巻号一覧
194 巻 (2001)
- 4 号 p. 197-
- 3 号 p. 141-
- 2 号 p. 75-
- 1 号 p. 1-
194 巻, 1 号
May
選択された号の論文の8件中1～8を表示しています
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Review
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Stephan R. Orth, Christiane Viedt, Eberhard Ritz2001 年 194 巻 1 号 p. 1-15
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーSmoking is a known risk factor for cardiovascular diseases, cancer, and several other health problems. It is the number one preventable cause of death in modern countries. The first evidence that smoking may be a renal risk factor was published in 1978. Since then, several studies documented that smoking is nephrotoxic in patients with diabetic and non-diabetic renal disease. Data from the Multiple Risk Factor Intervention Trial indicate that smoking even increases the renal risk in the general male population: an increased relative risk for end-stage renal failure (ESRF) was found for smokers as compared to non-smokers (up to 1.69 for heavy smokers). Several potential mechanisms of smoking-induced renal damage have been discussed, e.g. increase in blood pressure, alteration of intrarenal hemodynamics, as well as activation of the sympathetic nerve, the renin-angiotensin and the endothelin systems. The pathomechanisms are, however, only partly understood. Once ESRF has become established, the failure to discontinue smoking adversely affects the prognosis of patients on renal replacement therapy, mainly by increasing the risk of cardiovascular complications. Discontinuation of smoking has been shown to improve both renal and cardiovascular prognosis in the renal patient and is probably the single most effective measure to retard progression of renal failure.抄録全体を表示PDF形式でダウンロード (1098K)
Regular Contributions
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Ken-ichi Suzuki, Senji Hoshi, Seiichi Orikasa2001 年 194 巻 1 号 p. 17-22
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーRecurrence pattern of metastatic testicular cancer after the initial treatment was investigated. Seventy-seven patients with metastatic testicular cancer were treated by cisplatin-based chemotherapy. Patients with residual masses after chemotherapy and whose tumor markers were normalized underwent surgical resections. Of the 77 patients, 61 achieved cancer free status and 4 who did not need the study criteria excluded. Recurrences were detected in 12 (21.1%) patients, 2 (7.1%) patients among 28 stage II patients; 10 (34.5%) patients among 29 stage III patients; none (0%) patients among 14 seminoma patients and 12 (27.9%) patients among 43 non-seminoma patients. All recurrences were detected within 17 months (median, 3) after the initial treatment. Of the 12 patients experiencing recurrence, 4 died of cancer. The recurrence rate of the patients in stage III was significantly higher than that in stage II. No recurrence was detected in patients with seminoma. Follow-up studies after treatment should include serum tumor markers and computed tomographic scanning of lung, abdomen and pelvis at defined intervals. Intensive follow-up will be needed especially for the patients in stage III and with non-seminoma. Follow-up within the first two years is especially important in detecting recurrence after chemotherapy.抄録全体を表示PDF形式でダウンロード (341K) -
Junko Kukidome, Ikuko Kakizaki, Keiichi Takagaki, Akihiko Matsuki, Aki ...2001 年 194 巻 1 号 p. 23-34
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーCOLO 201, human colon adenocarcinoma cells were incubated with artificial primers, p-nitrophenyl-glycoside derivatives at 1.0 mmol (mM) in the medium containing 10% fetal bovine serum to detect sugar chain elongation. However, when p-nitrophenyl-β-N-acetylglucosamine (β-GlcNAc-PNP) was added, the medium changed color to yellow and the cells were dead. To explain this finding, the cells were incubated with 1.0 mM each of β-GlcNAc-PNP and 4-methylumbelliferyl-β-N-acetylglucosamine, then the number of living cells was measured in a time course. In β-GlcNAc-PNP, the living cells were decreased at 24 hours. The cells were survived with N-acetylglucosamine, whereas in the presence of p-nitrophenol (PNP) the living cells were decreased. It was suggested that PNP released from β-GlcNAc-PNP induced the cell death. Activity of β-D-N-acetylglucosaminidase was detected in fetal bovine serum. It was shown that PNP induced the cell death in time-and-dose dependent manner. Genomic DNA from COLO 201 analyzed by agarose gel electrophoresis was fragmentated. PNP analogues were tested for toxicity, and the results suggested that the phenolic OH-group linked to benzene ring and nitro-group linked to the structure in para-form (PNP) was the most effective.抄録全体を表示PDF形式でダウンロード (2078K) -
Takayuki Igarashi, Mayumi Abe, Manami Oikawa, Toshihiro Nukiwa, Yasufu ...2001 年 194 巻 1 号 p. 35-43
