巻号一覧
110 巻 (1973)
- 4 号 p. 311-
- 3 号 p. 209-
- 2 号 p. 105-
- 1 号 p. 1-
110 巻, 4 号
選択された号の論文の11件中1～11を表示しています
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KEISHIRO KARITA, KYOJI TASAKI1973 年 110 巻 4 号 p. 311-318
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーThe optic nerve response of the octopus (Octopus vulgaris) was recorded from the isolated preparation of the eye and the attached optic nerve. Photically initiated response was found to be most difficult to record and only in a few preparations was it possible to succeed in recording the optic nerve discharge. Even in such favorable cases light elicited nerve response diminished shortly after the preparation was isolated. On the contrary, the compound action potential of the optic nerve elicited by electric stimulation of the nerve could be recorded sufficiently long to be studied. Since the isolated retina was known to survive for several days responding with normal ERG, it was concluded from the present results that between the visual cells and their axons there is some region which is highly susceptible to oxygen deficiency, such locus being suggested to be the trigger zone.抄録全体を表示PDF形式でダウンロード (2163K) -
TOSHIRO SAKURADA, REIKO DEMURA, SEIJU ONODERA, SHINTARO SAITO, NAOYA M ...1973 年 110 巻 4 号 p. 319-327
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーA 35-year-old man had vague complaints as headache, vertigo, nausea and fatigability. His face was slightly edematous but ocular symptoms or goiter were not observed. BMR and serum BEI were low; thyroidal 24-hours 131I-uptake was low in the normal range and 131I-T3 resin sponge uptake was normal. Plasma TSH was not detectable. Thin-layer chromatographic analysis of iodinated compounds extracted from both serum and thyroid gland revealed the existence of triiodothyronine but no thyroxine. This patient was diagnosed as T3-secretor with hypometabolism and was treated with ι-T4, which resulted in amelioration of his complaints.抄録全体を表示PDF形式でダウンロード (2340K) -
TOSHIRO SAKURADA, SHINTARO SAITO, TORU YAMAGUCHI, MAKIKO YAMAMOTO, REI ...1973 年 110 巻 4 号 p. 329-340
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーImmunization of rabbits with triiodothyronine-methyl ester hydrochloride conjugated to bovine serum albumin resulted in the production of antibody against triiodothyronine. Using dextran-coated charcoal technique, a practically useful and specific radioimmimoassay method for triiodothyronine was developed.抄録全体を表示PDF形式でダウンロード (543K) -
TATSUO SAITOH, NAOSHI NAKAMURA, WATARU TAKAHASHI, NOBUYUKI KOBAYASHI1973 年 110 巻 4 号 p. 341-345
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーChanges in lipid concentration in serum and hepatic bile in patients with gallstones were investigated before and after treatment with chlorophenoxyisobutyrate (CPIB). After 14 days of CPIB treatment, there was no remarkable change in the cholesterol and phospholipid concentration in serum, while the level of serum triglycerides was much reduced. Significant increase of cholesterol concentration in hepatic bile was observed after 14 days of CPIB treatment. These results seem to indicate that CPIB has an effect to increase the cholesterol and phospholipid levels in bile. It is suggested that CPIB, an inhibitor of cholesterol synthesis in the liver, may promote excretion of cholesterol into bile from hepatic cells.抄録全体を表示PDF形式でダウンロード (274K) -
MASAFUMI SHIRAI, SHOTARO MATSUDA1973 年 110 巻 4 号 p. 347-357
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーThe authors have experienced 22 cases of Klinefelter's syndrome. In all of these 22 cases, the sex chromatin was positive, and the sex chromosome complement was XXY. Gynecomastia was seen only in 4 cases. The testes in all these eases were quite small. The histological findings showed no spermatogenesis, with marked hyalinization of the seminiferous tubules. However, interstitial cells were relatively well preserved. With respect to the values of the hormone determinations, plasma testosterone was markedly decreased in all cases, compared with the levels in normal males. HOG loading or insulin loading tests resulted in scarcely any increase of plasma testosterone. Urinary or plasma gonadotropin gave considerable variation and high values were not always obtained. However, the pituitary reacted to insulin hypoglycemia or LH-releasing hormone. These facts would indicate that the sensitivity of the interstitial cells to gonadotropin and the sensitivity of the seminiferous tubules to androgen in patients with positive chromatin and XXY chromosome complement are essentially different from that of normal males.抄録全体を表示PDF形式でダウンロード (557K) -
KUNIAKI NARISAWA, YOSHIYUKI HONDA, TSUNEO ARAKAWA1973 年 110 巻 4 号 p. 359-365
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーWhen rats were made folate deficient and given diphenylhydantoin (DPH), it was found that there were an increase in formation of 14CO2 from urocanate-2-14C and histidine-2-14C by liver slices, a decrease in urinary formiminoglutamic acid (FIGLU) after urocanate load, and an increase in the incorporation of formate-14C into serine by liver slices. These results suggested that utilization of single carbon from FIGLU and formate via folate pathway proceeded more effectively in folate deficient rats when DPH had been administered.抄録全体を表示PDF形式でダウンロード (431K) -
