巻号一覧
123 巻 (1977)
- 4 号 p. 297-
- 3 号 p. 197-
- 2 号 p. 99-
- 1 号 p. 1-
123 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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SHIGERU SATO, MASAHIKO KAWAKAMI, SANAE SHIMURA, RYUITSU FUJIMOTO, TOSH ...1977 年 123 巻 2 号 p. 99-108
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーSelective alveolo-bronchography (SAB) was performed in 14 patients with type B chronic obstructive lung disease to evaluate the morphologic changes of their “small airways”. The distance from the branching portion of the segmental bronchus (B9) to the end of the conducting airway was divided into three equal parts (central, middle and peripheral). In the peripheral part, interruption of the airway with a rounded or tapering end was noted at a high incidence (9 cases). Dilatation of the bronchus, irregular outline of the bronchial wall and increased angle of branching were also conspicuous in this part. Inadequate lateral branchings of airways were often observed in the middle and the peripheral part, particularly in the latter (10 cases). Generalized narrowing of an airway and narrowing especially at a branching point were observed in about one half of the cases. Fringes and/or spikes were most often seen in the central part of the airway (9 cases). These pathological appearances are considered to reflect morphologic changes in “small airway disease”, and thus SAB can serve as a useful method for detecting lesions of the small airways.抄録全体を表示PDF形式でダウンロード (1625K) -
RYOICHI MOTOKI, KENJI HONDA1977 年 123 巻 2 号 p. 109-124
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーSerial clinical observations and hemodynamic measurements were made on seventeen patients with sepsis and ten control cases. Control patients were slightly hypovolemic immediately after operation. In the eleven high flow patients, that is, those with the initial cardiac index higher than 3.0 liters/min/m2, we observed characteristic hemodynamics with lowered vascular resistance, higher cardiac output and hypotension. The anomalous vascular resistance began to return to normal approximately 48 hr after operation. In three cases pulmonary complication developed at this time and therefore pulmonary artery pressure and/or pulmonary wedge pressure exceeded the normal range. In these cases treatment was aimed at lowering the pulmonary pressure. Pulmonary complication was improved when these pressures returned within normal range. In the seven low flow patients, that is, those with cardiac index lower than 2.9 liters/min/m2, we observed decreased cardiac index with increased systemic and pulmonary vascular resistance. In these cases pulmonary complication appeared to develop by increased permeability of the pulmonary capillary wall. Elevated pulmonary artery pressure might accelerate the progress of the complication. Monitoring and controlling pulmonary artery pressure and pulmonary wedge pressure were effective in prevention and treatment of pulmonary complication in this group.抄録全体を表示PDF形式でダウンロード (821K) -
KENJI HONDA, SHUNICHI HOSHINO1977 年 123 巻 2 号 p. 125-137
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーHemodynamics and cardiac function in the immediate postoperative period following open heart surgery were studied by means of a Swan-Ganz catheter and a thermodilution output computer. Pulmonary arterial pressure decreased at 3 hr after operation in congenital and mitral valvular diseases either with or without pulmonary hypertension. Then pulmonary arterial pressure maintained the decreased level subsequently in patients without pulmonary hypertension or with moderate pulmonary hypertension. However, in cases of severe pulmonary hypertension, pulmonary arterial pressure increased concomitantly with the increase of pulmonary arterial resistance in adult cases, but maintained the decreased level in juvenile cases. Pulmonary wedge pressure decreased at 3 hr after operation and maintained the decreased level. Right atrial pressure fluctuated within normal range. The cardiac index and left ventricular stroke work index increased between 3 to 6 hr after operation in congenital and mitral valvular diseases and decreased temporarily between 9 to 30 hr and then increased again. The cardiac index and left ventricular stroke work index in mitral valvular diseases showed values lower than those in congenital heart diseases. The increase of cardiac index and left ventricular stroke work index after open heart surgery was more remarkable in mitral valvular diseases than in congenital heart diseases.抄録全体を表示PDF形式でダウンロード (717K) -
