巻号一覧
31 巻 (1965)
- 6 号 p. 433-
- 5 号 p. 343-
- 4 号 p. 235-
- 3 号 p. 175-
- 2 号 p. 107-
- 1 号 p. 1-
31 巻, 4 号
選択された号の論文の43件中1～43を表示しています
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清水 祥一, 加藤 忠克, 福井 三郎原稿種別: 本文
1965 年 31 巻 4 号 p. 235-245
発行日: 1965/04/25
公開日: 2018/02/09
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宮地 一馬, 石津 汪, 中村 佐知子原稿種別: 本文
1965 年 31 巻 4 号 p. 246-251
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーIn a previous paper it has been shown about the effects of partial hepatoectomy on flavin enzymes in the livers of normal and riboflavin deficient mise. Present study was undertaken to determine how flavin contents change in the regenerating liver of mice or rat under the normal and the deficient conditions of riboflavin or iron. Only 10 percent of the liver was resected because the riboflavin or iron deficient animals were so emaciated, and riboflavin in the regenerating liver was determined during a restoration (postoperative) period of 24 to 55 hours. The riboflavin content was proved to increase significantly under the condition of riboflavin deficiency, in which the content in the liver was very low before operation, whereas it decreased under the normal or iron deficient condition in which the content was, of course, normal. Xanthine oxidase activity was also determined under the same conditions, and the activity was proved to increase not only in the regenerating liver, but also in the spleen and small intestine of rats partially hepatectomized under the normal condition as well as the deficient conditions. On this latter result it is probably seen that the animals might be similarly influenced by the partial hepatectomy no matter whether they are in normal or deficient state. Nevertheless, increment phenomena of riboflavin in the regenerating liver was not seen unless the riboflavin content in the liver was very low before partial hepatectomy. Consequently, it is presumed that some riboflavin is mobilized from other tissues to liver to take part in the regenerating process in the case of riboflavin deficiency in which riboflavin content in the liver is very low.抄録全体を表示PDF形式でダウンロード (702K) -
小柳 達男, 及川 圭子原稿種別: 本文
1965 年 31 巻 4 号 p. 252-254
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーIn rats fed with a riboflavin-deficient diet containing soybean oil, fatty acid content in serum with 4 double bonds was lower, whereas that with 2 double bonds was higher than that of control animals. The low percentage of fatty acid with 4 double bonds in serum of deficient animals showed perhaps the failure of synthesis of arachidonic acid from linoleic acid in these animals.抄録全体を表示PDF形式でダウンロード (401K) -
高橋 直身, 加藤 耕輔, 岩井 広一郎原稿種別: 本文
1965 年 31 巻 4 号 p. 255-259
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーMale White Leghorn chicks of 7 days old were fed on diets containing 10% of lecithinefree soy bean oil, with or without the addition of 0.1 or 0.2g/kg of carnithine and 4g/kg of choline for 3 weeks. The supplementation of carnithine or choline caused the improvement of growth over 10% of the control. Any sign of fatty liver was not recognized in all groups and differences were not found in saponification and iodine values of liver fats between carnithine- and choline- supplemented groups. In the feeding experiment with the choline-free diet, consisting ground corn, fish meal, vitamin mixture and 10% soy been oil, it was proved that 0.2g/kg of carnithine had almost equal growth potency as 4g/kg of choline.抄録全体を表示PDF形式でダウンロード (602K) -
山本 良子原稿種別: 本文
1965 年 31 巻 4 号 p. 260-266
