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勝井 五一郎
原稿種別: 本文
1958 年 15 巻 p.
1-15
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
15-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
15-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
15-
発行日: 1958年
公開日: 2017/12/22
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沼田 克彦, 木村 光二
原稿種別: 本文
1958 年 15 巻 p.
16-18
発行日: 1958年
公開日: 2017/12/22
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One mg of β-carotene solubilized in Tween 80 was orally administered to rats and changes in vitamin A and carotene in liver were followed and compared with the case with β-carotene in oil. The change was the same both qualitatively and quantitatively, reaching a maximum level 12-15 hours after administration. The changes in the level of vitamin A and carotene in serum were found also to be the same in both cases, reaching a maximum level about 9 hours after administration. Varying amounts (1-200 mg) of α-tocopherol were also administered together with 1 mg of solubilized β-carotene, but no effect was found on the vitamin A level in liver 14 hours after administration.
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高田
原稿種別: 本文
1958 年 15 巻 p.
18-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
18-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
18-
発行日: 1958年
公開日: 2017/12/22
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沼田 克彦, 木村 光二
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1958 年 15 巻 p.
19-21
発行日: 1958年
公開日: 2017/12/22
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After orally administering 500 μg of solubilized vitamin A to rats, changes in the levels of the vitamin in liver as well as in serum were followed and compared with the case with the vitamin dissolved in oil. The maximum level in the liver was reached about 9 hours after administering the solubilized vitamin, whereas about 15 hours after administering the vitamin in oil, the highest value of the fromer being about 1.6 times that of the latter. The rise in each hour was always higher in the former than in the latter. The level of the vitamin in serum was highest about 2 hours after administration in the case of the solubilized vitamin, whereas about 4 hours in the case of the vitamin in oil, the highest value being about 1.8 times that of the latter. In short, the solubilized vitamin A is markedly more easily absorbed and utilized than the vitamin in oil.
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沼田 克彦, 木村 光二
原稿種別: 本文
1958 年 15 巻 p.
21-23
発行日: 1958年
公開日: 2017/12/22
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Changes in vitamin A and carotene levels in two human subjects after administering solubilized vitamin A and β-carotene were followed and it was found that the solubilized vitamin A appeared more and sooner in serum than the vitamin in oil, i.e., a maximum level of the former was reached in 1-2 hours, whereas that of the latter in 3-5 hours, the highest rise in the level of the former being about 1.5 times that of the latter. In the case of β-carotene, the highest carotene level in serum was reached in both cases in 5-6 hours, and that of vitamin A in 3-4 hours without any difference between the two.
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沼田 克彦
原稿種別: 本文
1958 年 15 巻 p.
24-27
発行日: 1958年
公開日: 2017/12/22
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The assay method for vitamin D of the present author was tested using another preparation of Superfiltrol, Grade 1,of Filtrol Corporation and it was found to be unsatisfactory when the same procedure was followed. Another preparation of Superfiltrol, Grade 1,SV-6801,was tested under varying conditions and its water content was found to be an essential factor. An appropriate procedure for producing a suitable preparation was described.
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高田
原稿種別: 本文
1958 年 15 巻 p.
27-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
27-
発行日: 1958年
公開日: 2017/12/22
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沼田 克彦
原稿種別: 本文
1958 年 15 巻 p.
