巻号一覧
90 巻, 2 号
選択された号の論文の10件中1～10を表示しています
- |<
- <
- 1
- >
- >|
-
榎原 周平原稿種別: 本文
2016 年 90 巻 2 号 p. 61-67
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーVitamin B_<12> (B_<12>) is an essential nutrient and functions as the coenzyme for methylmalonyl-CoA mutase and methionine synthase in mammals. B_<12> deficiency has been reported to cause growth retardation and severe hematological and neurological abnormalities. However, the biochemical mechanisms for these abnormalities caused by B_<12> deficiency are poorly understood. In the present study, therefore, metabolic abnormalities caused by B_<12> deficiency were examined using B_<12>-deficient rats as an experimental B_<12>-deficient model. The following findings were indicated in this study; (1) amino acid metabolism in rats was disordered by B_<12> deficiency and, in particular, serine and threonine in the plasma and urine were abnormally increased by the deficiency, (2) the expression of serine dehydratase participating in the metabolism of serine and threonine in liver was significantly lowered by B_<12> deficiency without no direct involvement of B_<12> in the enzyme reaction, (3) these abnormalities were consequently induced by impairment of glucagon signal transduction activating adenylyl cyclase system. In addition, it was found that a megaloblastic anaemia-like symptom was induced when the B_<12> deficient rats were exposed to hypoxia.抄録全体を表示PDF形式でダウンロード (800K) -
宮澤 陽夫原稿種別: 本文
2016 年 90 巻 2 号 p. 68-76
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーThe antiangiogenic and anticancer functions of tocotrienol (an unsaturated vitamin E) were discovered, and their molecular mechanisms were clarified in studies using cell cultures and experimental animals. Tocotrienol inhibits hypoxia-induced vascular endothelial growth factor secretion, and suppresses vascular endothelial growth factor and interlukin-8 expression at both mRNA and protein levels in tumor cells. The physiological functions of tocotrienol based on its intestinal absorption, its tissue organ distribution, its skin anti-inflammation and its improved lipid metabolism were also explained. The tocotrienol-rich rice plant strain was established, and the daily intake of tocotrienol in Japanese population and the safety of dietary intake of tocotrienol were confirmed. These investigations indicate the physiological significance of tocotrienol ingestion as a fat-soluble vitamin and a functional component in food products.抄録全体を表示PDF形式でダウンロード (4600K) -
青山 結貴, 澤村 弘美, 湯浅 正洋, 榎原 周平, 渡邊 敏明, 吉村 美紀原稿種別: 本文
2016 年 90 巻 2 号 p. 77-82
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーWe investigated the effects of biotin deficiency on the sense of taste in rats. Male wistar rats aged 3 weeks, were divided into three groups: Control group (C), pair-fed group (PF) and biotin-deficient (BD) group. All rats in the three groups were fed for Sweeks. 48-h two-bottle preference test was conducted on the 3-4th and 7-8th week of each feeding. Food intake and body weight were decreased from the 3rd week in the BD group. Plasma and liver biotin levels were significantly decreased in the BD group. The 48-h preference test showed that the preference ratios for salty taste at 300 and 500 mM NaCl on the 3rd week were relatively higher in the BD group than in the C and PF groups. However, there were no significant differences in the preference ratios for salty taste on the 7th week among the three groups. For the bitter taste test on the 4th week, the preference ratios at all concentrations of caffeine used were relatively higher in the BD group than in the C and PF groups. On the 8th week, the preference ratio for bitter taste at 3 mM caffeine was higher in the BD group than in the PF group. These results indicate that biotin deficiency has an effect on the sense of taste in rats. The results also suggest the possibility that the recognition threshold value for taste is increased in BD rats.抄録全体を表示PDF形式でダウンロード (2693K) -
石澤 通康, 水島 優介, 風間 智彦, 松本 太郎, 池田 和正, 槇島 誠原稿種別: 本文
2016 年 90 巻 2 号 p. 83-84
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (304K) -
2. 7,8-cis-19-Norvitamin D_3の合成とVDR結合および7,8-cis-vitamin D_3の化学的性質(研究発表,第348回会議研究発表要旨,脂溶性ビタミン総合研究委員会)澤田 大介, 松本 洋太郎, 川越 文裕, 竹内 明子, 角田 真二, 上村 みどり, 橘高 敦史原稿種別: 本文
2016 年 90 巻 2 号 p. 84-85
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (314K) -
藤原 葉子, 池上 寛子, 石川 朋子, 川和 理恵, 市 育代原稿種別: 本文
2016 年 90 巻 2 号 p. 85-
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (201K) -
野口 範子, 新井 洋由原稿種別: 本文
2016 年 90 巻 2 号 p. 85-86
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (346K) -
嶋中 雄太, 河野 望, 武富 芳隆, 村上 誠, 新井 洋由原稿種別: 本文
2016 年 90 巻 2 号 p. 86-87
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (349K) -
宮澤 陽夫, 伊藤 隼哉, 仲川 清隆, 加藤 俊治, 永井 利治原稿種別: 本文
2016 年 90 巻 2 号 p. 87-89
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (397K) -
原稿種別: 文献目録等
2016 年 90 巻 2 号 p. 90-95
発行日: 2016/02/25
公開日: 2017/12/26
ジャーナル フリーPDF形式でダウンロード (522K)
- |<
- <
- 1
- >
- >|