巻号一覧
97 巻, 12 号
選択された号の論文の6件中1～6を表示しています
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早川 享志原稿種別: 随想（私とビタミン研究）
2023 年 97 巻 12 号 p. 527-539
発行日: 2023/12/25
公開日: 2024/12/31
ジャーナル オープンアクセスPDF形式でダウンロード (1532K) -
津下 英明原稿種別: 総合論文
2023 年 97 巻 12 号 p. 540-551
発行日: 2023/12/25
公開日: 2024/12/31
ジャーナル オープンアクセスADP-ribosylation is a reversible post-translational modification defined by adding ADP-ribose moieties from NAD + to the target. As bacterial toxins, cholera toxin ADP-ribosylates a specific arginine in the Gsα of heteromeric G-proteins, and diphtheria toxin ADP-ribosylates the eukaryotic elongation factor 2 (eEF2). Later, the ADP-ribosylating enzymes in cholera toxin and diphtheria toxin were named ARTC family and ARTD family, respectively, because there is each specific motives characterized ADP-ribosylating enzymes in cholera toxin and diphtheria toxin. We have studied functional studies based on the ARTC crystal structures. We especially revealed the complex structure of Ia-actin and C3-RhoA and the critical recognition mechanism of Arg and Asn ADP-ribosylation. Next, we revealed the ScARP structure, which participates in ADP-ribosylation from GDP. From these studies, we have concluded that although there are various substrates for ADP-ribosylating enzymes, there is a common substrate recognition mechanism regardless of protein and DNA for ADP-ribosylation. In addition, we have studied the protein translocation mechanism in binary toxins, such as C.perfringens iota toxin and C.difficile CDT. Using cryo-EM, we have revealed the binary toxin complex structure and the first unfolding structure of Ia and CDTa in these pore complexes.抄録全体を表示PDF形式でダウンロード (1947K) -
田中 清, 青 未空, 堀尾 文彦原稿種別: 総説
2023 年 97 巻 12 号 p. 552-557
発行日: 2023/12/25
公開日: 2024/12/31
ジャーナル オープンアクセスMany papers have been published on the relationship between vitamin C (VC) and disease risk. However, marked discrepancy exists in the relationship between VC and disease between the observational and intervention studies and the relationship is mostly positive in the former and negative in the latter. In this review article, we make a consideration underlying such discrepancy between VC and cardiovascular disease (CVD) risk.
Cohort and nested case-control studies have almost unequivocally shown that higher VC intake or higher plasma VC concentration is associated with decreased risk of various diseases including CVD. Of note, CVD risk exhibits a linear relationship with plasma VC level, while it exhibits a non-linear relationship with VC intake, which can be explained by the VC’s kinetic characteristics. Since intestinal absorption and renal tubular reabsorption of VC are tightly regulated, plasma VC concentration reaches a plateau with the increased VC intake.
In contrast, the negative results have been reported mostly in the intervention studies including the largest scale one, Physicians’ Health Study Ⅱ, in which more than 7,000 subjects in each group of the placebo and intervention were followed for 8 years. Such results could be explained by the following reasons: most participants are VC-sufficient and vitamin intervention is effective in the deficient subjects, but not in sufficient ones.抄録全体を表示PDF形式でダウンロード (1344K) -
中村 朱里, 福井 浩二原稿種別: トピックス
2023 年 97 巻 12 号 p. 558-560
発行日: 2023/12/25
公開日: 2024/12/31
ジャーナル オープンアクセスPDF形式でダウンロード (1156K) -
佐藤 綾美, 石神 昭人原稿種別: トピックス
2023 年 97 巻 12 号 p. 561-563
発行日: 2023/12/25
公開日: 2024/12/31
ジャーナル オープンアクセスPDF形式でダウンロード (1238K) -
2023 年 97 巻 12 号 p. 564-569
発行日: 2023年
公開日: 2024/12/31
ジャーナル オープンアクセスPDF形式でダウンロード (763K)
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