The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
191 巻, 2 号
June
選択された号の論文の6件中1~6を表示しています
Regular Contributions
  • Hirotaka Suzuki, Naofumi Iwatsuki, Keishiro Karita, Hiroshi Izumi
    2000 年 191 巻 2 号 p. 59-70
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    The involvement of nitric oxide (NO) in the lower lip vasodilatations mediated via parasympathetic and antidromic mechanisms was examined in α-chloralose/urethane-anesthetized cats, with the two types of blood flow responses being recorded separately (by laser Doppler flowmeter) from the two sides of the lower lip. The central cut end of the lingual nerve (LN) or the peripheral cut end of the inferior alveolar nerve (IAN) was electrically stimulated to elicit parasympathetic or antidromic vasodilatation, respectively, in the lower lip. NG-nitro-L-arginine methyl ester (L-NAME), but not NG-nitro-D-arginine methyl ester (D-NAME) (each at 30 mg/kg), markedly reduced the increases in lip blood flow evoked by stimulation, the reduction being to a similar degree irrespective of whether LN or IAN was stimulated. Pretreatment with L-arginine did not prevent the L-NAME-induced attenuation of either type of vasodilatation. In conclusion, these results suggest that synthesized NO may have a common site of action in antidromic and parasympathetic vasodilator pathways to the cat lower lip.
  • Naoko Sasaki, Tetsuaki Kawase, Masaki Ogura, Tomonori Takasaka
    2000 年 191 巻 2 号 p. 71-78
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    The effects of the addition of contralateral noise on the level of distortion product otoacoustic emissions (DPOAEs) were examined. In the present study, the DPOAEs were recorded for a relatively long period (2 minutes), and the time-course of the effects of contralateral sound on the level of DPOAEs were considered. In general, the addition of the contralateral noise resulted in suppression of the level of DPOAEs. The time-course of this suppression appeared to depend on the level of the contralateral noise. When the level of the contralateral noise was low, the suppression of the level of DPOAEs seemed to be largely unchanged for at least 2 minutes. In contrast, when a relatively high level of contralateral noise was used, the suppression of the level of DPOAEs decreased with time.
  • Shiun Dong Hsieh, Hideyo Yoshinaga, Takashi Muto, Yutaka Sakurai
    2000 年 191 巻 2 号 p. 79-84
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    The body mass index (BMI), waist circumference, waist to hip ratio, waist to height ratio and skinfolds (near-umbilical and iliac areas) in three age groups (35-44, 45-54 and 55-64 years) were compared in 3117 men and 997 women in Tokyo. In both genders, height was significantly shorter, while the waist to hip ratio and waist to height ratio were significantly higher, in the older groups. In the men, there were no significant differences in BMI and waist circumference among the three age groups, but the iliac skinfold was significantly thinner in each older group, and the paraumbilical skinfold was thinner in the group aged 55-64 years. In the women, the paraumbilical skinfold was significantly thicker in each older group, while waist circumference and the iliac skinfold were significantly larger or thicker in the group aged 55-64 years, and BMI was larger in the groups aged 45-54 and 55-64 years. There were age-related discrepancies between BMI and other obesity indices in the different genders, in that only the waist to height ratio and waist to hip ratio increased with age in both genders.
  • Steven Gallant, Maria Kukley, Sergey Stvolinsky, Elena Bulygina, Alexa ...
    2000 年 191 巻 2 号 p. 85-99
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied. Carnosine was shown to improve the animals orientation and learning in “Open Field” and “T-Maze” tests, and this effect was accompanied with an increase in glutamate binding to N-methyl-D-aspartate (NMDA) receptors in brain synaptosomes. Long-term brain ischemia induced by both sides' occlusion of common carotid arteries resulted in 55% mortality of experimental rats, and those who survived were characterized by partial suppression of orientation in T-maze. In the group of rats treated with carnosine, mortality after ischemic attack was decreased (from 55% to 17%) and most of the learning parameters were kept at the pre-ischemic level. Monoamine oxidase B (MAO B) activity in brain of the carnosine treated rats was not changed by ischemia significantly (compared to that of ischemic untreated rats) but NMDA binding to brain synaptosomal membranes being increased by ischemic attack was significantly suppressed and reached the level characteristic of normal brain. The suggestion was made that carnosine possesses a dual effect on NMDA receptors resulting in increase in their amount after long-term treatment but decrease the capacity to bind NMDA after ischemic attack.
  • Masahiko Inagaki, Akio Kimura, Masaru Miyataka, Kinji Ishikawa
    2000 年 191 巻 2 号 p. 101-111
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    The extent to which local administration of basic fibroblast growth factor (bFGF) increased regional myocardial blood flow (Qm) to acutely-infarcted areas of the heart, thereby mediating myocardial salvage, was examined in this study. Myocardial infarction was induced in two groups of rats by ligation of the left coronary artery. The bFGF group (n=16) received 100 μg bFGF in physiological saline by intramyocardial injection into the infarcted area, while the control group (n=7) received only saline. The rats were then maintained for four weeks. Among the controls, Qm decreased in the infarcted areas to 6.5±6.7% of that in the noninfarcted areas immediately after coronary ligation, then increased to 11.5±8.6% during the four-week maintenance period. In the bFGF group, Qm immediately decreased to 17.5±14.7% following ligation and remained stable thereafter (18.3±9.1%). There were no significant differences between the bFGF and control groups with respect to Qm, the number of viable myocardial cells or the extent of myocardial fibrosis. In this study we failed to show any significant effect of bFGF on coronary angiogenesis in acutely-ischemic myocardium in rats. Application of bFGF using different dosage, different routes of administration, measuring new capillaries morphologically will be needed to confirm the present negative results.
  • Masuko Mori, Haruo Ohtani, Yoshitaka Naito, Motoyasu Sagawa, Masami Sa ...
    2000 年 191 巻 2 号 p. 113-118
    発行日: 2000年
    公開日: 2005/06/28
    ジャーナル フリー
    CD8+ T cells infiltrating within cancer cell nests in human colorectal cancer were associated with a favorable patients' survival, suggesting the presence of anti-tumor immunity. The present study was designed to examine this concept in non-small cell lung cancer (NSCLC) by a retrospective analysis of 128 surgically resected cases. Immunohistochemical analysis showed that the number of CD8+ T cells within cancer cell nests in NSCLC was related to the histological subtype (large cell carcinoma or squamous cell carcinoma>adenocarcinoma) and the degree of dedifferentiation (undifferentiated type>differentiated type). In contrast to colorectal cancer, the number of CD8+ T cells in NSCLC had no statistically significant impact on the patients' survival. The present study demonstrated that the degree of infiltration of CD8+ T cells within cancer cell nests is dependent on the dedifferentiation of cancer cells in NSCLC, which could be one of the important aspects for the study of tumor immunity.
feedback
Top