The auther carried out a series of animal experiments to study effect of 1-phenyl-Propanol on the formation of Conteben Calculi and the Nephrocalcinosis due to administration of parathormon.
Changes of the liver function have also been examined simultaneously.
The results are summarized as follows:
1) The formation of Conteben calculi is noticed in 78.6% of the mice by oral administration of Conteben 15mg daily for eight days.
On the other hand, 52.5% of mice developed Conteben calculosis by combined dosage of 2% 1-Phenyl-Propanol and Conteben; and 50.0% mice by 5% 1-Phenyl-Propanol and Conteben.
2) The main factor of 1-Phenyl-Propanol to prohibit formation of Conteben calculi is to increase the protecting of the urinary colloids and the detoxicating function.
3) 1-Phenyl-Propanol also prohibits development of Nephrocalcinosis in case of hypercalcemia in rats by administration of parathormone.
It is because that 1-Phenyl-Propanol works to preserve liver function.
4) The PAS positive substance is seen in the calcified area of the kidney which has the formation of Conteben calculi or the Nephrocalcinosis due to administration of parathormone.
It is thought that a close correlation will exist between development of calcium deposition and changes of the renal tubular epithelium.
5) In case of hypercalcemia in rats by administration of parathormone an impairment of liver is suspected in the histological findings.
6) A close correlation is suspected between hepatic change and degree of calcification of the kidney.
7) There is no noticeable side reaction to the liver and kidney by use of 1-Phenyl-Propanol. The same is confirmed by histological studies.

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1. Purpose of investigation
Hormonal relations are significantly concerned in the development and maintenance of human organisms, and this hold true also in the fetus. During the early period of gestation, the maternal body naturally supplies various hormones, but it is also certain that the endocrine system is fairly well developed at the 2nd, 3rd or 4th month of pregnancy as confirmed by autopsy. It is, therefore, believed that after the fetus has developed to a certain degree, the hormonal relationship is maintained partly by the maternal body and partly by the fetus itself. Hormones are essential particularly at the early stage of fetal life but some are also indispensable during the later stage of gestation. In postnatal life the endocrine demands are met by autogenous secretions and the fetus is in the process of preparation for this vital function. The author made observation on these relationships for the purpose of elucidating the general process of fetal development
2. Methods of Study
The present investigation forms a part of the studies of Japanese fetuses, including the morphology and histological structure of the kidneys and renal pelvis, the ureter, the urinary bladder and the urethra, together with the changes occurring the developmental process. In Report VII an extensive study was made of the fetal body surface with measurements at over 40 different locations. All data and other items on the cases concerned in the present paper are described in the appropriate reports above cited. This investigation, forming Report VIII in the series, utilized fresh materials by autopsy. As soon as the body surface has been measured, the organs of internal secretion, particularly, the hypophysis, thyroid, thymus, adrenals, prostate, seminal vesicle, testis and epididymis are subjected to mensural observations. Furthermore, an experimental study was made on the functional development of pituitary transplantation in animals.
3. Results of investigation
A. The weight of every endocrine organ was measured according to the fetal age from the 4th to the 10th month of gestation and the findings and their summaries have been shown in tables and graphs. The increase in the weight of various endocrine glands indicates the greatest gain to have been attained by the thymus (8226.68mg), followed by the adrenals (3339.66mg), the thyroid (1538.75mg), testis and epididymis (1009.24mg), the prostate-seminal vesicle (688.33mg) and the hypophysis (75.58mg) in the order named.
B. The multiple increase of fetal development during 4-10 gestation months shows 87.83 times for the thymus, 73.41 times for the thyroid, 33.6 times for the prostate and seminal vesicle, 13.09 times for the pituitary, 10.67 times for the testis and epididymis and 6.66 times for the adrenals. These figures, when compared with the body surface values for the same period, are 42.5 times for body weight, 3.29 times for body length 5.76 times for the penis, 4.54 times for both bidigital span and genital fold. These findings indicate that the development of endocrine glands appear so far surpass the general physical growth.
C. During the period specified above the adrenals shows the greatest weight up to the 7th fetal month but the thymus gains in weight after the 8th month. In other words, the adrenals and thymus change their order in matter of weight increase at the 7-8 fetal months.
D. The proportion of the endocrine glands in comparison with body weight reveals:
a) The weight of the hypophysis and adrenals decreases with the progress of gestation.
b) A tendency to parallel increase with body growth is shown by such endocrine glands as the prostate, seminal vesicle, testis, epididymis and thyroid.
c) The thymus gains in weight with the progress of gestation.
The weight of endocrine glands increase as the gestation progresses, but its relation to body weight does not describe a uniformly ascending curve, since it may be descending, parallel