SUSUMU SATOH, KOROKU HASHIMOTO1973 年 110 巻 4 号 p. 367-375
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーResponses of dog splenic vascular bed to various compounds administered into the splenic artery were investigated under a constant perfusion pressure. Adrenergic drugs; epinephrine, norepinephrine and dopamine produced a marked vasoconstriction which was followed by a vasodilation. Phenylephrine, tyramine, methoxamine and ephedrine produced only vasoconstriction. Isoproterenol dilated the splenic vascular bed. Cholinergic drugs; cholinesters and pilocarpme caused a vasodilation, while physostigmine produced a vasoconstriction. Ganglion stimulants; McN-A-343, TMA and lobeline produced a vasodilation, while DMPP and nicotine caused a vasoconstriction. TEA, one of ganglion blockers, caused a vasoconstriction. Angiotensin II, lys-vasopressin, oxytocin and 5-hydroxytryptamine produced a vasoconstriction. Bradykinin, kallikrein and histamine caused a vasodilation. Various nucleosides and nucleotides, i.e., adenosine, AMP, ADP, ATP, uridine, UMP, UDP, UTP, DPN and TPN induced peculiar oscillatory vascular responses. Vasodilators including nitroglycerin, papaverine, verapamil, dipyridamole, hydralazine and caffeine dilated the splenic vascular bed, while cocaine, guanethidine and ergotamine constricted it. Procaine, morphine, bretylium, tolazoline showed a vasodilation. These results indicated that the splenic vascular bed has a very characteristic behavior.抄録全体を表示PDF形式でダウンロード (491K) -
Multicenter Clinical StudySHOICHI YAMAGATA, AKIRA ISHIMORI, HACHIRO SATO, HARUYA OKABE, KUNI ISH ...1973 年 110 巻 4 号 p. 377-404
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーIn an attempt to examine the clinical effectiveness of pharmacotherapy for peptic ulcer through the standardized formula, clinical investigations were performed in a total of 255 cases of peptic ulcer at 13 medical institutes with the double blind technique. The antipepsin agents, namely degraded carrageenin was used as an active drug and aluminum sucrose sulfate as an active placebo, and lactose as an inactive placebo. The results indicated that both antipepsin agents are effective for the treatment of peptic ulcer without noticeable side effects. The therapeutic effect was more clearly shown on the following findings or symptoms, viz., x-ray and endoscopic findings, hypochodralgia, vomiting, epigastralgia, belching, meteorism, sense of distention, anorexia, retching, sense of gastric discomfort, abnormal fermentation, fecal occult blood reaction, tenderness, heartburn, constipation, and nausea. It was also disclosed that the global judgement of effectiveness had beenn made based chiefly on the x-ray and gastroscopic findings, and then on the outcome of such subjective symptoms as retching, vomiting, nausea, and anorexia. Problems involved in the clinical evaluation of pharmacotherapy for peptic ulcer by the double blind technique were also discussed.抄録全体を表示PDF形式でダウンロード (1389K) -
TOSHIO SUGANUMA, NAKAO ISHIDA1973 年 110 巻 4 号 p. 405-406
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーA new antiviral agent Virazole (1-B-D-Ribofuranosyl-1, 2, 4-triazole-3-carboxamide) was tested for its antiviral effect against influenza A virus infections both in vitro and in vivo. Withoutt any virocidal effect, virostatic effect against PR 8 strain was evident in HeLa S3 cells at 25 meg/ml, the concentration which shows a definite but reversible inhibitory effect on the multiplication of host HeLa cells. In vivo effect against the same influenza A infections in mice was evident at the dose of 25mg/kg when given intraperitoneally 3 times before infection, 4 times on the day of infection and twice daily for consecutive 4 days after infection. A total of 50mg/kg dose under the same schedule revealed toxic signs to mice.抄録全体を表示PDF形式でダウンロード (132K) -
TSUNEHIKO S. SUZUKI, YASUE FUKUSHI, TAIZO SUZUKI1973 年 110 巻 4 号 p. 407-408
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーSubstance R is a new biologically active substance extracted from bovine brain. This substance caused the hyperpolarization of membrane potential of the smooth muscle of guinea-pig taenia coli. The time course of this hyperpolarization was considerably longer than that of noradrenaline or isoproterenol. This may suggest that the mechanism of hyperpolarizing effect of Substance R is different from that of catecholamines.抄録全体を表示PDF形式でダウンロード (88K) -
NAOFUMI IWATSUKI, KENICHI IWATSUKI1973 年 110 巻 4 号 p. 409-410
発行日: 1973年
公開日: 2008/11/28
ジャーナル フリーDirect effect of cyclic AMP (c-AMP) on myocardial contractility was investigated in the isolated canine heart muscle. c-AMP at a concentration of 3.3×10-4M produced a decrease in isometric peak force to 75.8% of the control on the average. The result suggests a difference on the effect of exogenous c-AIVLP from that of endogenous one on the contractile behavior of the heart muscle.抄録全体を表示PDF形式でダウンロード (669K)
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