28-33
発行日: 1958年
公開日: 2017/12/22
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The concentration of vitamin D in various tissues and feces was determined at intervals following an oral administration of 1000 μg of ergocalciferol. After 24 hours, about 1/3 of the dose was detected in the body and feces, and 2/3 had been consumed. Of the vitamin detected, about 1/3 was found in the body and 2/3 in feces. After 48 hours, 7 per cent of the dose was recovered in the body and 93 per cent had been consumed. Of all the tissues, the level of the vitamin was highest in liver, amounting to about 2/3 of the total vitamin in the body. Pursuing the vitamin levels in liver after orally administering 1000 μg of ergocalciferol to rats, it was found to be highest 10 to 14 hours after the dose, about 10 per cent of the dose being contained in the organ. Thereafter it fell gradually. The vitamin levels in liver and feces after successive doses of ergocalciferol were determined and the daily fecal excretion of the vitamin was found to be about 40 per cent of the dose following successive administrations of 25 to 50 μg of the vitamin and 30 per cent following an administration of 100 μg. The fecal excretion never rose gradually with successive doses. The vitamin in liver rose by 20 per cent of the dose following administration of less than 100 μg irrespective of the amount given, whereby the body weight rose normally. With the rise of the dose aobve 500 μg, the body weight began to fall, whereas the vitamin level in liver rose markedly. Supplementation of 100 to 400 μg of α-tocopherol to 1000 μg of ergocalciferol resulted in no significant rise in the vitamin level in tissues and feces.
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高田
原稿種別: 本文
1958 年 15 巻 p.
33-
発行日: 1958年
公開日: 2017/12/22
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田中 孝久
原稿種別: 本文
1958 年 15 巻 p.
34-36
発行日: 1958年
公開日: 2017/12/22
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Thiamine-decomposing thermostable factor of an edible fern (Pteridium aquilinum var.japonicum) isolated according to Hasegawa's method was examined by hydrolysis and paper chromatography for elucidating its structure. By hydrolysis of 32 mg of the factor, yellow needles of aglycone were obtained and identified as kaempferol by ultraviolet absorption spectrum, mixed melting point, and elementary analysis. The sugar part was analyzed by paper chromatography using butanol・acetic acid・water (4 : 1 : 2) as a developing solvent system, whereby two spots were detected by spraying ammoniacal AgNO_3 solution. One of them agreed with glucose and the other with maltose in Rf values. The factor of fern was thus identified as kaempferol-maltoside, possibly kaempferol-3-maltoside.
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川崎 尚
原稿種別: 本文
1958 年 15 巻 p.
36-39
発行日: 1958年
公開日: 2017/12/22
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The existence of disulfide type of thiamine was demonstrated in beef, pork and some viscera by reducing with cysteine. But the level is generally very low as compared with the total thiamine level, at most 40 per cent of the total thiamine.
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山口 順
原稿種別: 本文
1958 年 15 巻 p.
39-43
発行日: 1958年
公開日: 2017/12/22
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It was observed by human experiment that the pantothenic acid excreted in feces as well as the vitamin synthesized markedly increased with the change of the an ordinary diet to a vegetable one. On the contrary, both values of the vitamin definitely decreased after a switch of an ordinary diet to a meat one. The addition of cellulose to each diet caused a definite rise in both amounts of the vitamin, suggesting that the main promoting effect of the vegetable diet is due to cellulose contained therein. The change in urinary excretion was not so marked as that in feces.
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高田
原稿種別: 本文
1958 年 15 巻 p.
43-
発行日: 1958年
公開日: 2017/12/22
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松山 茂樹
原稿種別: 本文
1958 年 15 巻 p.
44-50
発行日: 1958年
公開日: 2017/12/22
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The amount of thiamine degraded was determined in a system, in which both thiaminase I and II simultaneously existed. It was found that about the same amount of thiamine was degraded, in the presence of the both culture supernatant, aniline or pyridine, as that by thiaminase I alone. Accumulative action of both thiaminases was never observed. On the other hand, when thiamine was degraded by the combined suspension of washed cells of both types producing thiaminase I and II with about equal activity, the amount of thiamine degraded was largely dependent of thiaminase II. A definite accumulative action was scarcely observed. The centrifuged supernatant of Bacillus thiaminolyticus Matsukawa et Misawa was found to have antibacterial activity against Escherichia coli whereas that of Bacillus aneurinolyticus Kimura et Aoyama failed to show the activity. The possible infection mechanism of Bacilluus thiaminolyticus in human intestine was discussed.
