TOMIO ONUMA, TORU KIKUCHI, MICHITAKA SHIMURA, MASAHIRO TSUTSUI, JUN MA ...1994 年 173 巻 2 号 p. 209-216
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーONUMA, T., KIKUCHI, T., SHIMURA, M., TSUTSUI, M., MATSUI, J., BOKU, A. and TAKEBE, K. Lipoprotein(a) as an Independent Risk Factor for Diabetic Retinopathy in Male Patients in Non-Insulin-Dependent Diabetes Mellitus. Tohoku J. Exp. Med., 1994, 173 (2), 209-216-Relationship of the lipoprotein(a) [Lp(a)] concentration as a risk factor independent of other factors with the severity of diabetic retinopathy were evaluated by multiple regression analysis. The subjects were 158 patients with non-insulin-dependent diabetes mellitus (NIDDM). Multiple regression analysis was carried with the severity of diabetic retinopathy as the dependent variable and 13 independent variables, namely the Lp(a) concentration, sex, age, body mass index, duration of diabetes, ischemic heart disease, fasting plasma glucose, glycosylated hemoglobin A1c, total cholesterol, triglyceride, high-density lipoprotein cholesterol, anti-diabetic treatments, and diabetic nephropathy. The analysis was performed separately in all subjects, males only, and females only. The standard partial regression coefficient of Lp(a) was significant (0.293, p<0.01), and the multiple correlation coefficient was 0.611 in the males. However, the standard partial correlation coefficient of Lp(a) was not significant in all patients and in females only. The rank of contribution of Lp(a) to retinopathy was the third in males, following triglyceride and nephropathy and followed by anti-diabetic treatments. These results suggest that Lp(a) might be an independent risk factor for diabetic retinopathy in male patients with NIDDM.抄録全体を表示PDF形式でダウンロード (746K) -
SHUNSUKE KOBAYASHI, SHINICHIRO OKADA, HIROYUKI YOSHIDA, TORU HASUMI, N ...1994 年 173 巻 2 号 p. 217-229
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーKOBAYASHI, S., OKADA, S., YOSHIDA, H., HASUMI, T., SATO, N., INABA, H., NAKADA, T, and FUJIMURA, S. Syalil-SSEA1 (SLX) Levels in Supernatant of Cultured Human Lung Carcinoma Cell Lines. Tohoku J. Exp. Med., 1994, 173 (2), 217-229-SLX levels in the culture supernatant of the following 50 cell lines were measured by RIA: pulmonary carcinoma cell lines derived from 46 patients, cell lines of other human cancers derived from 4 patients, and 2 passaged human fibroblast cells as control. Of the 46 pulmonary carcinoma cell lines, 17 (37%) were SLX positive. When the SLX-positive rate was analyzed in relation to the histological type of pulmonary carcinoma, the positive rate was 71% (10/14) for adenocarcinoma, 27% (3/11) for squamous cell carcinoma, 33% (2/6) for large cellcarcinoma, 0% (0/11) for small cell carcinoma and 50% (2/4) for adenosquamous cell carcinoma. Analysis of the relationship between tumor cell proliferation and SLX level in 20 patients revealed that the SLX level in the supernatant of SLX-producing cell lines becomes higher in proportion to the increase in the number of these cells. The SLX-positive rate did not differ significantly among different stages of pulmonary carcinoma at the time of tissue collection. There was no significant correlation between SLX production and prognosis. SLX production by each cell line was not correlated with the doubling time of the same cell line in vitro or in vivo (in nude mice). SLX production also showed no correlation with the duration of tumor cell passage.抄録全体を表示PDF形式でダウンロード (2789K) -
TADASU YAMAMOTO, TOKIHISA KIMURA, KOZO OTA, MASARU SHOJI, MINORU INOUE ...1994 年 173 巻 2 号 p. 231-245
