The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Volume 24 , Issue 1
Showing 1-11 articles out of 11 articles from the selected issue
  • TAXONOMY OF STREPTOMYCES ROCHET VAR. VOLUBILIS VAR. NOV. AND PRODUCTION OF THE ANTIBIOTICS AND AN ESTERASE
    EIJI HIGASHIDE, TAKAESHI FUGONO, KAZUNORI HATABNO, MOTOO SHIBATA
    1971 Volume 24 Issue 1 Pages 1-12
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    The characteristics of streptomycete strain No. T-2636 producing antibiotics T-2636A, B, C, D, E, F and Mare given and Streptomyces rochei var. volubilis is proposed as the name for this new taxon. The antibiotics T-2636 A, B, C and D show antibacterial activity against Gram-positive bacteria and antibiotic T-2636 M shows antifungal activity. The production ratio of components A, B, C and D depends on cultural conditions. An esterase produced by the organism hydrolyzes the acetyl group of antibiotic T-2636 A converting it into antibiotic T-2636 C.
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  • ISOLATION AND CHEMICAL PROPERTIES OF T-2636 ANTIBIOTICS
    SETSUO HARADA, Toyokazu KISHI, KOMEI MIZUNO
    1971 Volume 24 Issue 1 Pages 13-22
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    Five anti-Gram-positive bacterial components were isolated from the fermented broth of Streptomyces rochet var. volubilis and named as T-2636 A, B, C, D and E. T-2636 A, C, D and E are N-containing neutral lipophilic antibiotics and have the molecular formulae of C27H35NO8, C25H33NO7, C27H37NO8 and C26H37NO6, respectively. T-2636 B, C43H72O17, is a neutral macrolide. T-2636 Mobtained from the mycelium was assumed to be a polyene macrolide. The physico-chemical characterization of these components reveals that T-2636 B, D and E are new antibiotics and that T-2636 A, C, D and E belong to the lankacidin group. T-2636 A and C are identical with bundlin B and lankacidin, respectively.
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  • A NEW COMPONENT, T-2636 F
    TAKESHI FUGONO, SETSUO HARADA, EIJI HIGASHIDE, TOYOKAZU KISHI
    1971 Volume 24 Issue 1 Pages 23-28
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    A new antibiotic T-2636 F was isolated from three different sources, 1) the reaction mixture of T-2636 D with the esterase of Streptomyces rochei var. volubilis (No. T-2636), 2) the filtered broth of the Streptomyces strain, and 3) the bile and urine samples of rabbits, which was pre-administered T-2636 C parenterally. T-2636 F has the following chemical properties : colorless needles, m.p. 178-179°C(decomp.), imax 228 mju (EtOH), [α]24D -210° (c 1.0, DMF), molecular formula C25H35NO7-CH3OH. T-2636 F shows moderate activities against Gram-positive bacteria. The preparation of the enzyme of Streptomyces and application of the enzyme for bioassay of T-2636 antibiotics are described.
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  • IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY OF T-2636 ANTIBIOTICS
    KANJI TSUCHIYA, TOSHIYUKI YAMAZAKI, YOKO TAKEUCHI, TOKIKO OISHI
    1971 Volume 24 Issue 1 Pages 29-41
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    T-2636 C shows a strong in vitro antimicrobial activity against a variety of Gram-positive bacteria, Neisseria gonorrhoeae and Vibrio cholerae, while T-2636 A, D and F are relatively weak in this respect. T-2636 A and C are more active in vitro at pH 6.0 than at pH 9.0. The antibacterial in vitro activity is enhanced by decrease in bacterial inoculum size. Presence of horse serum in the mediumresults in the decreased activity. The development of resistance of the sensitive bacteria to T-2636 C is demonstrated by exposure according to the serial transfer method. In the cross resistance test using Staphylococcus aureus which had been maderesistant to T-2636 C or macrolide antibiotics in vitro, T-2636 C show a weak activity against microorganisms resistant to spiramycin and triacetyl-oleandomycin, but T-2636 C resistant S. aureus was sensitive to macrolide antibiotics. T-2636Cis effective against staphylococci, isolated from patients, at the similar concentration against the standard laboratory staphylococci. T-2636 demonstrated also bacteriostatic activity. The primary active site of T-2636 C on S. aureus is inhibition of the protein synthesis. T-2636 A and C are effective against experimental infections in mice by S. aureus and Streptococcus pyogenes, when administered intraperitoneally or orally. But T-2636 A was less effective by subcutaneous route.
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  • MICROBIAL PRODUCTION AND BIOLOGICAL CHARACTERISTICS
    EDWARD O. STAPLEY, DAVID HENDLIN, MARION JACKSON, A. KATHRINE MILLER, ...
    1971 Volume 24 Issue 1 Pages 42-47
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    A new antibiotic, azirinomycin, has been discovered in the culturejbroth of newly isolated strains of actinomycetes. It was produced by submerged culture in shaken Erlenmeyer flasks in complex organic media. Azirinomycin and its methyl ester were found to exhibit broad spectrum antibiotic activity, in vitro, against both Gram-positive and Gram-negative bacteria. Both azirinomycin and its methyl ester were toxic to mice, and failed to protect them against lethal bacterial infections.
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  • ISOLATION AND CHEMICAL CHARACTERIZATION AS 3-METHYL-2(2H) AZIRINECARBOXYLIC ACID
    THOMAS W. MILLER, EDWARD W. TRISTRAM, FRANK J. WOLF
    1971 Volume 24 Issue 1 Pages 48-50
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    Azirinomycin is a new antibiotic and is the first example of a natural product containing an azirine ring. It was isolated by ion-exchange and solvent extraction and is unstable, especially in concentrated form. It was identified as 3-methyl-2(2H) azirinecarboxylic acid by spectral measurements of its methyl ester and by identification of L-a-aminobutyric acid as a hydrogenation product.
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  • IDENTIFICATION OF THE SUGAR MOIETY OF SCOPAMYCIN A AS 2-O-METHYL-L-RHAMNOSE
    J. B. MCALPINE, J. W. CORCORAN, R.S. EGAN
    1971 Volume 24 Issue 1 Pages 51-56
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    The antifungal agent scopamycin A has been the subject of further chemical study. On treatment with acid it yields a 6-deoxy sugar which has been determined by nmr spectroscopy and chemical synthesis to be 2-O-methyl-L-rhamnose (6-deoxy-2-O-methyl-L-mannose).
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  • DEGRADATION STUDIES
    SATOSHI HORII, TAKASHI IWASA, YUKIHIKO KAMEDA
    1971 Volume 24 Issue 1 Pages 57-58
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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  • VALIDAMINE, HYDROXYVALIDAMINE AND VALIDATOL, NEW CYCLITOLS
    SATOSHI HORII, TAKASHI IWASA, EIZI MIZUTA, YUKIHIKO KAMEDA
    1971 Volume 24 Issue 1 Pages 59-63
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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  • GIANCARLO LANCINI, RENATO CRICCHIO, LISE THIRY
    1971 Volume 24 Issue 1 Pages 64-66
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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  • KATSUO SASAKI, HITOSHI MINATO, KEN KATAGIRI, SHOHEI HAYAKAWA, Takashi ...
    1971 Volume 24 Issue 1 Pages 67-68
    Published: January 25, 1971
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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