巻号一覧
38 巻 (1968)
- 6 号 p. 423-
- 5 号 p. 331-
- 4 号 p. 229-
- 3 号 p. 151-
- 2 号 p. 81-
- 1 号 p. 1-
38 巻, 3 号
選択された号の論文の26件中1～26を表示しています
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勝井 五一郎原稿種別: 本文
1968 年 38 巻 3 号 p. 151-157
発行日: 1968/09/25
公開日: 2018/02/17
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安藤 肇原稿種別: 本文
1968 年 38 巻 3 号 p. 158-162
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe experiment was performed to observe an influence of excessive dose of thiamine derivatives upon the hepatic CoA concentration in young rat. The animals used in this experiment were young male rats weighing 50g, and were divided into control (A) and thiamine derivative administered (B) groups. Group A was given orally 18% casein diet and group B was given 18% casein diet with 500μg of S-benzoylthiamine O-monophosphate per rat daily for 3 weeks. Hepatic CoA concentration was determined by Kaplan・Lipmann method at 1st, 2nd and 3rd week of feeding. As a result, the hepatic CoA concentrations of group B were 85 to 100 units/g and reduced significantly as compared to 120 to 150 units/g in group A. The hepatic CoA concentration revealed the same tendency when thiamine tetra-hydrofurfuryldisulfide was administered as an other thiamine derivative.抄録全体を表示PDF形式でダウンロード (560K) -
安藤 肇原稿種別: 本文
1968 年 38 巻 3 号 p. 163-168
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーIn the previous paper, it was shown that the hepatic CoA value determined by Kaplan・Lipmann's method were reduced significantly by the administration of thiamine derivatives. In the present paper, the effects of excessive administration of thiamine tetrahydrofurfuryldisulfide (TTFD) on the concentrations of CoA, pantothenic acid and vitamin B_6 of rat liver were studied. The precursors of CoA, such as dephospho-CoA, phosphopantetheine or phosphopantothenoylcysteine, are included in CoA value determined by Kaplan・Lipmann's method, while Wakil's method is specific for CoA. When 500μg of TTFD was given orally for 2 weeks, the values of total pantothenic acid and CoA determined by Kaplan・Lipmann's method decreased markedly, while CoA value by Wakil's method and vitamin B_6 value by Atkin's method were unchanged compared with those of control. The value of total pantothenic acid returned to normal and those of CoA-precursors were recovered to 85% of normal by the administration of 5mg of pantothenic acid daily, but 1.5mg of vitamin B_6 had no influence on CoA and pantothenic acid. From these results, it is supposed that an excessive administration of thiamine derivatives causes a reduction of CoA-precursors owing to the inhibition of phosphorylation of pantothenic acid.抄録全体を表示PDF形式でダウンロード (631K) -
安藤 肇原稿種別: 本文
1968 年 38 巻 3 号 p. 169-174
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe effects of thiamine on the phosphorylation of pantothenic acid by its kinase (pantothenate 4'-phosphotransferase) and of the administration of excessive amount of thiamine derivative on the kinase activity of rat liver were studied. No inhibitory action of thiamine on the phosphorylation of pantothenic acid was recognized, in vitro. The young rats were administered 500μg of thiamine tetrahydrofurfuryldisulfide (TTFD) for 2 weeks and compared the kinase activity of liver with control animals. The average specific activities of the kinase were 0.683 in t e control and 0.496 in TTFD administered rats. From these results, it is supposed that the kinase activity is lowered by an administration of excessive amount of thiamine derivative and lowers the hepatic total pantothenic acid and CoA-precursors.抄録全体を表示PDF形式でダウンロード (601K) -
山田 雅子, 稲越 徳子, 塚原 叡原稿種別: 本文
1968 年 38 巻 3 号 p. 175-181
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーA favourable condition for obtaining a reproducible and sharply defined growth zone in the plate method was indicated as follows. Assay medium : U.S.P. XV composition with 1% agar, 1.5 mm plate thickness, pH 6.5 to 7.0. Biotin solution : pH 6.0 to 7.0. Inoculum size of test organism : 0.075 OD in final. Incubation : 37℃, 20 to 24 hrs. Under the optimal condition there was a linearity of the dose-response to pure solution of biotin over a wide range of 4 to 200 mμg per ml. In the statistical evaluation of the results the maximum errors were below 14%. The biotin contents in several biological materials determined by the plate method were nearly equal to those obtained by the turbidimetric ones. Also, the recoveries of the added vitamin were satisfactory enough except for the case of a few animal samples, and the dose-response lines for all samples used hardly had any drift from that for pure biotin solution. These results may suggest that the cup-plate method using L. arabinosus as test organism is useful for the microbioassay of biotin in natural products.抄録全体を表示PDF形式でダウンロード (976K) -