AKIRA OKUAKI1977 年 123 巻 2 号 p. 139-145
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーDibutyryl cyclic-AMP was administered to a group of anesthetized dogs at the doses of 5, 10, 20 and 40 mg/kg, and changes in stroke volume, cardiac output and myocardial contractility were observed. Also, effects of this substance on contractile performance of isolated cardiac muscle were investigated in another group of dogs. Results were as follows: 1) Dibutyryl cyclic-AMP increased heart rate, stroke volume and cardiac output in a dose-related manner in the range from 5 to 40 mg/kg. 2) As indices of myocardial contractility, Vmax and maximum dF/dt were examined. These also showed a dose-dependent increase in response to dibutyryl cyclic-AMP. In isolated dog hearts, dibutyryl cyclic-AMP raised the maximum velocity of shortening (V'max) dose-dependently. 3) Total peripheral resistance declined in a dose-related way. On the other hand, mean arterial pressure and CVP dropped slightly without showing dose-dependence-These results show that dibutyryl cyclic-AMP produces positive inotropic and chronotropic effects and cause dilatation of the peripheral vessels in dose-dependent manners.抄録全体を表示PDF形式でダウンロード (1015K) -
HARUKI WAKASA, SHIGERU AMANO1977 年 123 巻 2 号 p. 147-159
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーThe human testes in cases of malignant hematopoietic tumors, especially of leukemia, were histologically examined to characterize the mode of leukemic infiltration in comparison with that of malignant lymphoma. Materials were obtained from 56 autopsy cases, composed of 47 of leukemia, 7 of reticulum cell sarcoma and 2 of lymphosarcoma. Leukemic infiltration was confirmed in 43 (19%) of all leukemic cases and the pattern was divided into three types; diffuse, patchy and perivascular. A high grade infiltration was most common in lymphocytic leukemia. The testicular involvement was unexceptionally bilateral with occasional differences in the grade of infiltration, slight to moderate. There was no regional difference in incidence of leukemic infiltration in the testicular interstitium. A thin-walled canal located closely between the proper lamina of seminiferous tubules and the interstitial cell cluster was suggested to be lymphatics, which were extremely irregular in shape and occasionally did not have endothelium. Therefore human testicular lymphatics might not be a constant canal system, but rather akin to narrow tissue space. A network of argyrophilic fibers was pronounced in the lesion of leukemic infiltration. The frequency and grade of an involvement of the testes in malignant lymphoma were lower and lesser than those in leukemia.抄録全体を表示PDF形式でダウンロード (5001K) -
YASUMASA HAYASHI, TETSU NAGATA, KUNIO SHIOMI1977 年 123 巻 2 号 p. 161-176
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーEye movement potentials (EMPs) were recorded from the superior colliculus (SC) of awake cats. When cats moved the eyes in front of a patterned or diffuse field, the EMP appeared as a sequence of the three components; EMP1, EMP2 and EMP3. The EMP1-EMP2-complex occurred while the eyes were moving and it had a wave form similar to that of the flash-evoked response. The EMP3 was seen 30-50 msec after the end of eye movement. In dark only the EMP3 was observed; its delay after the end of eye movement was as large as 70 msec. By placing electrodes at various depths of SC, the EMP was found to originate in the superficial layers. In immobilized, encéphale isolé cats, placed in dark or made blind by enucleation, the followings were observed; 1) Passive movements of the eye did not give rise to any significant electrical activity of SC. 2) Spontaneous mass activity of the oculomotor nucleus, that would result in eye movements if the cats were not paralysed, was followed by sharp wave activity of SC and this was the same after the visual cortex had been ablated bilaterally. From these findings it is concluded for the EMPs of awake cats that the EMP1-EMP2-complex is a response to retinal impulses caused by movements of images, whereas the EMP3 is due to an extraretinal factor such as the corollary mechanism. Besides the EMPs as described above, some activity was found to occur about 150 msec before the onset of eye movement. This EMP, called early EMP, seemed to appear when it was followed by eye movements with relatively high speeds.抄録全体を表示PDF形式でダウンロード (986K) -