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高田
原稿種別: 本文
1958 年 15 巻 p.
50-
発行日: 1958年
公開日: 2017/12/22
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上原
原稿種別: 本文
1958 年 15 巻 p.
50-
発行日: 1958年
公開日: 2017/12/22
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上久保 正
原稿種別: 本文
1958 年 15 巻 p.
51-53
発行日: 1958年
公開日: 2017/12/22
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Investigations were made on a high rate anaerobic digestion procedure for treating distillers' wastes mixed with night soil, and waste water from slaughter houses from a viewpoint of vitamin B_<12> resources. The precipitated fractions obtained by centrifuging the supernatant liquor in the digesters might be used as raw materials for crystalline vitamin B_<12> or APF sources, since the fractions contain the vitamin as much as over 20 μg/g on a dry basis as in case of anaerobic digestion products of night soil, activated sludge and distillers' wastes.
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高田
原稿種別: 本文
1958 年 15 巻 p.
53-
発行日: 1958年
公開日: 2017/12/22
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天野 太郎
原稿種別: 本文
1958 年 15 巻 p.
54-58
発行日: 1958年
公開日: 2017/12/22
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Microbiological assay of vitamin B_6 with Escherichia coli mutant 1024 was undertaken. The basal medium employed was Davis-Mingioli's synthetic medium enriched with 0.5 per cent of vitamin free casein hydrolysate. The vitamin B_6 content of drugs and human sera determined with E.coli mutant was fairly good consistent with that obtained with Saccharomyces carlsber gensis 4228. The dose response curve of E.coli mutant was disturbed in the presence of some vitamins, purines and pyrimidines.
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藤田 秋治, 沼田 克彦
原稿種別: 本文
1958 年 15 巻 p.
59-
発行日: 1958年
公開日: 2017/12/22
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藤田 秋治, 木村 光二
原稿種別: 本文
1958 年 15 巻 p.
59-
発行日: 1958年
公開日: 2017/12/22
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藤田 秋治, 川口 露子
原稿種別: 本文
1958 年 15 巻 p.
59-60
発行日: 1958年
公開日: 2017/12/22
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勝井 五一郎, 三枝 礼子
原稿種別: 本文
1958 年 15 巻 p.
60-
発行日: 1958年
公開日: 2017/12/22
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森 高次郎, 内藤 幸次, 福士 敏雄
原稿種別: 本文
1958 年 15 巻 p.
60-
発行日: 1958年
公開日: 2017/12/22
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稲垣 長典, 福場 博保, 三平 玉世, 武藤 薫代
原稿種別: 本文
1958 年 15 巻 p.
60-61
発行日: 1958年
公開日: 2017/12/22
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川崎 近太郎, 松浦 恒雄
原稿種別: 本文
1958 年 15 巻 p.
61-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
61-
発行日: 1958年
公開日: 2017/12/22
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上久保
原稿種別: 本文
1958 年 15 巻 p.
61-
発行日: 1958年
公開日: 2017/12/22
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上原
原稿種別: 本文
1958 年 15 巻 p.
61-
発行日: 1958年
公開日: 2017/12/22
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上原
原稿種別: 本文
1958 年 15 巻 p.
62-
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
62-63
発行日: 1958年
公開日: 2017/12/22
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高田
原稿種別: 本文
1958 年 15 巻 p.
63-64
発行日: 1958年
公開日: 2017/12/22
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桑田 智
原稿種別: 本文
1958 年 15 巻 p.
65-75
発行日: 1958年
公開日: 2017/12/22
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上原
原稿種別: 本文
1958 年 15 巻 p.
75-
発行日: 1958年
公開日: 2017/12/22
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上久保
原稿種別: 本文
1958 年 15 巻 p.
75-
発行日: 1958年
公開日: 2017/12/22
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上久保
原稿種別: 本文
1958 年 15 巻 p.