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The diagnosis of primary hyperparathyroidism is very difficult because of following reasons: the tumor of the parathyroid gland cannot be palpable; hypercalcemia, hypophosphatemia, hypercalciuria and hyperphosphaturia are not always specific complications of this disease; and the serum parathyroid hormone cannot be estimated. From these points of view, we must wait for the accumulation of more accurate laboratory evidences before we try to incise the neck which is quite independent to the urinary tract, and for this purpose various laboratory tests are employed.
In this paper, the results of various laboratory clinical tests for diagnosis of this disease are discussed, comparing with the other control groups, and the simplified method for the determination of theoretical renal phosphorus threshold (TRPT) was introduced.
From the results of laboratory tests, I conclude that it is the best way for screening the patient with primary hyperparathyroidism to perform these tests in regular order of following three stages:
1. The First Stage
a) Clinical signs
b) Determination of serum calcium and phosphorus levels
c) Determination of urinary calcium and phosphorus excretions
2. The Second Stage
a) Urine concentration test
b) Estimation of % TRP
3. The Third Stage
a) Calcium tolerance test
b) Calculation of parathyroid index
c) Determination of theoretical renal phosphorus threshold

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On the nine rabbits, which were operatively strictured on the right ureter, focus by staphylococcus was set up by the nasal sinus window method, and Strong Neo-Minophagen C was injected into them every day (about two months).
On 3 cases, calculus or “Steinkrise” was observed on the strictured side; on the other cases it was negative. This is of lower average in comparison with the cases having focal infection only. (They are the cases which were not given an injection of Strong Neo-Minophagen C.) On the group of focal infection, the average is 11/15, as stated in my last report.
As histological observation of the kidney, fibrosis around the blood vessels and its swelling-allergic reaction of the tissue-are slight, and undoubtedly this shows that this drug has anti-allergic effect. Therefore, when urolithiasis is caused by focal infection, it is considered very effective to use Strong Neo-Minophagen C which is anti-allergic agent, together with antibiotics against bacteria in focus.
It has been said that Strong Neo-Minophagen C has strengthening effect on urinary protective colloids; that is, it is prophylactic to stone formation. Nowadays anti-allergic effect of this drug has an important significance at the earliest stage of stone formation.

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Sulfamin, Penicillin etc. was very popular and welcomed at the first, but soon became ineffective after prolonged treatment with large doses. We had been using the former treatment which were not satisfactory.
I had been studied, correlation of pH between mucosa and bacteria, and discovered especially mucosal pH at Ureth. gono. was over 8 (Table 1).
Then, I filled the apparatus (Fig. 1) with phy. NaCl solution, put sekretus in, well mixed, and electrolized. After 30 minutes, the sekretus collected in the Anode (+side).
Concerning cultured gonococcus, bacillus, eosin, fuchsin etc. as well as upper, but small portion of tuberculosis bact. collected in the Cathode as methylen blue. These, I think, will cause that G. Co dyed well with m. b. and Gram negative.
Fig. 2 shows that m. b. infiltrated into rectum mucosa of human body about 5m/m depth as hemisphere.
To apply to urethritis, I used silver bar, wrapped in cotton, wet by 0.05% AgNO₃ solution, which is not only unirritable but also continuously Ag ion is producted (Fig. 3).
Microscoping urethra mucosa, which is excised after the treatment, Ag granula infiltrated into submucosal tissue (Fig. 5).
Low frequency rectangular current is the most convenient form for this therapy compared with another waves (Fig. 4).
(Appendix)
The upper current is also the effective form of stimulation when the patients are suffered from impotencia coeundi (Fig. 6).

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