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Volume 37, Issue 7
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Yoshio MATSUI1963 Volume 37 Issue 7 Pages 233-236
Published: October 20, 1963
Released on J-STAGE: November 25, 2011
JOURNAL FREE ACCESSDysentery cases due to antibiotic resistant bacilli have increased in number since 1962 in Shimizu city, 21 antibiotic-resistant cases being undcr 147 cases.
In treatment of these 21 cases and a case of typhoid fever caused by chloramphenicol resistant bacilli, Paromomycin proved to be significantly effective.
Paromomycin was administered to adults 0.5 gr each 6 hours (2 gr a day) for 4 days.
In dysentery, stool culture of bacilli turned negative in 18 out of 21 cases. Reappearance of bacilli (of the same strain) was observed only in 3 casesesView full abstractDownload PDF (362K) -
Yoshito SAHEKI, Yoshinori WAGATUMA, Hiroo IIDA, Norio SAKURADA, Nanao ...1963 Volume 37 Issue 7 Pages 237-240
Published: October 20, 1963
Released on J-STAGE: November 25, 2011
JOURNAL FREE ACCESSAn epidemic of Herpangina due to Coxsackie A5 virus occurred in Sapporo City during spring and summer in 1961.
Results of the clinical, epidemiological and virological examination were reported elsewhere.
The present paper deals with a case in which viremia was demonstrated at the beginning of the disease.
Clinical details of the patients, results of the virological and serological examination and pathological findings in inoculated suckhng mice are reported.View full abstractDownload PDF (3048K) -
Yasuzo NAKAMIZO, Ryoji TAKAHASHI, Ei TANAKA1963 Volume 37 Issue 7 Pages 241-247
Published: October 20, 1963
Released on J-STAGE: November 25, 2011
JOURNAL FREE ACCESSNalidixic Acid (Win 18, 320) is a new naphthyridine derivative synthesized by Lesher at the Sterling-Winthrop Research Institute. In general, Nalidixic Acid possesses more potent bacteriostatic activity against Gram-negative than against Gram -positive pathogens.
Nalidixic Acid was applied to 36 patients of bacillary dysentery for the purpose of in-vestigating its anti-Shigella activity, clinical effectiveness and the increase of resistance through successive in vitro cultures.
1. The sensitivity of dysentery bacilli against Nalidixc Acid ranged from 3.1mcg/ml to 6.2mcg/ml, and this bacteriostatic effect was same both in 3-drugs (Streptomycin, Tetracycline, Chloramphenicol)-sensible strains and 3-drugs-resistant strains.
2. Nalidixic Acid was effective in doses of 40mg/kg/day for five days.
3. By the treatment with Nalidixic Acid the recovery of the stools in number and character was reached within 2-3 days and Shigella excretion subsided also within 2-3 days.
4. Rate of reappearance of Shigella bacilli in the stool after the treatment was 8.4%.
5. Generally it was demonstrated that clinical effect of Nalidixic Acid in severe cases of bacillary dysentery was almost equal to those of Tetracycline and Chloramphenicol.
6. The increase of resistant in vitro experiment against Nalidixic Acid was inhibited only when this agent had been combined with Zygomycin.
7. Signs or symptoms which might be regarded as side effects could not be noted in any of our cases.View full abstractDownload PDF (938K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1963 Volume 37 Issue 7 Pages 248-269
Published: October 20, 1963
Released on J-STAGE: November 25, 2011
JOURNAL FREE ACCESSDownload PDF (5914K) -
1963 Volume 37 Issue 7 Pages 285-286
Published: October 20, 1963
Released on J-STAGE: November 25, 2011
JOURNAL FREE ACCESSDownload PDF (251K)
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