As the third of this series, following Report I and II which presented data on possessing rate of neutralizing antibody to rubella virus among inhabitants of Kumamoto city and Tokyo city, respectively, this report offered data on the same matter among some inhabitants of Otsu city and its suburb.
Serum samples tested were 420 in total, that were mainly obtained from pregnant women visiting prefectural Otsu Hospital during a period from May to July in 1966, from pupils of a school of the blind, and from school children of the First and Second Biwako Gakuen; the latter two were tested in June to July in that year.
At first, the antibody possessing rate by age distribution and by sex among all persons tested is described, then in considering the particular concern which has been existing about relationships between rubella and intra-uterine infections and some congenital eye diseases, the data on the pregnant women and the blinds are commented separately. Further, in pre-adult cases, a comparative study was made with HI antibody possessing rate to measles virus.
1) The antibody possessing rate by age distribution among all persons tested was as follows: It began to rise at 10, as was the case in Kumamoto city, and reached a maxmum, about 55%, at 20 to 24, showing no appreciable decline thereafter. This curve is considerably lower than reported figures on Tokyo (in Report II), Osaka, and New York city, and a little higher than that of Kumamoto city (Report 1). This probably means that no rubella epidemics of appreciable size have been experienced in and around Otsu city in the past ten years.
2) No difference of worth mentioning in the possessing rate by sex was observed in any age group, as was the case in Kumamoto city.
3) Possessing rate of the antibody among the pregnant women in the city was about 50%, the figure considerably lower compared with that of large city of Japan, such as Tokyo or Osaka. That means the risk of infection at the time of pregnancy is higher here.
4) There was no evidence suggestive of whether the cases with congenital eye diseases were related, in whatever degree, with intra-uterine transmission of the virus at their mothers' pregnancy.
5) To pre-adult age groups, mainly consisting of pupils of the First and Second Biwako Gakuen, measuring of HI antibody to measles virus was paralleled. It showed an average of the nation's statistics for their age.

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The most characteristic change in the recent epidemiological aspects of bacillary dysentery in this country is the prevalence of Shigella Sonnei as causative agents. The trend has been seen since 1962 and the percentage of them in Shigella isolations throughout the country has surpassed 70%, most recently. Mass outbreaks due to Shigella sonnei have also been increasing year by year. In Yamaguchi prefecture, there were as many as 21 bacillary dysentery epidemics in 1966, all of which were due to Shigella Sonnei.
In these circumstances in this country, interest in colicine typing of Shigella sonnei has increased rapidly and as the reports available accumulated, the reliability of this technique as an epidemiological marker has become widely recognized.
In this paper, the authors presented the results of colicine typing done by Abbott and Shannon's method on 1, 028 strains of Shigella sonnei ; 788 strains of them were those originated from 31 epidemic occasions occurring in Yamaguchi prefecture from July, 1963 to June, 1966; the remaining 240 were those isolated in 1966 in its neighboring prefectures, namely Tottori, Shimane, Ehime, Tokushima and Ooita prefecture, and sent to this institute.
It was proved that most of these strains belonged to either of two groups; one is a group compounding Type 4 and Type 14, the other a group compounding Type 6 and Type 11. It, however, is hard by usual technique to separate either Type 4 from Type 14 or Type 6 from Type 11. Then, in order to distinguish them, the authors applied Fredericq's agar stabbed technique Using three mutants of Escherichis coli K12 (Row/E, Row/I, K 12-30/I) as additional indicators in accordance with Okada's advocacy.
In 31 epidemics in Yamaguchi prefecture, 12 were proved caused by Type 14, 7 were by Type 0, 6 were by Type 6, 3 were by Type 4 and one was by Type 13; the remaining two occasions were found caused by mixed two types, Type 0 and Type 14 in one and Type 0 and Type 6 in another. There found some colicine types other than types above mentioned, though each being in a small number.
In strains sent from the neighboring prefectures, Type 14 maintained the most superior position in number, Type 6 ranked next, and Type 2 and Type 0 followed in order. Besides, a small number of Type 4, 5, 3, 8, 13 and 3A were also found.

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A total of 47 patients of bacillary dysentery admitted to this hospital from April to September 1967, 32 (68%) of which were due to CP, TC, SM resistant bacilli, were treated with combination of Methacolimycin (MCM) and Wintomylon (NA).
Daily dose of 0.8g (24, 000, 000 Units) of MCM and 3.0g of NA in adults, 0.4g (12, 000, 000 Units) of MCM and 2.0g of NA in children, were given on 4 times per day in successive 5 days.
All the patients treated haven't shown bacillary reemergence within 2 weeks after the treatment.

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