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーYAMAMOTO, T., KIMURA, T., OTA, K., SHOJI, M., INOUE, M., OHTA, M., SATO, K., FUNYU, T. and ABE, K. Effects of Interleukin-1β on Blood Pressure, Thermoregulation, and the Release of Vasopressin, ACTH and Atrial Natriuretic Hormone. Tohoku J. Exp. Med., 1994, 173 (2), 231-245-To assess how interleukins (IL) affect the release of vasopressin (AVP), atrial natriuretic hormone (ANH), and ACTH and the regulation of blood pressure (BP), heart rate (HR) and rectal temperature (RT), the 3 doses of 1.73 (low dose, LD), 8.63 (medium dose, MD), and 43.16pmol/100gBW (high dose, HD) of human recombinant IL-1β were intravenously (iv) administered in conscious rats, and plasma AVP, ANH, and ACTH, BP, HR and RT were determined simultaneously. In the control group (CON), the drug was omitted. Circulatory IL-1β levels were determined in each dose, and indomethacin (1mg/rat, IM) was administered iv in the HD and CON groups. Plasma IL-1β increased transiently following IL-1β administration in each group. Plasma AVP, ANH, and ACTH increased in the LD, MD, and HD groups, respectively. Mean arterial BP (MABP) and RT increased in the LD group, but HR did not change. In the MD and HD groups, MABP decreased at 30min followed by its increase at 120min, but RT in both groups decreased. In the CON group, these parameters did not change. IM attenuated plasma AVP and ACTH responses to HD and also inhibited decreases in MABP and RT. These results suggest that IL-1β affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1β may not be mediated by PGs.抄録全体を表示PDF形式でダウンロード (1325K) -
MICHITAKA SHIMURA, TOMIO ONUMA, MASAHIRO TSUTSUI, TORU KIKUCHI, JUN MA ...1994 年 173 巻 2 号 p. 247-257
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーSHIMURA, M., ONUMA, T., TSUTSUI, M., KIKUCHI, T., MATSUI, J., BOKU, A. and TAKEBE, K. Three Types of “Mid-Band” Lipoproteins in Non-Insulin-Dependent Diabetes Mellitus: Relation to Metabolic Abnormalities and Vascular Complications. Tohoku J. Exp. Med., 1994, 173 (2), 247-257-A number of fine bands which occur in positions between the β- and pre-β-lipoproteins in polyacrylamide gell electrophresis are called mid-bands (MB). In this study, the relationship between the occurrence of these MB and metabolic abnormalities or vascular complications was evaluated in 181 patients with non-insulin-dependent diabetes mellitus (NIDDM). The incidence of MB in diabetic patients was significantly higher than that in 149 healthy control subjects (35 vs. 20%, p<0.01). Analysis according to the type of MB revealed that the incidence of the central type in diabetic patients was significantly higher than that in healthy control subject (11 vs. 5%, p<0.05). When the values of HbAlc were elevated, the incidence of MB and its central type slightly increased. The occurrence of the lower type of MB showed no relationship with the levels of HbAlc. The incidence of MB and its central type were significantly higher in patients with type IIb hyperlipidemia (86 and 41%, respectively) and with type IV hyperlipidemia (63 and 25%) than in those with normolipidemia (21 and 5%) (p<0.01 of all). The incidence of the lower type of MB was significantly higher in patients with type ha hyperlipidemia (25%) and with type IIb hyperlipidemia (36%) than in those with normolipidemia (11%) (p<0.05, p<0.01, respectively). There was no significant difference in the occurrences of MB and of the central and lower types of MB between the normolipidemic patients and healthy control subjects. The incidence of MB and its central type were significantly higher in patients with nephropathy (54 and 23%, respectively) than in those without nephropathy (32 and 9%) (p<0.05 of all). There was no significant difference in the incidence of lower type of MB between patients with and without nephropathy. These results indicate that the incidence of central type of MB may be high in NIDDM, and that the occurrence of central type may be associated with abnormal metabolism of glucose or lipid and with diabetic nephropathy.抄録全体を表示PDF形式でダウンロード (1159K) -
AKIRA NAITO, MICHIHIRO YAJIMA, HIDEHIKO FUKAMACHI, KOJI USHIKOSHI, YAS ...1994 年 173 巻 2 号 p. 259-267
