In order to investigate the role of the RES in the nonspecific resistance, mice were infected with dysentery bacilli after the administration of Typhoid-Paratyphoid vaccine (T-P vaccine), zymosan and carbon particlees (Pelikan ink).
Alterations in the phagocytic activity of the RES, rectal temperature, white blood.cell count in the circulating blood, rate of clearance of intravenously injected dysentery bacilli, resistance against dysenterial infection and the histological changes in the liver and. spleen were examined in the animals.
The following results were obtained.
1) After the administration of T-P vaccine and zymosan the phagocytic activity of the RES was elevated as well as the resistance against dysenterial infection.
2) The elevated resistance and the phagocytic activity due to the above substances were lowered by the blockade of the RES with intravenously injected carbon particles.
3) The elevation of the resistance and the phagocytic activity by these substances were prevented by the prior blockade of the RES.
4) After the administration of T-P vaccine the rectal temperature showed a slight.decline and the white blood cell count in the circulating blood decreased markedly
5) The rate of clearance intravenovsly injected dysentery bacilli incresed in theanimals inoculated with T-P vaccine, whereas it was lowered by the blockade of the RES.
6) There was a parallel change between the clearance rate of dysenteriy bacilli and.the resistance against them.
7) The administration of T-P vaccine affected the distribution of intravenously injected carbon particles within the liver, Spleen, lungs and kidneys.
8) In the group inoculated with T-P vaccine, there were few abscesses in the liver 24 hours after the intravenous injection of dysenterial bacilli.
On the contrary, in the groups into which carbon particles were injected after T.P' vaccine was given after carbon particles, as in the controll group, many abscesses were observed in the liver.

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