巻号一覧
61 巻, 12 号
選択された号の論文の16件中1～16を表示しています
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梅澤 智佐江原稿種別: 本文
1987 年 61 巻 12 号 p. 585-597
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーThe hepatic NAD decreased significantly in the rats fed a 10% or 20% casein diet supplemented with 5% leucine for 2 weeks. The effects of leucine and its related compounds on NAD biosynthesis from tryptophan or nicotinic acid were investigated in isolated rat hepatocytes. Leucine was ineffective, while α-ketoisocaproic acid, α-keto acid of leucine, and ketone bodies were inhibitory. α-Ketoisocaproic acid was quickly metabolized to ketone bodies by hepatocytes. Palmitic acid, which was not structurally related to leucine but quickly metabolized to ketone bodies, was also inhibitory. The hepatic ketone bodies of the rats fed a leucine-supplemented diet were raised to the level where inhibition of NAD biosynthesis could occur. Intestinal absorption and incorporation of tryptophan into liver and the biosynthesis of hepatic protein were not inhibited by excessive leucine when orally administered with an amino acid mixture. From the results, it was concluded that excessive ketone bodies derived from dietary supplemented leucine acted inhibitory on NAD biosynthesis.抄録全体を表示PDF形式でダウンロード (1128K) -
柴田 克已原稿種別: 本文
1987 年 61 巻 12 号 p. 599-604
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーAn ultramicro-determination of N^1-methylnicotinamide by high-performance liquid chromatography is elaborated. N^1-methylnicotinamide reacted with ace-tophenone in a strong alkali medium at 0℃ in the presence of a large amount of isonicotinamide. After being kept for 10 min, formic acid was added and the mixture was kept for another 15 min at 0℃. Then, the mixture was heated at above 93℃ for 5 min. The reaction product, 1-methyl-7-phenyl-1, 5-dihydro-5-oxo-1, 6-naphthyridine was analyzed by high-performance liquid chromatography. The method employs adsorption on a Chemcosorb 300-SCX (150 × 4.6mm, I.D., 7 μm) column, elution with 25 mM KH_2PO_4 containing 20% acetonitrile (pH 4.5) at a flow rate of 1.0 ml/min, and estimation at excitation wavelength of 382 nm as well as emission wavelength of 440 nm. The detection limit was 0.01 pmol (1.36 pg in terms of N^1-methylnicotinamide). The technique was applied to the analysis of niacin-deficient rat urine. The total HPLC analysis time is approximately 10 min.抄録全体を表示PDF形式でダウンロード (571K) -
秋山 康博, 原 久仁子, 加藤 義則, 滝沢 貴美枝, 田島 鉄弥, 篠 光正原稿種別: 本文
1987 年 61 巻 12 号 p. 605-609
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーThe restoring effect of MK-4 on the extrinsic coagulation activity was compared with that of MK-7 using hypoprothrombinemic rats induced by warfarin. With regard to oral administration, both MK-4 and MK-7 dose-dependently enhanced the coagulation activity, but the effect of MK-4 was observed more rapidly at 1 mg/kg body weight and more potently at all dosages examined than that of MK-7. In intravenous administration, the activity of MK-4 was the same as for oral administration. On the other hand, the concentration of MK-4 in liver was lower than that of MK-7 in both oral and intravenous administrations. These results suggest that MK-4 is more active than MK-7 in the production of vitamin K-dependent coagulation factors.抄録全体を表示PDF形式でダウンロード (451K) -
橋爪 清松, 戸田 千登世, 安井 照代, 永納 秀男原稿種別: 本文
1987 年 61 巻 12 号 p. 611-616
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリー4-Amino-2-butylthio-5-hydroxymethylpyrimidine (3) corresponding to the 2-subst,ituted pyrimidine moiety in thiamine was prepared from ethyl ethoxy-methylenemalonate in an overall yield of 46.7% in 4 steps. This product was chlorinated with thionyl chloride followed by condensation with 4-methyl-5-(β-hydroxyethyl)thiazole in dioxane to give 2-butylthiothiamine (2). The inhibitory effect of (2), (3) and 2-methylthiothiamine (1) on the growth of Saccharomyces carlsbergensis was examined under the following three culture conditions: a) vitamin B_1 and B_6 free medium, b) B_6 supplemented medium, and c) both B_1 and B_6 supplemented medium. Both compounds inhibited the growth of S. carlsbergensis under these conditions, the order of inhibitory po-tency being a) (1)>(3)>(2), b) (1)>(2)>(3), and c) (2)≧(1)>(3).抄録全体を表示PDF形式でダウンロード (555K) -
宮沢 陽夫, 藤本 健四郎, 金田 尚志原稿種別: 本文
1987 年 61 巻 12 号 p. 617-618
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (287K) -
山本 順寛, 二木 鋭雄, B.N. Ames原稿種別: 本文
1987 年 61 巻 12 号 p. 618-
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (172K) -
三木 正之, 美濃 真原稿種別: 本文
1987 年 61 巻 12 号 p. 618-619
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (305K) -
五十嵐 脩, 陳 玲妙原稿種別: 本文
1987 年 61 巻 12 号 p. 619-620
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (310K) -
山本 尚三原稿種別: 本文
1987 年 61 巻 12 号 p. 620-
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (174K) -
加藤 秋男原稿種別: 本文
1987 年 61 巻 12 号 p. 621-
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (69K) -
原稿種別: 付録等
1987 年 61 巻 12 号 p. 622-624
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (209K) -
柴田 克己原稿種別: 本文
1987 年 61 巻 12 号 p. 625-627
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (421K) -
糸川 嘉則原稿種別: 本文
1987 年 61 巻 12 号 p. 627-
発行日: 1987/12/25
公開日: 2018/03/16
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稲田 雅美原稿種別: 本文
1987 年 61 巻 12 号 p. 627-628
発行日: 1987/12/25
公開日: 2018/03/16
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山本 逸雄原稿種別: 本文
1987 年 61 巻 12 号 p. 628-630
発行日: 1987/12/25
公開日: 2018/03/16
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神取 秀樹, 吉沢 透原稿種別: 本文
1987 年 61 巻 12 号 p. 630-631
発行日: 1987/12/25
公開日: 2018/03/16
ジャーナル フリーPDF形式でダウンロード (269K)
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