Journal of the Japanese Association for Infectious Diseases

1. Suppression of normal intestinal microbial flora in mice had developed about 8 hours after oral administration of 7500 μg of streptomycin (SM) and the equal dose of erythromycin (EM), but on the 48 hour after the treatment, the flora became normal in number of microorganisms.
2. Mice administered with SM-resistant Shigella bacilli within a period of 8 hours after receiving SM and EM, were proved to excrete Shigella bacilli continuously in feces for about a week, and thereafter, SM-resistant E. coli bagan to appear instead of Shigella.
3. Using the mice treated as mentioned above, influence of Clostridium butyricum to the excretion of Shigella was studied. It was demonstrated that, as a result of inhibiting effect on the proliferation of Shigella bacilli, Cl. butyricum stimulates the establishment of resistant E. coli in intestine of mice.

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Until 1950 some significant reports dealing with human infection with Salmonella choleraesuis appeared in the literature. Since then, however, no additional report has been published in Japan.
The purpose of this paper is to present a case of human infection with Salmonella choleraesuis. Our case study dealt with a septic woman who came to the attention of our clinic at the age of 27 years with the complaints of fever and jaundice that occurred immediately after abortus. During the course of the disease she developed pain and swellings in the upper and right lower portions of the chest, right tibia, right index finger and so on. Incision was performed in the left upper portion of the chest and a small quantity of pus was yielded. A culture was taken of the pus and revealed Salmonella choleraesuis which was determined by serological and biochemical procedures. Venous blood culture was also positive for Salmonella choleraesuis.

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