巻号一覧
47 巻, 8 号
選択された号の論文の15件中1～15を表示しています
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小林 正原稿種別: 本文
1973 年 47 巻 8 号 p. 381-390
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーRecent progress in total synthesis of vitamin D_3 (cholecalciferol) and syntheses of vitamin D_3 active metabolites is reviewed. First, the method of total synthesis of vitamin D_3 via previtamin D_3 without photo-reaction (reported by Lythgoe et al.^<10)〜16)>) is mainly introduced. Next, the methods of syntheses of 25-hydroxycholecalciferol (25-HCC), 1,25-dihydroxycholecalciferol (1,25-DHCC), 24,25-dihydroxycholecalciferol (24,25-DHCC) and 25,26-dihydroxycholecalciferol (25,26-DHCC) are described.抄録全体を表示PDF形式でダウンロード (799K) -
橋詰 直孝原稿種別: 本文
1973 年 47 巻 8 号 p. 391-399
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーParenteral administration of 1 mg per 100 g body weight of thiamine・HCl to the rats fed with control and thiamine deficient diet caused a temporal accumulation of fat in the liver. The effect was enhanced when the diets had high fat or low protein. The diet high in protein did not inhibit the effect. MCT (median chain triglyceride) supplemented diet inhibited the accumulation. The liver in severe thiamine deficiency showed swelling of mitochondria and some destructions of nucleolonema, indicating defects in energy and nucleic acid metabolism. These findings disappeared by thiamine injection and yet fat deposition was increased. The fat accumulating effect of thiamine was not seen in the rats treated with CCl_4. The fat in the liver biopsy specimen of the patients who received high doses of thiamine was not increased.抄録全体を表示PDF形式でダウンロード (1553K) -
木村 和子, 飯尾 利弘, 大熊 哲汪, 太幡 利一原稿種別: 本文
1973 年 47 巻 8 号 p. 401-407
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーThe degradation of thiamine and its modified compounds with autoxidized linoleic acid was investigated : the degradation of thiamine depended on the temperature and peroxide value of in the reaction mixture. Among the used compounds, thiamine was the most rapidly decomposed, thiothiamine was somewhat resistant, while disulfide compound such as thiamine propyldi-sulfide or thiamine disulfide were very stable to the oxidized linoleic acid. The degradation of thiamine by oxidized linoleic acid under aerobic was higher than that under anaerobic condition. The degradated compound of thiamine was isolated by chromatographic fractionation using Dowex 50W×4,and identified as 2-methyl-4-amino-5-aminomethylpyrimidine by means of UV, IR, NMR and mass spectra.抄録全体を表示PDF形式でダウンロード (681K) -
松井 邦夫原稿種別: 本文
1973 年 47 巻 8 号 p. 409-414
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーThe glycogen content of liver of vitamin B_2-deficient mouse was about half of that of mouse which was supplied with sufficient amount of B_2 by injection or feeding. But the glycogen content of liver of mouse fed with sufficient amount of B_2 was not affected by injection of B_2. The incorporation of glucose in vitro into glycogen of sliced liver was not affected by the presence of B_2 in incubation medium even in the liver of B_2-deficient mouse. It was concluded that the effect of B_2 increasing glycogen content of liver (in vivo) would be secondary.抄録全体を表示PDF形式でダウンロード (523K) -
倉田 裕充原稿種別: 本文
1973 年 47 巻 8 号 p. 415-419
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーIt is well known that a large dose injection of nicotinamide caused a striking rise in liver NAD in rats as well as in liver nicotinamide. Consequently, the vitamin and its metabolites were excreted in the urine, especially relatively large amounts of N'-methylnicotinamide (MNA) which is normally arised from nicotinamide resulting in breakdown of NAD in the liver. In order to know the origins of urinary MNA, female rats were given nicotinamide (500 mg/kg body weight) intraperitoneally. The time course of urinary excretion of nicotinamide and MNA was studied on the urine collected with a small glass catheter inserted into urethra and it was compared with the hepatic contents of nicotinamide and NAD with time. Urinary excretion of nicotinamide showed a maximal peak at 2 hours after administration and then it rapidly decreased. This excretory pattern reflected the hepatic content levels of nicotinamide which reached the maximum immediately after its administration, and reduced repidly. On the contrary, significant amounts of MNA were excreted at later time periods ; its excretion increased slowly and almost linearly upto 10 hours after administration and its maximal level continued for 8〜10 hours. This finding of MNA excretion corresponds closely to the change of liver NAD contents which were gradually increased and began to drop at 8 hours after administration of nicotinamide. These results suggest that nicotinamide administered in a large amount was hardly methylated directly for the formation of MNA during the early period and that after once synthesized to the hepatic NAD, it was excreted as substrate for the formation of MNA over the later period.抄録全体を表示PDF形式でダウンロード (490K) -
北原 覚雄, 鈴木 洋一, 豊田 泰原稿種別: 本文
1973 年 47 巻 8 号 p. 421-422
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーPDF形式でダウンロード (300K) -
峰下 銕雄, 吉村 弘二原稿種別: 本文
1973 年 47 巻 8 号 p. 422-
発行日: 1973/08/25
公開日: 2018/03/02
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藤原 元典, 糸川 嘉則, 曾良 訪, 名取 恭子原稿種別: 本文
1973 年 47 巻 8 号 p. 422-423
発行日: 1973/08/25
公開日: 2018/03/02
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松井 邦夫原稿種別: 本文
1973 年 47 巻 8 号 p. 423-
発行日: 1973/08/25
公開日: 2018/03/02
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前川 昭男, 徳田 寛原稿種別: 本文
1973 年 47 巻 8 号 p. 423-424
発行日: 1973/08/25
公開日: 2018/03/02
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田村 善蔵, 中村 洋原稿種別: 本文
1973 年 47 巻 8 号 p. 424-425
発行日: 1973/08/25
公開日: 2018/03/02
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上原 喜八郎, 細見 三郎原稿種別: 本文
1973 年 47 巻 8 号 p. 425-426
発行日: 1973/08/25
公開日: 2018/03/02
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外林 秀紀原稿種別: 本文
1973 年 47 巻 8 号 p. 426-
発行日: 1973/08/25
公開日: 2018/03/02
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上久保 正, 林 光則, 武信 英夫原稿種別: 本文
1973 年 47 巻 8 号 p. 426-427
発行日: 1973/08/25
公開日: 2018/03/02
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福井 三郎, 田中 渥夫, 寺西 豊, 大隅 正子原稿種別: 本文
1973 年 47 巻 8 号 p. 427-428
発行日: 1973/08/25
公開日: 2018/03/02
ジャーナル フリーPDF形式でダウンロード (250K)
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