Journal of the Japanese Association for Infectious Diseases

It was recognized.t hat the pernasal inoculation of JBE virus established the infection. In the case of pernasal inoculation, JBE virus invaded into the lymph and blood stream to cause general viremia. JBE virus given pernasally was not detected in stool. Virus given pernasal got to the central nerves and caused such histological changes as were noticed when it was inoculated directly into the brain. When CF test was measured on the 23rd day after the inoculation with JBE virus, CF titer showed 8 times.

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Investigations were carried out on the combined use of various drugs against antibiotic-resistant strains of dysentery bacilli.
Combined use of 2 drugs were studied with 49 combinations revealing the following 6 combinations to demonstrate an increase of antibiotic activity against drug-resistant strains: TC-KM, TC-PM, TC-Pol-B, TC-B.E, TC-FM and CP-Pol-B. Synergistic effects were noticed only between FM and Vic. On the other hand, antagonistic effects were noticed between KM and Co.S and in other 17 combinations, whereas the other 25 combinations demonstrated neither synergistic nor antagonistic effects. These results might suggest no great expectation on an increase of antibiotic activity by combined use.
Prevention of the acquirement of antibiotic resistance was investigated with 3 combinations of 2 drugs. FM-Vic and KM-Co.S demonstrated an inhibition of increase of resistance against Vic and KM, whereas KM-TC raised more rapidly drug-resistance as compared with alone use.

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