巻号一覧
114 巻 (1974)
- 4 号 p. 301-
- 3 号 p. 195-
- 2 号 p. 93-
- 1 号 p. 1-
114 巻, 2 号
選択された号の論文の11件中1～11を表示しています
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MAKOTO SEIJI, MASAAKI TAKAHASHI1974 年 114 巻 2 号 p. 93-107
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーFive cases of malignant melanoma with adjacent intraepidermal proliferation of melanocytes are reported. Two were on the plantar surface, two on mucous membrane, and one subungual. All of these cases may be classified histopatho-logically as lentigo maligna melanoma, but clinically differ from descriptions of lentigo maligna in being not on exposed surfaces and in their greater degree of malignancy and resultant prognosis. The intraepidermal proliferation of melanocyte (lentigo maligna type) took place after the onset of malignant melanoma in two cases. Although there may be differences in sites related to race, in ages of patients at onset and in biological behavior, malignant melanomas with adjacent intraepidermal proliferation of melanocytes on the sole of the foot and mucous membrane may be quite malignant with generalized metastases and death. It would be wise to consider these lesions on the sole of the foot or on the mucous membrane as full malignant melanoma.抄録全体を表示PDF形式でダウンロード (7709K) -
SETSUKO KAWAMURA, YUTAKA YOSHIDA1974 年 114 巻 2 号 p. 109-120
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーElucidation of the changes in the process of heme synthesis is considered to be most important for the understanding of the mechanism of anemia in various diseases. For this reason, the activiies of ALA synthetase and ALA dehydrase have been studied by many authors. In the present study, the activity of heme synthetase, an iron-protoporphyrin chelating enzyme which is another important enzyme in heme synthesis, in the bone marrow cells was investigated in various diseases. The paste of nuclei-mitochondria obtained from lysates of bone marrow cells was used as the enzyme source. A considerable increase in the enzyme activity was seen in iron deficiency anemia and in cancer without cachexia. No significant difference from the controls was seen in the hepatic and renal diseases. A decreased activity was seen in some of panmyelo-pathy, cancer with cachexia and hyperthyroidism. Based on these findings, the factors regulating the enzyme activity and their relationship to the development of anemia were discussed.抄録全体を表示PDF形式でダウンロード (677K) -
TAKESHI SEKINE, TSUNEO SHIRATORI1974 年 114 巻 2 号 p. 121-130
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーExperimental gastric ulcers were produced by ligating gastric vessels accompanied with or without histamine administration. A total of 62 adult mongrel dogs were divided into five groups, and intramuscular injection of histamine-beeswax mixture was given. In each group, macroscopic findings of the gastric mucosa, microscopic findings of ulcer, incidence of production of ulcers and acid secretory response to histamine were observed. Duration of observations ranged from 1 to 4 weeks. The results were as follows: (1) Gastric ulcers were closely similar to those seen in human except little regeneration of mucosa or proliferation of connective tissue at the base and margin of the ulcer. (2) The incidence of gastric ulcers was extremely high in groups underwent both histamine administration and gastric vessel ligation as compared with those where only histamine injection was given. Gastric acid secretion in response to histamine also showed a fall in free acidity and a marked decrease in volume. These results suggest that decrease in mucosal resistance induced by ligation of gastric vessels may play an important role as an etiologic factor rather than a factor of gastric acid secretion in the pathogenesis of gastric ulcers.抄録全体を表示PDF形式でダウンロード (1830K) -
MASAFUMI SHIRAI, SHOTARO MATSUDA, SHIRO MITSUKAWA1974 年 114 巻 2 号 p. 131-139
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーA 74-year-old man with chief complaints of underdeveloped external genitalia and dysuria was seen at our clinic. His penis was extremely undergrown, with true phimosis and preputial balanitis which were confirmed to be responsible for the difficulties in urination. His testes were both abnormally small. Hair had not grown at the axillary, pubic or upper lip areas, although he bore no feminized breast. His sex chromosome constitution showed a mosaic of XY (40%) and XXY (60%) on a leukocyte culture. Hormone assay showed low levels for LH as well as for plasma testosterone. LH-RH loading tests failed to result in increase in gonadotropin or testosterone. Histological examinations indicated that the testes were abnormally undergrown, that the diameters of the seminiferous tubules were very small, and that the basement membrane was extremely thin. The tubular epithelium consisted only of Sertoli cells with no sign of spermatocytes. The presence of intratubular bodies stained homogeneously with eosin was confirmed. The stroma was edematous and contained neither Leydig cells nor their clumps.抄録全体を表示PDF形式でダウンロード (3752K) -
YASUO TSUKAHARA, HAJIME HOSHI, KYOJI TASAKI1974 年 114 巻 2 号 p. 141-143
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーHistochemical study in the abalone retina revealed that AChE is localized in the plexiform layer which consists of axons of visual cells. It is postulated that the inhibitory interaction in the retina is mediated by the choliner-gic transmitter in the plexiform layer.抄録全体を表示PDF形式でダウンロード (916K) -
MASAFUMI SHIRAI, SHOTARO MATSUDA, SHIRO MITSUKAWA, MAMORU NAKAMURA, KE ...1974 年 114 巻 2 号 p. 145-158
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーPlasma levels of FSH, LH and testosterone were determined in 13 patients of ages from 44 to 85 who had been orchidectomized on account of prostatic cancer and most of whom were receiving additional treatments with anti-androgenic hormone. In 12 of them a LH-RH loading test was performed to examine its effects on the pituitary secretory function and on the adrenal cortical function of testosterone secretion. In 1 of the 12 cases a HCG loading test was also applied to study response of the adrenal gland to HCG. It was found that the combined therapy of orchidectomy with subsequent administration of anti-androgenic hormone caused a rapid fall of the plasma levels of FSH, LH and testosterone, whereas in the early stage the pituitary continued to respond to LH-RH loading. Clinically, pain in urination and that resulted from bone metastases thoroughly disappeared after this combined therapy, although no appreciable changes were seen in the prostatic tumor itself. After more than 6 months' application of anti-androgenic hormones, the plasma level of testosterone began to rise. However, there was no correlation between the increase in plasma testosterone and the aggravation of the tumor.抄録全体を表示PDF形式でダウンロード (782K) -
