巻号一覧
129 巻 (1979)
- 4 号 p. 311-
- 3 号 p. 207-
- 2 号 p. 105-
- 1 号 p. 1-
129 巻, 1 号
選択された号の論文の14件中1～14を表示しています
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HIKARU WATANABE, NOBUO HIWATASHI, YOSHIO GOTO1979 年 129 巻 1 号 p. 1-8
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーIn order to clarify the role of biopsy in distinguishing Crohn's disease from intestinal tuberculosis before surgery, the histologic findings of the biopsy specimens from 8 cases of Crohn's disease were investigated in comparison with those from 19 cases of intestinal tuberculosis. The samples were obtained under direct vision through a fibercolonoscope from areas showing a cobblestone appearance or narrowing, and then approximately 60 serial sections of each sample were prepared whenever Crohn's disease was suspected on the basis of x-ray and endoscopic findings and clinical features. As a result, characteristic histologic findings such as small and discrete mucosal, noncaseating granulomas, disproportional inflammation, discontinuity of the lesion, and submucosal neuromatous hyperplasia were found in the majority of Crohn's disease cases. Granulomas were also found frequently in the cases of intestinal tuberculosis, although other findings were rare in such cases. Among granulomas in the intestinal tuberculosis cases, the number of submucosal granulomas was large and they showed a tendency to confluence, but the granulomas in the mucosa were small and discrete, as was the cases in the granulomas in Crohn's disease. There were no cases of caseating granulomas in the intestinal tuberculosis cases and the results of cultures for tubercle bacilli from biopsied samples were negative in the majority of cases in which cultures were attempted. Accordingly, it is thought to be difficult to differentiate Crohn's disease correctly from intestinal tuberculosis on biopsy alone, although biopsy under direct vision itself is a useful diagnostic procedure in Crohn's disease.抄録全体を表示PDF形式でダウンロード (3917K) -
SEIYA TAURA, MICHIKO TAURA, AKINORI KAMIO, FRED A. KUMMEROW1979 年 129 巻 1 号 p. 9-16
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーCoronary atherosclerosis developed in normolipemic swine fed a basal ration supplemented with 125, 000 IU, 62, 500 IU and 31, 250 IU of vitamin D3/kg of diet for 3 months and subsequently only the basal ration for the following 3 months. Lesions consisted of intimal atheromata and calcified internal elastics and caused luminal narrowing. The incidence of atherosclerotic lesions was proportional to the vitamin D3 doses. The present experimentally induced lesions had many morphological features resembling those in coronary arteries from human subjects.抄録全体を表示PDF形式でダウンロード (2640K) -
KINJIRO KOIZUMI, MASAYUKI OKUBO, SHUICHI INOUE, HISAYUKI MASUDA1979 年 129 巻 1 号 p. 17-24
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーSubcutaneous injections of a large dose of tetragastrin (2mg/day) into a rat for 4 weeks caused hypertrophy of parietal cells of the stomach, intestinal glandular cells of the duodenum, and pancreatic acinar cells. The histometrical analysis revealed that these trophic effects of tetragastrin were produced in varying degrees in different sites.抄録全体を表示PDF形式でダウンロード (2585K) -
SEIYA TAURA, MICHIKO TAURA, HIDESHIGE IMAI, FRED A. KUMMEROW1979 年 129 巻 1 号 p. 25-39
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーThe aortic endothelium in weanling swine was rubbed ten times with an inflated balloon catheter in a repeated balloon denudation. This procedure produced more drastic, extensive and uniform changes in the aortic wall than the commonly used balloon denudation. Sequential alternations of regenerated endothelium, intimal thickening and medial reaction, and the incidence of mitotic cells were studied by scanning and transmission electron microscopy. Complete endothelial loss was confirmed from the descending thoracic aorta to the right femoral artery within 24hr. By the third day, regenerated endothelium began to cover over the endothelial defect area from the uninjured areas such as the aortic arch and the orifices of branching arteries. Thrombus formation and fibromuscular intimal thickening were observed in the endothelial defect areas by the fifth and seventh days. Three types of mitotic cells, such as endothelial, intimal and medial cells were noted in the aortic wall. Mitotic endothelial and mitotic medial cells were most frequent at Day 3; the latter were closely associated with dead medial cells. Mitotic intimal cells initially appeared at Day 3 and were most frequent at Day 7. Mitotic intimal and mitotic medial cells were frequently present in the aortic wall subjacent to the endothelial defect areas containing interstitial blood components. The large numbers of mitotic aortic cells indicated that endothelial cells give rise to new endothelial cells, intimal cells to new intimal cells, and medial cells to new medial cells.抄録全体を表示PDF形式でダウンロード (4259K) -
HIROSHI SATOH1979 年 129 巻 1 号 p. 41-44
