Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Search
Advanced search
OR
Browse
Search
Volume 52, Issue 1
Displaying 1-17 of 17 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Contents
  • Retraction: Activation of endogenous adult neural stem cells to promote functional recovery following stroke
    RYOTA TANAKA
    2006 Volume 52 Issue 1 Pages 2-10
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.2
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We hereby notify, in relation to “Ryota Tanaka: The therapeutic potential for cerebral infarction using neural stem cells” published in Juntendo Medical Journal, Vol.52, No.1 (2006), pp.2-10, as follows: 1. A foreign researcher has claimed that the author published the researcher's paper containing unpublished diagrams and figures as the author's own article without obtaining prior con-sent from him. The author accepted the claim and agreed to withdraw the article. 2. Therefore , we have decided to suspend the publication of the article , and deleted files con-taining it in the retrieval system on the Internet. 3. We would like to ask readers to delete the article mentioned above from the printed versions of Juntendo Medical Journal.
    View full abstract
    Download PDF (1841K)
  • For the sick children
    HIROYUKI KOBAYASHI
    2006 Volume 52 Issue 1 Pages 11-27
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.11
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The field of pediatric surgery covers the treatment of a variety of conditions, and of these, 1.organ transplantation, 2. Hirschsprung's disease (HD) and HD related disorders, 3. pyloric stenosis (PS), 4. congenital diaphragmatic hernia (CDH), 5. vesicoureteric reflux (VUR), and biliary atresia (BA) are drawing attention because of basic clinical research. A feature of pediatric surgical conditions is that most are considered to be congenital, and as a result, research focuses on identifying etiologic factors. Recently, study of the long-term outcome of conditions that progress during postoperative follow-up has become possible, and research into management options has become popular as a consequence. In this report, the authors discuss what can be done for children suffering from the abovementioned conditions by explaining their latest research results simply, and referring to recent findings.
    View full abstract
    Download PDF (4515K)
  • Mechanism of protective effects of magnesium on cardiac reperfusion injury
    TAKAO OKADA
    2006 Volume 52 Issue 1 Pages 28-34
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.28
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A high concentration (12mM) of magnesium (Mg) during hypoxia accelerated reoxygenation-induced contractile recovery and improved the final level of pressure development in an isolated rat heart. This protective effect of Mg was not solely due to its effect as a “natural Ca blocker”, but seemed due to the opening of the mitochondrial KATP channel. High Mg-treated myocytes showed morphologically intact mitochondria and ther membrane potential remained near normal after prolonged hypoxia-reoxygenation.
    View full abstract
    Download PDF (1520K)
  • Role of anesthesiologists in medical care
    EIICHI INADA
    2006 Volume 52 Issue 1 Pages 35-44
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.35
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Anesthesiologists play an important role in the anesthetic management of various surgical patients, postoperative care, and intensive care because anesthesiologists are accustomed to manage critically ill patients under acute stresses such as trauma, surgery and exacerbation of medical illness. Anesthesiologists also play a key role in the management of patients with chronic pain and those with terminal illness. Another role of anesthesiologists is the management of operating theaters and intensive care units. Both the Japanese Society of Anesthesiologists and American Society of Anesthesiologists have engaged in risk management programs including closed claims projects and the establishment of standard practices enthusiastically for a decader. Unfortunately, the important role of anesthesiologists in medical care remains poorly understood, and the shortage of anesthesiologists is an important social issue.
    View full abstract
    Download PDF (1615K)
  • Research history for keratinizing disorders at Department of Dermatology, Juntendo University School of Medicine
    SHIGAKU IKEDA
    2006 Volume 52 Issue 1 Pages 45-54
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.45
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    (Congenital) keratinization disorders are a group of rare and origin-unknown diseases in which many responsible genes have been identified recently in accordance with advances in molecular genetics techniques. In this presentation, we have summarized the clinical findings and identified the disease-gene of each (major) keratinization disease in addition to the history of clinical and basic research for keratinization disorders performed in the Department of Dermatology, Juntendo University School of Medicine. These observations indicated that keratinization disorders are defined as being caused by mutations in the genes specifically expressed in keratinocytes. Moreover, keratinocytes are unexpectedly multifunctional.
