巻号一覧
131 巻 (1980)
- 4 号 p. 313-
- 3 号 p. 209-
- 2 号 p. 103-
- 1 号 p. 1-
131 巻, 4 号
選択された号の論文の12件中1～12を表示しています
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TOHRU TAKAHASHI, JUN MATSUMOTO1980 年 131 巻 4 号 p. 313-325
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーOn microscopic picture of cirrhosis and allied disorders, ‘degree of nodular separation’ ρ∂ was established to measure the advancement of cirrhotic change. Based on mathematical treatment of the curvature of linear boundaries between the parenchymal and interstitial areas, ρθ is defined as: ρθ=θA(net)/θA(abs) (-1_??_ρ∂_??_+1) where θA (net) is the net sum and θA(abs) the absolute sum of the angles subtended by the boundaries in an area A, provided that plus and minus angles are distinguished according to whether the curvature is convex or concave toward the interstitium. ρθ=+1 when all nodules are round and completely separated, and diminishes with advancing internodular coalescence, finally to a negative value when the interstitium is disconnected to separate parts by nodular joining. The parameter thus describes patterns of different connectivity, serving as a measure of architectural disorganization. ρθ is easily determined by tangent counting on histological picture. The method was applied to 70 autopsy cases including cirrhosis and chronic hepatitis, and the results were related to the hepatic weight, development of hepatoma, and so on.抄録全体を表示PDF形式でダウンロード (5154K) -
MASAHIKO ENDO, OSAMU NAMIKI, ZENSAKU YOSIZAWA1980 年 131 巻 4 号 p. 327-337
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーTo elucidate precise nature of urinary glycosaminoglycans (GAG), GAG in the acidic subfractions obtained in a previous paper (Endo et al. 1980) were quantitated by digestion with mucopolysaccharidases, nitrous acid treatment and by quantitative cellulose acetate membrane (Separax) electrophoresis. Hyaluronic acid, chondroitin sulfates and chondroitin, dermatan sulfate and dermatan, heparan sulfate, keratan sulfate, and acidic glycopeptide were found in wide distribution in these subfractions. The results suggested the presence of various degree of the depolymerization products of each GAG and of wide range of the desulfation products of each sulfated GAG. Distribution map of each GAG in the subfractions showed more detailed polydispersity of GAG in normal human urine than that reported previously.抄録全体を表示PDF形式でダウンロード (659K) -
FUMIAKI KOIZUMI, AKIRA ISHIMORI, MASARU KOIZUMI1980 年 131 巻 4 号 p. 339-346
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーRadioimmunoassay for measurement of mucosal secretin revealed that HCl was more efficient than distilled water for the extraction of secretin from canine duodenal mucosa. The rapid degradation of secretin within untreated mucosal specimens observed at room temperature could be effectively prevented by the storage at 4°C. In dogs, immunoreactive secretin distributed most abundantly in the upper and middle portion of the duodenum with a tendency to decrease gradually to the anal side. Secretin was not detected, however, in the esophagus, stomach, lower ileum, colon, liver and pancreas. The effect of intraduodenally instilled 0.1 N HCl on plasma and mucosal secretin was also investigated in conscious dogs. Plasma secretin rose promptly after the start of infusion and reached the maximum at 10min, while mucosal secretin responded later than plasma secretin.抄録全体を表示PDF形式でダウンロード (468K) -
HIROKO KODAMA, SHINTARO OKADA, KOJI INUI, TORU YUTAKA, HYAKUJI YABUUCH ...1980 年 131 巻 4 号 p. 347-353
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーUrinary excretion of the organic acids in patients with type I and III glycogenosis was investigated. In all patients with type I glycogenosis, urinary α-ketoglutarate concentration was about 10 times the normal value. α-Ketoglutaric aciduria was not improved by the acute or prolonged administration of a large dose of cofactors for pyruvate and α-ketoglutarate dehydrogenase complex. On the other hand, the level of α-ketoglutarate in the urine from type I patients decreased in conjunction with the decrease of plasma lactate and pyruvate concentration after repeated oral glucose loading. Oral citrate loading brought an increased excretion of α-ketoglutarate in type I glycogenosis. It is possible that α-ketoglutarate dehydrogenase is the rate-limiting step in tricarboxylic acid cycle and in patients with glycogenosis type I, the excessive excretion of α-ketoglutarate may be caused by the limited activity of α-ketoglutarate dehydrogenase with excessive substrate.抄録全体を表示PDF形式でダウンロード (372K) -