TOSHIYUKI TANAKA, AKIRA SEKI, JUN FUJII, HIROSHI KURIHARA, MASAO IKEDA1977 年 123 巻 2 号 p. 177-183
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーThe content and turnover of norepinephrine (NE) in the hypothalamus, midbrain, pons-medulla, mesenteric artery, aorta and left ventricle were studied in the normal rabbit. Turnover rate of NE was determined by measuring the rate of decline in NE content of the tissue after blockade of synthesis with α-methyl-p-tyrosine. The NE content of the hypothalamus (1.44±0.03 μg/g) was significantly higher than those of the midbrain (0.25±0.01 μg/g) and the pons-medulla (0.36±0.01 μg/g) (p<0.001), whereas the rate constant of NE turnover for the pons-medulla (0.213±0.009 hr-1) was significantly greater than those for the hypothalamus (0.164±0.008 hr-1, p<0.001) and the midbrain (0.180±0.008 hr-1, p<0. 01). In the cardiovascular tissues examined, the NE content was highest in the mesenteric artery (6.33±0.19 μg/g), moderate in the left ventricle (2.08±0.10 μg/g) and lowest in the aorta (0.70±0.06 μg/g). The differences among them were significant (p<0.001). However, the rate constant of NE turnover for the aorta (0.119±0.014 hr-1) was significantly greater than those for the mesenteric artery (0.59±0.008 hr-1, p<0.001) and the left ventricle (0.069±0.006 hr-1, p<0.005). The turnover rate of NE in the mesenteric artery was high, 0.372 μg/g•hr, which suggests the very active NE synthesis. These results indicate that there are regional differences in content and turnover of NE of the cardiovascular tissues as well as of the brain.抄録全体を表示PDF形式でダウンロード (503K) -
KAZUYA SATO, KIYOHIDE KOJIMA, CHIKAKO SATO1977 年 123 巻 2 号 p. 185-190
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーWe applied cell electrophoresis to detect the effect of anesthetics on membrane, and clarified the concentration - effect relationship and the term of reversibility. The cell electrophoretic mobility of rat erythrocytes decreased with time of incubation with intravenous anesthetics (thiopental or droperidol) at clinical concentrations and reached a minimum value of 25% reduction in 30 min. The effect changed gradually in the concentration range of 0.5-1000 μg/ml of thiopental, and changed markedly with 0.3-1 μg/ml of droperidol. Washing out of the anesthetics and subsequent incubation in serum-containing medium resulted in the complete recovery in the mobility when 5 μg/ml thiopental or 1 μg/ml droperidol was used. With high concentration of thiopental (100 μg/ml) or droperidol (10 μg/ml), however, unrecovered fraction of cells increased with time of treatment. The critical time for retaining the reversibility was about 2 hr.抄録全体を表示PDF形式でダウンロード (353K) -
SHOICHI SADAKATA, SHIGEHO TANAKA, KEIZO CHIYOTANI, KENICHI SAITO, MICH ...1977 年 123 巻 2 号 p. 191-196
発行日: 1977年
公開日: 2008/11/28
ジャーナル フリーThe present communication deals with the follow-up study of 24 patients with bilateral silicotuberculosis in whom only unilateral operation was carried out for major lesions. The operative procedure consisted of pulmonary resection, thoracoplasty or combined operation such as cavernostomy, intracavitary filling of a pedunculated muscle flap and thoracoplasty. The follow-up period ranged 1 year to 12 years and 5 months. The results of surgical treatments for unilateral major lesions and their effect on the contralateral minor lesions were clinically assessed by alterations in the chest X-ray findings and tubercle bacilli in sputum. In 16 of 24 patients (67%) alleviation was obtained, whereas no change occurred in 3 (13%) and aggravation in 5 (21%). The surgical treatment for unilateral major lesion brought about 41% of improvement in the contralateral minor lesion. Contralateral minor lesions remained unchanged in 46% of patients and aggravated in 14%. This shows a value of the surgical treatment for bilateral silicotuberculosis. It should be emphasized that surgical treatments more aggressive than have been heretofore practiced can be employed.抄録全体を表示PDF形式でダウンロード (384K)
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