    View full abstract
    Download PDF (2344K)
  • Gender identity disorder
    TERUO ABE
    2006 Volume 52 Issue 1 Pages 55-61
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.55
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    In the past ten years, situations relating to Gender Identity Disorder (GID) have changed greatly in Japan. In 1997, the Japanese Society of Psychiatry and Neurology established guidelines for GID Diagnosis and Treatment, and a publicly acknowledged Sex Reassignment Surgery (SRS) was held for the first time in Japanese history in 1988. Furthermore, in 2003, the GID law was enacted to enable people with GID to change their gender on their Koseki (Family Census Register) when they meet certain conditions established under this law. Now there is a new trend among those who were self-diagnosed with GID and opted to receive hormone treatment and surgical procedures. They now seek an official diagnosis with letters of support from two independent psychiatrists in order to be eligible for their Koseki gender change. University hospitals in different regions are making efforts to meet the large and increasing number of patients but their facilities are stretched. In this paper, the basic concept of GID based on my experience with approximately 1,500 cases will be presented with a focus on the differences between primary GID and secondary GID, the differences between homosexuality and GID, and some important issues for the future. In addition to this, the key topics and issues that general praetitioners should be aware of when they engage in the diagnosis and treatment of GID will be presented.
    View full abstract
    Download PDF (1127K)
  • Evaluation of the expression of pyrimidine metabolic enzyme genes in colorectal cancer cells using the Danenberg tumor profile method
    TETSURO YAMAMOTO, NAOHITO TAKITA, HIRONOBU SENGOKU, TAKESHI OKADA, MIT ...
    2006 Volume 52 Issue 1 Pages 62-68
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.62
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : Recently, a novel technique was developed by Danenberg (Danenberg Tumor Profile method ; DTP method), by which we can measure the expressions of various genes separately, in tumor and normal cells microdissected from paraffin-embedded specimens. In this study, we evaluated the mRNA expression of pyrimidine metabolic enzymes in tumor and normal cells using this technique. Materials and Methods : Paraffin-embedded specimens of tumor and adjacent normal tissues were obtained from 33 patients with colorectal cancer. Expression of mRNA transcripts for thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT) and thymidine phosphprylase (TP) was measured by the real time reverse transcript-polymerase chain reaction method after RNA extraction from tumor and normal cells microdissected from the specimens. Results : The OPRT mRNA expression level in tumor cells was significantly higher than that in normal cells (p<0.001), while DPD mRNA expression in tumor cells was significantly lower than that in normal cells (p<0.001). There was no correlation in the mRNA expression of TS, DPD, TP and OPRT mRNAs between tumor and normal cells. In both tumor and normal cells, however, there were significant correlations between TS mRNA and OPRT mRNA, and between DPD mRNA and TP mRNA. Conclusions : The pattern of mRNA expression of pyrimidine metabolic enzymes in tumor cells, with enhanced DNA synthesis, suggested the sensitivity of tumor cells to 5-fluorouracil (5-FU). We believe that the DTP method is very useful for evaluation of the clinical significance of colorectal cancer by measuring the expression of genes for the pyrimidine metabolic enzymes separately in tumor cells and stromal cells of tumor tissues.
    View full abstract
    Download PDF (853K)
  • Usefulness and Potential a New Method of Enteroscopy (double-balloon method)
    HISASHI HARADA, YOSHIYUKI TAKEI, AKIHITO NAGAHARA, KAZUKO BEPPU, NAOTO ...
