巻号一覧
93 巻 (1967)
- 4 号 p. 301-
- 3 号 p. 199-
- 2 号 p. 105-
- 1 号 p. 1-
93 巻, 1 号
選択された号の論文の10件中1～10を表示しています
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Tsuneo Arakawa, Kuniaki Narisawa, Kaneo Tanno, Kazuo Ohara, Ototaka Hi ...1967 年 93 巻 1 号 p. 1-22
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーA probably new entity of metabolic error of folic acid was described of an infant whose clinical and biochemical characteristics were: 1) mental retarda-tion and a marked dilatation of cerebral ventricles, 2) abnormally high serum L. casei folate activity, 3) abnormally high levels of folate precursor in erythrocytes, and 4) a marked rise in reticulocyte count by an exogenous folate supplementation.
The results of investigation on tetrahydrofolate-dependent enzymes of liver specimens revealed a decreased activity of N5 methyltetrahydrofolate transferase of our own patient.
It seems therefore likely that an impaired utilization of N5 methyltetrahy-drofolate and its precursor in tissues due to a decreased activity of N5 methyl-tetrahydrofolate transferase led to an abnormal accumulation of N5 methyl-tetrahydrofolate and its precursor in serum and erythrocytes, and that trapping of folate compounds at an N5 methyltetrahydrofolate level caused a functional deficiency of folates with sequence of development of a megaloblastic change in the bone marrow and of an impaired purine biosynthesis of the brain with a marked dilatation of cerebral ventricles.抄録全体を表示PDF形式でダウンロード (1470K) -
Chikako Sato, Masatoshi Sakka1967 年 93 巻 1 号 p. 23-30
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーRibonucleic acid extracted from the thymus of C57BL mice by the sodium dodecyl sulfate-phenol method was irradiated with 106R of Co-60 γ-rays. After the exposure, Sephadex column chromatography revealed that 27.7 per cent of original RNA had been decomposed to smaller molecules with molecular weights below 10, 000. The irradiated solution was then injected subcutaneously to new-born mice of the same strain. White hairs were recognized in the fur of the mice in-jected with irradiated RNA solution, but not in the animals which received non-irradiated RNA. The difference in the proportion of depigmented hairs between the two groups was statistically significant. In later hair generations, white hairs were replaced by darker ones. A variation in the pigment content of cortical cells of dark hairs was also observed.抄録全体を表示PDF形式でダウンロード (2029K) -
Toshio Morikawa, Keiya Tada1967 年 93 巻 1 号 p. 31-38
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーAn intracellular transport of proline and glycine was examined by using Ehrlich ascites carcinoma cells. The pH optima and the effect of heat inactivation on the intracellular uptake were found to be completely the same for both proline and glycine. The Michaelis type constant of glycine transport was the same as its inhibition constant to the proline transport. Moreover the Michaelis type constant of proline transport was almost the same as its inhibition constant to the glycine transport. The inhibition constants of hydroxyproline, and also of cycloleucine, were proved to be the same as those of both proline and glycine transport. From these results the existence of a transport system common to both imino acids and glycine was emphasized.抄録全体を表示PDF形式でダウンロード (330K) -
Kenichi Iwatsuki, Yuko Aoba, Kazuya Sato, Naofumi Iwatsuki1967 年 93 巻 1 号 p. 39-48
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーCI-581, a phencyclidine derivative, was used intravenously as well as in-tramuscularly in 150 patients and its action as an anesthetic agent was evaluated. The results indicated that the drug was an effective anaglesic and anesthetic agent in intravenous dose of 2mg/kg and intramuscular dose of 10mg/kg, respectively. The onset of its action was rapid even on intramuscular administration. The duration of action was short in cases of a single dose injection, but the recovery from anesthesia was prolonged remarkably after its repeated intramuscular admin-istrations. Respiratory depression was slight and transient. Blood pressure rose sometimes up to undesirable levels following the intravenous administration of the drug. At the emergence from anesthesia a considerable number of patients had vivid dreams, which were usually short-lasting and seldom associated with severe mental confusion or irrational behavior. In spite of these shortcomings in its pharmacological properties, CI-581 seemed useful as an anesthetic for surgical procedures of short duration, particularly in infants and children on intramuscular administration.抄録全体を表示PDF形式でダウンロード (439K) -
Takashi Miura, Tatsuya Kasai1967 年 93 巻 1 号 p. 49-55
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーThe fluorescent antibody technique was applied to detect possible immunological difference between the two species, Trichophyton asteroides and T. interdigitale. The anti-T. asteroides antibody and the anti-T. interdigitale antibody were labeled with fluorescein isothiocyanate, and the fungal smears made with strains belonging to each species were stained with either one of the prepared conjugates. From the results of the staining and of the agar gel precipitation test using each of the unconjugated antibodies, it was concluded that there was no immunologically essential difference between T. asteroides and T. interdigitale.抄録全体を表示PDF形式でダウンロード (2495K) -
