In a mass incidence of bacillary dysentery, 62 so-called healthy carriers were divided into 5 therapeutic groups and their stools were examined every day for 4 weeks.
The following results were obtained:
1) According to the report that hypofunction of adrenal cortex can de detected in carriers, 200mg Cortison a day in 2 times was administed together with tetracyclin 2000mg a day in 4 times. This treatment has proved effective in only 4 out of 9 persons. The improvement of adrenocortical function had consequently no marked effectiveness for the treatment of carriers.
2) The combination of 50mg chloramphenicol (CM)/kg with thiocarbamisin (0.3gm a day for adults and 6mg/kg for infants) for 5 days was effective in 8 out of 13 persons. The results were better compared with the alone use.
3) Lactomin (a powder prepared by desiccation of frozen pure ctlture of streptococcus faecalis) was administed for adults in amount of 5gm a day and 3-4gm for young infants. This medicament proved effective in 2 out of 14 persons.
4) In the case of Sulzol regarded as noneffective because of the endowment of resistance: 3gm a day for adults, 1-2gm for infants for 5 days, excretion of bacilli. could no longer be found in 5 out of 13 cases. Therefor the sulfonamide therapy would have to be reexamined.
5) Five cases with continuous discharge of bacilli for 4 weeks were picked up from the above mentioned groups and given 5mg CM/kg for intravenous use for 5 days. This therapy demonstrated eftectiveness for all the cases. The transitory rise of CM concentration in the blood seems to bring about striking effect on the dysenteric ulcers

View full abstract