    2006 Volume 52 Issue 1 Pages 69-75
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.69
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : We evaluated the applications, usefulness, and potential of double-balloon enteroscopy as a new therapeutic approach. Object and Method : Fifty-six patients treated at Urayasu Ichikawa City Hospital between June 2004 and July 2005 were selected (M : F sex ratio 39 : 32, mean age 58.3 years). The 71 patients presented with gastrointestinal bleeding and/or positive fecal occult blood test or abdominal pain. However, there was no lesion causing hemorrhage detected on either upper or lower gastrointestinal endoscopy. Reasons for the examination were as follows : 49 cases of positive fecal occult blood test and melena, 21 cases of abdominal pain, and 1 case receivins stent placement. Results : In 55 cases (78.6%), we successfully performed total enteroscopy. Of the 49 melena cases, angiodysplasia was the most common lesion detected (26 cases=53.1%), and ileal ulcers (6 cases), polyps (3), Meckel diverticulum (2), gastric ulcer (1), jejunal stromal tumor (1), and Crohn's disease (1) were also detected. In nine cases, there were no culprit lesions detected. In all 26 cases of angiodysplasia (64 lesions), hemostatic therapy was successful, and there was no recurrence during the two-to thirteen-month observation periods. In five of the twenty-one abdominal pain cases, inflammatory small bowel disease, and in two cases, ileal ulcers were detected. However, there were no lesions found in the remaining fourteen cases. The only case receiving stent placement was an inoperable case of advanced colorectal cancer in the ascending colon, and stent placement was performed relatively easily using the double-balloon method. Conclusion : Double-balloon enteroscopy was useful for diagnosis of the small intestine lesion. With this method, hemostatic therapy and polypectomy were possible, and it also enabled endoscopic ultrasonography, balloon dilation, and stent placement in the deep colon. s
    View full abstract
    Download PDF (1002K)
  • Macrodomain formation of alveolar endothelial cells during perinatal lung maturation
    HIROSHI NAGANO, HIDETAKE KURIHARA, KATSUYUKI KINOSHITA, TATSUO SAKAI
    2006 Volume 52 Issue 1 Pages 76-83
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.76
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objectives : During the perinatal lung development, dramatic anatomical and functional changes occur in the organ. Continuous alveolar formation is necessary for lung maturation after birth. Vascularization and formation of air-blood barrier are included in the event. In the present study, we investigated the expression of alveolar endothelial cell surface proteins during lung maturation. Methods : Lung tissues from fetal (day 20 of gestation), postnatal and mature (8-week-old) Wistar rats were prepared for immunocytochemistry and electron microscopy. Lysates from those tissues were prepared for immunoblot analysis. Several antibodies against endothelial cell surface proteins (Podocalyxin, ICAM2 and I-10 antigen) were used in this study. Results : Podocalyxin, a major sialoglycoprotein of endothelial cells, and ICAM2 were constantly expressed on the whole cell surface of pulmonary capillary endothelial cells during lung maturation. I-10, a new monoclonal antibody raised against isolated glomeruli, was found to recognize the cell surface of endothelia facing the interstitial space, but was virtually absent from the surface of endothelial processes forming the air-blood barrier. Immunogold staining with I-10 demonstrated that the antigen was located at the avesicular membrane. During lung development, I-10 antigen was expressed in both fetal and postnatal lung alveolar endothelial cells. In the fetal lung, I-10 antigen was constantly distributed on the cell surface of endothelia forming alveolar capillaries along with Podocalyxin and ICAM2. I-10 antibody detected an 80-kD protein in both renal glomeruli and lung on immunoblot analysis. Conclusions : The characteristic localization of I-10 during lung development suggests that alveolar endothelial cells are structurally and functionally heterogenous and form macrodomains between the side exposed to air and the interstitial side in alveolar capillaries.
    View full abstract
    Download PDF (1754K)
  • Localization of pulmonary surfactant protein D in kidney.
    SATOSHI MANO, HIROYUKI OHI, MARIKO TAMANO, MACHIKO IKEGAMI, JEFFREY A. ...
    2006 Volume 52 Issue 1 Pages 84-93
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.84
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : Pulmonary surfactant protein D (SP-D) is one of the collectins that plays an important role in host defense in the lung by binding to a variety of microbial carbohydrates. It has been previously reported that the presence of SP-D and SP-D mRNA is not restricted to a subset of cells in the lung, but is also expressed on mucosal surfaces of other organs. The objectives of the present study were to determine the localization pattern of SP-D in the kidney and clarify the difference in SP-D expression between human and mouse kidneys. Methods : Renal biopsy tissues from patients with glomerulonephritides and normal human kidneys were stained immunohistochemically. The pulmonary and renal tissues of wild type, transgenic mice with over-expressed SP-D and transgenic mice with increased SP-D in the plasma were also stained. The transgenic mice which over-expressed fibroblast growth factor-7 (FGF-7) in the lung by doxycycline treatment showed an increase of SP-D in the plasma. Results : Consistent SP-D was observed in renal distal tubular epithelial cells (TEC), but seldom in glomeruli. The pattern and intensity of SP-D staining in normal human kidneys were similar to those in patients with glomerulonephritides. In contrast, SP-D was not detected in kidneys from normal and SP-D transgenic mice. In these conditional FGF-7 mice, SP-D staining was observed in glomeruli but was rarely observed in tubules. Conclusions : The present study demonstrated that occasionally observed SP-D in human glomeruli might be a result of increased plasma SP-D. SP-D was synthesized in renal distal urinary TEC in humans although it was not observed in the mouse kidney. This SP-D synthesis in TEC was not altered inpatients with glomerulonephritides. It appears that SP-D constantly present in the urinary tubules may play an important role in host defense in the kidney.
