Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 21, Issue 4
Displaying 1-18 of 18 articles from this issue
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Contents
  • Antinuclear Antibodies and Anti-DNA-Antibodies in Connective Tissue Diseases and the Other Miscellaneous Diseases
    HIROSHI HASHIMOTO, JIRO KOBAYASHI, HOSHIBUMI SUZUKI, YUZI UTAGAWA, YUK ...
    1975 Volume 21 Issue 4 Pages 379-389
    Published: December 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.379
    JOURNAL FREE ACCESS
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    Nine hundred and twenty-seven sera of patients with connective tissue diseases and general medical diseases were tested for antinuclear antibodies (ANA) and anti-DNA antibodies (A-DNA A) by the immunofluorescent antibody technique between April, 1974 and March, 1975. ANA and A-DNA A were detected most frequently in sera from patients with systemic lupus erythematosus (SLE). High titer of ANA (especially in peripheral staining pattern) and A-DNA A were also found most frequently in SLE sera. The frequency of Positive ANA and A-DNA A in discoid lupus erythematosus (DLE) was as much as in SLE patients, but the titers of ANA and A-DNA A in DLE wera lower than in SLE and peripheral staining pattern was not seen in patients with DLE. ANA and A-DNA A were also demonstrated in sera from patients with systemic scleroderma, Sjögren syndrome or Hashimoto's disease following SLE and DLE in frequency. In patients with other connective tissue diseases and the other miscellaneous diseases, ANA and A-DNA A in sera were occasionary detected. The detection was however less frequent and the titers were lower than in the above mentioned diseases.
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  • A Study of the Low Molecular Weight Urinary Protein
    Study on the Low Molecular Weight Protein in Urine
    JUTARO TADANO
    1975 Volume 21 Issue 4 Pages 390-407
    Published: December 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.390
    JOURNAL FREE ACCESS
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    Urinary protein was obtained from 60 patients suffering from chronic nephritis, nephrotic syndrome, diabetes mellitus or pyelonephritis. The protein was fractionated (Diaflo filter paper) to be devided into proteins of different molecular size, those of less than 50,000 of M.W. and those of 50,000-100,000. Each protein fraction was examined by immunoelectrophoresis, single radial immunodiffusion techniques and ultracentrifugation. The proteins below 50,000, in M.W. consisted of albumin, α1-glycoprotein, transferrin and Ig-G. The proteins ranging from 50,000 to 100,000 consisted of albumin, and α1-glycoproten. The major constituents of the γ-globulin fraction in human urine appeared to be one fifth to one sixth of the serum γ-globulin in size and has coefficient of approximately 2.0S. This low molecular weight fragment of γ-globulin was antigenically closely related to serum 7S-γ-globulin. Also, the molecule size of the albumin in urin was about half of the serum albumin and showed a coefficient of approximately 1.8S. The possibility that the fractions represent naturaly breakdown products of plasma proteins was discussed.
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  • [title in Japanese]
    MINORU KURIHARA, TSUGUHIKO IZUMI, KEIICHI MIYASAKA, HIKOO SHIRAKABE, A ...
    1975 Volume 21 Issue 4 Pages 408-414
    Published: December 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.408
    JOURNAL FREE ACCESS
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