The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
123 巻, 1 号
選択された号の論文の10件中1~10を表示しています
  • KUNIAKI NARISAWA, TAKASHI SAITO, SHIGEO HISA, HIROSHI SUZUKI, KIYOSHI ...
    1977 年 123 巻 1 号 p. 1-8
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    An assay method for the methyl-malonyl-CoA mutase of leukocytes obtained from 3 ml of blood was established. The enzyme activity which was measured with or without the in vitro addition of 5'-deoxyadenosylcobalamin was found to be of value for the diagnosis of two variants of methylmalonic acidemia (vitamin B12 responsive and unresponsive), and also for the detection of heterozygotes with the vitamin B12 unresponsive type.
  • TAKASHI KUBO, SHUHEI SASAKI, SUSUMU NUMASATO, SAKIZO TAKAHASHI, TOSHIY ...
    1977 年 123 巻 1 号 p. 9-22
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    An extraluminal ureteral bipolar needle “indwelling” electrode with recording wire was devised to study the ureteral function, and daily recording of the ureteral myogram in human and experimental animal has been successfully carried out. Using this new electrode, ureteral myogram and intraureteral pressure were simultaneously recorded in humans and dogs under various experimental conditions, and the following results were obtained: (1) The average ratio of peristaltic frequency of the renal pelvis to that of the ureter was 3:1 under ordinary diuretic condition. Following Furosemide administration, the peristaltic frequency of the renal pelvis remained unchanged while both the intrapelvic pressure and the peristaltic frequency of the ureter increased, with an average ratio of 1:1. (2) When the middle portion of the ureter was transected and anastomosed with a vinyl ureteral catheter to block the myogenic conduction, an excitation was evoked at the stump of the lower ureter by the stimulation of urinary flow and almost normal peristalsis was observed. There was no relationship in the direction of peristalsis between the lower ureter and the rest of the ureter. (3) Following operation of the ureters in dogs, ureteral myograms were recorded daily. Abnormal discharges were evoked immediately after surgery in the lower part of the ureter below the surgical site. After urinary fistula formation in humans, abnormal discharges were more frequently observed, and at the same time the ureteral peristalsis across the surgical site was decreased. These abnormal discharges disappeared by 7 days after surgery in the group without postoperative fistula formation, but in the humans with urinary fistulation they disappeared only after the fistula was healed. (4) The rate of peristalsis through the surgical site of the canine ureter was greater than 50% in the group without hydronephrosis, but less than 50% in the group with postoperative hydronephrosis. Therefore, it was assumed that postoperative hydronephrosis due to ureteral obstruction would not occur, if the peristaltic rate is maintained greater than 50%.
  • TOYOKICHI MAETA, YOSHIYUKI FUJIWARA, TETSUNOSUKE OHIZUMI, EIICHI KATO, ...
    1977 年 123 巻 1 号 p. 23-32
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    One of the major causes of death in infants with congential esophageal atresia is the lung complication. Analysis of the Annual of Pathological Autopsy Cases in Japan from 1966 to 1969 revealed that the lung complications were seen in 81 percent of total cases. We have carried out a detailed histological study of the trachea and lung in 4 infants who died of congenital esophageal atresia. In three of them, ciliated epithelium of the trachea was replaced by stratified squamous epithelium and the alveoli were filled with numerous foamy cells. There were only a little inflammatory change in sections studied. The constant association of these two lesions suggests cause-and-effect relationship, and we are inclined to think that retention of foamy cells in the alveoli is due to the impaired mucociliary transport mechanism in the respiratory tract.
  • HIDEYA OKUYAMA, MINORU ENDO, YOSHIRO OHARA, SADAO TAKASE, KATSUYA ITAH ...
    1977 年 123 巻 1 号 p. 33-47
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Circadian variations of plasma cortisol were studied in four different groups of subjects; 17 patients with prolonged coma, 3 patient with tetraplegia with alert consciousness and without body movement, 4 patients with stabilized chronic infection with alert consciousness and with normal body movement, and control subjects consisting of 7 healthy volunteers and 5 patients with various neuromuscular disease without disturbance of con-sciousness, motor dysfunction or infection. The maximum level of plasma cortisol attained during the circadian variations was low in prolonged coma, whereas the minimum level was high in prolonged coma, as compared to other three groups. The amplitudes between the maximum and the minimum level were significantly smaller in prolonged coma than in control (p<0.005). The tendency that the maximum level appeared at early morning and the minimum at late evening was similarly observed in both prolonged coma and control groups suggesting that there is no phase shift of the circadian rhythm of cortisol in prolonged coma. The responses of plasma TSH to synthetic TSH-releasing hormone or those of plasma cortisol to ACTH were not different between prolonged coma and control, suggesting that the reduced amplitude in prolonged coma is not attributed to the function of the patients' pituitary and/or adrenal cortex. Also, there were no differences in diurnal variations in plasma glucose or non-esterified fatty acid between the prolonged coma and control, nevertheless the former was fed with liquid food via a _??_ asal tube. Therefore, highly significant reduction of the amplitude of circadian variation of cortisol in prolonged coma may not be due to exogenous factors, such as a poverty of body movement, complications due to chronic infection, or tube feeding. The results seem to suggest that the reduced amplitude of the circadian variations in plasma cortisol may have relation to the unconsciousness of prolonged coma due to severe damage to the central nervous system.
