巻号一覧
35 巻 (1967)
- 6 号 p. 421-
- 5 号 p. 349-
- 4 号 p. 263-
- 3 号 p. 175-
- 2 号 p. 85-
- 1 号 p. 1-
35 巻, 4 号
選択された号の論文の29件中1～29を表示しています
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飯田 民次原稿種別: 本文
1967 年 35 巻 4 号 p. 263-271
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーThe fluctuations of vitamin A and carotene levels in serum of normal pregnant women were studied and the resulte were compared with those of non-pregnant and toxemic pregnant women. The placental permeability for vitamin A was also investigated. It was recognized that the individual difference of the carotene levels in serum of normal women was statistically significant, but vitamin A level was not significant. The carotene levels in serum of the normal pregnant women were significantly increased at the 10th month of pregnancy, delivery and 6th day post partum, respectively in comparison with normal women. The vitamin A levels in serum, however, were significantly increased only at delivery. The vitamin A levels in serum of toxemic pregnancy were significantly decreased in comparison with normal pregnancy.抄録全体を表示PDF形式でダウンロード (854K) -
飯田 民次原稿種別: 本文
1967 年 35 巻 4 号 p. 272-278
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーExperimental studies on the uptake of ^<14>C-labelled vitamin A in several organs were done for female rats weighing 150-200 g by means of liquid scintillation method. The uptake of vitamin A-^<14>C was investigated on the hypophysis, adrenals, uterus, ovary, blood, liver, intestinal contents, feces and urine at the expected times. The uptake of hypophysis in nonpregnant state was low in comparison with other organs. It was recognized, that the adrenals had the affinity with vitamin A and it was retained for long time. In the ovary and uterus, vitamin A was rapidly expended. The absorption from the intestine was very high and discharge rate in the intestinal contents, feces and urine was low. The placental permeability for vitamin A was better in 14th day than 18th day of pregnancy.抄録全体を表示PDF形式でダウンロード (805K) -
岡田 正原稿種別: 本文
1967 年 35 巻 4 号 p. 279-289
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーIt was found that the transketolase activity of tissues of internal organs in rat with thiamine deficiency lowers and is recovered by an addition of thiamine diphosphate, in vitro (tentatively named as TDP-effect). In this case, the addition of thiamine hydrochloride to hemolysate or erythrocyte suspension is ineffective for the recovery, while various thiamine derivatives, such as thiamine propyldisulfide cause the recovery of transketolase activity. An administration of oxythiamine to rat for two weeks, causes the decrease of the enzymatic activity in all tissues, except that of brain. When 2 mg of oxythiamine was given only once to thiamine deficient rat, the TDP-effect was depressed, while the transketolase activity was not influenced. The transketolase activity and TDP-effect were tested with 63 patients suffering from various diseases. In some cases of hepatic disease and alcoholism, the hemolysate transketolase activity was recognized to decrease and TDP-effect was well correlated with thiamine deficient state.抄録全体を表示PDF形式でダウンロード (1184K) -
岡田 正原稿種別: 本文
1967 年 35 巻 4 号 p. 290-294
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーThe transketolase activity of liver tissue was slightly depressed in acute and chronic CCl_4 damaged rat. Amino acid or protein composition of diet had little or no effect on hepatic transketolase activity in chronic liver injury. Considering from the thiamine level and TDP-effect, it was supposed that the metabolic disturbance of thiamine causes the depression of the enzymatic activity. Partial hepatectomy caused the elevation of liver transketolase activity in normal rat, while in thiamine deficient rat the activation was not recognized. It is suggested that the thiamine deficiency is disadvantageous for liver regeneration.抄録全体を表示PDF形式でダウンロード (601K) -
