The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
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Volume 22, Issue 10
Displaying 1-14 of 14 articles from this issue
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  • STUDIES ON SIOMYCIN. V
    DERIVATIVES OF SIOMYCIN A PREPARED WITH THIOLCARBOXYLIC ACID
    MITSUO EBATA, KUNIKO MIYAZAKI, HIDEO OTSUKA
    1969 Volume 22 Issue 10 Pages 451-456
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.451
    JOURNAL FREE ACCESS
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    Derivatives of siomycin A were prepared by reaction with thiolcarboxylic acids such as thioglycolic acid or thiomalic acid. Sodium salts of the derivatives were remarkably soluble in water, while the parent siomycin A was quite insoluble. These " soluble derivatives " of the antibiotic were still active against many Gram-positive bacteria, although the activities were approximately one fifth of that of siomycin A.
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  • AABOMYCIN A, A NEW ANTIBIOTIC. I
    PRODUCTION, ISOLATION AND PROPERTIES OF AABOMYCIN A
    SHOJIRO AIZAWA, YUKO NAKAMURA, SHIRO SHIRATO, RYUSUKE TAGUCHI, ISAMU Y ...
    1969 Volume 22 Issue 10 Pages 457-462
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.457
    JOURNAL FREE ACCESS
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    Aabomycin A is a new antifungal antibiotic produced by a hitherto unidentified species of the genus Streptomyces. The active substance in fermented mash may be purified by solvent extraction followed by the chromatography on alumina column and then crystallization. Aabomycin A is easily soluble in many organic solvents, but is insoluble in water. It exhibits inhibitory activity against many fungi, especially against Piricularia oryzae, and has limited antiviral activity. The toxicity of aabomycin A for higher plants and animals is very low. Aabomycin A is similar in some properties to a few known antifungal antibiotics but differs from them in certain special characteristics.
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  • AABOMYCIN A, A NEW ANTIBIOTIC. II
    BIOLOGICAL STUDIES ON AABOMYCIN A
    ISAMU YAMAGUCHI, RYUSUKE TAGUCHI, KENG TANG HUANG, TOMOMASA MISATO
    1969 Volume 22 Issue 10 Pages 463-466
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.463
    JOURNAL FREE ACCESS
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    The effects of aabomycin A on Piricularia oryzae, the causative agent of the rice blast disease and on the multiplication of Tobacco Mosaic Virus (TMV) were examined. Aabomycin A exhibited marked inhibition on the whole life cycle of P. oryzae including spore germination, mycelial growth and sporulation. The spore germination was the most influenced. The inhibitory activity of aabomycin A was not decreased in kasugamycin-resistant and blasticidin S-resistant clones. The rice blast disease on rice plants was remarkably suppressed by aabomycin A at a concentration of 20ppm. It showed a protective effect rather than a curative effect, contrary to blasticidin S. No phytotoxicity was observed, even at a concentration of 1, 000ppm. The multiplication of TMV was remarkably inhibited by aabomycin A at a concentration of 1-100mcg/ml and no phytotoxicity was observed even at a concentration of 1, 000mcg/ml.
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  • STUDIES ON SUBSPORIN. I
    ISOLATION AND CHARACTERIZATION OF SUBSPORINS A, B AND C
    MITSUO EBATA, HUNIKO MIYAZAKI, YASUO TAKAHASHI
    1969 Volume 22 Issue 10 Pages 467-472
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.467
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    From the culture of Bacillus subtilis PCI 219, three new peptide antifungal substances were isolated. Based on the physicochemical properties of the three antibiotics, they were named subsporins A, B and C. Subsporin A, the main component of the antibiotic mixture, consisted of fourteen amino acidresidues and of a nitrogen-containing long chain compound. Constituent amino acids of subsporin A were L-Asp4, D-Asp2, D-Tyr2, L-Glu2, L-Pro2 and D-Ser2. Subsporins are active against filamentous fungi and yeast, while no activity is observed against bacteria.
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  • STUDIES ON TSUSHIMYCIN. II
    THE STRUCTURES OF CONSTITUENT FATTY ACIDS
    JUN'ICHI SHOJI, HIDEO OTSUKA
    1969 Volume 22 Issue 10 Pages 473-479
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.473
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    The constituent fatty acids of the antibiotic tsushimycin were examined by gas-liquid chromatography, mass spectrometry, nuclear magnetic resonance and infrared spectroscopy. Also, periodate-permanganate oxidation unequivocally indicated the position of double bonds. The structures of two major constituent fatty acids were determined as cis-3-isotetradecenoic acid and cis- 3-anteisopentadecenoic acid. As a result of parallel experiments, the main constituent fatty acid of the antibiotic amphomycin was also elucidated as cis-3-anteisotridecenoic acid.
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  • STUDIES ON THE EFFECT OF ADMINISTRATION OF TETRACYCLINE ON FREE FATTY ACID METABOLISM IN ADRENALECTOMISED AND CONTROL RATS
    DEBESH MUKHERJEE, HEMEN GHOSH, SUPROVAT MUKHERJEE
    1969 Volume 22 Issue 10 Pages 480-483
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.480
    JOURNAL FREE ACCESS
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    Administration of therapeutic doses of tetracycline hydrochloride to rats results in increased accumulation of triglyceride in the liver. Phospholipid concentration of the liver is decreased under such conditions, whereas both free and esterified cholesterol levels remain unaffected. Elevation of the free fatty acid level of plasma, induced by tetracycline administration, is due to increased mobilisation of free fatty acids from adipose tissue. The antibiotic was found to be ineffective in stimulating the mobilisation of free fatty acids from the epididymal fatpad of adrenalectomised rats.