  • YASUO SHIRAIWA, TSUNEO HIRAI, TOMONORI DATE, SADATOSHI ICHIJO
    1977 年 123 巻 1 号 p. 49-56
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Cryosurgery has been performed on 18 patients with prostatic hypertrophy, and the following conclusions are reached: The quotient obtained by dividing the estimated weight of the prostate gland by the frozen weight obtained by an equation is called the freezing index, and this index can be introduced into the evaluation of the results of cryosurgery on the prostate gland. Cryosurgery was not markedly effective in cases of freezing indices over 0.76, and the incidence of complications was high in cases of freezing indices not more than 0.5. The ideal freezing index obtained empirically was 0.6. No dysuria has recurred during past three years in the cases where cryosurgery was assessed satisfactory in effect within two to three months.
  • TSUNETAKA MATOBA, HISAO KUSUMOTO, YASUSHI MIZUKI, HIROSHI KUWAHARA, KA ...
    1977 年 123 巻 1 号 p. 57-65
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Clinical features and laboratory findings of 300 inpatients with vibration disease before and after treatments were reviewed. Having been using chain saws or pneumatic hammers for a long period, the patients were afflicted with Raynaud's phenomenon, numbness, pain or stiffness of fingers, pain of elbows and neck, stiffness of shoulders and lumbago. They had high incidences of complaints due to the disorder of the central nervous system, especially of the higher center of the autonomic nervous system; i. e. headache (52.0%), palmar hyperhidrosis (70.0%), forgetfulness (78.2%), fatiguability (61.3%), tinnitus (41.8%), impotence (55.1%), etc. Laboratory findings of the autonomic nerve activity tests, electroencephalograms and audiograms also suggested the disorder of the central nervous system. Treatments during three months had improved significantly the subjective symptoms and the objective findings (p<0.05 to 0.001). Thus, vibration disease should be considered as a systemic disease, including disorders of the central nervous system, especially of the higher center of the autonomic nervous system, and disturbances of the peripheral functions.
  • TSUNETAKA MATOBA, HISAO KUSUMOTO, YASUSHI MIZUKI, KOJI YAMADA
    1977 年 123 巻 1 号 p. 67-75
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Sixty inpatients with vibration disease were examined on the effect of dl-α-tocopheryl nicotinate by comparative double-blind study. The observed period was 6 weeks and the dose was 6 capsules a day (600 mg as dl-α-tocopheryl nicotinate, Juvela Nicotinate®, referred to as EN). The physical exercise therapy was applied to all patients throughout the test period. EN group became better with a significant difference from P (placebo) group in the subjective symptoms, the clinical examinations and the collective improving rate (p<0.01, 0.05, 0.01), respectively. The improvement of the subjective symptoms of both groups was higher 6 weeks than 3 weeks after administration. Most items in EN group became better significantly (p<0.05) as compared with those in P group. The examinations of the peripheral functions in EN group showed a significant improvement 6 weeks after administration in comparison with those in P group. Blood chemistry, blood cell counts and serum electrolytes changed within normal range. Thus, this preparation would be a curative agent for patients with vibration disease.
  • YUZURU KAGAWA, SHINICHI NITTA, NAOSHI SATOH, KOMEI SAJI, YUTAKA SHIBOT ...
    1977 年 123 巻 1 号 p. 77-89
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    Sound spectroanalysis was carried out for diagnosis of malfunctioning prosthetic heart valves in 50 cases, which consisted of 31 mitral, 14 aortic, 4 mitral+aortic and 1 tricuspid valve replacements with the age ranging from 17 to 57 years. Types of prosthetic valves used in this series were Starr-Edwards silicon ball valves, metal ball valves, disc valves, Kay-Shiley valves, Smeloff-Cutter valves and a Björk-Shiley valve. The system used in this study consisted of a moving coil microphone, a preamplifier, a filter (160/24 db octave) and a sound spectrograph (Rion Co. S. G. (7). Contour sound spectrograms (SSG) were drawn and peak frequency, wave pattern and frequency-intensity curves were investigated as characteristics of implanted valvular function. Peak frequencies of valvular opening and closing sounds were recorded between 1800 to 5000 Hz and differed according to the types of prosthesis. In mitral + aortic valve replacements, valvular sounds of two prostheses were clearly separated and this finding was very useful for determining the prosthesis which fell into malfunction. Decrease in peak frequency of valvular sounds or abnormal wave patterns in contour SSG were observed in 9 cases (18%). Of 9 cases, 4 cases underwent re-replacement and 2 cases died of congestive heart failure. Operative or autopsy findings gave proof to the findings in sound spectroanalysis.
  • SHIGEAKI OHNO, G. RICHARD O'CONNOR, SAMUEL J. KIMURA
    1977 年 123 巻 1 号 p. 91-94
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    HLA (Human Leukocyte-A) antigens of 20 patients with toxoplasmic retinochoroiditis were determined by the standard microlymphocyte cytotoxicity test to see if these patients have different immunogenetic backgrounds from the normal controls. The results showed that there were no significant differences between the patients and the normal controls.
  • MASANA OGATA, JUNKO MIZUGAKI, KAZUKO UEDA, MIKIKO IKEDA
    1977 年 123 巻 1 号 p. 95-98
    発行日: 1977年
    公開日: 2008/11/28
    ジャーナル フリー
    The activities of superoxide dismutase and glutathione peroxidase in the red cells of normal and acatalasemia bloods were compared. Superoxide dismutase activity in the red cells of Japanese acatalasemia blood was higher than in normal control, while glutathione peroxidase activity remained within normal limits. Cyanide sensitivity of superoxide dismuta se in the red cells of acatalasemia blood was similer to that in normal control.
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