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーThe supernatant solutions of homogenates of organs of pregnant mice and fetuses on day 14 and 17 of gestation were measured for hemoglobin (Hb) content after a maximal blood extraction at sacrifice. Residual blood volumes of the organs and fetuses were calculated from the HS contents and blood Hb concentrations. The greatest value was found for the spleen and the lowest for the brain. The residual blood volumes of the uterus, placenta and fetuses on day 17 were greater than on day 14 of gestation.抄録全体を表示PDF形式でダウンロード (183K) -
AKIRA OHNEDA, TAKASHI KOBAYASHI, JIRO NIHEI, MASANORI UMEZU, TAKEAKI S ...1979 年 129 巻 1 号 p. 45-54
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーIn order to investigate secretion of extrapancreatic glucagon in dogs, plasma glucagon and total immunoreactive glucagon (IRG) in response to arginine were determined with antisera specific and non-specific for pancreatic glucagon, respectively. Only a tiny rise of plasma glucagon was observed in the portal vein following arginine infusion performed immediately after total pancreatectomy in a group of 5 normal dogs. In contrast, total IRG in the portal vein increased significantly after arginine infusion even after pancreatectomy. In alloxan diabetic dogs, arginine infusion after total panereatectomy caused a rise in plasma glucagon in the portal vein, although not significantly. The response of total IRG to arginine in the portal vein was exaggerated in alloxan diabetic dogs. In a group of one-week post-pancreatectomized animals, plasma glucagon and total IRG increased significantly in response to arginine infusion. Furthermore, in these dogs, response of plasma glucagon and plasma total IRG to arginine infusion was abolished after gastrectomy. From the present results it is concluded that secretion of extrapancreatic glucagon increased in response to arginine infusion in the diabetic state, both alloxan diabetic dogs and one-week post-pancreatectomized dogs. In addition, a rise in extrapancreatic glucagon following arginine infusion in the chronically pancreatectomized dogs almost certainly derived from the stomach, as the rise was abolished by gastrectomy.抄録全体を表示PDF形式でダウンロード (614K) -
YUSAKU TAZAWA, TASUKE KONNO1979 年 129 巻 1 号 p. 55-63
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーThe sulfated and nonsulfated bile acids in urine were determined in 28 infants with cholestasis, including 14 patients with neonatal hepatitis and 14 patients with biliary atresia. The mean age of the group with neonatal hepatitis was 80 days, ranging from 32 days to 111 days, and that of the group with biliary atresia was 51 days, ranging from 28 to 79 days. The major bile acids were cholic acid and chenodeoxycholic acid, and nonsulfated cholic acid was excreted predominantly. In the group of neonatal hepatitis, the values of nonsulfated cholic acid, nonsulfated chenodeoxycholic acid, sulfated cholic acid and sulfated chenodeoxycholic acid were 16.40±14.25, 1.49±1.11, 0.72±0.61 and 1.46±0.82mg per day, respectively. In the group of biliary atresia, these were 8.96±6.19, 0.90±0.51, 0.58±0.26 and 1.43±0.88mg per day, respectively. However, there was no significant difference in values of urinary bile acids between the two groups. In elder children and adults with cholestasis, the values of nonsulfated cholic acid, nonsulfated chenodeoxycholic acid, sulfated cholic acid and sulfated chenodeoxycholic acid were 39.43±25.29, 13.37±11.12, 10.92±6.21 and 25.54±12.89mg per day, respectively. No predominancy of nonsulfated cholic acid was found. To compare the urinary bile acid pattern of infants with cholestasis with that of elder children and adults with cholestasis, urinary bile acid was determined in terms of per mg creatinine. In the group of infants with neonatal hepatitis or biliary atresia, nonsulfated cholic acid was excreted in larger amounts than in the group of elder children and adults with cholestasis (p<0.05), and sulfated chenodeoxycholic acid was excreted less than in the group of elder children and adults with cholestasis (p<0.01). Small peaks were recognized on the chromatograms, one of which was identified as 3β-hydroxy-5-cholenoic acid in many cases. Besides, a small peak were found in trace amount in a case with fatal intrahepatic cholestasis, which has relative retention time of 3.04.抄録全体を表示PDF形式でダウンロード (551K) -
RYOJI MINAMI, SHIGEO SATO, TOORU KUDOH, KAZUHIKO OYANAGI, TOORU NAKAO1979 年 129 巻 1 号 p. 65-70
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーThe specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of six lysosomal enzymes in human liver during development were studied. The levels of total β-D-glucuronidase and N-acetyle β-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of β-D-glucuronidase and β-D-galactosidase in fetal liver were about ten times higher than those in childhood liver. The elution patterns on DEAE 52 of β-D-glucuronidase and on Sephadex G-150 of α-D- and β-D-galactosidases changed with aging. It is suggested that lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans change during development.抄録全体を表示PDF形式でダウンロード (332K) -
TETSURO NISHIHIRA, HIROSHI ISHII, MORIO KASAI, TAKEHIKO TACHIBANA1979 年 129 巻 1 号 p. 71-74