    View full abstract
    Download PDF (2430K)
  • Usability of the QOL questionnaire as an indicator for the therapeutic effect of chemotherapy for gastrointestinal cancer
    -using EORTC QLQ-C30-
    JUNKO KATO, AKIHITO NAGAHARA, KATSUYORI IIJIMA, NOBUKO SERIZAWA, TARO ...
    2006 Volume 52 Issue 1 Pages 94-102
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.94
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : Studies which utilize the quality of life (QOL) questionnaire as an indicator for the therapeutic effect of chemotherapy for gastrointestinal cancer are scarce. The purpose of this study was to evaluate whether QOL can be an indicator for the clinical benefit of chemotherapy, by analyzing changes in the QOL score of patients who underwent in-hospital chemotherapy for gastrointestinal cancer. Patients and Methods : 43 patients with gastrointestinal cancer who were planned to undergo in-hospital chemotherapy were studied. The QOL score was measured with a questionnaire, called the European Organization for Research Treatment of Cancer (EORTC) QLQ-C30 (ver 3.0, Japanese version), either before chemotherapy, or 2 weeks (2W) and 1 month (1M) after the initiation of chemotherapy. The clinical response to chemotherapy was evaluated with an imaging study 1 month after the initiation of chemotherapy, by which patients were divided into 3 groups. Changes in the QOL score between before and after chemotherapy were compared between groups. Measurement and Results : Response rates for the questionnaire were 95.1% at 2W, and 85.4 % at 1M. Clinical responses could be evaluated in 41 cases, of which the number of cases in each group was 14 in Partial Response (PR), 16 in No Change (NC), and 11 in Progressive Disease (PD). Global QOL scores improved at 1 month in all groups, suggesting chemotherapy would be effective in improving QOL. In group PD, 'physical', 'cognitive', and 'social' scores were significantly deteriorated, and 'role' scores had a tendency to deteriorate. In groups PR and NC, 'nausea and vomiting' scores were significantly deteriorated at 2W, and then im-proved at 1M. The 'sleep disturbance' and 'diarrhea' scores showed the same tendency. The 'pain' scores significantly improved in groups PR and NC. On the other hand, 'fatigue' scores remained high in all groups. Conclusions : In the evaluation of QOL, group NC showed improvement by chemotherapy, as well as group PR, in spite of there being no improvement in the clinical response. The measurement of QOL scores was thus suggested to be meaningful since it revealed a benefit of chemotherapy other than the tumor reduction effect.
    View full abstract
    Download PDF (1029K)
  • Psychiatric and mental support system on solitary islands
    -Questionnaire survey of 65 solitary islands in Japan-
    NOBUYUKI ARAI, MIKIO WATANABE, HEII ARAI, KIYOKO WATANABE, TAKU YOSIO
    2006 Volume 52 Issue 1 Pages 103-110
    Published: March 31, 2006
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.52.103
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Purpose : The aim was to clarify the conditions of psychiatric care, mental health, welfare activity, and the social resources of solitary islands. Based on the research, the ideal mental health care situation was also discussed. Object : Sixty five islands with more than 100 inhabitants were selected from all remote Japanese islands for this research. Method : A questionnaire survey was performed at 32 public health centers or health centers administrating the health care on each island. As for the questionnaire, effective answers were returned concerning eight items from all institutions (effective answer rate of 100%). Results : Fourteen islands have a population of more than 10,000 ; 27 have from 1,000 to 10,000 ; 24 have less than 1,000. Fourteen islands among the 65 selected have no daily transportation to and from the mainland. Thirteen islands with a population of more than 10,000 have medical institutions specialized in psychiatry. Twelve with a population of less than 1,000 have no medical institutions. The improvement of social resources is observed on islands where the staying period for a public health nurse is three to four years. Conclusion : It is necessary to establish a system of psychiatric medical care on solitary islands with no psychiatrist. Continuous support is essential from a public health nurse working with the local community. People with mental impairment will need more regional support in the future. Medical treatment provided by visiting staff along with cooperation from related organizations in the region are necessary on solitary islands.
    View full abstract
    Download PDF (1095K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top