MASAHIKO ENDO, MASAHIKO YAMAMOTO, HIROSHI MUNAKATA, REIKO YAMAMOTO, OS ...1980 年 131 巻 4 号 p. 355-361
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーTo elucidate precise chemical nature of urinary glycosaminoglycans (GAG), GAG in the seven major acidic subfractions in a previous paper (Endo et al. 1980a) were analyzed for the chemical compositions and studied on the linkage between carbohydrate and peptide. All the subfractions examined contained galactosamine, hexuronic acid as the major constituent sugars, and xylose, galactose, L-fucose as the minor ones. Some of the subfractions contained additional glucosamine. Sulfate was also found in all the subfractions as their major constituent. The contents of total amino acids ranged from 1.20 to 17.9%. Serine, threonine, aspartic acid, glutamic acid, glycine, alanine and leucine were found as major amino acids. Pronase digestion did not significantly change their molecular size. The presence of O-xylosyl-serine linkage between carbohydrate chains and peptide moieties was verified by an alkali treatment. Nevertheless, the presence of small portions of galactose and xylose residues at the reducing ends of the carbohydrate chains suggested a possibility of exertion of endo-β-galactosidase and endo-β-xylosidase activities for the linkage regions.抄録全体を表示PDF形式でダウンロード (403K) -
KATSUHIRO ENDO, MASARU KOIZUMI, YOSHIHIKO KANAZAWA, SHIN YOSHIDA, MORI ...1980 年 131 巻 4 号 p. 363-371
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーWe have designed a four lumen tube which has enabled us to aspirate duodenal juice while infusing endogenous stimuli into the lower part of the duodenum. Exocrine pancreatic secretion and plasma immunoreactive secretin (IRS) levels have been simultaneously observed in response to in-traduodenal infusion of 1-phenyl-1-hydroxy-n-pentane (PHP) and 0.1 N HCl in normal subjects. patients with diabetes mellitus and patients with chronic pancre. atitis by use of this tube. (1) Pancreatic flow rate and bicarbonate concentration were found to increase to twice those of basal levels and plasma IRS levels rose significantly after infusion of PHP or HCl in normal subjects. The same tendency was observed in patients with diabetes mellitus. (2) Exocrine pancreatic secretion did not change after infusion of PHP or HCl in patients with chronic pancreatitis. Pancreatic flow rate, bicarbonate concentration and amylase output were significantly low in patients with chronic pancreatitis as compared with those of normal subjects and patients with diabetes mellitus. (3) Pancreatic flow rate and bicarbonate concentration increased to about twice those of basal levels after both PHP and HCl infusion. On the other hand, although pancreatic amylase output increased significantly after infusion of HCl as compared with basal secretion, it did not change after infusion of PHP. It appeared reasonable to conclude that PHP is a more specific substance for releasing secretin than HCl.抄録全体を表示PDF形式でダウンロード (1142K) -
AKIHIKO YAMAGUCHI, KOSAKU YOSHIDA, MITSUYUKI FUKUDA, YUKITAKA FUKUSHIM ...1980 年 131 巻 4 号 p. 373-380
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーA significant correlation was found between the bone marrow colony number and the hemoglobin value and, leucocyte and platelet numbers in cases of aplastic anemia. It is thought, therefore, that the colony number may be a useful index in determing when drug therapy can be halted.抄録全体を表示PDF形式でダウンロード (271K) -
NOBUO HIWATASHI, TAKAO KIKUCHI, OSAMU MASAMUNE, EIETSU OUCHI, HIKARU W ...1980 年 131 巻 4 号 p. 381-385
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーHLA antigens were studied in 60 patients with ulcerative colitis, 10 with Crohn's disease and 120 healthy Japanese controls. HLA typing was performed by the microdroplet lymphocyte cytotoxicity test. B5 was recognized in 62% of the patients with ulcerative colitis, whereas in 40% of controls (p<0.01). Furthermore, in these patients, B7 was decreased in incidence (p<0.05) and there was the highest relative risk alue for A3 (R.R.=6.3). When the patients were classified into 2 groups according to the extent of the lesions, left-sided or total colitis group and proctitis group, B5 was recognized in 65% of the patients with left-sided colitis or total colitis; and this increase was statistically significant. However, no significant difference in the incidence of B5 was recognized between the patients with proctitis and controls, probably because the number of patients studied was too small for evaluation. In the patients with Crohn's disease, B27 was recognized in one patient, showing an increase in incidence (p<0.001), although the number of patients studied was very small.抄録全体を表示PDF形式でダウンロード (261K) -