KOJI MINAI1974 年 114 巻 2 号 p. 159-170
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーCircadian variations of plasma renin activity (PRA) and plasma osmolality (Posm) were simultaneously measured in 5 normal subjects and 32 patients with various diseases. Under the conditions studied, PRA in normal subjects exhibited a significant circadian variation with the maximum in the morning and the minimum in the late afternoon (p<0.01), while Posm showed a significant but reversed variation to that of PRA (p<0.01). There was a reciprocal correlation between individual values of PRA and Posm throughout a day (r=-0.564, p<0.01). These consistent circadian variations of PRA and/or Posm tended to be abolished in essential hypertension (EH), renovas-cular hypertension (RVH), primary aldosteronism, Cushing's syndrome, hyperthyroidism and chronic glomerulonephritis. Any correlation between PRA and Posm was not found in these disorders. However, the patients with hyperthyroidism tended to restore normal circadian variations of PRA and Posm after treatment with propranolol. When PRA value at 8:00 a.m. was compared with its median level for a day, there was a considerable difference without any correlation between them in the cases of EH and RVH. These results may support the concept that renin-angiotensin (RA) system is closely related to the physiological control of the body fluid and electrolytes and finely modulated under its pathological states. Clinically, it appears that a single determination of PRA may not be enough to detect the basal activity of RA system in various diseases. It should be requisite to consider about the circadian variation when PRA and Posm are evaluated for clinical purposes.抄録全体を表示PDF形式でダウンロード (623K) -
AKIRA OHNEDA, MUNEHIKO SATO, SHOICHI YAMAGATA1974 年 114 巻 2 号 p. 171-182
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーInsulin response to the oral administration of 100 g glucose (glucose tolerance test, GTT) did not differ significantly in eight normal subjects from that to GTT with 50 g glucose. Repeated injection of tolbutamide revealed a small rise in plasma insulin in a group of five normal subjects. Insulin response to glucose was delayed and elevated in mild diabetics while that was minimum in moderate and severe diabetic patients. However, there was no significant difference between the insulin response to glucose in normal and diabetic subjects, because of a wide scattering. When 50 g glucose was ingested 60 min after the injection of 1 g tolbutamide (TGTT), insulin response in diabetics rather decreased. Insulin levels 30 min after oral glucose in TGTT was significantly lower in diabetics than in the normal subjects. It was suggested from the present experiment that TGTT provides a discrimination of insulin response in diabetics from that in normal subjects.抄録全体を表示PDF形式でダウンロード (717K) -
KAZUO WAKUI, TATSUO UENO, HIROYOSHI KUMATA, HIROSHI SUZUKI, YASUYUKI T ...1974 年 114 巻 2 号 p. 183-188
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーHepatitis associated antigen (HB Ag) was measured using a single radial immunodiffusion (SRID) method or an immunoadherent hemag-glutination (IAHA) method in patients under various clinical conditions including acute hepatitis, chronic hepatitis, liver cirrhosis, hepatoma, various malignant tumors and other diseases as well as in normal subjects. HB Ag was found to be frequently positive in patients with hepatoma and with malignant tumor with liver metastasis by the immunoadherent hemagglutination method. The significance of this finding is discussed.抄録全体を表示PDF形式でダウンロード (317K) -
SEIGI TSUCHIDA, IKUTARO KUMAGAI, KUNIO MIURA, SHIGERU MORI1974 年 114 巻 2 号 p. 189-191
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーThe single needle dialysis system developed by Kopp et al. has some disadvantage of using costly solenoid clamp, necessary for the shift of blood flow in the dialyzer circuit. The present authors have devised a single two-lumen cannula system to overcome this disadvantage. It is possible to operate this system without the solenoid clamp and also to enhance the dialytic effect. In the single two-lumen cannula, two needles, semicircular in cross section, are arranged contiguous to each other so as to form a single cannula, circular in cross section. The tip orifices of the two needles are 1.7 cm apart in order to prevent the mixture of inflowing and outflowing blood. At their bases the needles are connected, one to the inflow and the other to the outflow line. Clinical trials of the new dialysis system have given positive results. The system has been found to be simple in operation, safe and effective. Its use is recommended for routine chronic hemodialysis.抄録全体を表示PDF形式でダウンロード (161K) -
SHIGETOSHI CHIBA1974 年 114 巻 2 号 p. 193-194
発行日: 1974年
公開日: 2008/11/28
ジャーナル フリーConstant pressure perfusion of the canine sinus node artery was performed in 9 isolated atrium preparations and in 4 in situ preparations anesthetized with i. v. sodium pentobarbital, 30 mg/kg. Insulin, 1, 3, 10 or 20 units, was injected into the sinus node artery. Doses of more than 10 units of insulin induced a positive chronotropic response in the isolated preparations and in 2 out of 4 in situ preparations. The positive chronotropic effect became less prominent by repeated injections of insulin but never disappeared completely. This insulin-induced sinus acceleration was not completely blocked by propranolol which blocked norepinephrine action. It is concluded that insulin at large dose level induces a positive chronotropic response which is not due to cardiac β-adrenergic stimulation.抄録全体を表示PDF形式でダウンロード (122K)
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