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーThe TBA-value (thiobarbituric acid value) was estimated with the liver of riboflavin-deficient rat, and the influence of the administration of riboflavin on the TBA-value was studied. The mean of the TBA-values was calculated as follows : riboflavin-deficient rat, 0.248-0.320 [D(x)=0.036], riboflavin-administered rat (10μg per day for a rat) 0.135-0.167 [D(x)=0.048], riboflavin-administered rat (100μg per day for a rat) 0.137-0.151 [D(x)=0.007], and riboflavin-administered rat (1000μg per day for a rat) 0.174-0.190 [D(x)=0.008]. Assuming that the TBA-value indicates the amount of the fatty acid peroxide or aldehyde of the sample, these results could be interpreted as that riboflavin deficiency causes the accumulation of these substances in the liver and the administration of 1000 μg of riboflavin per day for a rat as well, and that 10-100μg per day for a rat decreases such substances, which could be attributed to the enzymatic and/or non-enzymatic action of riboflavin.抄録全体を表示PDF形式でダウンロード (568K) -
金子 安之, 井上 泰弘原稿種別: 本文
1965 年 31 巻 4 号 p. 267-274
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーPhotochemical oxidative activities of fluorescent substances produced by Aspergillus were investigated. It was demonstrated that the substances promote the oxidation of Dopa to melanin as well as that of several amino acids by irradiation like riboflavin and other pterins. In this experiment Fe^<2+> and Cu^<2+> possibly form complexes with fluorescent substances to overcome lag period in oxidation.抄録全体を表示PDF形式でダウンロード (808K) -
難波 良司, 福田 博之, 椎名 宏原稿種別: 本文
1965 年 31 巻 4 号 p. 275-277
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーThe present investigation was undertaken to see the effect of thiamine disulfide bismonophosphat (TDSMP) on the movement of the Thiry-Vella jejunal loop and an extirpated part of the small intestine of dogs. A remarkable promotion of the intestinal movement was observed for 40 minutes or more by intravenous injection of 6.3-12.5 mg of TDSMP per kg of body weight. Furthermore, intravenous injection of 6.3mg/kg of TDSMP recovered conspicuously the movement of the intestine, weakened by an administration of sodium pentobarbital. In addition, movement of an extirpated specimen of small intestine adhered to longitudinal and circular muscles was remarkably accelerated by administration of 10 mg of TDSMP per 100ml solution. The efficacy was almost as high as that of 1 mg/100 ml of acetylcholine. On the other hand, no effect was observed on the movement of the extirpated small intestine with only circular muscle. In view of the above fact, it may be supposed that TDSMP mainly works on nerve-factor in the intestinal wall and accelerates the intestinal movement.抄録全体を表示PDF形式でダウンロード (407K) -
村田 希久, 甲斐 邦子, 藤原 邦達原稿種別: 本文
1965 年 31 巻 4 号 p. 278-282
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーIt was observed that alliinase was capable to decompose sulfoxide of S-(2-methyl-4-aminopyrimidinyl-(5)-methyl)-cysteine, which is the reaction product of thiamine and cysteine catalyzed with the purified bacterial thiaminase I, and produced pyruvic acid stoichiometrically. A presumed allicin substance was positive to sodium nitroprusside and phosphomolybdic acid reagents, but negative after developing on a paper by means of the paper chromatography. Michaelis constant of alliinase (determined at pH6.4) for S-(2-methyl-4-aminopyrimidinyl-(5)-methyl)-cysteine sulfoxide was Km=9.9×10^<-3>M, while Km was 5×10^<-3> for alliin. From the result it is apparent that the sulfur atom of the cysteine derivatives is not essential to link to an aliphatic group such as allyl, methyl, etc., as mentioned somewhere.抄録全体を表示PDF形式でダウンロード (577K) -
六尾 勝美原稿種別: 本文
1965 年 31 巻 4 号 p. 283-296
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーThe present paper is concerning on the thiamine metabolism before and after the portacaval anastomosis in the patients with portal hypertension. After the subcutaneous injection of 20mg of thiamine to the patients with portal hypertension, who were belonged to the 2nd and the 3rd group by prof. Imanaga's classification, fluctuations of total and bound thiamine in the blood and of thiamine in the 3 hours' urine were examined. At the same time, pyruvic acid in the blood was also determined. It was revealed that the thiamine metabolism in the 2nd group were similar to that in normal group, meanwhile, in the 3rd group, free thiamine in the blood and in the 3 hours' urine were increased after the surgery. When symptoms of portal systemic encephalopathy, "Eck fistula syndrome" developed, free thiamine in the blood and in the 3 hours' urine were remarkably increased. An administration of thiamine diphosphate or thiamine derivatives may be recommened to restore the abnormal thiamine metabolism in the patients of 3rd group.抄録全体を表示PDF形式でダウンロード (1583K) -