新村 寿夫, 鈴木 隆雄, 佐橋 佳一原稿種別: 本文
1967 年 35 巻 4 号 p. 295-300
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーThe stimulative action of glucose in the formation of biotin from desthiobiotin by washed cells of Saccharomyces cerevisiae was investigated. The biotin-deficient cells took up a greater amount of desthiobiotin than the biotin-sufficient cells, and then the intracellular levels of biotin became approximately constant. The uptake of desthiobiotin by washed cells increased markedly by the addition of glucose, and the effect was inhibited by the addition of iodoacetic acid or dinitrophenol. With the increase of desthiobiotin concentration in a incubation system without glucose, the uptake increased proportionally, but the biotin formation did not increase. The uptake of desthiobiotin by the washed cells is appeared to occur by two mechanisms which are glucose-independent and -dependent. The rate of biotin formation from desthiobiotin in the optimal temperature raised approximately 2.5 fold by the addition of glucose. It was suggested that the formation of biotin from desthiobiotin required further energy source.抄録全体を表示PDF形式でダウンロード (570K) -
奥村 健太郎, 小寺 啓司, 大稲 豊生, 小田 達夫原稿種別: 本文
1967 年 35 巻 4 号 p. 301-307
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーPyridoxal or its phosphate reacts with DL-homocystcine in aqueous solution to give 2-(3-hydroxy-5-hydroxymethyl-2-methylpyridyl-4)-tetrahydro-1,3-thiazine-4-carboxylic acid (I) or 2-(3-hydroxy-5-phosphoryloxymethyl-2-methyl-pyridyl-4)-tetrahydro-1,3-thiazine-4-carboxylic acid (II). (I) and (II) are comparatively stable in slightly acidic solution and crystallize from the reaction solution. (I) is obtained in a good yield by an addition of pyridoxal hydrochloride to a solution containing DL-homocysteine thiolactone hydrochloride. Polymorphism is observed in (I), the one with mp. 128-130℃ which is a stable form and the other with mp. 159-160℃ which is a semistable form. These two forms of (I) are interconvertible. UV spectra of the two are identical, however the IR spectra are different in a sharp absorption at ν 1735 cm^<-1> which is seen only in the former. The chemical structure of (I) is confirmed by means of NMR spectrum.抄録全体を表示PDF形式でダウンロード (798K) -
増川 健二, 古崎 喜市郎, 茂中 寛明, 上場 正司, 奥村 健太郎原稿種別: 本文
1967 年 35 巻 4 号 p. 308-321
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーInvestigations were made on the reaction between pyridoxal and DL-homocysteine and the physical and chemical properties of the reaction product, pyridoxal-DL-homocysteine (I). The ultraviolet spectra of (I) have been studied at various pHs in buffer solution and in dioxane-water. In neutral aqueous solution, it has two absorption maxima, one at 332 mμ and the other at 251 mμ and the dipolar ionic form predominates but significant amounts of the uncharged forms are also present. Dissociation constants obtained by spectrophotometric method are pK_1=2.2,pK_2=7.2,pK_3=9.4 and the value of equilibrium Kz between dipolar ionic and uncharged neutral forms is about 5. For the separation of (I) from the reaction product, paper electrophoresis is most suitable. The reaction of pyridoxal and homocysteine is seemed to proceed by two steps and the velocity constants for hemiacetal formation and the formation of the cyclic product under various pHs and concentrations of reactants has been studied. An aqueous solution of (I) is comparatively unstable at 50℃ but is stabilized in an excess of homocysteine, particularly at PH 9.0.抄録全体を表示PDF形式でダウンロード (1031K) -
団野 保, 桧垣 鴻, 中間 元隆, 山口 容常, 石川 勉, 奥村 健太郎原稿種別: 本文
1967 年 35 巻 4 号 p. 322-333