75-
発行日: 1958年
公開日: 2017/12/22
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沼田 克彦, 森元 博久
原稿種別: 本文
1958 年 15 巻 p.
76-81
発行日: 1958年
公開日: 2017/12/22
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Rats weighing about 40 g raised with rachitogenic diets were given a single dose of 1 mg ergocalciferol. Twenty-four hours after the dose, about 16 per cent was detected, of which 1/3 was in the body and the rest in feces. Eighty-four per cent of the dose had been consumed in 24 hours. Following a single dose of 1 mg ergocalciferol, the vitamin in the liver rose gradually, reaching a maximum level in 12 hours, whereby about 7 per cent of the dose had been recovered. Thereafter it fell gradually. After successive doses, varying in amount in each, of ergocalciferol, the vitamin in the body rose with a rise in the vitamin given. The vitamin in the feces showed no tendency to rise with the duraton of administration. The rise in body weight after giving 50 or 100 μg ergocalciferol was about the same as the control. After giving 500 or 1000 μg, the body weight fell from the fifth day, and the animals in the latter case fell into a serious condition.
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清水
原稿種別: 本文
1958 年 15 巻 p.
81-
発行日: 1958年
公開日: 2017/12/22
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上久保
原稿種別: 本文
1958 年 15 巻 p.
81-
発行日: 1958年
公開日: 2017/12/22
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堀田 一雄, 石黒 伊三雄, 友田 正勝, 今泉 惇
原稿種別: 本文
1958 年 15 巻 p.
82-85
発行日: 1958年
公開日: 2017/12/22
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For separation of riboflavin in paper ionophoresis, a 1% borax solution or a M/2O phosphate buffer of pH 5.6 was most satisfactory, but with an alkaline buffer there was decomposition of riboflavin. Alkaline decomposition products of riboflavin, lumichrome and lumiflavin were separated with difficulty by paper ionophoresis. The separation of riboflavin by ion exchange resin was prcduced fairly satisfactorily with Amberlite IRA-400,but with difficulty with other riboflavin related compounds.
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堀田 一雄, 石黒 伊三雄, 田中 喜平治, 安藤 収
原稿種別: 本文
1958 年 15 巻 p.
86-93
発行日: 1958年
公開日: 2017/12/22
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Riboflavin content in urine of a rabbit to which 6,7-dimethyl-2-keto-1-D-ribityl-3-quinoxaline carboxylic acid (B_2-keto acid) was given subcutaneously reached its highest level in 4-6 hours after the injection. There was also an obvious increaa of riboflavin in urine in a day. Riboflavin content in urine increased even when sulfamine and B_2-keto acid were given at the same time, but the content was less than when sulfamine was not given. The riboflavin content in liver and kidney of a mouse increaed in 2-4 hours after B_2-keto acid had been given. In this case, the given B_2-keto acid was not detected in organs by the paper partition chromatography. From these results it was concluded that B_2-keto acid activated the riboflavin metabolism and increased the riboflavin content in urine.
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上原
原稿種別: 本文
1958 年 15 巻 p.
93-
発行日: 1958年
公開日: 2017/12/22
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安藤 収
原稿種別: 本文
1958 年 15 巻 p.
94-98
発行日: 1958年
公開日: 2017/12/22
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Fluorescent substances distributed in the leaves of the plant are different in accordance with the species of plants and 7 or 8 fluorescent spots were found on the paper partition chromatography. These fluorescent colours are chiefly blue but their chemical structures are not clear. Determination of riboflavin content in the plant tissue by lumiflavin method is extremely difficult. The reason is that riboflavin fluorescence is inhibited by the above fluorescent substances. Experiment on each of the fluorescent substances distributed in the plant tissue showed that this influence was caused by two fluorescent spots on the paper partition chromatography.
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清水
原稿種別: 本文
1958 年 15 巻 p.
98-
発行日: 1958年
公開日: 2017/12/22
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