加藤 英彦原稿種別: 本文
1965 年 31 巻 4 号 p. 297-302
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーThe well-known requirements of thiamine and lipoic acid for the oxidative decarboxylation of α-keto acids suggested the possibility that the metabolism of lipoic acid might be affected during thiamine deficiency. Hence, I have performed experimental studies on the biosynthesis of protein-bound lipoic acid in thiamine deficient rats. The biosynthetic activity of protein-bound lipoic acid in liver homogenate were reduced in a deficient state. In a recovery state, following the oral administration of thiamine, the level of thiamine in liver homogenate was recovered rapidly, but the biosynthetic activity of bound lipoic acid was recovered more slowly. The biosynthetic activity was not improved when thiamine or its pyrophosphate was added in vitro to liver mitochondria of thiamine deficient rat.抄録全体を表示PDF形式でダウンロード (652K) -
加藤 英彦原稿種別: 本文
1965 年 31 巻 4 号 p. 303-308
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーThe biosynthetic activity of protein-bound lipoic acid in liver mitochondria and the level of total lipoic acid in liver homogenate were not affected in riboflavin deficient rats. In a pyridoxine deficient state, the biosynthetic activity of bound lipoic acid and the level of total lipoic acid were decreased markedly, and the reduction of the biosynthetic activity was paralleled to the decrease in GOT activity of liver homogenate. But the biosynthetic activity was not improved when pyridoxine or pyridoxal phaphate was added in vitro to liver mitochondria of pyridoxine deficient rat. In a recovery state following the oral administration of pyridoxine, the biosynthetic activity of bound lipoic acid was recovered in a few week.抄録全体を表示PDF形式でダウンロード (628K) -
加藤 英彦原稿種別: 本文
1965 年 31 巻 4 号 p. 309-314
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーInfluences of daily administration of a large amount of thiamine, thiamine tetrahydrofurfuryl disulfide (TTFD), riboflavin and pyridoxine to rats for a month were investigated by observations on the growth of rats, the biosynthesis of protein-bound lipoic acid in liver mitochondria and the activity of glutamic oxalacetic transaminase in liver homogenate. Overdose of thiamine (1,10 and 50mg/kg) and TTFD (1 and 10mg/kg) induced an increased biosynthetic activity of protein-bound lipoic acid, but over-dose of TTFD (50mg/kg) and pyridoxine induced a decreased biosynthetic activity. Over-dose of riboflavin did not effect the biosynthetic activity of protein-bound lipoie acid. The activity of glutamic oxalacetic transaminase was not affected in those states.抄録全体を表示PDF形式でダウンロード (688K) -
竹内 勝, 麻生 和雄, 内海 滉, 加藤 友衛, 塩見 輝雄原稿種別: 本文
1965 年 31 巻 4 号 p. 315-319
発行日: 1965/04/25
公開日: 2018/02/09
ジャーナル フリーApplied the ointment mixed with high concentration of dicarbethoxythiamine (DCET) to albino rat, rabbit and man cutaneously, the significant increase of thiamine level in blood and urine was observed, while thiamine hydrochloride could hardly be absorbed cutaneously. Ointment including 10% DCET was most stable and its cutaneous absorption was excellent. Hydrophilic ointment was more applicable than absorption ointment, and hydrophilic vaseline and ointment mixed with DCET-base was more efficient than with DCET-HCl. After application of 10-30% DCET-HCl ointment on the plucked skin of rats, the thiamine levels of skin, liver, kidney, and muscle were considerably high as compared with the controls. The histochemical investigation on the skin treated with DCET ointment showed the massive concentration of thiamine around the hair follicles.抄録全体を表示PDF形式でダウンロード (597K) -