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーThe transcription factor ETS-1 expressed in endothelial cells (ECs) regulates angiogenesis by inducing MMP-1, MMP-3, MMP-9, u-PA and integrin β3 in endothelial cells (ECs). Here, we examined whether anti-angiogenic retinoic acids affect the expression of ETS-1 in ECs. The expression of ets-1 mRNA was up-regulated in sparse to subconfluent ECs and down-regulated in confluent ECs. When confluent ECs were stimulated with basic fibroblast growth factor (bFGF), ets-1 mRNA was induced. All-trans retinoic acid (ATRA) as well as 9-cis retinoic acid reduced the augmented expression of ets-1 mRNA in both subconfluent ECs and bFGF-treated confluent ECs. This inhibitory effect of ATRA was dose dependent and was evident at a concentration as low as 10−7 M. ATRA did not alter the stability of ets-1 mRNA. Moreover, promoter analysis indicated that ATRA repressed the expression of ets-1 mRNA at transcriptional level. As a result, ATRA reduced the binding of ETS-1 protein to the ETS binding motif. These results indicate that the anti-angiogenic effect of retinoic acids is mediated at least in part by the transcriptional repression of ets-1 mRNA in ECs.抄録全体を表示PDF形式でダウンロード (1032K) -
Kunihiko Hoshi, Yutaka Ejima, Ryuichi Hasegawa, Kohji Saitoh, Shun Sat ...2001 年 194 巻 1 号 p. 45-54
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーThe extubation criteria of pressure support ventilation (PSV) in infants and children were not yet established. We studied the differences in respiratory parameters during continuous positive airway pressure (CPAP) using a constant flow type ventilator and PSV using a demand valve type ventilator. Nineteen children (1.9±2.9 years old) who were ready to extubate were studied. All patients had recovered from their respiratory failure and had finished the weaning process of the ventilatory support. They were scheduled for extubation on the next day when their ventilatory mode had attained to a PSV of 3 cmH2O with a positive end-expiratory pressure (PEEP) of 3 cmH2O. On the extubation day, tidal volume (TV) and respiratory frequency (RR) were measured with a respiratory monitor at two modes (CPAP of 3 cmH2O and PSV), and the duty ratio (DR) and mean inspiratory flow (MF) were calculated. The sequence of the ventilatory mode was random. No case required reintubation. TV was 61.6±54.9 during CPAP and 67.7±61.4 ml during PSV, and RR was 38.5±10.6 and 37.1±8.8 beats/min., respectively. DR was 0.382±0.067 and 0.359±0.085, and MF was 96.6±78.3 and 101.0±69.0 ml/sec., respectively. The measured parameters and calculated values showed no significant difference between CPAP and PSV. It was found that the respiratory parameters were almost the same with CPAP and PSV immediately before the extubation, and the previous extubation criteria of CPAP can be used.抄録全体を表示PDF形式でダウンロード (507K) -
Satoko Watanabe, Jiro Imanishi, Masako Satoh, Kotaro Ozasa2001 年 194 巻 1 号 p. 55-63
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーAlthough there are various kinds of complementary and alternative medicine (CAM) therapies, it is conjectured that medical doctors consider individual CAM therapies to be heterogeneous in nature. Therefore, to investigate the relationship among Kampo (Japanese traditional medicine) and other CAM, a survey using a structured, self-administered questionnaire was performed for 540 randomly selected doctors of the Kyoto Medical Association (KMA). The results showed that some form of CAM was practiced by 73% of the KMA doctors. The most common CAM practice was Kampo, which corresponded to 96.1% of CAM-practicing doctors. A smaller percentage of doctors practiced other forms of alternative medicine. Kampo was best known by doctors among other CAM therapies. Almost all doctors believed in the effectiveness of Kampo. Doctors who believed in the effectiveness of Kampo tended to believe that other CAM therapies were also effective. Cluster analysis revealed that Kampo was distant from the other CAM. It was concluded that Kampo was most frequently practiced and most believed by doctors in Japan among CAM therapies. Since Kampo was independent of other CAM therapies, Kampo's place in CAM therapies was very unique in Japan.抄録全体を表示PDF形式でダウンロード (496K) -
Yutaka Masuda, Toshihiro Sugiyama2001 年 194 巻 1 号 p. 65-69
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーWe found a protein binding non-antibody human IgG in Helicobactor pylori cell wall, when the IgG was enzymically deglycosylated. The protein had the amino acid sequence AEDGAHVAFM. IgG of H. pylori patients also bound to the protein and the IgG lost the sugar chain structure reactivities. These findings indicate that H. pylori binds human IgG without the sugar chains on its cell wall and suggest that H. pylori infection has a relation to the human IgG deglycosylation.抄録全体を表示PDF形式でダウンロード (269K)
Case Report
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Hiroshi Tanaka, Shinobu Waga, Tohru Nakahata, Koichi Suzuki, Tatsuo It ...2001 年 194 巻 1 号 p. 71-74
発行日: 2001年
公開日: 2005/01/19
ジャーナル フリーTwo Japanese sisters with persistent uveitis showed significant increased levels of urinary β-2 microglobulin. A percutaneous renal biopsy performed in the younger sister revealed tubulointerstitial nephritis (TIN) with helper/inducer T cell infiltrates. Also, abnormal 67-gallium accumulation in the kidneys, suggesting TIN, was observed in the other one at the same time. Although patients with the syndrome of tubulointerstitial nephritis and uveitis (TINU) have been reported to date, its occurrence in siblings has rarely been seen. Both of them shared same human leukocyte antigen (HLA) DR6, suggesting the potential association between HLA-DR6 and TINU.抄録全体を表示PDF形式でダウンロード (541K)
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