Forty cases of glandular abnormalities of the uterine cervix were identified histologically by our department from January, 1984 to April, 1992. These included 17 cases of endocervical glandular dysplasia (EGD), 6 of adenocarcinoma in situ (AIS), 5 of microinvasive adenocarcinoma (MI), and 12 of invasive adenocarcinoma (AD). Epithelial mucin and immunohistochemical localizations of CEA, CA19-9, SLX, and STN in EGD and related lesions were examined histochemically. Serial sections were examined by the following procedures : 1) Periodic acid Schiff reaction 2) Alcian blue pH2.5 staining 3) High iron diaminealcian blue pH2.5 staining 4) Immuno-peroxidase method.
Histochemically, sialomucin was predominant in EGD while CEA was predominant in AD immunohisto-chemically. The CA19-9, SLX, and STN antigens were found in EGD. However, they were present in AIS, MI, and AD with increasing frequency, with AD having the highest level.
We noted that initially, glycosynthesis were beginning and aberrant glycosylations were accumulating in EGD. EGD therefore, may involve precancerous lesions. [Adv Obstet Gynecol 45 (5); 589-601, 1993 (H5. 9)]
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