早石 修原稿種別: 本文
1965 年 31 巻 4 号 p. 320-321
発行日: 1965/04/25
公開日: 2018/02/09
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村上 増雄原稿種別: 本文
1965 年 31 巻 4 号 p. 321-
発行日: 1965/04/25
公開日: 2018/02/09
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牧野 堅原稿種別: 本文
1965 年 31 巻 4 号 p. 321-322
発行日: 1965/04/25
公開日: 2018/02/09
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緒方 浩一原稿種別: 本文
1965 年 31 巻 4 号 p. 322-323
発行日: 1965/04/25
公開日: 2018/02/09
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和田 博原稿種別: 本文
1965 年 31 巻 4 号 p. 323-324
発行日: 1965/04/25
公開日: 2018/02/09
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宿谷 良一原稿種別: 本文
1965 年 31 巻 4 号 p. 324-
発行日: 1965/04/25
公開日: 2018/02/09
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勝沼 信彦原稿種別: 本文
1965 年 31 巻 4 号 p. 324-326
発行日: 1965/04/25
公開日: 2018/02/09
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坂本 幸哉原稿種別: 本文
1965 年 31 巻 4 号 p. 326-
発行日: 1965/04/25
公開日: 2018/02/09
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古武 弥人原稿種別: 本文
1965 年 31 巻 4 号 p. 326-327
発行日: 1965/04/25
公開日: 2018/02/09
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山田 弘三原稿種別: 本文
1965 年 31 巻 4 号 p. 327-329
発行日: 1965/04/25
公開日: 2018/02/09
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北村 義男原稿種別: 本文
1965 年 31 巻 4 号 p. 329-330
発行日: 1965/04/25
公開日: 2018/02/09
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福井 三郎原稿種別: 本文
1965 年 31 巻 4 号 p. 330-331
発行日: 1965/04/25
公開日: 2018/02/09
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山田 光男原稿種別: 本文
1965 年 31 巻 4 号 p. 331-332
発行日: 1965/04/25
公開日: 2018/02/09
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陳 震東原稿種別: 本文
1965 年 31 巻 4 号 p. 332-
発行日: 1965/04/25
公開日: 2018/02/09
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早石 修, 伊地知 浜夫, 市山 新原稿種別: 本文
1965 年 31 巻 4 号 p. 334-
発行日: 1965/04/25
公開日: 2018/02/09
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勝沼 信彦, 松沢 健夫, 勝沼 恒彦原稿種別: 本文
1965 年 31 巻 4 号 p. 334-335
発行日: 1965/04/25
公開日: 2018/02/09
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今永 一原稿種別: 本文
1965 年 31 巻 4 号 p. 335-
発行日: 1965/04/25
公開日: 2018/02/09
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奥田 邦雄, 貝戸 達也原稿種別: 本文
1965 年 31 巻 4 号 p. 335-336
発行日: 1965/04/25
公開日: 2018/02/09
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脇坂 行一, 内野 治人, 白川 茂, 吉田 弥太郎, 藤堂 彰男原稿種別: 本文
1965 年 31 巻 4 号 p. 336-
発行日: 1965/04/25
公開日: 2018/02/09
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上原 喜八郎, 桑島 淳二原稿種別: 本文
1965 年 31 巻 4 号 p. 336-337
発行日: 1965/04/25
公開日: 2018/02/09
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牧野 堅原稿種別: 本文
1965 年 31 巻 4 号 p. 337-
発行日: 1965/04/25
公開日: 2018/02/09
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上田 喜一原稿種別: 本文
1965 年 31 巻 4 号 p. 337-
発行日: 1965/04/25
公開日: 2018/02/09
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川崎 近太郎, 平岡 栄一, 紀氏 汎恵原稿種別: 本文
1965 年 31 巻 4 号 p. 338-
発行日: 1965/04/25
公開日: 2018/02/09
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小池 正彦, 岡部 桂一郎, 早川 太郎, 平島 正泰原稿種別: 本文
1965 年 31 巻 4 号 p. 338-
発行日: 1965/04/25
公開日: 2018/02/09
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水上 明彦, 和田 忠男, 小林 晋作原稿種別: 本文
1965 年 31 巻 4 号 p. 339-
発行日: 1965/04/25
公開日: 2018/02/09
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藤原 元典, 笹川 祐成, 糸川 嘉則, 池田 幸, 中田 利一原稿種別: 本文
1965 年 31 巻 4 号 p. 339-340
発行日: 1965/04/25
公開日: 2018/02/09
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藤原 元典, 笹川 祐成, 糸川 嘉則, 池田 幸, 中田 利一原稿種別: 本文
1965 年 31 巻 4 号 p. 340-
発行日: 1965/04/25
公開日: 2018/02/09
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西沢 義人原稿種別: 本文
1965 年 31 巻 4 号 p. 340-
発行日: 1965/04/25
公開日: 2018/02/09
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児玉 貞介原稿種別: 本文
1965 年 31 巻 4 号 p. 340-
発行日: 1965/04/25
公開日: 2018/02/09
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木村 潔原稿種別: 本文
1965 年 31 巻 4 号 p. 340-341
発行日: 1965/04/25
公開日: 2018/02/09
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