The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
81 巻, 3 号
選択された号の論文の9件中1~9を表示しています
  • 佐藤 哲, 館山 光昭, 笹森 長次郎, 小林 蕃, 千葉 弥一郎, 武田 吉正
    1963 年81 巻3 号 p. 207-214
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    On 25 cases of hypertension and 16 cases of postapoplectic patients with hypertension the cerebral carbohydrate metabolism was estimated, simultaneously with the cerebral hemodynamics, using Kety's N2O method. The cerebral glucose consumption was generally smaller in these patients than that of healthy subjects. It was found not to stand in such a close relationship with cerebral oxygen consumption as it was the case in healthy subjects. It depends on the glucose content in arterial blood to some extent. Some disturbances are presumed in the blood glucose transfer into the brain tissue. No significant difference was detected between the hypertensive and the postapoplectic subjects in respect of the cerebral glucose consumption. An increased lactic acid forma-tion was presumed in the brain of these patients, especially in the hypertensive patients: The amount of lactic acid carried out of the brain was in many cases too large to be explained by the decrease in oxidized part of blood glucose owing to the reduced oxygen supply.
  • 佐藤 哲, 館山 光昭, 笹森 長次郎, 小林 蕃, 千葉 弥一郎, 武田 吉正
    1963 年81 巻3 号 p. 215-221
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    On 19 healthy subjects distributed in almost all age ranges, the glucose, the pyruvic acid and the lactic acid contents were measured in the blood samples taken from the internal jugular vein and the femoral artery, simultaneously with the cerebral hemodynamics by N2O method, to determine the amount of metabolized carbohydrates in unit weight of brain tissue. The cerebral glucose consumption (CMRgl) was found in a close relationship with CMRO2, suggest-ing that the blood glucose is the most important source of energy for the brain. Cerebral arteriovenous differences of glucose and cerebral blood flow were in a negative correlation, indicating the constancy of glucose supply as energy source. Pyruvic acid and lactic acid were estimated to be carried out from the brain in almost all cases, but the correlation between the outflow of these acids and the cerebral oxygen consumption was obscure. The mean value of cerebral glucose consumption was almost equal to the sum of mean values of the cerebral oxyda-tion of glucose and the amounts of acids transferred out of the brain. Hence, an equilibrium in carbohydrate metabolism of therbrain of healthy persons was .elucidated. In aged subjects, the derangement of carbohydrate metabolism is evident with a well balanced equilibrium on a lower level, presumably as a physiological senile phenomenon.
    These findings and presumptions should be evaluated in future by more accurate methods, which enable us to analyze obtained values more exactly. From the present stand-point, we should be satisfied with the present summaries.
  • 長沢 純一郎
    1963 年81 巻3 号 p. 222-237
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    Sodium and potassium movements in smooth muscle of guinea-pig taenia coli were measured with radioactive isotopes. In low temperature (20°C and 2°C), uptake of 42K and loss of 24Na were reduced considerably, but loss of 42K and uptake of 24Na were not so much affected. Adrenaline (1×10-5g/ml) had no significant effect upon the movement of 24Na, though it had suppressed the spontaneous contraction completely. Acetylcholine, adrenaline, histamine and serotonin also increased the efflux of 42K.
  • 鈴木 寿夫, 塚原 保夫
    1963 年81 巻3 号 p. 238-245
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    A thermoelectric recorder using a tiny thermistor bead heated by an electric current of suitable strength is described. When immersed in a flowing fluid, the recorder is very sensitive to flow changes, and the rate of response is much higher than that of usual recorder using a heated thermocouple. A needle-type element of this device having the thermistor bead on its tip is small enough to be inserted deep into the brain without any serious injury of the tissue. Its usefulness for measuring instantaneous changes of local blood flow in the brain tissue has been confirmed by several experiments.
  • 吉永 馨, 阿部 圭志, 三輪 勣, 相田 光保, 前橋 賢, 和田 保男
    1963 年81 巻3 号 p. 246-253
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    An assay method of urinary kinin was described. It consists of extraction of the peptide into n-butanol, re-extraction back to a weak acid solution, concentration under reduced pressure, neutralization and bioassay on the isolated guinea-pig ileum.
    The method was fairly simple and can be carried out without difficulty. The recoveries and the accuracy proved satisfactory. The method is also specific for the kinin in urine.
    Ten to thirty micrograms of kinin were excreted daily by healthy persons.
  • 加藤 政孝
    1963 年81 巻3 号 p. 254-255
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
  • 小島 瑞, 菊田 和子, 太宰 厚
    1963 年81 巻3 号 p. 256-266
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    Among 249 cases of leukemia examined, there were 88 cases (35.3%) which were associated with tumor formation. These tumors occurred singly or multiply, in various kinds of leukemias and favorably in the kidney, mediastinum, skin and periosteum. Concerning the frequency of tumor formation, chloroleukemia had the highest rate, followed by monocytic leukemia, while myeloid leukemia showed a considerably lower rate. There was no difference in the frequency of tumor formation between acute and chronic leukemia, nor in relation to the number of mitotic figures of the leukemic cells. Consequently the tumor forming leukemia is hardly regarded as the more malignant form of leukemia, but is to be considered nothing but one type of neoplastic growth of blood cells. Finally it is considered that the condition of the host seems to be significant as the factor, determining tumor formation as well as the sort and character of leukemic cells.
  • 武藤 完雄, 間島 進, 吉田 弘一, 軽部 克己, 手島 貞一, 山口 巌
    1963 年81 巻3 号 p. 267-278
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
  • 武藤 院雄, 間島 進, 吉田 弘一, 軽部 克己, 手島 貞一, 山口 巌
    1963 年81 巻3 号 p. 279-296
    発行日: 1963/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    In 1037 cases of stomach cancer who survived subtotal gastrectomy at the authors' department, the relations between various pathologic as well as clinical aspects of stomach cancer and the end-results were analyzed. Of the factors studied, the extent of the extragastric spread of carcinoma was the most closely related to the longevity of patients, while the nature of the primary tumor less faithfully indicated the prognosis. The authors' P. C. classification, a grading for the extent of peritoneal dissemination, was proved to be a good measure of the prognosis and it was emphasized that the omenta should be extensively excised on the radical surgery for stomach cancer.
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