TATSUSUKE SATO, MICHIO SUGA, HAJIME KUDO, TAKASHI WAGA, MASAMICHI OGAS ...1980 年 131 巻 4 号 p. 387-391
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーNon-inbred rats of the Gifu strain were intraperitoneally challenged with Hirosaki sarcoma (tetraploid type, 105 cells) after repeated immunization with gamma-irradiated (13, 000 rads 60Co) allogeneic non-viral tumors of ascites type (tetraploid or diploid type of Hirosaki sarcoma, Usubuchi sarcoma or AH130). In rats immunized not only with the same tumor as the immunizing tumor but also with a different tumor, the growth of the challenge tumor was markedly inhibited as compared with the control in non-immunized rats. It is considered that these tumors retained common antigen(s) by the resistance to irradiation because of their form of ascites tumor. The marked cross-immunity in rats immunized with AH130 may be explained by the fact that gamma-irradiated AH130 cells were alive longer in the peritoneal cavity than other tumors on account of its high resistance to irradiation.抄録全体を表示PDF形式でダウンロード (296K) -
HIROSHI SATOH, YASUHIKO IWASAKI, AKIYUKI OHKUBO, TOMOE BEPPU, SHUNJI F ...1980 年 131 巻 4 号 p. 393-397
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーBoth cryptogenic liver cirrhosis and idiopathic portal hypertension without pathological findings of liver cirrhosis (IPH) are relatively common in Japan. To find difference between IPH and cryptogenic liver cirrhosis of Japanese, we investigated human leukocyte antigen (HLA), familial clustering of liver diseases as well as prevalence of HBs antigen in 31 patients with IPH. The age of patients with IPH ranged between 6 and 67 years old (mean, 40 years). The ratio of female to male in patients with IPH was 3.1. The incidence of chronic liver diseases in the relatives of patients with cryptogenic liver cirrhosis was significantly high (29.1%), whereas that in the relatives of patients with IPH was not high (12.9%) as compared with hospitalized controls (8.9%). The phenotype frequencies of the specificities of HLA A and B loci in patients with IPH did not differ from those in healthy controls. And the incidence of HBs antigen and antibody in patients with IPH (3.2% and 20.7%, respectively) was similar to those in normal subjects in Japan. These findings suggest that IPH in Japan is a different clinical entity from cryptogenic liver cirrhosis and that HB virus may not be one of the main causes of IPH.抄録全体を表示PDF形式でダウンロード (243K) -
KUNIHIKO GOTO, HARUO SATO1980 年 131 巻 4 号 p. 399-407
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーA mixture of an ethanolic solution of phospholipid and water was sonicated, kept at 50°C for 30min, and then observed by a phasecontrast microscope. A large number of cell-sized, single-layered liposomes thus obtained were different in shape and thickness from the liposomes prepared by conventional methods. Fixation with La(NO3)3 and KMnO4, stabilized the liposomes. As a result they remained unchanged in the organic solvents used for dehydration and embedding. Ultrathin sections of the liposomes could, therefore, be observed with an electron microscope. The nature of these liposomes was discussed in relation to the structure and function of the cell membrane.抄録全体を表示PDF形式でダウンロード (2985K) -
SANAE SHIMURA, TOORU AOKI, SHIGERU SATO, TAMOTSU TAKISHIMA1980 年 131 巻 4 号 p. 409-410
発行日: 1980年
公開日: 2008/11/28
ジャーナル フリーType II alveolar cells from healthy (control) and from pilocarpine-treated rats were studied using transmission electron microscopy of ultra-thin sections and freeze fracture replicas. In freeze-fracture preparations, a bar-like laminated structure about 0.4 μm in diameter and 1_??_6Δm in length was found in type II alveolar cells; it seemed to be identical to the membrane-bound slits containing electron dense materials which were also observed in ultra-thin sections. The frequency of this structure in the cells increased together with an increase in the number of lamellar bodies after injection of pilocarpine, suggesting a close connection between the bar-like structure and the formation of pulmonary surfactant.抄録全体を表示PDF形式でダウンロード (740K)
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