巻号一覧
170 巻 (1993)
- 4 号 p. 207-
- 3 号 p. 135-
- 2 号 p. 63-
- 1 号 p. 1-
170 巻, 1 号
選択された号の論文の7件中1～7を表示しています
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TAKAO FUKAYA, CHIEKO KAKUTA, HIDEO TOZAWA, CHARLES MANSFIELD, AKIRA TS ...1993 年 170 巻 1 号 p. 1-9
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーFUKAYA, T., KAKUTA, C., TOZAWA, H., MANSFIELD, C., TSUIKI, A., YOHKAICHIYA, T. and YAJIMA, A. The Role of Inhibin on Pituitary FSH Secretion and Maturation of Pituitary-Gonadal Axis in Immature Female Rats. Tohoku J. Exp. Med., 1993, 170 (1), 1-9 - The possible physiological significance of endogenous inhibin was evaluated in prepubertal female rats during sexual maturation. Ovarian/serum inhibin, serum FSH levels were measured from 4th day to 35th day of life by RIA. Serum inhibin levels were first detected on 4th day of life, thereafter, progressively increasing up to 27th day. Serum FSH levels gradually increased up to the 14th day with a sharp fall in the FSH levels on day 15 which afterwards was maintained at a lower level. Pregnant mare serum gonadotropin (PMSG) treatment on day 14 and day 22 rats showed different patterns of serum FSH and inhibin changes. In 14 day group, there was no difference between control and PMSG treatment, but in 22 day group, not only significant difference between control and PMSG treatment but also inverted relations between FSH and inhibin after PMSG treatment were found. It can be postulated from these findings that secretion of inhibin from the granulosa cells is initiated by FSH by its direct action on the ovary whereas the level of FSH itself is controlled by inhibin after FSH reaches peak values. Also it can be inferred that the feedback control mechanism of inhibin seems to be established around 3rd week of life. - inhibin; FSH; immature stage; onset of estrous cycle抄録全体を表示PDF形式でダウンロード (790K) -
NORIYOSHI NAGAMOTO, YASUKI SAITO, MASAMI SATO, MOTOYASU SAGAWA, KEIJI ...1993 年 170 巻 1 号 p. 11-23
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーNAGAMOTO, N., SAITO, Y., SATO, M., SAGAWA, M., KANMA, K., TAKAHASHI, S., USUDA, K., ENDO, C., FUJIMURA, S. and NAKADA, T. Lesions Preceding Squamous Cell Carcinoma of the Bronchus and Multicentricity of Canceration - Serial Slicing of Minute Lung Cancers Smaller Than 1mm. Tohoku J. Exp. Med., 1993, 170 (1), 11-23 - A total of ten minute squamous cell carcinomas smaller than 1mm were found in surgical lung specimens from 108 patients who had roentgenographically occult lung cancer. These minute lesions were detected by submitting, in all the 108 specimens, the whole bronchial tree to 2-mm-thick sequential transverse slicing which was then followed by microscopic examination of each slice on an H-E stained section. When a focus of minute carcinoma was found, the slice was further serially sectioned to study whether there were such carcinoma-related lesions as dysplasia or other atypical changes of epithelia, and when there were, the spatial relation of these with the carcinoma. It was demonstrated that all the minute carcinomas were closely associated with either dysplasia or what we call “basal cells with marked atypia”, cells with markedly enlarged nuclei arranged in linear fashion on the basement membrane. The contiguity of these changes with minute carcinoma strongly suggested that they are lesions preceding overt carcinoma. Also, there were some minute foci of carcinoma, which, though not involving the entire epithelial thickness, proved to have already begun microinvasion. - roentgenographically occult lung cancer (ROLC); minute carcinoma; dysplasia; basal cells with marked atypia; incomplete carcinoma抄録全体を表示PDF形式でダウンロード (4313K) -
KOZO ITO1993 年 170 巻 1 号 p. 25-34
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーITO, K. Clinical and Pathological Investigation of. Endometrial Mixed Mesodermal Tumor. Tohoku J. Exp. Med., 1993, 170 (1), 25-34 - Four cases of mixed mesodermal tumor (MMT) of uterine origin were histologically and cytologically studied. In the case of occurrence of rhabdomyosarcoma, the cells in the aspiration smear appeared independently and sporadically and were relatively large in size and polyhedral in shape. The cell margins were not clearly distinguishable, and the cytoplasm was non-uniformly and heavily stained light green in general except for some pale red eosinophilic areas. The swollen and elliptical nuclei had a high N/C ratio. The chromatin showed a densely stained coarse granular pattern, and the nuclear margin was expanded. On the imprint smear, the cells contained abundant cytoplasm with amoeboid protrusions. The cytoplasm was light green in general, was filled with granules of various sizes which were non-uniformly and heavily stained. The chromatin showed coarse granulation, and a large nucleolus was observed, - uterus; endometrial carcinoma; carcinosarcoma; cytology抄録全体を表示PDF形式でダウンロード (3563K) -
SHOGO YAMADA, YOSHIHIRO TAKAI, KENJI NEMOTO, YOSHIHIRO OGAWA, YOSHIHIS ...1993 年 170 巻 1 号 p. 35-43
