1. It was shown that from the feces of hamsters, inoculated perorally with JBE virus suspension, the virus was was excreted for 1 to 4 days after infection. The concentration of the virus in the feces was 10^1.5 to 10^2.5 TCD₅₀.
2. The hamsters fed with meat were less infectious than those with vegetables.
3. When CF test was carried out on the 32nd day after the inoculation with JBE virus, CF titer showed less than 4 times.
4. The group of hamsters which received reinfection on the 30th day after the first inoculation was more resistant than the control group.
More marked histologic changes were observed in cases of reinfection than in those of the primary infection.
In the cases of reinfection were observed the same histologic changes as in those of intracerebral inoculation.

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A non-paralytic polio case only with manifestation of facial paralysis is reported in this paper.
A 3 year-old female was admitted with chief complaints of paralisis of lower facial muscle and orbital muscle. No paralysis of cranial nerves and extremities was noted, except facial one.
This fairly advanced muscle paralysis disappeared after six weeks.
Attempts to isolate causative organismus were made with spinal fluid and stool specimens through HeLa and MK cells resulting in successful isolation of polio virus type 1.
Complement fixation test was repeated from the 7th to the 28th day of illness.
Whereas antibody titer against polio virus type 1 was elevated from 1/16 to 1/32, those against type II and III remined 1/8 even during convalescence.
These clinical and laboratory findings proved this case to be one with polio virus type 1.

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Twenty-one patients of endocarditis lenta (subacute bacterial endocarditis) admitted to the First National Hospital of Tokyo during the past 8-year period were analyzed in this review. The causative organisms isolated from the patients venous or arterial blood stream were Streptococcus viridans in nineteen cases and Streptococcus fecalis in two cases.
There were 13 males and 8 females. The age range of patients was from 11 to 73 years. Thirteen patients had underlying cardiac disease: 5 congenital heart failure and acquired valvular disease.
Dental sepsis or manipulations were frequent possible initiating factors (9/21). The most frequent abnormal physical and laboratory findings were fever (21), cardiac murmurs (21), abnormal ECG (17), hepatomegaly (17), chilly sensation (13), increased erythrocyte sedimentation rate (12) and anemia (12). Seven patients died in the hospital. Younger patients fared much better than those over 31. The advanced age, appearance of the symptoms of infarction and prolonged duration of illness prior to systemic chemotherapy were associated with a poor prognosis. The prognosis did not depend on the number of organisms in the blood stream and presence of the underlying cardiac diseases.
Sensitivity test of the causative organisms revealed that almost all the strains of streptococcus viridance were sensitive to chloramphenicol, tetracycline, erythromycine and penicillin, and partly resistant to streptomycine and sulfa drugs. Two strains of streptococcus fecalis showed a different sensitivity pattern. One was sensitive to all antibiotics beside sulfa and another was resistant to all antibiotics including kanamycine. The latter case was treated successively with a single dosage of aminobenzyl penicllin.

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Sixty patients with septicemia admi tted to the First National Hospital during the past 8-year period was reviewed in this chapter. Six cases confirmed by autopsy and/or bacteriological examination were added to the previously described 54 cases.

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Thirteen patients with the bacillary dysentery and five carriers of the dysentery bacillus were treated by the oral administration of a new nitrofuran delivate “Panfuran S”.
In the in vitro sensitivity test, various strains of dysentery bacillus were extremely sensitive against this drug.
In the majority of the cases, acute symptoms subsided rapidly, and stool culture became negative soon after the beginning of the treatment. However, there were a severe case, where no effect of this drug was recognized for the improvement of symptoms, and a case, where stool cultures remained positive for a long time after the treatment.
No side effects were seen.

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1. A new Nitrofuran derivate, 3-di (hydroxylmethyl)-amino-6 (5'-nitrofurylethenyl)-1. 2. 4-triazine (Panfuran 5) was administered to 39 cases of bacillary dysentery.
2. In order to avoid side effects, these cases were divided into 3 groups of the following daily dosis; 8 mg/Kg, 16 mg/Kg and 32 mg/Kg, for 5 days, respectively.
3. A marked effect (decrease in the number of stools) was not recognized against diarrhea in the acute stage of severe and moderate cases of the 3 groups.
4. Bacilli disappeared in each group within 10 days. It was also the case with anitibiotic-resistant strains.
5. Reappearance of bacilli was observed in 50% of the 8 mg/Kg group, in 36% of the 16 mg/Kg group and in 14% of the 32 mg/Kg group. This tendency, decrease of reappearance rate with increased dosis, was also observed in cases due to antibioticresistant strains, no reappearance of bacilli in the 2 cases of the 32 mg/Kg group.
6. Consequently, Panfuran S without side effects in daily dosis, 32 mg/Kg or more should be considered in therapy of bacillary dysentery, especially due to antibioticresistant strains.

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