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーNAITO, A., YAJIMA, M., FUKAMACHI, H., USHIKOSHI, K., HANDA, Y., HOSHIMIYA, N. and SHMIZU, Y. Electrophysiological Studies of the Biceps Brachii Activities in Supination and Flexion of the Elbow Joint. Tohoku J. Exp. Med., 1994, 173 (2), 259-267-Activities of the biceps brachii (long head: BiL, short head: BiS) on the elbow joint were studied using an electrical neuromuscular stimulation (ENS) and an electromyography (EMG). In ENS study, ENS to BiL or BiS was performed in seven volunteers. Before ENS, the volunteer relaxed the upper extremity on a table with the elbow extended and the forearm pronated. Then ENS-induced movements of the upper extremity were examined. Movements of elbow flexion and forearm supination were induced simultaneously by ENS to BiS in all volunteer and by ENS to BiL in six volunteers. ENS to BiL of one volunteer resulted in only elbow flexion. In EMG study, averaged EMGs of BiL and BiS during a to-and-fro motion from prone to supine of the forearm with holding a load were analyzed in eight volunteers. The volunteer acted the movements with keeping the elbow joint in different angles. Although an increase and a decrease of EMG activities in BiL and BiS were observed accompanied by the degree of forearm supination, patterns of changes in quantities of EMG activities to changing elbow angles varied from individual to individual. These findings seem to indicate that each human subject has an individual use of the biceps brachii for supination movements, while the action of the muscle on the elbow joint is similar among the subjects.抄録全体を表示PDF形式でダウンロード (1416K) -
AKIRA NAITO, MICHIHIRO YAJIMA, HIDEHIKO FUKAMACHI, KOJI USHIKOSHI, YAS ...1994 年 173 巻 2 号 p. 269-273
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーNAITO, A., YAJIMA, M, FUKAMACHI, H., USHIKOSHI, K., HANDA, Y., HOSHIMIYA, N. and SHIMIZU, Y. Functional Electrical Stimulation (FES) to the Biceps Brachii for Controlling Forearm Supination in the Paralyzed Upper Extremity. Tohoku J. Exp. Med., 1994, 173 (2), 269-273-Control of forearm supination using the functional electrical stimulation (FES) to the biceps brachii was studied in a C4 quadriplegic patient. As a result of FES to the biceps brachii, and the other elbow flexors and extensors, supination was induced in maintenance of the elbow in the maximum flexion and extension, respectively. Although a range of the movements was still small and limited, these findings indicated a possibility of FES to the biceps brachii for controlling supination in paralyzed upper extremities.抄録全体を表示PDF形式でダウンロード (1022K) -
TETSURO NISHIHIRA, HIROMICHI KOMATSU, YOSHIHIRO ENDO, RYUSABURO SHINEH ...1994 年 173 巻 2 号 p. 275-282
発行日: 1994年
公開日: 2006/08/31
ジャーナル フリーNISHIHIRA, T., KOMATSU, H., ENDO, Y., SHINEHA, R., SAGAWA, J., NAKANO, T., HOSHINO, A., YOSHIDA, K. and MORI, S. New Technology for Continuous Intravenous Infusion via the Central and Portal Veins in the Rat. Tohoku J. Exp. Med., 1994, 173 (2), 275-282-Total parenteral nutrition via the central vein is a technique used extensively in basic and clinical research. Recent research has also focused on the administration of various drugs and nutrients via the portal vein. To date, however, no technique which would permit prolonged continuous infusion simultaneously through both the central vein and the portal vein in the rat has been reported. The development of such a technique would open up new possibilities for utilizing the advantages of each of these two routes and contribute to progress in metabolic and nutritional research. To establish such a technique, the authors implemented several unique improvements such as the application of clamps to minimize bleeding during catheter insertion and an increase in the number of sutures to prevent catheter dislodgment. With these improvements, it was possible to continuously administer specified doses of infusion solution in both veins for 6 days in 156 of 158 rats (99%) in the main experiment. We herein describe the techniques used and some of the results obtained with this experimental system.抄録全体を表示PDF形式でダウンロード (764K)
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