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーYAMADA, S., TAKAI, Y., NEMOTO, K., OGAWA, Y., KAKUTO, Y., Hosni, A. and SAKAMOTO, K. Prognostic Significance of CT Scan in Malignant Glioma. Tohoku J. Exp. Med., 1993, 170 (1), 35-43 - In 91 malignant gliomas treated with radiation therapy, CT scan which was taken before treatment was reviewed to examine the significance as a prognostic indicator. The irradiation methods and the surgical resectability did not affect the survival. Similarly, the tumor location and the grade of the low density area (LDA) surrounding the contrast enhanced area (CEA) had no significance on the prognosis. As a result of the multi-variate analysis, the histopathologic diagnosis, the CEA size and the CEA pattern were significantly important prognostic factors. Astrocytoma grade III, a CEA diameter of under 4cm and a homogeneous CEA were favorable indicators of the malignant gliomas. Tumors with a heterogeneous or a ring-like CEA in the diameter of more than 4cm have the worse prognosis and should be treated extensively by radiation therapy. - brain neoplasm; malignant glioma; CT; therapeutic radiology; prognostic factor抄録全体を表示PDF形式でダウンロード (706K) -
HIROKO KITAOKA1993 年 170 巻 1 号 p. 45-52
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーKITAOKA, H. Numerical Density of Alveoli in the Human Lung - Measurement Using Serial Thin Slices as Three-Dimensional Probes- Tohoku J. Exp. Med., 1993, 170 (1), 45-52 - The numerical density of alveoli was estimated in a surgical lung specimen taken from a female, aged 51, for adenocarcinoma of the left upper lobe. The specimen was fixed by intrabronchial infusion with a mixture of polyethylene glycol and formalin. Using a special slicer, 36 serial slices were prepared at a thickness of 0.2 mm; in these, a rectangular 3-D sampling probe, 2.0mm×2.0mm×0.2mm, was set, and the number of alveoli contained in it was counted under a stereo microscope. After the serial slice were subjected to computer-assisted 3-D reconstruction of the acini and supplying airways, two acini, with a volume of 140 and 104mm3, respectively, were selected, in each of which five sampling probes were set, two in the centriacinar and three in the peripheral region. Counting, performed according to the Bisector rule, gave a mean alveolar numerical density of 121/mm3 (SD=5.6). No significant difference in density proved to exist not only between the two acini but between the central and peripheral portions of each acinus. This justifies the premise, on which the conventional stereological methods have been based, that the numerical density of alveoli of the lung is uniformly distributed over the whole organ - lung alveolus; morphometry; numerical density; serial thin slices; three-dimensional probe抄録全体を表示PDF形式でダウンロード (1200K) -
MIKIO IMAMURA, HIDEMI YAMAUCHI, YOSHITO NAKAJIMA, SADAHITO SHIN1993 年 170 巻 1 号 p. 53-58
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーIMAMURA, M., YAMAUCHI, H., NAKAJIMA, Y. and SHIN, S. Improved Radioimmunoassay of Cholecystokinin (CCK) Using OAL-656 by Ethanol Extraction of Human Plasma. Tohoku J. Exp. Med., 1993, 170 (1), 53-58 In the radioimmunoassay of human plasma cholecystokinin (CCK) using an antiserum OAL-656, it has been difficult to get stable fasting values as well as prominent postprandial increase. Therefore, we tried to extract human plasma with ethanol before the radioimmunoassay, and could solve these problems, that is fasting concentrations became stable (16.7±2.5pg/ml) (mean±S.D., n=9), and CCK concentrations were augumented promptly after feeding and were kept at higher levels for a certain period. - cholecystokinin; human plasma; radioimmunoassay; OAL-656; ethanol extraction抄録全体を表示PDF形式でダウンロード (492K) -
ICHIRO NAKAZAWA, MASAMOTO IWAIZUMI, KAZUO OHUCHI1993 年 170 巻 1 号 p. 59-61
発行日: 1993年
公開日: 2006/08/31
ジャーナル フリーNAKAZAWA, I., IWAIZUMI, M. and OHUDHI, K. Some Features of Prostaglandin Synthesis of the Cancer Cells Metastasized into Liver from Gastric Cancer Lesions. Tohoku J. Exp. Med., 1993, 170 (1), 59-61 - In order to study the mechanism of cancer metastasis, AH100B rat hepatoma cells were transplanted to the stomach of male Donryu rats. Each hepatic metastatic nodule was collected with the respective primary gastric lesions. Each sample thus obtained was injected separately into the peritoneal cavity of male Donryu rats to make free cancer cells; then, intact cancer cells of the hepatic metastatic and primary gastric lesions were collected. After washing in Dulbecco's phosphate-buffered saline (Ca2+ and Mg2+-free, pH 7.2), the definite number of the metastatic and primary gastric cancer cells were incubated in the phosphate-buffered saline containing [1-14C] arachidonic acid at 25°C for 30min. Arachidonic acid metabolites formed during the incubation period were extracted and subjected to thin-layer chromatography, followed by autoradiography. Each radioactive spot was scraped off the plate and measured for its radioactivity. The pattern of the ability to produce PGs was different between the cancer cells which metastasized to the liver and those of the primary lesions, that is, percentage of PGF2α was higher (p<0.05) and that of PGE2 was quite higher (p<0.01) in the hepatic metastatic cancer cells as compared with those of the primary gastric lesion. These results suggest that PGs produced by hepatic metastatic cancer cells might play an important role in hepatic metastatic formation. - cancer metastases; liver; gastric cancer抄録全体を表示PDF形式でダウンロード (366K)
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