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  • THE JOURNAL OF ANTIBIOTICS OCT. 1969 TRANSMISSION OF THE R FACTOR BY CONJUGATION FROM A NATURALLY-ISOLATED, MULTIPLE DRUG-RESISTANT STRAIN OF VIBRIO ELTOR TO SHIGELLA AND SALMONELLA
    SACHIKO GOTO, SHOGO KUWAHARA
    1969 Volume 22 Issue 10 Pages 484-489
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.484
    JOURNAL FREE ACCESS
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    Out of the four multiple drug-resistant strains of El Tor vibrio which were isolated in the Philippines in 1964 and 1965, one strain (D226) was confirmed to transmit its quadruple drug-resistance to sensitive strains of Salmonella and Shigella. The recipients maintained their resistance after repeated subcultures in drug-free media, and are able to transfer their resistances to sensitive strainsof Vibrio and Aeromonas. The resistant strains thus obtained lost easily their transmitted resistance after a few subcultures in drug-free media. The remaining three triple-resistant strains of El Tor vibrio failed to transmit their resistance. These strains maintained their resistance quite stably during several years, although the strain D226 lost its resistance about one year afterisolation.
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  • THE DIUMYCINS
    NEW MEMBERS OF AN ANTIBIOTIC FAMILY HAVING PROLONGED IN VIVO ACTIVITY
    EDWARD MEYERS, DOROTHY SMITH SLUSARCHYK, JACQUELINE L. BOUCHARD, FRANK ...
    1969 Volume 22 Issue 10 Pages 490-493
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.490
    JOURNAL FREE ACCESS
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    The diumycins are new members of a group of phosphorus-containing antibiotics that provide prolonged protection to mice infected with Streptococcus pyogenes. The diumycins are differentiated from other group members by their amino sugar composition.
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  • STUDIES ON THE ANTIBIOTICS FROM STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS. I
    TAXONOMIC AND FERMENTATION STUDIES WITH STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS
    SHINJURO NAMIKI, SADAFUMI OMURA, HIROSHI NAKAYOSHI, JIRO SAWADA
    1969 Volume 22 Issue 10 Pages 494-499
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.494
    JOURNAL FREE ACCESS
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    Streptomyces sp. TPR-885 which produced the new antibiotics, kujimycins, was isolated from a soil sample from the Kuji District of the Ibaragi Prefecture, Japan. The strain belonged to a chromogenic type of Streptomyces similar to St. spinichromogenes, St. griseochrontogenes and St. cavourensis. From the taxonomic studies, the strain TPR-885 resembled with St. spinichromogenes in the morphological and physiological properties. This strain was accordingly named Streptomyces spinichromogenes var. kujimyceticus. It produced in excess of 150 mcg/ml of kujimycins in flask and jar fermentation, and the kujimycins showed inhibitory activities against gram-positive bacteria and Mycobacteria.
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  • STUDIES ON THE ANTIBIOTICS FROM STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS. II
    ISOLATION AND CHARACTERIZATION OF KUJIMYCINS A AND B
    SADAFUMI OMURA, SHINJURO NAMIKI, MICHINORI SHIBATA, TOSHIO MURO, HIROS ...
    1969 Volume 22 Issue 10 Pages 500-505
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.500
    JOURNAL FREE ACCESS
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    Two new antibiotics, kujimycins A and B, were isolated from the fermentation broth of Streptomyces sp. TPR-885 and purified by the extraction with ethyl acetate, gel filtration on Sephadex LH-20 and silica gel column chromatography. Kujimycin A was obtained as colorless powder, m. p. 114-115°C, C40H70O15. Kujimycin B was obtained as colorless prisms, m.p. 178-180°C, C42H72O16. They were suggested to be neutral macrolides which have antimicrobial activities against Gram-positive bacteria.
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  • STUDIES ON SIOMYCIN. IV
    ACYL DERIVATIVES OF SIOMYCIN A
    MITSUO EBATA, KUNIKO MIYAZAKI, HIDEO OTSUKA
    1969 Volume 22 Issue 10 Pages 506-507
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.506
    JOURNAL FREE ACCESS
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  • A VOLATILE METABOLITE OF ACTINOMYCETES, 2-METHYLISOBORNEOL
    NANCY N. GERBER
    1969 Volume 22 Issue 10 Pages 508-509
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.508
    JOURNAL FREE ACCESS
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  • TRANS-3-(METHYLTHIO)- ACRYLIC ACID, A NEW METABOLIC PRODUCT FROM STREPTOMYCES LINCOLNENSIS
    J. VISSER, H. F. MEYER
    1969 Volume 22 Issue 10 Pages 510
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.510
    JOURNAL FREE ACCESS
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  • THE MOLECULAR STRUCTURE OF ASCOCHLORIN
    YOSHIHARU NAWATA, KUNIO ANDO, GAKUZO TAMURA, KEI ARIMA, YOICHI IITAKA
    1969 Volume 22 Issue 10 Pages 511-512
    Published: October 25, 1969
    Released on J-STAGE: April 12, 2006
    DOIhttps://doi.org/10.7164/antibiotics.22.511
    JOURNAL FREE ACCESS
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