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーIn acute toxicity test on mice, it was proved that the toxicity of pyridoxal-DL-homocysteine (I) is lower than that of pyridoxal phosphate (II) or pyridoxine hydrochloride (III). (I) showed the vitamin B_6 activity approximately equivalent to that of (II) or (III) for the growth of vitamin B_6-deficient rat and also for the convulsion caused by antivitamin B_6 agents. In detoxication and hypercholesteremic tests, (I) was more effective than either (II) or (III). (I) had also anti-anemic potency and additive effect on diuretic. In riboflavin and vitamin B_6 deficient rat, the rates of elevatinon of total vitamin B_6 and (II) levels in tissues after an administration of (I) were nearly the same with (II) or pyridoxal. The blood levels of vitamin B_6 in dog and rat after an oral administration of (I) was almost equal to that of (II), while the levels was sustained longer in the intracutaneous injection of (I) than that of (II). The microbiological activity for various lactic bacteria and Saccharomyces carlsbergensis, (I) was almost equivalent to pyridoxal.抄録全体を表示PDF形式でダウンロード (1128K) -
桂 英輻, 中村 明子, 川村 利子原稿種別: 本文
1967 年 35 巻 4 号 p. 334-
発行日: 1967/04/25
公開日: 2018/02/10
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上原 喜八郎, 溝口 正, 細見 三郎原稿種別: 本文
1967 年 35 巻 4 号 p. 334-335
発行日: 1967/04/25
公開日: 2018/02/10
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早石 修原稿種別: 本文
1967 年 35 巻 4 号 p. 335-
発行日: 1967/04/25
公開日: 2018/02/10
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福井 三郎, 田中 渥夫, 大石 誠子原稿種別: 本文
1967 年 35 巻 4 号 p. 335-336
発行日: 1967/04/25
公開日: 2018/02/10
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坂本 幸哉, 神田 正幸, 島 宏子, 吉川 邦彦, 杉立 彰夫, 東 胤昭原稿種別: 本文
1967 年 35 巻 4 号 p. 336-
発行日: 1967/04/25
公開日: 2018/02/10
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林 髞原稿種別: 本文
1967 年 35 巻 4 号 p. 336-337
発行日: 1967/04/25
公開日: 2018/02/10
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脇坂 行一, 右京 成夫, 外林 秀紀, 日比野 敏行原稿種別: 本文
1967 年 35 巻 4 号 p. 337-338
発行日: 1967/04/25
公開日: 2018/02/10
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岩井 和夫, 鈴木 襄原稿種別: 本文
1967 年 35 巻 4 号 p. 338-
発行日: 1967/04/25
公開日: 2018/02/10
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村田 希久, 丸川 澄子原稿種別: 本文
1967 年 35 巻 4 号 p. 338-339
発行日: 1967/04/25
公開日: 2018/02/10
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川崎 近太郎, 近藤 雅臣, 紀氏 健雄, 手島 邦和, 西井 正博原稿種別: 本文
1967 年 35 巻 4 号 p. 339-
発行日: 1967/04/25
公開日: 2018/02/10
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川崎 近太郎, 篠田 純男原稿種別: 本文
1967 年 35 巻 4 号 p. 339-
発行日: 1967/04/25
公開日: 2018/02/10
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内海 勇, 河野 啓一, 垣江 喜明, 溝辺 雅一原稿種別: 本文
1967 年 35 巻 4 号 p. 339-340
発行日: 1967/04/25
公開日: 2018/02/10
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平野 弘, 沼田 光雄原稿種別: 本文
1967 年 35 巻 4 号 p. 340-
発行日: 1967/04/25
公開日: 2018/02/10
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峰下 銕雄, 上田 元彦原稿種別: 本文
1967 年 35 巻 4 号 p. 341-
発行日: 1967/04/25
公開日: 2018/02/10
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荒蒔 義知, 鈴置 二郎, 岩塚 寿, 志野 晟生, 村上 紀志子, 白川 裕弘原稿種別: 本文
1967 年 35 巻 4 号 p. 341-
発行日: 1967/04/25
公開日: 2018/02/10
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佐橋 佳一, 前川 昭男, 盛永 宏太郎原稿種別: 本文
1967 年 35 巻 4 号 p. 342-
発行日: 1967/04/25
公開日: 2018/02/10
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田村 善蔵, 今成 登志男原稿種別: 本文
1967 年 35 巻 4 号 p. 342-
発行日: 1967/04/25
公開日: 2018/02/10
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田村 善蔵, 高梨 茂原稿種別: 本文
1967 年 35 巻 4 号 p. 342-343
発行日: 1967/04/25
公開日: 2018/02/10
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勝沼 信彦, 岡田 美津子原稿種別: 本文
1967 年 35 巻 4 号 p. 343-344
発行日: 1967/04/25
公開日: 2018/02/10
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坂本 幸哉, 神田 正幸, 岡田 尚武, 阿部 裕, 小泉 岳夫原稿種別: 本文
1967 年 35 巻 4 号 p. 344-
発行日: 1967/04/25
公開日: 2018/02/10
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山田 弘三, 辻 稔, 阿部 和世原稿種別: 本文
1967 年 35 巻 4 号 p. 344-345
発行日: 1967/04/25
公開日: 2018/02/10
ジャーナル フリーPDF形式でダウンロード (334K)
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