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーBy applying somatic cell hybrids to transplantation immunity, the prolongation of survival time of mouse skin allografts was investigated. The hybrid cells (LJ) were made by cell fusion between L cells derived from C3H/He mouse and JLS-V9 cells derived from BALB/c mouse with UV-irradiated Sendai viruses. Skin grafts from female (C3H/He.Jms×BALB/c.Slc) F1 donors were transplanted to male BALB/c.Sle. The survival of the transplant in BALB/c pretreated with the LJ cells and prednisolone showed a significant prolongation, compared with that in animals pretreated with only prednisolone or the LJ cells. The mean survival time and standard deviation of the grafts in mice injected with 1×105 LJ cells i. v. 4 days before the grafting, and subsequently treated with prednisolone 50mg/kg i.p. 1 day before and at the time of the grafting were 17.3±2.2 days. Controls were 9.2±0.4 days. The mechanisms of prolongation of skin grafts were discussed in terms of cell-mediated immunity and humoral factors. Somatic cell hybrids are useful, not only for inducing immunological enhancement, but also for studying the function of major histocompatibility antigens in cellular immunity and can be applied to clinical organ transplantation.抄録全体を表示PDF形式でダウンロード (243K) -
AKIRA YAJIMA, HISASHI HIGASHIIWAI, AKIRA SATO, MASAAKI WATANABE, TOSHI ...1979 年 129 巻 1 号 p. 75-81
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーOf a total of 1321 cases of severe dysplasia of the uterine cervix, 237 lesions (18%) were found by punch biopsy and cytological examination to have progressed to carcinoma in situ or microinvasive carcinoma later in the course of follow-up. The changes in exfoliated cells during the progression to malignancy were examined in 95 of the 237 cases. Results obtained were as follows: (1) The ratio of parabasal (immature) cells to the whole dysplastic cells gradually increased in each specimen. (2) Immature dysplastic cells showing increased nuclear membrane tension and irregular staining of the nuclear membrane gradually increased. (3) The number of immature dysplastic cells with finely or coarsely granular chromatin patterns gradually increased.抄録全体を表示PDF形式でダウンロード (344K) -
SHINJI NIIZUMA1979 年 129 巻 1 号 p. 83-90
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーA new improved technique for the visualization of intrahepatic bile ducts with oral contrast agent has been developed. The right lateral decubitus position was employed to avoid drainage of contrast medium from the common bile duct into the duodenum. 0.2-0.3μg/kg of Caerulein was injected intramuscularly (350 cases) or 0.02 ttg/kg of Kinevac was injected intravenously (15 cases) to induce rapid contraction of the gallbladder. The extruded contrast medium, which would normally flow into the duodenum, flowed backward into the intrahepatic bile ducts due to gravity. With this technique, improved visualization of intrahepatic bile ducts was achieved with use of oral contrast medium; it also obviated the problem of colonic gas over-lapping the gallbladder and gallstones in cholecystography.抄録全体を表示PDF形式でダウンロード (3409K) -
SHOW TORIKAI, MASASHI IMAI1979 年 129 巻 1 号 p. 91-99
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーA simple method to determine adenylate cyclase activity in isolated single nephron segments is described. Segments of the proximal convoluted tubule or the cortical collecting tubule were isolated from rabbit kidney slices pretreated with collagenase. After the tubule membranes were made permeable by adding hypotonic medium and freezing-thawing, each sample was incubated at 30°C for 30min in a medium containing ATP and theophylline. Generated cAMP was suecinylated and served for radioimmunoassay. Addition of the incubation medium did not interfere the radioimmunoassay. Recovery of added cAMP was 96%. In the proximal convoluted tubule, either 8mM NaF or 1U/ml parathyroid hormone (PTH) markedly stimulated adenylate cyclase activity, but 1mU/ml arginine vasopressin (AVP) did not. By contrast, in the cortical collecting tubule, either 8mM NaF or 1mU/ml AVP markedly stimulated adenylate cyclase activity, but 1U/ml PTH did not. These data imply that this method is sensitive enough to detect either specific or nonspecific response of adenylate cyclase activity in single nephron segments.抄録全体を表示PDF形式でダウンロード (1039K) -
YUKIO YAMADA, SEIKI ITO, RYO KAYAMORI, YOICHI IWASAKI, AKIRA SHIBATA, ...1979 年 129 巻 1 号 p. 101-102
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーRats with hypercalcemia induced by injection of vitamin D2 had a decreased thyroid somatostatin content, whereas the somatostatin content in their pancreas was almost within the normal range. This suggests that somatostatin in different organs acts specifically on each particular organ as a local hormone or hormone-like substance.抄録全体を表示PDF形式でダウンロード (97K) -
TAKUSEI UMENAI, YOSHIHIKO SAITOH, SHOICHI TAKANO, ETSUKO SHOJI, KYOKO ...1979 年 129 巻 1 号 p. 103-104
発行日: 1979年
公開日: 2008/11/28
ジャーナル フリーThe isolation of Erwiniae from the vagina became positive just before the occurrence of erwiniuria. It is proposed that the appearance of Erwiniae in the vagina is an important indicator in the prediction of urinary tract infection by Erwiniae.抄録全体を表示PDF形式でダウンロード (121K)
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