Vibrio parahaemolyticus is an important causative organism in food poisoning during the summer in japan. No report has, however, been made on sensitivity of the organism to various drugs. To select therapeutic agents for enteritis due to
Vibrio parahaemolyticus, drug-sensitivity of the
Vibrio was tested. At the same time
Vibrio El- Tor strain was also examined for drug-sensitivity and comparison was made between patterns of the drug-sensitivity of both organisms. Experiments were carried out using 860 strains of
Vibrio parahaemolyticus, 17 strains of
Vibrio alginolyticus and 100 strains of
Vibrio El-Tor.
The results obtained are as follows:
1) Nalidixic acid (NA), Demethylchlortetracycline, Tetracycline (TC) and Chloramphenicol (CP) showed marked antimicrobial activity against V. El-Tor, MIC of Streptomycin (SM) and Kanamycin (KM) being about 12.5 mcg per ml. Among agents of nitrofuran series, Dihydroxy-methyi-furatrizine (FT) was noted to have the most remarkable antimicrobial activity.
2) Against
Vibrio parahaemolyticus FT was most effective being followed by CP, TC and NA in order.
3) Both SM and KM which were found to be inhibiotry to some extent against the growth of
V. El-Tor showed a remarkably low antimicrobial activity against
V. parahemolyticus. A distinct difference was observed between them about sensitivity to these drugs.
4) Also against the both organisms Colistin was definitely less effective.
5) Drug-sensitivity of
V. parahaemolyticus had no relation to the bacterial type. In addition, no difference in drug-sensitivity was observed between
V. parahaemolyticus and
V. alginolyticus.
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