大前 雅彦, 勝井 五一郎原稿種別: 本文
1968 年 38 巻 3 号 p. 182-188
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe stability of vitamin K_1 in powder preparations was studied by assaying the component and investigating the degradation products after 75 days storage at 45℃. Vitamin K_1 was found to be stable in organic vehicle, but unstable in inorganic one. In inorganic powders, there were detected the same decomposition products as detected when vitamin K_1 was irradiated with ultraviolet under aerobic condition, such as 2-methyl-3-(3',7',11',15'-tetramethyl-1'-hexadecenyl)-1,4-naphthoquinone-hydroxide(3'), phytone, phthiocol, polymer. Besides, there were also noticed the decomposition products, the structure of which were not determined. Percent retention of vitamin K_1 in each powders were as follow : magnesium oxide, 11% ; magnesium silicate, 19% ; magnesium carbonate, 21% ; silica gel, 23 or 52% ; aluminium silicate synthetic, 26 %.抄録全体を表示PDF形式でダウンロード (503K) -
中井 芳治, 真杉 文紀, 大石 誠子, 福井 三郎原稿種別: 本文
1968 年 38 巻 3 号 p. 189-195
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe coenzyme forms of vitamin B_6 analogues containing 2-hydroxymethyl group instead of 2-methyl group (designated as ω-hydroxy PAL-P and ω-hydroxy-PAM-P were obtained as follows : (1) Transformation from acetylated PAM-N-oxide into ω-hydroxy-PAM (I) by refuxing in acetic anhydride solution, followed by hydrolysis with HCl・ethanol. (2) Phosphorylation of I with P_2O_5 and H_3PO_4, followed by treatment with hot water in order to hydrolyze resulting polyphosphate and purification by column chromatography with Amberlite CG-50. Crystallization of ω-hydroxy PAM-P (II) in colorless needles (mp. 135-137℃). (3) Conversion of II to ω-hydroxy PAL-P (III) by transamination using pyridine-2-aldehyde in nitrogen atmosphere at room temperature. Purification by Dowex 50X8 column chromatography. Pale yellow crystals (mp. 94-96℃ (decomp.)). The structures of II and III were confirmed by their absorption spectra in the absence and presence of borate ion, IR- and NMR- spectra and the results of other tests.抄録全体を表示PDF形式でダウンロード (533K) -
川崎 近太郎, 紀氏 健雄, 都丸 明子原稿種別: 本文
1968 年 38 巻 3 号 p. 196-201
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe growth of Sacch. carlsbergensis and its thiamine-adapted strains B_1-1 and B_1-100 was inhibited by the presence of such antithiamine compounds as pyrithiamine, oxythiamine and imidazolothiamine. The inhibition of Sacch. carlsbergensis was partly and that of strain B_1-1 or B_1-100 was completely reversed by thiamine, but not reversed by any other vitamins including vitamin B_6. The inhibition indices of pyrithiamine and imidazolothiamine were 63〜69, 10〜68 on Sacch. carlsbergensis arid 193〜228, 32〜119 on strain B_1-1, respectively. At the absence of thiamine, oxythiamine showed inhibitory effect with the same concentration as pyrithiamine, but at the presence of thiamine, did so weak and irregular inhibitory effect that its inhibition index was impossible to be calculated. Pyrithiamine, imidazolothiamine and oxythiamine showed inhibitory effect on the growth of Sacch. cerevisiae Hansen and baker's yeast (Oriental) as well as Sacch. carlsbergensis and the inhibition was reversed by the addition of thiamine too.抄録全体を表示PDF形式でダウンロード (534K) -
川崎 近太郎, 紀氏 健雄, 西原 力原稿種別: 本文
1968 年 38 巻 3 号 p. 202-206