Keiya Tada, Haruko Hirono, Tsuneo Arakawa1967 年 93 巻 1 号 p. 57-61
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーEndogenous renal clearance rates of free amino acids were determined by use of automatic amino acid analyzer on ten control children, two patients with prolinuria and a Hartnup patient. Prolinuric patients showed markedly high rates in the proline and glycine clearance and almost normal clearance rates in the other amino acids. In a Hartnup patient, the clearance rates of monoamino-monocarboxylic amino acids were found to be highly elevated.抄録全体を表示PDF形式でダウンロード (221K) -
Ryuji Shioji, Shozo Rikimaru, Hiroshi Ito1967 年 93 巻 1 号 p. 63-69
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーUrinary citrate output was studied in 5 cases of primary aldosteronism, in 3 of Addison's disease and in 8 of normal subjects. The urinary citrate output was decreased in 4 of 5 cases of primary aldosteronism, and the citrate output could not be normalized by removal of adrenocortical adenoma. In patients with primary aldosteronism citrate excretion was somewhat increased by admini-stration of potassium chloride, but rather decreased by spironolactone. In these patients urinary citrate output could not be correlated with either plasma CO2 content or plasma potassium concentration. The low urinary citrate excretion in primary aldosteronism may not be satisfactorily explained either by direct action of aldosterone on the kidney or by intracellular acidosis.抄録全体を表示PDF形式でダウンロード (294K) -
Yoichiro Sasai, Kaikichi Irisawa1967 年 93 巻 1 号 p. 71-77
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーThe histochemical property of amyloid substance was studied in four cases of lichen amyloidosus. Alcian blue and periodic acid Schiff were used for staining acid mucopolysaccharides and glycoprotein and/or sugar-containing compounds respectively. Bromphenol blue was utilized for detection of basic proteins. In a further attempt to identify the various polyanions histochemically, staining was carried out with Alcian blue containing different concentrations of electrolytes. Methylation, saponification, mild acid hydrolysis and hyaluronidase, sialidase and peptic digestions were also employed. The results suggest that amyloid substance in lichen amyloidosus consists of a sialic acid-containing mucopolysaccharide protein complex.抄録全体を表示PDF形式でダウンロード (1891K) -
Hiyoshimaru Oyamada, Takeshi Yoneyama, Mizuyoshi Sakura, Eitaka Tsuboi ...1967 年 93 巻 1 号 p. 79-91
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーThe scintigram obtained on the lung with iodine-131 tagged macroaggregated albumin (131I-MAA) demonstrates the distribution of pulmonary blood flow. There-fore, this technique is often utilized to estimate the relative amount of bilateral pulmonary blood flow on the basis of density appearing on the scintigram. As is well known, however, the scintigram is usually affected by the factors of the scanner used.
In the method to be reported here, which is also applied to estimate the relative amount of bilateral pulmonary blood flow, a specially designed slit-type collimator is used to obviate the above-mentioned disadvantages. According to this technique, the amount of blood flow is shown as a curve having two peaks corresponding to each lung. This method is not affected by the factors of the scanner and is very easy to perform. The authors applied this on cases of pulmonary carcinoma to investigate changes in pulmonary blood flow in connection with radiotherapy. In 5 out of 9 cases of hilar type there was a marked improvement in the pulmonary blood supply. In peripheral type, however, no improvement was detected in all 4 cases.抄録全体を表示PDF形式でダウンロード (6040K) -
Masahito Nagasaka, Masao Takahashi, Teiryo Maeda, Yawara Yoshitoshi1967 年 93 巻 1 号 p. 93-103
発行日: 1967年
公開日: 2008/11/28
ジャーナル フリーA multiple regression equation for the life expectation of patients with chronic glomerulonephritis was derived by the least-squares method from the laboratory investigations on 13 patients admitted to our clinic during 1962-65. Components of the regression were blood urea nitrogen, maximum urinary specific gravity, and hemoglobin (per cent, Sahli) obtained at the first examination, which had apparently the closest correlation with the life length of the patients. First-order regression reduced the dispersion already more than any of a single component, and second-order regression did the same further.
This regression equation is useful in: 1) Estimation of the severity of the patients' condition; 2) classification of glomerulonephritis into slowly and quickly progressing types, if such exist, by comparing the difference between two estimations made at different time and the actual lapse of time between the estimations; and 3) evaluating therapeutic efficacy.
The same regression equation (first-order) seems to be applicable to a wide range of the severity of glomerulonephritis, since it permits to predict changes in the maximum urinary specific gravity over the age from 20 to 80 years in Japanese subjects.抄録全体を表示PDF形式でダウンロード (474K)
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