CHAPTER I Urinary 17-KS
As a fundamental study on the effects of castration and of the administration of sexual hormone on a living body (male), determination of urinary 17-KS was conducted using clinical patients and rabbits as subjects with the following results obtained.
1. Both in human beings and rabbits, urinary 17-KS showed a temporary decrease as a result of castration and then returned to the former state after a certain period of time. This was also the case when unilateral orchiectomy was carried out, only the extent of decrease was slight and the length of time during which it returned to normalcy was shorter.
2. When hexestol (4, 4-Dihydroxy-γ, δ-diethyl-n-hexane) was administered, urinary 17-KS showed a low value permanently, and in the case of P. H. P. (Parahydroxy-propiophenone) it showed a temporary low value as in the case of castration. Honvan (Diethyl dioxystilben-diphosphate) showed a tendency of slight decrease, but the change was not remarkable.
3. When a comparison was made between the administration of estrogene and castration, the decrease of urinary 17-KS was permanent in the former case, and temporary in the latter. Judging from this, it seems advisable in the antiandrogenic therapy of prostatic carcinoma to administer estrogene continuously following castration.
4. In the case of rabbits which underwent bilateral adrenoectomy after castration, urinary 17-KS decreased almost to naught, and in cases where cortisone was administered after castration, it also decrease to between one-third and one-fifth the normal value. Judging from this, it seems that this therapy is worth trying in treating prostatic carcinoma resistant for female hormone though it is open to criticism from various quarters.
5. When testosterone propionate was administer continuously to rabbits simultaneously with bilateral orchiectomy, urinary 17-KS decreased to a slight extent and was restored to the former state in a short time.
6. In the case of testicular insufficiency or dysfunction of sexual gland, the decrease of urinary 17-KS was not striking in many cases owing to the compensative function of the suprarenal gland. It is thought, therefore, that urinary 17-KS plays no more than a secondary part in diagnosing these diseases.
CHAPTER II Humoral Metabolism
In order to investigate the effects of orchiectomy and the administration of sexual hormone on the living body (male), serum electrolyte (Na, Cl, K), body fluid (total body fluid, intracellular and extracellular fluid, circulating blood plasma, circulating blood, intercellular fluid, hematocrit index) and serum protein (volume, analysis, lipoprotein and glucoprotein analysis) were determined. The weight of the kidney and suprarenal gland and their tissue respiration were also determined, with the following results.
1. In the case of dysfunction of sexual gland (eunuchoidism, testicular retention, impotent), no changes in various body fluid metabolites were striking, and in the case of parasexual gland (prostatic hypertrophy and carcinoma) the changes in various body fluid metabolites were not remarkable so long as no dysfunction of kidney or general hyposthenia existed.
2. Orchiectomy, the administration of female hormone, P. H. P. and of Honvan as an antiandrogenic therapy for prostatic carcinoma have a slight effect, if any, on body fluid metabolites. When female hormone was sdministered, however, a decrease of volume of serum protein and increase of γ-globurin were perceived.
3. As a result of orchiectomy of male rabbits, changes appeared in various metabolites (total body fluid, intracellular and extracellular fluid, circulating blood, circulating blood plasma, intracellular fluid, Na, Cl, K, serum protein, A/G index, γ-globurin). But they were only temporary, and returned to normalcy in a short time. The suprarenal gland trophied, and seemed to make recompense.
4. When hexestrol was administered to male rabb

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A case of hemangioma of the urinary bladder in a 26-year-old man is presented, which is associated with Klippel-Weber disease of the right lower extremity. 63 previously reported cases, 48 in the foreign and 15 in the Japanese literature, are reviewed. Of total 64 eleven cases, namely 17. 1 per cent, were associated with other angiomatous lesions.

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