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThiamine mono- and diphosphate, when incubated with Sacch. carlsbergensis, were completely absorbed by the yeast and were demonstrated as free thiamine in cells. Pyridoxal phosphate was not absorbed by cells but pyridoxal was easily absorbed by the yeast. The cell-free extract of Sacch. carlsbergensis was shown to have phosphatase activity for hydrolysis of thiamine phosphates but no activity for pyridoxal phosphate. From these results, it was considered that the growth inhibition of Sacch. carlsbergensis by thiamine phosphates was due to the absorption of free thiamine formed quickly from the phosphates by hydrolysis on the yeast and that pyridoxal phosphate could not reverse the inhibition by thiamine, because of no activity of the yeast for hydrolysis of pyridoxal phosphate.抄録全体を表示PDF形式でダウンロード (490K) -
麻生 和雄, 栢口 弘, 竹内 勝原稿種別: 本文
1968 年 38 巻 3 号 p. 207-210
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーThe rate of incorporation of riboflavin into the rat liver fractions such as nucleus, mitochondria, microsome and supernatant was studied after the subcutaneous administration of ^<14>C-labelled riboflavin and its tetrabutyrate. In the riboflavin administered group, the rate of incorporation into each fractions was not characteristic. On the other hand, in the butryrate group the incorporation rate increased in parallel with the period of administration and dosis.抄録全体を表示PDF形式でダウンロード (453K) -
神村 瑞夫, 松沢 徹原稿種別: 本文
1968 年 38 巻 3 号 p. 211-216
発行日: 1968/09/25
公開日: 2018/02/17
ジャーナル フリーBy spraying ^<14>C-labeled riboflavin tetrabutylate on the surface of the skin, and by conducting microautoradiographic investigations on the condition of its absorption, the following observation have been acquired, and at the same time, some discussion have been made. 1) Riboflavin tetrabutylate is absorbed well through the healthy hartless skin. 2) There are two routes of absorption from the surface of the skin to dermis. The first one leads through the horny layer, the epidermis and the borderline between the epidermis and the dermis. The second one goes through the pilo-sebaceous canal, the inner and outer root sheaths and connective-tissue sheaths. 3) Hesitation in the absorption of the material and the rather thick layer outward has been observed in line with the lower part of the horny layer, the border line between the epidermis and dermis and the borderline of inner and outer root sheaths. 4) Noticeable microdistribution are observed in the fatty cell.抄録全体を表示PDF形式でダウンロード (1294K) -
能勢 善嗣, 河嶋 新一郎, 浜本 肇原稿種別: 本文
1968 年 38 巻 3 号 p. 217-
発行日: 1968/09/25
公開日: 2018/02/17
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福井 三郎, 中井 芳治, 大石 誠子原稿種別: 本文
1968 年 38 巻 3 号 p. 217-218
発行日: 1968/09/25
公開日: 2018/02/17
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牧野 堅, 村上 安子原稿種別: 本文
1968 年 38 巻 3 号 p. 218-
発行日: 1968/09/25
公開日: 2018/02/17
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牧野 堅, 井上 文英原稿種別: 本文
1968 年 38 巻 3 号 p. 218-219
発行日: 1968/09/25
公開日: 2018/02/17
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中村 恒男, 楠 智一, 曽山 浩吉原稿種別: 本文
1968 年 38 巻 3 号 p. 219-
発行日: 1968/09/25
公開日: 2018/02/17
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緒方 浩一, 梁 漢〓, 楠元 正宏, 岩原 章二郎, 栃倉 辰六郎原稿種別: 本文
1968 年 38 巻 3 号 p. 219-220
発行日: 1968/09/25
公開日: 2018/02/17
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田村 善蔵, 細田 信子原稿種別: 本文
1968 年 38 巻 3 号 p. 220-
発行日: 1968/09/25
公開日: 2018/02/17
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脇坂 行一, 山口 延男原稿種別: 本文
1968 年 38 巻 3 号 p. 221-
発行日: 1968/09/25
公開日: 2018/02/17
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砂川 玄俊, 山崎 光郎, 河田 克朗原稿種別: 本文
1968 年 38 巻 3 号 p. 221-222
発行日: 1968/09/25
公開日: 2018/02/17
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高見沢 映, 酒井 昇二原稿種別: 本文
1968 年 38 巻 3 号 p. 222-
発行日: 1968/09/25
公開日: 2018/02/17
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吉利 和, 安田 和人, 篠原 幸夫原稿種別: 本文
1968 年 38 巻 3 号 p. 222-223
発行日: 1968/09/25
公開日: 2018/02/17
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川崎 近太郎, 近藤 雅臣, 小野 照代原稿種別: 本文
1968 年 38 巻 3 号 p. 223-224
発行日: 1968/09/25
公開日: 2018/02/17
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林 良二, 西宗 高弘原稿種別: 本文
1968 年 38 巻 3 号 p. 224-
発行日: 1968/09/25
公開日: 2018/02/17
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林 良二, 二五田 公俊原稿種別: 本文
1968 年 38 巻 3 号 p. 224-
発行日: 1968/09/25
公開日: 2018/02/17
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林 良二, 山高 里盛, 西宗 高弘原稿種別: 本文
1968 年 38 巻 3 号 p. 224-225
発行日: 1968/09/25
公開日: 2018/02/17
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